Eva Hörmanseder
Science at work / Mom, Gardener & Knitter 🧶 at home
Scientific Grant Coordinator at IMP Vienna
Love for Development, Reprogramming, Epigenetics and Xenopus 🐸
- Reposted by Eva HörmansederInternational Genome Dynamics course in Institut Curie-Paris (April 8-15), experimental and computational methods in multiomics,with a #TE centered session. Free registration, until Jan 15th Don’t miss it! 👉https://training.institut-curie.org/courses/Genome-Dynamics-2026 @institutcurie.bsky.social
- Reposted by Eva HörmansederNow final version out: Our manuscript connecting histone modifications with metabolism: How H4K16 acylations regulate inter +intranucleosomal interactions and confer resilience to metabolic challenges in vivo. Thanks to the team+ @sandrani.bsky.social Enjoy 👇👇 www.cell.com/molecular-ce...
- Happy birthday to Xenbase! Our research would have not been possible without you and your fantastic community support 🤩
- Reposted by Eva HörmansederOur preprint "Predictive design of tissue-specific mammalian enhancers that function in vivo in the mouse embryo" is on bioRxiv: www.biorxiv.org/content/10.6... . Amazing collaboration by @shenzhichen1999.bsky.social, Vincent Loubiere (@impvienna.bsky.social,@viennabiocenter.bsky.social),... (1/2)
- Reposted by Eva HörmansederOur new preprint is out: www.biorxiv.org/content/10.6... We show that GRN benchmarks commonly used can overestimate performance due to negative-sampling choices, sometimes allowing simple degree-based baselines to rival more complex GNNs. A reminder of why bias-aware evaluation matters!
- Reposted by Eva HörmansederAfter a long journey, I'm happy to share that my PhD work is finally published in Nature Communications. Grateful to all my co-authors!
- We probably shouldn’t have favourites amongst projects in the lab, but this one was mine. I’m so pleased we can finally share it: Our work is now out in Nature Communications: 🔗 nature.com/articles/s41467-025-67692-7
- We probably shouldn’t have favourites amongst projects in the lab, but this one was mine. I’m so pleased we can finally share it: Our work is now out in Nature Communications: 🔗 nature.com/articles/s41467-025-67692-7
- In Xenopus laevis, we found that H3K4 methylation is already laid down at specific loci in gametes and silent early embryos. This pre-marking is essential for accurate zygotic genome activation and proper development.
- It’s a story of marks written early, carried through a long silence, and then suddenly speaking again. A bit like memory itself.
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View full threadone should stop when it is at its nicest :) and I am looking forward to seeing where these findings on epigenetic memory take the field next!
- Reposted by Eva HörmansederDo you want to play a key role in running a cutting-edge stem cell and embryology lab at reNEW @ucph.bsky.social ? We’re hiring a Lab Manager to support our team and help with stem cell and animal work. Apply before Feb. 1st : rb.gy/d5uf17
- Reposted by Eva HörmansederI’m thrilled to share that our project, FATERNA, has been awarded an ERC Consolidator Grant! We’ll explore the mechanisms of pre-mRNA fate control. Huge thanks go to our awesome research team, colleagues, and the fantastic support from @impvienna.bsky.social & @viennabiocenter.bsky.social CP.
- The results of the ERC Consolidator Grant call have been announced! 📣 349 researchers have been selected for funding. Congratulations to all! #ERCCogG! 👉 buff.ly/uu62uFV #FrontierResearch #EUfunded #HorizonEurope @scienceinnovation.ec.europa.eu
- Reposted by Eva HörmansederExcited to announce that our peer-reviewed manuscript is online in the Development journal @dev-journal.bsky.social. The manuscript was much improved through the peer-review process, and I am grateful to the reviewers for their valuable feedback. journals.biologists.com/dev/article/...
- Reposted by Eva HörmansederA close-up piece on the legacy of Sir John Gurdon - so happy to see this out at @natcomms.nature.com. Excellent editorial and community work by @ebardot.bsky.social & thank you, @evahoermanseder.bsky.social et al.! www.nature.com/articles/s41...
- Reposted by Eva HörmansederWe have just published a tribute to John Gurdon, reflecting on his scientific legacy and the profound influence he had on generations of developmental biologists. The piece is available open access in Nature Communications: www.nature.com/articles/s41...
- We are honored to share our Perspective in Nature Communications, reflecting on the legacy of John B. Gurdon. Beyond his discoveries, his generosity and curiosity inspired a community of scientists-we remember and celebrate his lasting impact. #JohnGurdon #Xenopus #NatureCommunications
- Yearly Lab Luncheon at John’s place. 2017
- Reposted by Eva HörmansederThe Americans are doing to Kseniia what the Russians did to Brittney Griner for having 0.7 grams of cannabis oil. Except no one is coming to negotiate her freedom and Harvard is sitting on their hands. I am so ashamed. Please share this story. www.nytimes.com/2025/04/11/s...
- Reposted by Eva Hörmanseder#EpigeneticsPodcast with #HelmholtzMunich expert Dr. Eva Hörmanseder, @epihmgu.bsky.social! 🎧 Listen and learn about epigenetic memories & more: 👉 t1p.de/30q54 👉Check out her latest findings on this topic: t1p.de/43yrw @epigeneticspod.bsky.social #Epigenetics #Podcast #Reprogramming #CellFate
- In this episode of the Epigenetics Podcast, we talked with @evahoermanseder.bsky.social from @www.helmholtz-munich.de about her work on epigenetic mechanisms in cellular memory and gene regulation. #podcast #epigenetics Listen here: activemotif.com/podcasts-eva...
- Reposted by Eva HörmansederIn the most recent episode we talked with @evahoermanseder.bsky.social from @www.helmholtz-munich.de about her work on epigenetic mechanisms in cellular memory and gene regulation. #podcast #epigenetics Listen here: activemotif.com/podcasts-eva...
- Reposted by Eva HörmansederThis is very disturbing. Harvard PhD student Kseniia Petrova (Russian citizen) was arrested by ICE for transporting xenopus embryos into Boston from Paris. She has been detained in Louisiana since Feb. 16. www.theguardian.com/us-news/2025...
- If I could do it all over again, I’d apply here for my postdoc- look at these fantastic opportunities! ⬇️
- Reposted by Eva HörmansederReprogramming efficiency varies across cell types in vivo and is modulated by somatic cell identity memory. Eliminating somatic cell transcriptional memory improves reprogramming success #nucleartransfer ow.ly/g1Au50VimTM @www.helmholtz-munich.de @isscr.org
- Reposted by Eva HörmansederWe’d like to thank our Editors and peer reviewers who made the #fastandfairpeerreview trial possible. Would you like to join our reviewer pool? Visit bit.ly/41N31tO for more details.
- Reposted by Eva HörmansederHarvard scientist opposed to Ukraine war faces deportation back to Russia: Friends. This sounds like Trump trying to please Putin rather than anything to do with US immigration. www.independent.co.uk/news/world/a...
- Our key collaborator, genius scientist and wonderful person Kseniia is in a horrendous situation right now, see article below. Why? Trump. Please share, please do not ignore, if you can, help. www.independent.co.uk/news/world/a...
- Thank you very much for this possibility to contribute to this podcast! …but, as it said in my recommendation letter, “she has a tendency to talk fast” :) Thanks to everyone who contributed to these discoveries discussed here 🙏 Especially to those I forgot to mention cause I was so nervous…
- In this episode of the Epigenetics Podcast, we talked with @evahoermanseder.bsky.social from @www.helmholtz-munich.de about her work on epigenetic mechanisms in cellular memory and gene regulation. #podcast #epigenetics Listen here: activemotif.com/podcasts-eva...
- Reposted by Eva Hörmanseder🚨NEW PAPER ALERT! 3 of our teams at IES collaborated to understand why some cells reprogram effectively while others fail @hamperllab.bsky.social @antonio-scialdone.bsky.social @evahoermanseder.bsky.social Congrats to all the authors of this exceptional paper published @stemcellreports.bsky.social
- Cell Fate Changes – Transcriptional Memory in Reprogramming Dr. Eva Hörmanseder, #HelmholtzMunich & team uncovered why some cells resist reprogramming – a key hurdle for regenerative medicine. 👉 t1p.de/43yrw @epihmgu.bsky.social #CellReprogramming #Epigenetics #StemCells #RegenerativeMedicine
- Reposted by Eva Hörmanseder🚨New preprint from @bonevlab.bsky.social 🚨: What are the key epigenetic mechanisms that drive species-specific gene regulation during primate neurogenesis - and how do they contribute to the evolution of the human neocortex? Here’s what we discovered 👇 www.biorxiv.org/content/10.1...
- Reposted by Eva HörmansederVery happy to share the preprint of my main PhD project in the @bonevlab.bsky.social! Huge thanks to @boyanbonev.bsky.social, all co-authors and members of the @bonevlab.bsky.social! This work wouldn’t have been possible without your contributions!
- 🚨New preprint from @bonevlab.bsky.social 🚨: What are the key epigenetic mechanisms that drive species-specific gene regulation during primate neurogenesis - and how do they contribute to the evolution of the human neocortex? Here’s what we discovered 👇 www.biorxiv.org/content/10.1...
- Reposted by Eva HörmansederThe last chapter of my PhD is finally out! Huge thanks to my supervisor @genikhovich.bsky.social for supporting “at first glance, stupid ideas” — which turned into a nice paper! That was so much fun!
- Tanya's @tclebedeva.bsky.social paper on endomesoderm specification in the beta-catenin-negative area of the Nematostella embryo is out! www.nature.com/articles/s41...
- Thank you Antonio for this great collaboration!
- Why do some cells resist nuclear reprogramming? Using nuclear transfer, we tracked single-cell fate changes in vivo and uncovered cell-type-specific barriers to reprogramming. Suppressing the old identity boosts success! www.cell.com/stem-cell-re...
- Reposted by Eva HörmansederCell Fate Changes – Transcriptional Memory in Reprogramming Dr. Eva Hörmanseder, #HelmholtzMunich & team uncovered why some cells resist reprogramming – a key hurdle for regenerative medicine. 👉 t1p.de/43yrw @epihmgu.bsky.social #CellReprogramming #Epigenetics #StemCells #RegenerativeMedicine
- Do you work with reprogrammed cells? Then look at our new paper! We asked: How well do reprogrammed cells differentiate into complete&functional tissues? We found that - some cell types form perfectly but others fail - reducing levels of one specific TF of the previous lineage can fix problems⬇️
- Tomas and Jonathan spearheaded this joint research project with the @antonio-scialdone.bsky.social lab
- Reposted by Eva HörmansederA preprint from the lab- Corrections in single cell migration path in vivo are controlled by pulses in polar Rac1 activation. www.biorxiv.org/content/10.1...
- Reposted by Eva HörmansederWe are hiring.🚨 The Tissue Gene Regulation Lab is looking for an experimental PhD student or PostDoc to join our efforts in devising new single cell methods and decoding gene regulation. 💻🔬🧫 Come join me and my lab in beautiful Copenhagen. 🇩🇰 PhD - lnkd.in/dtKz_gnA PostDoc - lnkd.in/dBgn6AcK
- Reposted by Eva HörmansederSAVE THE DATE! The next EMBO | EMBL Symposium on 'DNA replication and genome maintenance: from basic biology to disease' will be held October 20-23, 2026. Organized by Helle Ulrich (IMB), Johannes Walter (Harvard) and Anja Groth (Danish Cancer Institute). www.embl.org/about/info/c...
- Reposted by Eva Hörmanseder🚀 PREPRINT ALERT! 🐸 Research led by our PI @evahoermanseder.bsky.social reveals H3K4 methylation as an epigenetic memory in Xenopus embryos, vital for zygotic genome activation & development. 👏 Congratulations @meghana-oak.bsky.social & rest of authors. 📑 👀 shorturl.at/6MIRn 🔎 #OpenPeerReview
- Reposted by Eva Hörmanseder🎆Next #FragileNucleosome meeting is less than a week away! We are delighted to host @manucazottes.bsky.social, @robertadolling1.bsky.social & @leandrosboukas.bsky.social ! We will discuss evolution of XIST regulatory network, cancer epigenetics, and MDEMs! 🗓️ us06web.zoom.us/webinar/regi...
- Congratulations Marcel, Manuel and everyone involved! Wonderful work on transcription replication conflicts, check out highlights below ⬇️
- I am delighted to share the main work of my PhD project in the @hamperllab.bsky.social now out in @narjournal.bsky.social. TRCs drive R-loop-dependent nucleosome eviction and require DOT1L activity for transcription recovery. academic.oup.com/nar/article/... #TRC #r-loop #chromatin More below 👇
- Reposted by Eva HörmansederI am delighted to share the main work of my PhD project in the @hamperllab.bsky.social now out in @narjournal.bsky.social. TRCs drive R-loop-dependent nucleosome eviction and require DOT1L activity for transcription recovery. academic.oup.com/nar/article/... #TRC #r-loop #chromatin More below 👇
- Reposted by Eva HörmansederSingle Cell Precision Nanocarrier Identification tracks & quantifies targeted drug-delivery by nanocarriers at single-cell resolution 📹: @erturklab.bsky.social lab @www.helmholtz-munich.de in @naturebiotech.bsky.social ➡️: bpod.org.uk/archive/2025...
- Reposted by Eva Hörmanseder🚀Excited to share preprint as my last work in the Tachibana lab! Our study shows how the pioneer factor NR5A2 ensures robust gene activation through feed-forward regulatory loops with lineage-determining factors. A quick summary follows (1/n) www.biorxiv.org/content/10.1...
- Reposted by Eva HörmansederExcited to share my main postdoctoral work and our new insights into epigenome inheritance! Huge thanks to an amazing team—especially Alva Biran (@biranalva.bsky.social) & Anja Groth (@groth-anja.bsky.social). 🧵👇
- 𝐇𝐨𝐰 𝐝𝐨 𝐜𝐞𝐥𝐥𝐬 𝐫𝐞𝐦𝐞𝐦𝐛𝐞𝐫 𝐰𝐡𝐨 𝐭𝐡𝐞𝐲 𝐚𝐫𝐞 𝐚𝐟𝐭𝐞𝐫 𝐃𝐍𝐀 𝐫𝐞𝐩𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧? Our new study “Disabling leading and lagging strand histone transmission results in parental histones loss and reduced cell plasticity and viability” is out in 𝘚𝘤𝘪𝘦𝘯𝘤𝘦 𝘈𝘥𝘷𝘢𝘯𝘤𝘦𝘴. Led by @lleonie.bsky.social @biranalva.bsky.social 🧵 More below👇
- My colleague Meghana @meghana-oak.bsky.social will present her work this Thursday at THE virtual Maternal Zygotic Transition symposium! We are very excited about this opportunity! You can follow her talk by registering here: www.giraldezlab.org/symposium/
- Reposted by Eva Hörmanseder𝐇𝐨𝐰 𝐝𝐨 𝐜𝐞𝐥𝐥𝐬 𝐫𝐞𝐦𝐞𝐦𝐛𝐞𝐫 𝐰𝐡𝐨 𝐭𝐡𝐞𝐲 𝐚𝐫𝐞 𝐚𝐟𝐭𝐞𝐫 𝐃𝐍𝐀 𝐫𝐞𝐩𝐥𝐢𝐜𝐚𝐭𝐢𝐨𝐧? Our new study “Disabling leading and lagging strand histone transmission results in parental histones loss and reduced cell plasticity and viability” is out in 𝘚𝘤𝘪𝘦𝘯𝘤𝘦 𝘈𝘥𝘷𝘢𝘯𝘤𝘦𝘴. Led by @lleonie.bsky.social @biranalva.bsky.social 🧵 More below👇
- Reposted by Eva HörmansederIn 2025, we continue to advocate for policy based on scientific evidence. This 2020 Editorial, “We need leaders that believe in scientific evidence”, resonates today as loudly as ever: plos.io/34lyl59. PLOS Biology also continues to push for DEI and a diverse scientific community: plos.io/3rzxczU 🧪
- Reposted by Eva HörmansederNew Editorial from @natcomputsci.bsky.social out today. Bringing the data to show why diversity matters for everyone's success. www.nature.com/articles/s43...
- Reposted by Eva HörmansederUnpause! I'm super happy to now be able to share the published version of our paper at Science Advances showing that: 1) active histone mods occur independently of transcription 2) transcription coordinates histone deacetylation at active promoters www.science.org/doi/10.1126/...
- Reposted by Eva HörmansederInterested in exploring epigenetic cell memory? Join us!! 6 PhD and postdoc positions available in our new center, EpiC.
- 🚨𝐌𝐚𝐣𝐨𝐫 𝐉𝐨𝐛 𝐀𝐥𝐞𝐫𝐭!🚨The Groth @groth-anja.bsky.social, Mailand, Nilsson @nilssonlab.bsky.social & Krietenstein @nilskrietenstein.bsky.social labs are hiring 𝟔 𝐏𝐡𝐃&𝐩𝐨𝐬𝐭𝐝𝐨𝐜𝐬 to join the new Center for Epigenetic Cell Memory (EpiC) in Copenhagen, Denmark. Apply here: tinyurl.com/yvd93na2 & please share!
- Reposted by Eva HörmansederWow, this seems like an incredible opportunity!
- 🚨𝐌𝐚𝐣𝐨𝐫 𝐉𝐨𝐛 𝐀𝐥𝐞𝐫𝐭!🚨The Groth @groth-anja.bsky.social, Mailand, Nilsson @nilssonlab.bsky.social & Krietenstein @nilskrietenstein.bsky.social labs are hiring 𝟔 𝐏𝐡𝐃&𝐩𝐨𝐬𝐭𝐝𝐨𝐜𝐬 to join the new Center for Epigenetic Cell Memory (EpiC) in Copenhagen, Denmark. Apply here: tinyurl.com/yvd93na2 & please share!
- Wonderful work spearheaded by Marco @marcostock.bsky.social !! Interesting for everyone planning to do gene network analyses!!
- How can we improve gene regulatory network inference from noisy scRNA-seq data? Our new review in @molsystbiol.org explores the latest methods integrating prior knowledge to enhance reliability. Plus, some suggestions on how to improve benchmarking! www.embopress.org/doi/full/10....
- Reposted by Eva HörmansederHow can we improve gene regulatory network inference from noisy scRNA-seq data? Our new review in @molsystbiol.org explores the latest methods integrating prior knowledge to enhance reliability. Plus, some suggestions on how to improve benchmarking! www.embopress.org/doi/full/10....
- Reposted by Eva HörmansederCalling all students. The registration for the European Summer School on Stem Cell Biology and Regenerative Medicine is now open.
- Congratulations to all girls and women in science, but also to those who left or had to leave science. Unfortunately not everyone can stay in science, still, today. I would love to see pictures of women working now outside of academia, science, stem- what are you up to now? #STEM #womeninscience
- Reposted by Eva HörmansederBeing a young parent in academia can be rough. In the latest column of the Tilburg Young Academy in Univers, Myrthe Faber describes these challenges spot on. universonline.nl/nieuws/2025/... @universmagazine.bsky.social #academicsky
- Curious to see tomorrow what Juan Manuel Gomez @gomezjm-devmech.bsky.social has been up to!!
- Ana @anajaneva.bsky.social will talk about an amazing journey that started 2017 in Cambridge with John Gurdon and ended in Munich @epihmgu.bsky.social : 1958’s NT combined with 2025 AI to decode the epigenetic barriers to reprogramming ⬇️
- ⚡Next #FragileNucleosome meeting is less than a week away! Three amazing ECR scientists, 🔬@anajaneva.bsky.social, 🧠@anastasiahains.bsky.social, & 🧬@martyyang.bsky.social will discuss their research next Wed! 🗓️Don't forget to register: us06web.zoom.us/webinar/regi...
- Reposted by Eva Hörmanseder⚡Next #FragileNucleosome meeting is less than a week away! Three amazing ECR scientists, 🔬@anajaneva.bsky.social, 🧠@anastasiahains.bsky.social, & 🧬@martyyang.bsky.social will discuss their research next Wed! 🗓️Don't forget to register: us06web.zoom.us/webinar/regi...
- Reposted by Eva HörmansederCRISPR targeting of H3K4me3 activates gene expression and unlocks centromeric crossover recombination in Arabidopsis biorxiv.org/content/10.1101/202…
- Reposted by Eva HörmansederBrilliant work from @grazianomartello.bsky.social, tackling a major shift in the stem cell field to unlock large-scale experimentation with naïve human pluripotent stem cells. Great to see so many friends on the author list—science truly takes a village!
- With pleasure we share our preprint reporting robust and cost-effective expansion of naive human Pluripotent Stem Cells without feeder cells. A fantastic collaborative effort with @leeboratory.bsky.social @jzylicz.bsky.social @pasquelab.bsky.social and Nicolas Rivron. tinyurl.com/5n6z9rt9
- Reposted by Eva HörmansederJoin us next week (Wednesday!) for the next VGZT morning/eastern session ☀️ ☕️ seminar! We are looking forward to exciting 🪰🪲 talks by: Juan Manuel Gómez @gomezjm-devmech.bsky.social and Wolfram Pönisch @wolframponisch.bsky.social 🗓️ Wednesday, Feb 12 ⏰ 18:00 JST / 10:00 CET / 9:00 UTC
- Reposted by Eva HörmansederJob alert.🚨 Come join us in beautiful Copenhagen 🇩🇰 to develop computational tools to decode gene regulatory mechanisms from single cell data.💻🔬🧫 @randersson.bsky.social will be hiring either a PhD or a PostDoc. There is no supervisor I could recommend more! tinyurl.com/3v4uvmz4 tinyurl.com/yc83enfa
- Reposted by Eva HörmansederWe're hiring a motivated PhD student! Join reNEW @ucph.bsky.social & @nucleardn.bsky.social to study how metabolism regulates chromatin & stem cell fate thanks to generous Marie Skłodowska-Curie Fellowship. Remember to apply both at shorturl.at/yf7Qq & nuclear-dn.eu.
- 🚨 We’re hiring! 16 PhD opportunities in an emerging research field! 🚨 Are you ready to dive into innovative research in metabolic regulation of genome function in stem cells and cancer? 🔗 Learn more & apply now: nuclear-dn.eu #PhDOpportunities #StemCellBiology #CancerResearch #MSCA Please RP!
- Reposted by Eva HörmansederNext Wed 12.02. at 6pm CET I will be speaking about our latest preprint: www.biorxiv.org/content/10.1... and present our findings on how we developed a machine learning model that identified new reprogramming barriers, such as H3K27ac, and our in vivo experiments to test it. See you there!
- ⚡Next #FragileNucleosome meeting is less than a week away! Three amazing ECR scientists, 🔬@anajaneva.bsky.social, 🧠@anastasiahains.bsky.social, & 🧬@martyyang.bsky.social will discuss their research next Wed! 🗓️Don't forget to register: us06web.zoom.us/webinar/regi...
- Reposted by Eva HörmansederPlease RT. Join the sixth edition of our Training Unit @institut_curie international course on Genome Instability & Human Disease open to master students, PhDs and researchers! Amazing program. Registration dead line 2nd March 2025 at training.institut-curie.org/courses/geno...
- Reposted by Eva HörmansederSY-Stem 2025 Symposium: Registration deadline on February 15th! SY-Stem - a symposium focusing on the next generation of stem cell researchers - is organized by IMBA and @impvienna.bsky.social. Register online: bit.ly/4jekaDg Check out the program: bit.ly/4jDioM6
- Reposted by Eva HörmansederCongratulations Ana, Eva and all collaborators!
- I am thrilled to share that our latest pre-print from the @evahoermanseder.bsky.social lab 🐸🧬, is now online! Check it out here: www.biorxiv.org/content/10.1... Highlights and key findings from our study in the thread below 👇
