Elegant new work from the Hochedlinger lab describing an essential balancing act of bivalent chromatin during blood cell formation.
www.cell.com/cell/abstrac... #epigenetics #hematopoiesis
Bivalent chromatin instructs lineage specification during hematopoiesis
Yagi et al. show that, unexpectedly, H3K4 methylation is dispensable for hematopoietic
stem cell maintenance but essential for progenitor cell maturation into all blood
cell types by opposing H3K27 me...
