Santos lab
Quantitative stem cell biologist and group leader @TheCrick Institute. Cell decision-making. Cell fate and cell division. @Stanford, @EMBL alumna. ENTP. Mum. Diver.
- Reposted by Santos labWe wrote a protocol article detailing induction of dormancy in stem cells, embryos, and blastoids. We hope that it is useful to the community. As usual fun to work with @nicolasrivron.bsky.social, Heidar and Dhanur.
- Reposted by Santos labThis is such hard news to process. Such an amazing scientist and inspiration for so many of us. www.embl.org/news/embl-an...
- Reposted by Santos labLovely little pre-Christmas present to see this out @natcellbio.nature.com! Some 🔥 new results in here since the biorvix incl (1) a new RARE-GFP reporter ✳️🙌, (2) additional NMP quantification 🔢, (3) no neural tube patterning on RA inhibition 🙅 etc. Enjoy! 😍 www.nature.com/articles/s41...
- Reposted by Santos labGood to see the peer reviewed version of this published A chemo-optogenetic system for spatiotemporal control of gene expression We use it to: - Reconstruct SHH mediated neural tube patterning in vitro - Measure extracellular half-life of Shh www.cell.com/developmenta...
- Reposted by Santos labWhat is psychosis and how can we treat it? Crick group leader @kathaschmack.bsky.social explains how her lab is working to uncover new ways to treat psychosis by finding its biological roots. youtu.be/EUb3_5ecatU
- Reposted by Santos labWe are hiring for a web developer position, ideally with some experience in bioinformatics. This position is aimed at helping us turn our research in human genetics into useful tools. A background in either bioinformatics or web development is required. jobs.ethz.ch/job/view/JOP...
- Reposted by Santos labGreat to see this published: Fitting dynamical landscape models to single-cell data, creating interpretable maps of cell decision making & developmental logic Applied to neural tube patterning, we show how morphogen signals reshape landscapes and drive fate decisions www.pnas.org/doi/10.1073/...
- Reposted by Santos lab📣 We are moving to Barcelona to join the amazing @crg.eu and explore how centrosomes & cilia work, evolve & respond to the environment. We are looking for PhD students www.crg.eu/en/content/t... Postdocs gimm.pt/jobs/postdoc... Other calls to open, also for an experienced lab manager. Get in touch!
- Reposted by Santos labApplications are open for @dev-journal.bsky.social 2026 Pathway to Independence (PI) programme, supporting postdocs applying for group leader positions: Mentoring Profile raising Leadership training Network building Spread the word... www.biologists.com/grants/devel...
- So exciting to see this in print! Ever wondered how embryonic cells know what (fate) to become during early development? In particular when they might see different signaling cues? We investigated this! And a lovely cover from Zoe Ruiz and @oliveringe.bsky.social! www.cell.com/developmenta...
- Reposted by Santos labThe new issue @cp-devcell.bsky.social brings the final form of our opossum heterochrony work www.cell.com/developmenta... And it also brings two great papers from @oliveringe.bsky.social @santoslab.bsky.social and @tobyandrews.bsky.social @rashmi-priya.bsky.social 🙌 great #DevBio from @crick.ac.uk
- Reposted by Santos labEmergence and Self-organisation across biological scales! I hope you are ready for next year conference! It will be an incredible event April 20-22 2026. The first of many #LakeConference organised by @ehannezo.bsky.social @alleninstitute.org and James Sharpe @embl.org
- #CellBio community, this one is for you! Applications are open for the #LakeConference on Modeling Life from Cells to Tissues – co-hosted with Circuit Neuroscience Basel! 📆 April 20-22, 2026 📍 Seattle, USA 🔬 All career stages welcomed. Apply to attend by 12/12: alleninstitute.org/events/aics-...
- Reposted by Santos labCheck out that spindle 🤩🔥 At 63C, most eukaryotic cells would be busy exploding noisily, forget even trying to divide. The microbial universe never ceases to astound 😍 Thanks for letting us be a tiny part of this! #ExpandThemAll
- Reposted by Santos labTen days left to apply to be a @crick.ac.uk Early Career Group Leader Closing date 27th November www.crick.ac.uk/careers-stud...
- The @crick.ac.uk is recruiting Early Career Group Leaders - Lab set-up, research costs, salaries for up to 5 researchers - Support for up to 12 years - Access to our core facilities - Competitive salary - Fantastic colleagues - All areas of biology Deadline 27 Nov www.crick.ac.uk/careers-stud...
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- We had a blast tonight at the ‘Curious about the Crick’ event showcasing the science in our lab. Lots of enthusiasm and so many interesting questions. Was awesome to share this with my wonderful lab from brainstorming to communicating the science we love. Thank you to @crick.ac.uk for having us
- The Crick PhD program is open and there are amazing projects including our lab's. I couldn't recommend enough joining the program: brilliant community and excellent training and mentorship. Specific project with us will be decided based on your interests. Apply here www.crick.ac.uk/careers-stud...
- Reposted by Santos labnew preprint: Ubiquitin is a protein modification linked with degradation but known to regulate other functions. Over 100k ubiquitination sites have been discovered and here we (@julianvangerwen.bsky.social + others) try to prioritize those most critical to the cell www.biorxiv.org/content/10.1...
- Reposted by Santos labMany of you know, we lost Béla Novák this year. John Tyson, Francis Barr & I tried to capture his wonderful character & great mind so that those that didn't know him can see what a fantastic person he was. Thanks to @jcellsci.bsky.social for publishing. journals.biologists.com/jcs/article/...
- Reposted by Santos labOpening my lab @crick.ac.uk two years ago has been a privilege, a delight and ultimately the most transformative experience of my sciencific career. Discovery science without boundaries, inspiring colleagues and infinite possibilities. Come join us!
- We're now recruiting early career group leaders at the Crick to lead ambitious research programmes and explore bold scientific questions. Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research. Apply now ➡️ www.crick.ac.uk/careers-stud...
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- Reposted by Santos labVery sad news, John Gurdon has died. A developmental biologist's developmental biologist, Nobel prize winner His work is the foundation of much of today's dev & stem cell bio. An inspiration to many, including me. Always asking questions & wanting the answers www.magd.cam.ac.uk/news/profess...
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- Congratulations Isabela from the Dev Bio MSc program @imperialcollegeldn.bsky.social for finishing successfully your viva! Was an absolute pleasure to train you and have you in the lab! Beautiful work on cell cycle and fate and never ending enthusiasm! Best of luck with your next adventure!
- Reposted by Santos labEEE meeting is BACK! Early Embryogenesis & Epigenetics conference in Berlin 02/2026. Checkout great program and over 12 slots for (not so) short talks for submitted abstracts!. Early registration now open - w.molgen.mpg.de/embryo2026
- Farewell dinner for @oliveringe.bsky.social with our wonderful Santos lab family. Ollie was our 1st Crick PhD student! Lots to celebrate and many fun memories. We are so grateful to have had Ollie in the lab and cannot wait to see what’s next for him in the Morris lab at Harvard! Best of luck,Ollie!
- Reposted by Santos labThe goal of a PhD is not to learn some facts or read a few papers or learn a bunch of techniques. The goal of a PhD is to learn independence, problem solving, how to finish things you start, resilience, & gain the ability to adapt & think creatively. Learning these things is hard.
- Reposted by Santos labIt was fun to look back over a decade of 'From Stem Cells to Human Development' meetings at @dev-journal.bsky.social. This is one of the projects I most enjoyed during my time at the journal - and I really hope we helped to catalyse and support a community... journals.biologists.com/dev/article/...
- Reposted by Santos labI could not have summarised our article better than @katherine-brown.bsky.social!! Please see below and keep reading if you are interested in human embryo research policy. It was such a pleasure to write this piece with Susana, Mina and Catello.
- Just out in @dev-journal.bsky.social - important discussion on the availability of human embryos for research. Thanks @marta-shahbazi.bsky.social and co-authors for contributing this: journals.biologists.com/dev/article/...
- This is Mirjam, Santos Lab’ PhD student presenting her work at the EMBL meeting on Developmental Metabolism 🫶. Conference was incredible and Mirjam had an amazing time!
- Reposted by Santos lab2/3 Special thank you to my supervisor Silvia, her continued mentorship and support throughout the PhD and onto my next step. 🙏
- Reposted by Santos lab1/3 After 6+ years at @crick.ac.uk I split my last cells and hung up my lab coat! Thank you to the brilliant community from fellow PhDs/Postdocs, LOAs, STPs, academic training team and to all past/present @santoslab.bsky.social members. My Crick journey would not have been the same without you all!
- Our ✨ latest work ✨ is out today! Led by our incredibly talented PhD student @oliveringe.bsky.social and with @jamesbriscoe.bsky.social and many @crick.ac.uk friends and collaborators. Very grateful to all involved, and excited about this story. check out Ollie’s post www.cell.com/developmenta...
- 1/7 Really happy to see my PhD work published in ✨Developmental Cell✨ today! We find human endoderm is specified by two developmental trajectories 🔀, and the choice between alternate routes is dictated by the combinatorial BMP4/Activin signalling. www.cell.com/developmenta...
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- Reposted by Santos lab🤩 Very excited to share our new work! We have derived euploid and aneuploid trophoblast organoids and extra-embryonic mesoderm cell lines from early human embryos. In doing so, we have characterised the tissue requirements for their specification. If you want to know more, continue reading….
- Reposted by Santos labWant to acquire #ExM images like this and help us understand the true extent of cytoskeletal diversity across the tree of life? This position might be for you! embl.wd103.myworkdayjobs.com/en-US/EMBL/j... With @dudinlab.bsky.social @embl.org @biology-unige.bsky.social @moorefound.bsky.social
- Welcome Cayley to the Santos Lab! Cayley is going to spend a year in the lab as part of her undergraduate degree! Cayley is interested in the interplay between cell cycle and fate
- Reposted by Santos labA Summer reading recommendation: new primer in @dev-journal.bsky.social explains how dynamical systems theory unlocks the logic of developmental patterning Everything from bistable switches & oscillators to phase portraits & more with Python code to explore journals.biologists.com/dev/article/...
- Reposted by Santos labEMBL Cell Biology and Biophysics department is searching for a new director. A major position to lead this field in Europe and beyond. embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
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- Reposted by Santos labPlease pread the word. We have just launched the Hubrecht International PhD Program (HIPP). Are you looking for a PhD position in molecular and developmental biology or related subject in an international, very supportive and collaborative environment? Then apply to the HIPP!! 👇
- 🧬 Looking for a PhD position in molecular or developmental biology? 🔬 ✉️ The Hubrecht Institute now has its very own PhD program! Applications are open and will be accepted until September 15th. Read more here 👉 www.hubrecht.eu/hipp/
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- Reposted by Santos lab🚨Symposium alert! 🚨 Next edition of our biennial stem cell symposium is 4th Dec 2025 - focus on metabolism and development. Sponsored by @bsdb.bsky.social. Great lineup of speakers, hosted @mrc-lms.bsky.social in London. Registration is open. www.symposia.org.uk/courses/stem...
- A big mission of @crick.ac.uk is to bring Science to everyone. Thank you chris agathangelou and Clare green for your help with making our latest work on a new stem cell model of the human amnion accessible to all 🙏
- A little interview with my postdoctoral advisor Jim Ferrell about his life. Timely as we prepare to celebrate his 70th birthday with a Ferrell -Lab-family symposium youtu.be/ov9YMkmzUAg?...
- Always lovely to be in Vienna - wonderful visit yesterday at ISTA. Grateful to everybody who met me and shared their work - it is really a privilege to have a day of amazing science hearing what people are passionate about and learn new things. Thank you so much @kichevalab.bsky.social for having me
- Reposted by Santos labNature research paper: Spatiotemporal orchestration of mitosis by cyclin-dependent kinase go.nature.com/444lRhe
- Reposted by Santos lab🥰 Self-supervised, label-free 3D cell imaging is here Congrats to Cyril on this very cool first, first author publication 🏆! This started when he was a bachelor's student (and he's now completing his masters!). And many thanks to my other awesome co-authors🙏 elifesciences.org/articles/99848
- Reposted by Santos lab⚠️ I am really excited to share the work of Anastasios Balaskas, an excellent PhD candidate in the lab, with the wider world. Tasos made a significant advance: generating a stem cell-based embryo model that contains both posterior and anterior neural tissues of the late-stage gastrulating embryo.
- If you are going to sunny California to the Salk Cell Cycle meeting don't miss @eliascopin.bsky.social's talk! Elias is our cell cycle and cell fate enthusiast and his presenting new exciting results. Come and say hi! I wish i was there too - it is going to be a fantastic meeting!!
- Welcome to the lab Isabela De Almeida Rossi, masters student from Reproductive and Development Biology MSc at Imperial College London. Isabela is interested in the interplay between cell cycle and cell fate and is using 2D and 3D stem cell models of early human development in her project.
- Santos Lab barbecue at Borzo’s! Wonderful food 😍 and company #qscblab
- Unraveling mitochondrial influence on mammalian pluripotency via enforced mitophagy: Cell www.cell.com/cell/fulltex...
- Reposted by Santos labNew work on dynamics of morphogen signaling: Cells decode BMP gradient via temporal integration of signaling level, not instantaneous thresholds. While GRN gates response to provide additional spatial input Morphogen signalling dynamics + GRN for tissue patterning www.biorxiv.org/content/10.1...
- Reposted by Santos lab📣 New review! Dynamical systems and low-dimensional geometric structures in phase space help rationalize how embryos develop form and function, from large datasets. We focus on morphogenesis, cell differentiation, and their interconnection. @alex-plum.bsky.social sciencedirect.com/science/arti...
- Big welcome to new postdoc Javier de Haro Arbona @fjavierdha.bsky.social, developmental biologist at heart and coming from Sarah Bray’s lab in Cambridge! Javier has been very interested in how signals are decoded and fate decisions encoded. We are lucky to have him join our lab!
- Big welcome to the lab to physicist turned quantitative biologist Beth Westbrook @bethwestbrook.bsky.social! Beth did her PhD in Jonathan Chubb’s lab at UCL and has been very interested in how fate transitions are coordinated. We are lucky she joined our lab for her postdoc!
- Thank you very much @stemcellpodcast.com for highlighting our work (24:00-32:00) @crick.ac.uk
- Drs. Borzo Gharibi, Silvia Santos, and a team at @crick.ac.uk generated an ESC-derived 3D model of the post-gastrulation #amnion. 📄 @cellpress.bsky.social - bit.ly/45bJs0c 🎤 bit.ly/4kE4eKf
- Reposted by Santos labWomen make up only 16% of corresponding authors who submit to Nature, a new Springer Nature analysis revealed. This is not enough - there are 30-40% #womeninSTEM We want to change it, through targeted editorial policies & outreach. But change will take everyone! 🧪 www.nature.com/articles/d41...
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- What a privilege to hear talks celebrating the career and impact our colleague François Guillemot had in his trainees, collaborators and colleagues @crick.ac.uk A much deserved celebration. Congratulations Francois and Siew-Lan and thank you for being awesome (+ awesome neighbours) Happy retirement
