William Garland
RNA decay, RNA sorting, transcriptional regulation
Aarhus University, Denmark 🇩🇰
- Pleased to be a small part of this collaboration with the @labconti.bsky.social now published at @narjournal.bsky.social. Here we combine structure prediction, biochem, cryo-EM, and IP-based approaches to explore connections between RNA quality control to transcription termination complexes.
- Reposted by William GarlandMessenger RNA is made in the nucleus before it is exported to the cytoplasm for translation. But how are only correctly made mRNAs chosen and remodeled in the nucleus for export? Our new paper investigates the nuclear events leading to human mRNA export. www.nature.com/articles/s41.... (1/4)
- Reposted by William GarlandThrilled to share that I’ll be joining @imbmainz.bsky.social in February 2026 to start my own group! We will explore new mechanisms in eukaryotic gene expression, leveraging ‘evolutionary play’ to uncover how regulation, repurposing, and hijacking shape RNA biology. PhD positions available!
- How do cells sort which RNAs to keep or destroy? New preprint from THJ, Brenneke and Plaschka labs shows that export and decay machineries (TREX2/PAXT) both recognise UAP56-bound RNAs. Whether they’re exported or degraded depends on where in the nucleus this happens. www.biorxiv.org/content/10.1...
- Registration and abstract submission is open for the 10th annual Danish RNA Society meeting 🇩🇰 - this year in Aarhus! Deadline is October 1st danish-rna-society.nemtilmeld.dk/8/
- Postdoc positions available in the THJ group in Aarhus, Denmark 🇩🇰 Please share around 🤝
- Postdoc positions available in the Heick Jensen lab in sunny Aarhus. Sorting of good and bad RNAs in mammalian nuclei. Please get in touch for further information and/or use the following link to apply: mbg.au.dk/en/news-and-...
- Happy to share our latest collaboration with the Cusack and Kadlec groups—now published in @natsmb.nature.com Combining cryo-EM, structure-guided mutants & proximity labeling, we show how PHAX, CBC, CRM1 & Ran‑GTP assemble the snRNA export complex Article: rdcu.be/euC4U News & Views: rdcu.be/euC5l
- Reposted by William GarlandPostdoc positions available in the Heick Jensen lab in sunny Aarhus. Sorting of good and bad RNAs in mammalian nuclei. Please get in touch for further information and/or use the following link to apply: mbg.au.dk/en/news-and-...
- We put together a spotlight for @cp-cellchembiol.bsky.social highlighting the recent work from @baluapuri.bsky.social and @adelmanlab.bsky.social published in @cp-cell.bsky.social. Here they show how a breakdown in nuclear RNA regulation sends ripples of stress throughout the cell.
- Spotlight: shorturl.at/E6je8 Article: shorturl.at/cJsDG
- Happy to have played a small part in this new preprint on DGCR8, retrotransposons, and IFN regulation. Nice collaboration with @saramaciasrna.bsky.social @herassr.bsky.social www.biorxiv.org/content/10.1...
- I've been wanting to try something like this. Awesome to see that it works 👍
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- Reposted by William GarlandPhD position vacant in the lab. Please spread the news. Study topic: Mammalian nuclear RNA production and turnover systems. Learn more about the lab here: www.mRNP.au.dk
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- New postdoc opportunity in the THJ lab! Please share to anyone interested in nuclear RNA biology @molbiolau.bsky.social mbg.au.dk/en/news-and-...
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- Resident colour blind member of the lab here 🙋♂️ Please make your figures friendly to us.
- Having a color-blind colleague is a good reminder that we need to be more careful when designing figures for scientific publication 🧪 My lab has found this page especially useful for selecting color palettes, used in combination with different symbols: thenode.biologists.com/data-visuali...
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- Is there a common contaminant database for proximity labelling-MS data? I see that the CRAPome has a section for proximity-dependent biotinylation but it is limited to human cells. I keep seeing the same nonsense proteins enriched in mTurbo-experiments and would love to know if this is common crap.
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- Cell lines are frozen, chrome tabs, spreadsheets and documents have been closed. All done for this year ✌️ Back in Derbyshire and busy making sausage rolls. It's been a productive year, but i'm in dire need of a break.
- 📢 Latest publication from the lab! We explore how cells manage the excess pA− RNAs generated by pervasive transcription. While the NEXT complex usually takes charge, in its absence, a network of tailing enzymes, export factors, and exonucleases steps in to modify and degrade these RNAs.
- Reposted by William GarlandDon't use red and green data lines/surfaces in the same panel please #chemsky. It can be difficult for some colorblind readers to differentiate them. I've accepted (in principle) 2 papers today, and both sets of authors were asked to remove red/green colour contrasts www.nature.com/articles/d41...
- New preprint! Great to be a part of this collaboration with the Cusack and Kadlec groups. Here we have uncovered the cryo-EM structure of the snRNA export complex, revealing how PHAX bridges CBC-bound RNA to CRM1-RanGTP, committing it to export. www.biorxiv.org/content/10.1...
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Check it out! The RNA Society 2025 Meeting Site is now live! Registration will open in January RNASociety Note the fabulous artwork by former EmoryBCDB student Dr. Carly Lancaster- make your plans now to join us in San Diego May 27-June 1, 2025 - Reposted by William GarlandVery excited that our paper describing a critical role for the PNUTS-PP1 phosphatase complex in transcription pause release is up online! This was a massive team effort with @edimitrova.bsky.social and the rest of the @robklose.bsky.social lab www.cell.com/molecular-ce... A short thread: (1/8)
- at://did:plc:6ibjqishaentuj6beryedrcg/app.bsky.graph.starterpack/3laloocfm3b2m
- Reposted by William GarlandLike ‘old Twitter’: The scientific community finds a new home on Bluesky www.science.org/content/arti...
- Latest from the lab, finally out in Molecular Cell. Here we show a physical and functional link between the Microprocessor and a variant NEXT complex. Together, these complexes degrade the 5' flanks of pre-miRNAs and other stem-loop-containing RNAs. doi.org/10.1016/j.mo...
- This is more of a reminder to myself to keep checking this.
- We put together a Molecular Cell preview for the latest papers from Wojtek Galej and Stefanie Jonas uncovering fascinating new details about the Integrator complex. Preview here: t.co/XGMwJwBOZa Articles here: t.co/9lx1z3bvE6 t.co/k0EqO54gXB
- Representing MBG🇩🇰 at #RNA24 We actually got some sun out of Edinburgh
- Lovely bonus from #RNA24 was winning a (very generous) poster prize ✌️
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- Do you want to make high quality, customisable genome browser figures? Check out the lab's new STAR Protocol paper doi.org/10.1016/j.xp...
- New preprint! How does PP2A-B55 recognise its substrates? Great to be a part of this project. www.biorxiv.org/content/10.1...
- Following on from HUSH2, there are now ChAHP and ChAHP2 complexes www.biorxiv.org/content/10.1...
- Reposted by William GarlandGreat to join this Bluesky community. For anyone interested in Transposable Elements, there is now a curated feed to all things TEsky, called TEworldwide: bsky.app/profile/did:... Include TEsky and/or TEworldwide in your posts to be featured!
- Nice HUSH review from the Helin group. www.nature.com/articles/s41...
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