Antoine Molaro
Group Leader @GReD_Clermont
Chargé de Recherche @INSERM
Evolutionary biologist studying chromatin also drummer.
Jazz and epistemology. he/his
igred.fr/en/team/evolutionar…
- Reposted by Antoine MolaroTerrific paper on a new chromosomal compartment where extensive loop extrusion isolates domains from other such domains
- How do compartmentalization & loop extrusion organize eukaryotic genomes beyond classical model organisms? Hi-C analysis of silkworm chromosomes by Drinnenberg, Muller, Mirny et al reveals new combination of these mechanisms, and a new, secluded “S” compartment link.springer.com/article/10.1...
- Reposted by Antoine MolaroDuring germline epigenetic reprogramming, Polycomb must be restricted in the gametes to ensure proper genome regulation in the fertilized embryo. 2 must-read papers assess what happens when Ezhip (Polycomb antagonist) is lost. They come to highly similar conclusions and should be read in tandem 1/4
- Reposted by Antoine MolaroDoes anyone have experience with counter-selectable markers for Gram-negative bacteria besides sacB? It's been working poorly in our hands.
- Reposted by Antoine Molaro❗⏰ Please remember that the deadline for submitting your applications for abstracts and awards for SMBE 2026 ends today. Join us in Copenhagen from June 28 to July 2 for a fantastic meeting! #SMBE2026
- Abstract submission & Award applications for SMBE 2026 are now open! Submit your research and apply for SMBE awards via the submission portal. 📝 Read more & submit here: smbe2026.org/abstracts And symposium selection is now finalized! 👉 See all accepted symposia: smbe2026.org/programme #SMBE2026
- Reposted by Antoine MolaroThis just in. So honored and grateful...
- We're proud to join the Vilcek Foundation in recognizing HHMI Investigator Karolin Luger, whose dedication & groundbreaking nucleosome research has led to the development of innovative new drug treatments, including cancer medicines. hhmi.news/49VciEd @vilcekfoundation.bsky.social
- Reposted by Antoine MolaroNicole King will give a seminar in College de France on the 10th of february at 11.30, telling us about the secret lives of choanoflagellates. Don’t hesitate to join!
- Reposted by Antoine MolaroOne protein. One pathway. A whole germline fate. New paper from my postdoc @mpi-bio-fml.bsky.social out in PNAS: Germline fate determination by a single ARGONAUTE protein in Ectocarpus www.pnas.org/doi/10.1073/...
- Reposted by Antoine MolaroHello! Does anyone know of any 'seed' type grants/awards within Australia (or potentially abroad if they fund research internationally) that contribute toward research only costs (not salary)??
- Reposted by Antoine MolaroMeiotic drive has long been considered as a genetic curiosity. Genomic "footprints" suggest otherwise. Check out our new review doi.org/10.1093/molb..., a cross-taxa synthesis arguing that recurrent drive is a pervasive and underappreciated force in genome evolution.
- Reposted by Antoine MolaroThis will be a great meeting on host adaptation to viral infections. Abstract deadline approaching!
- 📣 *Abstract submission by January 31st* "Host adaptations to viral infections” International Meeting May 10th-13th 2026 @cnrs.fr Station Biologique Roscoff, Brittany, France Register & Join us +amazing international speakers! #CNRS @cnrsbiologie.bsky.social #IRP www.insb.cnrs.fr/fr/evenement...
- Reposted by Antoine Molaro🥁 #FragileNucleosome is back on Jan 28! We are very excited to host @au-ho-yu.bsky.social and @gcloner.bsky.social as our first speakers of 2026! 📋Please don't forget to register for our 2026 seminar series: us06web.zoom.us/webinar/regi...
- Reposted by Antoine Molaro📣 Please spread: we’re hiring a Lab Manager! It is a critical position in our new lab. As our lab moves to Barcelona and joins the @crg.eu, we’re looking for a Lab Manager to help build the lab and set the lab atmosphere. 🔗 Apply here 👉 recruitment.crg.eu/content/jobs...
- Reposted by Antoine MolaroGetting asked about how academics can continue to do science & inspire trainees even in the midst of a continued (escalated) assault on science, reason, truth, & human rights. I don’t have great answers. I would love to hear from mentors about advice they’re giving to trainees/ colleagues.
- Reposted by Antoine MolaroI am very happy (and a bit scared) to present to you what we have been working on over the last 4 years. This manuscript is exactly what I dreamt of when I started the lab and I could not be happier and prouder of the outcome!
- Evolutionary dynamics of temporal transcription factor series in the insect optic lobe biorxiv.org/content/10.64898/20…
- Reposted by Antoine Molaro🚨Application for the MPI-IE international PhD program is ongoing🚨 If you are interested in #epigenetics #genomics #cellbiology #devbio & more, apply before February 6th! My lab will recruit a student to work on the contribution of #transposable elements in development and disease 🧬🦠
- Fully-funded #PhD positions in #epigenetics, #biophysics & #metabolism, gene regulation, cell biology and more… Are you already on track to start an exciting research career @maxplanck.de & @uni-freiburg.de? This is your timeline. Apply by February 6th, 2026 www.ie-freiburg.mpg.de/apply-imprs-...
- Reposted by Antoine MolaroNeed a bit of escapism? Not exactly Lord of the Rings, but in similar vein: doi.org/10.1038/s443...
- Reposted by Antoine Molaro💥🥚 ANR-funded Assistant Engineer position open in our “Control & Dynamics of the Ovarian Cycle” group at IBDM Marseille 🇫🇷 Work on mouse lines + lab logistics + follicle culture/imaging 🔬 🗓️ Apply by 26 Jan: emploi.cnrs.fr/Offres/CDD/U... Please share widely — especially with colleagues in France!
- Reposted by Antoine MolaroNew work from @miyapan.bsky.social and our team, bringing ant, bee, and wasp labs together. @chuanxinyu.bsky.social shows that the ANTSR locus we discovered in ants has determined sex for 150+ My across bees and stinging wasps 🐜🐝, despite virtually no sequence conservation 😮 doi.org/10.1073/pnas...
- Reposted by Antoine Molaro🧬 @science.org A SWI/SNF-specific Ig-like domain, SWIFT, is a transcription factor binding platform | Science www.science.org/doi/10.1126/... @ckadoch.bsky.social @danafarber.bsky.social @harvardmed.bsky.social @broadinstitute.org @hhmi-science.bsky.social 🔬 #chromatin #transcription #cancer 🧫
- Reposted by Antoine MolaroLove this paper from @evahoermanseder.bsky.social and team; great to see it out. This is definitely "epigenetics" by any definition, but I wonder if it's premarking for activation or protecting against stable silence (i.e, DNAme), similar to Dppa2/4 targets in mammals www.nature.com/articles/s41...
- Reposted by Antoine MolaroA human embryo implantation model from the @Rugg-Gunn Lab *key for understanding the early extraembryonic-maternal interactions Congrats to everyone involved! It’s been great to see this project develop. Huge credit to the @babrahaminst.bsky.social authors 🥂🍾 www.cell.com/cell/fulltex...
- Learn more about this research in our interview with Peter Rugg-Gunn 🧪 youtu.be/2NYsWPp1UYk?...
- Reposted by Antoine MolaroMy lab is hiring a postdoc (ERC funded)! If you're interested, get in touch!
- Reposted by Antoine MolaroA major output of the 4D Nucleome project appeared today. This is the joint effort of many scientists working together and (publicly) sharing data and results for several years. We hope this is of interest to many genome biologists! www.nature.com/articles/s41...
- Reposted by Antoine MolaroDo you have an exciting new chromatin/transcription story that you'd like to share with the #FN community? Fill out this form to be considered for a talk in our Jan-June 2026 schedule! forms.gle/TBi38UgYxPAB... Please repost and share!
- Reposted by Antoine MolaroIf anyone has any ideas that they would like to work on in choanoflagellates or Nematostella (or both) then please reach out!
- Attention scientists from all over the world🙃 The Call for Letters of Intent for #HFSPResearchGrants 2027 is now open! 🧪 Get your international & interdisciplinary team. It's time to put your bold research idea into practice! 🔗https://bit.ly/48VsGCG 📅 15 Dec 2025–26 Mar 2026 #sts #LifeSciences
- Reposted by Antoine MolaroInsights into natural neocentromere evolution from a cattle T2T X chromosome. #CattleGenome #T2T #HaplotypeResolvedGenome #Centromeres #Genomics @natcomms.nature.com 🧪🧬 🖥️ www.nature.com/articles/s41...
- Reposted by Antoine MolaroPermanent Research Group Leader Position, Crete, Greece: Interested to assume long-term responsibilities for the Biodiversity Computing Group www.biocomp.gr I have set up in Crete? Apply now via apella.minedu.gov.gr/en/node/5998 (PDF also in English) - for questions email to stamatak@ics.forth.gr
- Reposted by Antoine MolaroNew preprint from our lab: ‘Retroviral insertions contributed to the divergence of human and chimpanzee brains’. Very proud of this piece which took almost a decade to finish. www.biorxiv.org/content/10.6...
- Reposted by Antoine MolaroFantastic #EvoChromo25. Wonderful iteration, learned a lot - and loved the Nirenberg gold Luger nucleosome prize ! Humor sun and outstanding and thought-provoking science.
- Reposted by Antoine MolaroTook us a bit, but proud of this published version. We now examine the genetic interaction of phosphorylation with oligomerization and where bulk and phospho-Swi6 localize. Wonder if chromatin affinity tuning to enable Suv39 H3K9me3 spreading is a conserved mechanism ? doi.org/10.1093/nar/...
- A preprint from the lab led by graduate student Dana R Kennedy. doi.org/10.1101/2024... Over 20 years ago, the Eissenberg lab showed that phosphorylation of HP1 is important for its silencing function. Why? Key observations from our study in fission yeast:
- Reposted by Antoine Molaro@pravrutharaman.bsky.social got super intrigued about EZHIP/CATACOMB, previously identified as a histone H3K27M mimic of PRC2. You can read about her efforts here: www.biorxiv.org/content/10.6... We hope these analyses will help spur more analyses in this very cool gene! 1/
- Reposted by Antoine MolaroPlease help! We are looking for tissue-specific RNA-seq datasets or pubs with both male and female individual gene expression data, not pooled, from animal species. If you know of any relevant resources, please drop a link in the comments or send me a DM. Also, please help spread the word - thanks!
- So long #EvoChromo2025! I encourage you to mark your calendars as soon as the next one is announced. Special congrats to the Nirenberg prize recipients - including our very own @germainekaram.bsky.social Here is a picture of Germaine receiving her Golden Luger from the hands of Nick Irwin. #ProudPI
- Reposted by Antoine MolaroHave you ever wondered how new DNA methylation patterns are established? Paradigm shift ahead! We discovered a new mode of DNA methylation targeting in plants that relies on transcription factors and sequence motifs rather than chromatin modifications to regulate the methylome. rdcu.be/eQ6L5 1/8
- Reposted by Antoine MolaroJoin our online seminar on December 16, 2025, at 16:00 UTC to celebrate the book release "The Paradox of the Organism". More info: internalconflictsstn.wordpress.com #conference
- Reposted by Antoine MolaroThe Department of Genetics at the University of Cambridge is seeking a talented Postdoctoral Research Associate to work in the group of Dr Felipe Karam Teixeira (www.gen.cam.ac.uk/research-gro...) ➡️For Further details see the link www.cam.ac.uk/jobs/postdoc...
- Reposted by Antoine MolaroConfused by all the histones that are cropping up in organisms that are decidedly NOT eukaryotes? check out our review - fantastic work by team NucEvo in the #Lugerlab The Expanding Histone Universe: Histone-Based DNA Organization in Noneukaryotic Organisms - www.annualreviews.org/content/jour...
- Reposted by Antoine MolaroYay! Joy & excitement for the #science ahead & for our #team @ciri-lyon.bsky.social, who is getting @erc.europa.eu #Consolidator grant support to work on the FUNctional EVOlution of mammalian innate immunity #FUNEVO ! So thankful to #ERC and #everyone who contributed & provided support along the way
- The results of the ERC Consolidator Grant call have been announced! 📣 349 researchers have been selected for funding. Congratulations to all! #ERCCogG! 👉 buff.ly/uu62uFV #FrontierResearch #EUfunded #HorizonEurope @scienceinnovation.ec.europa.eu
- Reposted by Antoine MolaroSophie Polo has been awarded an Impulscience grant from the Bettencourt Schueller Foundation to fund a research project on the establishment and maintenance of the inactive X chromosome in response to DNA breaks. This is wonderful news for the lab! We thank the Foundation for their support.
- Reposted by Antoine MolaroThe results of the ERC Consolidator Grant call have been announced! 📣 349 researchers have been selected for funding. Congratulations to all! #ERCCogG! 👉 buff.ly/uu62uFV #FrontierResearch #EUfunded #HorizonEurope @scienceinnovation.ec.europa.eu
- Reposted by Antoine Molaro✨New preprint! 🧵1/4 Excited to share our work on AI-guided design of minimal RNA-guided nucleases. Amazing work by @petrskopintsev.bsky.social @isabelesain.bsky.social @evandeturk.bsky.social et al! Multi-lab collaboration @banfieldlab.bsky.social @jhdcate.bsky.social @jacobsenucla.bsky.social🧬 🔗👇
- Reposted by Antoine MolaroAmazing. Got my first unsolicited email review of a paper from an AI company, also telling me what follow up work to do. So inexpensive to get even more insights! This is wonderful, and I am planning to budget for this in all future work, right below the priority to fund a space circus on the moon.
- Reposted by Antoine MolaroHow to keep in step when your (protein) partner speeds up… Here we investigated the adaptive remodeling of a protein-protein interaction surface essential for telomere protection. Congrats to whole team! www.science.org/doi/10.1126/...
- Reposted by Antoine MolaroWe have just published a tribute to John Gurdon, reflecting on his scientific legacy and the profound influence he had on generations of developmental biologists. The piece is available open access in Nature Communications: www.nature.com/articles/s41...
- Reposted by Antoine MolaroMore marsupial fun from @lab-turner.bsky.social. Congrats @sermenchero.bsky.social
- Reposted by Antoine MolaroAnother envelope protein in the human genome. Expressed in the placenta, of course.
- Reposted by Antoine MolaroSMBE2026 Symposium 4 | Mining the archive: evolutionary genomics from public repositories 📨 Abstract submission smbe2026.org/abstracts 📋 Programme details smbe2026.org/programme #SMBE2026
- Reposted by Antoine MolaroOpen postdoc position at @sangerinstitute.bsky.social Tree of Life to contribute to the Biodiversity Cell Atlas, with a focus on spatial transcriptomics. Apply by January 4 sanger.wd103.myworkdayjobs.com/en-GB/Wellco... Please share with anyone who might be interested!
- Reposted by Antoine MolaroNew Paper from the Murphy Lab - A Collaboration w Mitch O'Connell's group at URMC. Led by our joint student Brandon Park. Check it out!! CUT&Tag Overcomes Biases of ChIP and Establishes Chromatin Patterns for Repetitive Genomic Loci: iScience www.cell.com/iscience/ful...
- Reposted by Antoine MolaroPls Repost: I am putting together an edition of “Methods in Molecular Biology” focused on early development, encompassing gastrulation. I am making a list of potential authors for chapters. If interested, please contact me - An excellent opportunity for trainees to co-author with their advisors.
- Reposted by Antoine MolaroCongratulations to the new cohort of 28 EMBO Young Investigators! They are joining an international network of more than 800 life scientists – Welcome! Read the press release here: embo.org/press-releases/twen…
