Ollie Inge
Postdoctoral Fellow - Morris Lab @ Brigham and Women’s / Harvard Medical School. Prev. PhD @santoslab at The Francis Crick Institute. Single-cell dynamics, signalling and fate specification during development.
- Reposted by Ollie IngeNew lab preprint! We find that Wee1 phosphorylates Cdh1(FZR1) and suppresses APC/C(Cdh1) activity to promote S-phase entry A fantastic team effort from the combined forces of @lavuillemenot.bsky.social, Lucas Morales, Calin-Mihai Dragoi & Beth Pennycook www.biorxiv.org/cgi/content/...
- Reposted by Ollie IngeSo exciting to see this in print! Ever wondered how embryonic cells know what (fate) to become during early development? In particular when they might see different signaling cues? We investigated this! And a lovely cover from Zoe Ruiz and @oliveringe.bsky.social! www.cell.com/developmenta...
- Thank you to @cp-devcell.bsky.social for selecting our story to feature on the cover of today’s issue of Developmental Cell! Thank you to Zoë Ruiz for the wonderful art work! Read more here: www.cell.com/developmenta...
- “This image symbolizes lineage convergence and specification during early human development. The maze represents the diverse trajectories and histories of endoderm cells have before converging to a shared identity.”
- Reposted by Ollie IngeThrilled to share my main postdoc work with @jamesbriscoe.bsky.social We used genomic barcoding + scRNAseq in chick & human embryos to reveal a lineage architecture that reshapes how we understand neural tube development & cell fate decisions 🧵👇 www.biorxiv.org/content/10.1...
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- Reposted by Ollie IngeVery saddened to hear of John Gurdon’s passing. I’ve been lucky enough to interact with him at multiple points through my career - from undergrad lectures, through his position as former Chair of @biologists.bsky.social’s Board of Directors, and as an author at @dev-journal.bsky.social.
- Reposted by Ollie IngeJust over one week until this opportunity closes! If you’re an ambitious computational scientist looking for a Postdoc position, apply now
- @mariasecrier.bsky.social & I are looking for an enthusiastic & excellent data scientist for a 4-year postdoc to understand cell cycle dysregulation in cancer. Deadline 15th October. Get in touch if you have any questions. Please repost! More details: www.imperial.ac.uk/jobs/search-...
- Reposted by Ollie Inge🚀 Excited to share scPortrait! Led by Sophia Mädler & Niklas Schmacke w/ the Mann lab — a new @scverse tool for standardized single-cell image data. Enables ML-ready extraction, >1B cell processing, cross-omics, & cancer macrophage insights. 🔗 www.biorxiv.org/content/10.1...
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- Reposted by Ollie Inge@mariasecrier.bsky.social & I are looking for an enthusiastic & excellent data scientist for a 4-year postdoc to understand cell cycle dysregulation in cancer. Deadline 15th October. Get in touch if you have any questions. Please repost! More details: www.imperial.ac.uk/jobs/search-...
- Reposted by Ollie IngeGenes are not On/Off switches. In a new preprint we show that HDAC3 is key to establish correct transcriptional dose in development. Gr8 work from N. Stamidis @ucph.bsky.social and collab. @jamiehackett.bsky.social @gregersenlab.bsky.social . Huge thx to all authors! www.biorxiv.org/content/10.1...
- Reposted by Ollie IngeIt was fun to look back over a decade of 'From Stem Cells to Human Development' meetings at @dev-journal.bsky.social. This is one of the projects I most enjoyed during my time at the journal - and I really hope we helped to catalyse and support a community... journals.biologists.com/dev/article/...
- Reposted by Ollie IngeFresh from the press💥 We asked what happens when you evolve gene regulatory networks computationally at scale. Do general principles of GRN evolution jump out? Is the process predictable? Read on to find out @prxlife.bsky.social @crick.ac.uk @ucl-ipls.bsky.social 👉 journals.aps.org/prxlife/abst...
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- 1/3 After 6+ years at @crick.ac.uk I split my last cells and hung up my lab coat! Thank you to the brilliant community from fellow PhDs/Postdocs, LOAs, STPs, academic training team and to all past/present @santoslab.bsky.social members. My Crick journey would not have been the same without you all!
- 2/3 Special thank you to my supervisor Silvia, her continued mentorship and support throughout the PhD and onto my next step. 🙏
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- 1/7 Really happy to see my PhD work published in ✨Developmental Cell✨ today! We find human endoderm is specified by two developmental trajectories 🔀, and the choice between alternate routes is dictated by the combinatorial BMP4/Activin signalling. www.cell.com/developmenta...
- 2/7 🔢 Pairing quantitative measurements of cell fate proportions in response to signalling combinations and mathematical modelling we found that hESC differentiation was best captured by cell state transitions including multiple paths to terminal fates.
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- Reposted by Ollie IngeThrilled to bits to see our latest work online in Dev Cell! 🥳 We wanted to know how cells build functional organs with precision🫀🫁📏 Here we show how coupling of cell shape and organ function fine tunes the form and contractile power of the developing #zebrafish heart 1/n tinyurl.com/cell-stretch
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- Reposted by Ollie IngeNew preprint! We solve a mystery you didn't know existed. Mitotic cells lack new transcription but require ongoing translation. Interphase mRNA half life is only 2-4 hrs. So how do cells arrest in mitosis for hours without depleting their transcriptomes? www.biorxiv.org/content/10.1...
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- Was so lovely to be part of this work with @borzogharibi.bsky.social @santoslab.bsky.social ! Read below to learn more about this cool new model of extra-embryonic development.
