Sara R Heras
Transposable elements in development and disease
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- Deeply greatful to the 22q11.2 Andalucia Association and to all the artists and attendencees who filled the theater yesterday in Granada!! Your support helps us to move forward in understanding 22q11 Deletion Syndrome. #22q #22q11 #GENYO#UGR
- Reposted by Sara R HerasTE x ZFP = Evolution! Writing this with Olga @orpsf.bsky.social & Didier @trono-lab.bsky.social was a major highlight of my 🇨🇭sabbatical. Such a treat! 🍫Hope you enjoy it as much as we enjoy piecing it together.
- Thrilled to share our new review in Current Opinion in Genetics & Development on TE driven innovation in gene regulation🤘. I am honored to be part of this with two major TE aficionados @cedricfeschotte.bsky.social and @trono-lab.bsky.social #TEsky #TEworldwide authors.elsevier.com/c/1m6MC,LqAZ...
- Reposted by Sara R HerasToday in @nature.com, we present our work leveraging functional genomics and human blastoids to uncover a human-specific mechanism in preimplantation development driven by the endogenous retrovirus HERVK. Special thanks to the reviewers whose comments improved our manuscript a lot! rdcu.be/eI3tD
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- 🚨 Our new preprint! In collaboration with @saramaciasrna.bsky.social and @heick.bsky.social labs 🧬 Control of retrotransposon-driven activation of the interferon response by the double-stranded RNA binding protein DGCR8 and its implications in 22q11.2 deletion syndrome. #22q11 #TEsky #RNAsky
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- Reposted by Sara R HerasThe nucleolus....large, rather boring organelle in the nucleus? No! Our review led by @bryonyleeke.bsky.social just out @dev-journal.bsky.social, highlighting new findings on nucleoli dynamics in development, intriguing roles in chromatin organisation & more. journals.biologists.com/dev/article/...
- Reposted by Sara R HerasI am thrilled to share our preprint where we take advantage of the unique opportunities offered by human blastoids to uncover a human-specific mechanism potentially playing a role in preimplantation 🧵. www.biorxiv.org/content/10.1...
- Reposted by Sara R HerasNew preprint from my group! Here we studied the contribution of a subset of human- and hominoid-specific transposons (SVA, LTR5HS) to the evolution of human craniofacial development. We specifically focussed on cranial neural crest (CNCC) formation and migration 1/n www.biorxiv.org/content/10.1...
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- Reposted by Sara R HerasWe will put forward a 500 million package for 2025-2027 to make Europe a magnet for researchers. As well as ambitious proposals for R&I in the next EU budget. We will also offer the best and brightest the right incentives to come to Europe ↓
- Reposted by Sara R Heras💥🥳 At long last, our latest paper is out! Gag proteins of endogenous retroviruses are required for zebrafish development www.pnas.org/doi/10.1073/... Led heroically by Sylvia Chang & @jonowells.bsky.social A study which has changed the way I think of #transposons! No less! 🧵 1/n
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- Our latest paper is out in NAR! 🥳 In collaboration with @saramaciasrna.bsky.social, we show DGCR8 haploinsufficiency disrupts pluripotency in hESC by affecting primate-specific miRNAs and TEs. Our findings highlight a co-evolved miRNA-TE network in primates. Read: academic.oup.com/nar/article-...
