stadtfeldlab
Stem cell biologist intrigued by the developmental functions of epigenome regulators and how they can go awry. Father of two beautiful kids. Former Tour de France contender (in his dreams). Opinions expressed here are my own.
https://www.stadtfeldlab.com
- Reposted by stadtfeldlabFinal version of our paper now published. elifesciences.org/articles/109... Take homes: CHD4/NuRD directly limits transcription factor residence times. At active enhancers this keeps them working efficiently. At inactive enhancers it prevents TFs from getting a foothold and causing activation. 1/n
- An insightful account of the review process at one of the most pre-eminent and influential journals in developmental and stem cell biology, by @jamesbriscoe.bsky.social and fellow @dev-journal.bsky.social editors. #Development #how-to-review #how-to-publish journals.biologists.com/dev/article/...
- Very interesting pre-print from Chris Baker's lab at JAX on the mechanistic link between trans-acting genetic variants and heterochromatin formation in mice. #heterochromatin #epigenetics #variants www.biorxiv.org/content/10.6...
- Very excited to announce that our collaborative study with @efapostolou29.bsky.social on the transcriptional mechanisms distinguishing totipotent and pluripotent cells has been published (link.springer.com/article/10.1...). #totipotency #ZGA #stemcells #epigenetics #chromatin
- 1. Driven by Kaushiki Chatterjee and @cmuyehara.bsky.social, with a shout-out to @kritikakasliwal.bsky.social, we show that clusters of co-expressed genes, which we call ECORDs (EHMT2-coordinately repressed domains), are a defining feature of mouse totipotent-like cells.
- 2.While gene clusters such as Zscan4 and Obox have previously been associated with zygotic genome activation (ZGA), we identify ~1,000 highly expressed transcripts in mouse two-cell-like cells (2CLCs) that originate from >90 ECORDs, some of which encompass more than 50 genes.
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View full thread5. ECORDs may provide useful models for dissecting long-range mechanisms of gene repression and activation and for identifying and characterizing novel regulators associated with totipotency.
- Interesting and elegant study by Simon Braun's group in Geneva into redundant and unique functions of specific SWI/SNF components during mouse neurodevelopment. www.biorxiv.org/content/10.6... #degrons #neurodevelopment #chromatin
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- Reposted by stadtfeldlabApplications are open for @dev-journal.bsky.social 2026 Pathway to Independence (PI) programme, supporting postdocs applying for group leader positions: Mentoring Profile raising Leadership training Network building Spread the word... www.biologists.com/grants/devel...
- Reposted by stadtfeldlabnew Lai lab paper @natsmb.nature.com! Dicer is specifically mutated in cancer, but we don't fully understand its molecular/reg impacts. with @danweihuangfu.bsky.social, we characterized the first knockin Dicer hotspot in hESCs, and found unexpected defects in miRNA biogenesis! 🧬 1/4 rdcu.be/eOc0q
- Reposted by stadtfeldlab📣 Paper alert! I am delighted that our paper exploring the impact of Neanderthal-derived variants on the activity of a disease-associated craniofacial enhancer has been published in Development today! journals.biologists.com/dev/article/...
- Reposted by stadtfeldlabDon't miss the chance to attend the annual virtual meeting on the advances in Nuclear Topology and 3D chromatin Architecture in Cancer organized by @janeskok @iannisaifantis1 @artsinyc and Melnick. The registration is FREE (see barcode) and the speaker lineup SPECTACULAR.
- Very insightful study by @distefanolab.bsky.social and @brumbaugh-lab.bsky.social labs, revealing RNA sequestration as a mechanism to restrict and direct cellular plasticity.
- 1/ Excited to share our new study with @brumbaugh-lab.bsky.social, out in @natbiotech.nature.com! P-bodies selectively sequester RNAs encoding cell fate regulators, often from the preceding developmental stage. Releasing these RNAs can drive changes in cell identity. 🧵 www.nature.com/articles/s41...
- Reposted by stadtfeldlabFor over 20 years, the mouse model organism has helped scientists uncover the biology behind human health and disease. But the mouse reference genomes still have missing pieces. The first collection of telomere-to-telomere mouse genomes are now available for two key mouse strains. 🧬💻
- Really impressive study on spinal cord development by @giulia-boezio.bsky.social and @jamesbriscoe.bsky.social. #neurodevelopment
- Hierarchical lineage architecture of human and avian spinal cord revealed by single-cell genomic barcoding biorxiv.org/content/10.1101/202…
- Reposted by stadtfeldlabHappy to see some of the work I’ve done during my PhD officially published! Check it out!
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- Reposted by stadtfeldlab“It actually doesn’t take much to be considered a difficult woman. That’s why there are so many of us.” ― Jane Goodall 💙 RIP to a real one. My childhood hero
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- Reposted by stadtfeldlabWe are hiring an Assistant Professor of Biochemistry and Biophysics at Weill Cornell Medicine. Come join our collaborative research environment with state-of-the-art facilities in NYC! Application review starts Oct 22. biochem.weill.cornell.edu/join-our-fac...
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- Reposted by stadtfeldlabSome proteins are primarily regulated by one mechanism: RNA abundance, translation, or clearance. The regulation of most proteins is dominated by different regulatory mechanisms across cell types. Gratifyingly, this complex regulation defines simple rules ⬇️ www.biorxiv.org/content/10.1...
- Reposted by stadtfeldlabalert to all H1B holders, please share: Trump just banned H-1B employees from reentering US unless employer pays $100,000 "fee". Proclamation applies to both new H-1B entrants and current H-1B employees who are abroad. set to take effect tmrw sun sept 21. please return if you can. i am so sorry. 😢
- Reposted by stadtfeldlabFunctional maps of a genomic locus reveal confinement of an enhancer by its target gene www.science.org/doi/10.1126/...
- Reposted by stadtfeldlabCongrats Maria! very well deserved... @mskcancercenter.bsky.social @mskeducation.bsky.social
- Maria Jasin, whose fundamental research on repair of damaged DNA in cells has transformed our understanding of cancers linked to inherited gene mutations, has been selected as the 2025 recipient of the Pearl Meister Greengard Prize. Congratulations! #WomenInScience
- Very interesting pre-print by @moritz-negwer.mstdn.science.ap.brid.gy and @naelnadifkasri-lab.bsky.social using a new clearing technology to capture the abundance of specific neuron populations in a mouse model of ASD. #autism #neurodevelopment #Kleefstra www.biorxiv.org/content/10.1...
- Beautiful study, beautiful creatures.
- Hydra body axis balance: a fight between two transcription factors This Research Highlight showcases the work from Jaroslav Ferenc, Marylène Bonvin, Panagiotis Papasaikas, Jacqueline Ferralli, Clara Nuninger and Charisios D. Tsiairis: journals.biologists.com/dev/article/...
- Reposted by stadtfeldlab1/7 Really happy to see my PhD work published in ✨Developmental Cell✨ today! We find human endoderm is specified by two developmental trajectories 🔀, and the choice between alternate routes is dictated by the combinatorial BMP4/Activin signalling. www.cell.com/developmenta...
- Reposted by stadtfeldlabWe’re pleased to exclusively announce the longlist for the 2025 National Book Awards for Young People’s Literature. See it here.
- Just read this paper by @tesarlab.bsky.social lab and collaborators on the role of SOX6 in oligodendrocytes and found it highly insightful and stimulating. www.cell.com/cell/fulltex... #development #transcription #enhancers
- Reposted by stadtfeldlab🚨🚨🚨 Please repost We are looking for postdocs to join our lab at NIH. Apply: www.nichd.nih.gov/research/atNICHD/Investigators/rocha/apply Learn more about training at NIH : www.training.nih.gov/research-tra...
- Reposted by stadtfeldlab🧵 An open letter to the US Open and USTA: Trump will attend the #USOpen as a guest of ROLEX. Yesterday, Trump declared 'WAR' on Chicago. The USTA has called for media censorship of dissent against Trump today. I played NCAA tennis many years ago and still play. Today I resign my #USTA membership.
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- Reposted by stadtfeldlab“A mouse organoid platform for modeling cerebral cortex development and cis-regulatory evolution in vitro” Nice work by @danielmedinacano.bsky.social @tvierbuchen.bsky.social @em6wong.bsky.social @stadtfeldlab.bsky.social 🧪🧫🧠 www.cell.com/developmenta...
- Reposted by stadtfeldlab… my work with the Stadtfeld lab @stadtfeldlab.bsky.social on the role of OTX2 during definitive endoderm and anterior gut development is also out (tinyurl.com/3unwh3eb)! Thank you so much to all collaborators, and I’ll be more than happy to discuss these protocols with anyone interested!
- Reposted by stadtfeldlabNew paper from our lab! We found that LINE-1 transposons contribute to early human brain development. Funded by @asapresearch.parkinsonsroadmap.org www.cell.com/cell-genomic...
- Reposted by stadtfeldlabExcited to share our recent viewpoint with @storerlab.bsky.social led by Kirsten Sadler, on epigenetic mechanisms of regenerative resilience. Ageing versus developmental silencing: Answers from the epigenome - Sadler - The FEBS Journal - febs.onlinelibrary.wiley.com/doi/10.1111/...
- Excited to share our new study in @cp-devcell.bsky.social dissecting how the brain-associated transcription factor OTX2 drives anteriorization of the mammalian gut by enhancer remodeling using stem cell-based models. #development #enhancers #patterning #stemcells www.cell.com/developmenta...
- Led by Ly-sha Ee and @danielmedinacano.bsky.social, with thanks to our collaborators @tvierbuchen.bsky.social, Alex Polyzos, @efapostolou29.bsky.social and Kat Hanjantonakis.
- Reposted by stadtfeldlabAnother paper bluetorial! Today: how does the spatial location of genes influence their function? (1/n) www.nature.com/articles/s41...
- Reposted by stadtfeldlabOnline Now: Distinct specificity and functions of PRC2 subcomplexes in human stem cells and cardiac differentiation Online now:
- Reposted by stadtfeldlabExcited to see this published with additional data following our preprint a while back. Cool combination (in our biased view) of controlled TF expression and machine learning to decode chromatin sensitivity. www.sciencedirect.com/science/arti....
- Reposted by stadtfeldlabTo have this paper appear the same day that RFK Jr is canceling all mRNA vaccine funding is further indication that irony is not dead, even though we might all be soon.
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- Reposted by stadtfeldlab🚴 From @crg.eu to the roads of Europe, our PhD student Fabio and the #LongTREC team are combining cutting-edge science with sustainable travel. Now in London, and heading next to Cambridge! #LongCyclingForScience
- Reposted by stadtfeldlabOur latest work, just out now at JCI Insight on iPSC modeling of pulmonary fibrosis. The latest chapter in the Kotton-Beers collaboration! Congrats to co-first authors Drs. Rodriguez and Alysandratos for leading the way! insight.jci.org/articles/vie...
- There's nothing quite like a cat sleeping.
- Exciting new work by Miriam Gordillo and @toddevans24.bsky.social on signal-dependent lineage-promoting TF functions during mammalian gastrulation. www.biorxiv.org/content/10.1... #development #gastrulation #stemcells
- Elegant new work from the Hochedlinger lab describing an essential balancing act of bivalent chromatin during blood cell formation. www.cell.com/cell/abstrac... #epigenetics #hematopoiesis
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- Reposted by stadtfeldlabNew study published in Stem Cell Reports from @mskcancercenter.bsky.social identifies two enhancers essential for regulating #NANOG expression in human embryonic #stemcells ow.ly/JaI450W1bVa @isscr.org @cellpress.bsky.social @gairdnerawards.bsky.social @sickkidsvs.bsky.social
- Reposted by stadtfeldlab#FragileNucleosome seminar happening tomorrow!
- 🔔Upcoming Wednesday, June 4th! Join us for another #FragileNucleosome series! Two amazing talks by @1995dana.bsky.social & @chrishsiung.bsky.social! If you haven’t jooned for any of 2025 talks, register here: us06web.zoom.us/webinar/regi...
- Intriguing new pre-print from the @stefanschoenfelder.bsky.social lab on unusual human enhancers. www.biorxiv.org/content/10.1... #pluripotency #epigenetics #transcription
- Reposted by stadtfeldlabRegister now to attend our #DevPres webinar next week, featuring the winners of the @bsdb.bsky.social poster prize, @shifaant.bsky.social and @giuliapaci.bsky.social, and chaired by Abigail Tucker. 4 June at 15:00 BST us02web.zoom.us/webinar/regi...
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- Time to rub some noses. www.nytimes.com/2025/05/27/o...
- Very interesting talks from @trompoukilab.bsky.social and @chribue.bsky.social in the next couple of weeks at the Cambridge Cancer Chromatin and Epigenetics Club www.haem.cam.ac.uk/events/ccec/...!
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- Beautiful and important work by the group of @yichenglong.bsky.social at Weill Cornell on the molecular determinants that direct epigenetic repression by Polycomb complexes. www.biorxiv.org/content/10.1... #epigenetics #stemcells #cardiogenesis #polycomb
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- Reposted by stadtfeldlabGave a talk at my parents’ retirement community to describe how science is done, and what is at stake. There was a ton of interest, and anyone can do this. Get the word out about how science affects everyone. I’m happy to share slides with anyone who asks- just get in touch! youtu.be/BY_SFgi-Cig
- This interview with @sarawickstrom.bsky.social is an excellent and inspiring read.
- Hear from stem cell biologist Sarah A. Wickstrom www.cell.com/news-do/50-i... @sarawickstrom.bsky.social
- Very insightful summary of currently available approaches to model peri-implantation stages of human embryogenesis with stem cells. #development #embryogenesis #gastrulation.
- Stem cell-based models of early human development Read this Development at a Glance Article by Lizhong Liu @liliulab.bsky.social and Jun Wu @jun-wu-lab.bsky.social: journals.biologists.com/dev/article/...
- Reposted by stadtfeldlabBorn Apr 22, 1909, Rita Levi-Montalcini defied war and prejudice to unlock a key to the brain: the nerve growth factor. Nobel Prize in 1986, her legacy empowers generations of scientists and lights the path in the fight against neurodegenerative disease. #RitaLevi #RitaLeviMontalcini 🧪
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- Reposted by stadtfeldlabThe 2025 European Summer School in Stem Cell Biology and Regenerative Medicine will take place 12-19 Sept 2025, on the beautiful Greek island of Spetses. Keep an eye on our website www.stemcellsummerschool.org for updates, or give us a follow 😀 Deadline for applications: 30th May 2025
- Thank you for your inspiration and the many insights into the beautiful world of mammalian development, Alex Joyner!! bit.ly/4iSZoZ9 #science #devbio #genetics
- Interesting pre-print from Andrea Riccio's group describing a large population bioinformatics approach to discover modifiers of DNA methylation changes at imprinted genes. www.biorxiv.org/content/10.1...
- Reposted by stadtfeldlabEpigenetics Update - Three-dimensional regulatory hubs support oncogenic programs in glioblastoma bit.ly/4iDk8Ec Howard A. Fine and Effie Apostolou (Weill Cornell Medicine) reporting in Mol Cell #Epigenetics #GBM --- High-resolution insights without cell sorting at epigenometech.com
