Zunlong Ke
Assistant Professor @UT Austin | Structural Virology | cryo-EM and cryo-ET | Postdoc with John Briggs @MRC_LMB @MPI_biochem | PhD with Elizabeth Wright @GeorgiaTech @Emory
- Reposted by Zunlong KeVery happy to say that our work on how axonemes are generated is now available on bioRxiv: www.biorxiv.org/content/10.6... - if you’ve ever wondered how the incredibly beautiful, complex structures within motile #cilia are constructed then this is for you!
- Reposted by Zunlong KeAm I the only one increasingly annoyed by cryo-EM papers not showing *any* experimental density in figures? Sometimes not even in the supplementary material??
- @erwright73.bsky.social Welcome the Wright Lab to Bluesky! #Tomo
- Great work from the Wright Lab at MCCET, Madison! Congratulations to the team!
- Reposted by Zunlong KeFormation & function of #MembranelessOrganelles! #CryoET structures of #proteasome storage granules inside cells! Read our paper @cp-cell.bsky.social! ❕Publication: doi.org/10.1016/j.ce... ❕Press Release: www.biochem.mpg.de/en/pressroom @uoftmedicine.bsky.social @erc.europa.eu #UPSmeetMet
- Reposted by Zunlong KeCheck out our new preprint! We uncover the full molecular mechanism of rotavirus membrane penetration and cytosolic escape using cryo-ET, live-cell imaging, and single-molecule assays. (1/3) 🔗 biorxiv.org/content/10.6...
- Reposted by Zunlong Ke2026 has just begun and we are looking forward to welcoming you to EMBL for another year of groundbreaking science. Our programme now features even more events, check it out ➡️ s.embl.org/2026-poster
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- Reposted by Zunlong KeI am super happy to share this paper in its final form. We used FIB milling to "dig in to" cell lines and mouse brains infected with tick-borne flaviviruses, followed by cryo-ET to study the virus replication. It's open access, so have a look! #virology #teamtomo www.nature.com/articles/s41...
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- Reposted by Zunlong KeFully genetically encoded low-molecular-weight protein tags with defined shapes for direct molecular identification by cryo-electron tomography www.biorxiv.org/content/10.64898/2026.01.16.700029v1 #cryoEM
- Reposted by Zunlong KeThe ChimeraX DAQplugin computes DAQ scores showing the agreement between atomic models and cryoEM maps. Available from ChimeraX menu Tools / More Tools. cxtoolshed.rbvi.ucsf.edu/apps/chimera...
- Reposted by Zunlong KeI've reviewed about 150 CVs in the past few days. A few observations: (1) I am sooo impressed by the talent pool out there; (2) do not try to make your CV fit onto one page if it makes things difficult to read - just go multipage, keeping the key messages upfront;
- Reposted by Zunlong KeHappy to finally share the amazing results of our long-term collaboration with Karin Reinisch’s lab on how bridge lipid-transfer proteins (BLTPs) cooperate with partner proteins to orchestrate lipid delivery. A quick thread (1/7) www.biorxiv.org/content/10.6...
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- Reposted by Zunlong KeNEW article by me! We can now visualize pathogens down to atoms; design vaccines in weeks; manufacture them in microbial factories; engineer them more precise than ever before. We're living through a golden age of vaccine development, but only if we continue to invest in them.
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- Reposted by Zunlong Ke🌟 New Tool Alert! We present MemPrO – a toolkit for orienting and building membrane protein systems: ✅ Membrane protein orientation ✅ Mixed membrane building ✅ Double membranes & curvature ✅ Peptidoglycan cell wall support 🔗 github.com/pstansfeld/mempro 📖 pubs.acs.org/doi/10.1021/...
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- Reposted by Zunlong KeFinal version is out! Our large-scale cryo-ET dataset 🔬 of Chlamydomonas reinhardtii 🦠 is now published in @cp-molcell.bsky.social Huge collaborative effort! So glad to see the community already using it to develop new resources & tools. Check it out here: shorturl.at/z4i4c #CryoEM #CryoET
- Reposted by Zunlong KeCapsid flexibility during Ty1 virus-like particle assembly www.biorxiv.org/content/10.64898/2025.12.17.694965v1 #cryoEM
- Reposted by Zunlong KeCongratulations, Julia Mahamid! Julia Mahamid receives the @dfg.de Leibniz Prize for her work on structural cell biology! #LeibnizPreis
- Und hier sind sie – die 10 Preisträger*innen des Gottfried Wilhelm #LeibnizPreis' 2026 – ausgezeichnet für ihre exzellenten Forschungsarbeiten und Errungenschaften in der Wissenschaft! 🏆👏 Die Verleihung der Preise feiern wir am 18. März in Berlin. Einzelheiten & Kurzprofile: sohub.io/1uv1
- Reposted by Zunlong KeThis week, check out a new #Primer on #cryogenic electron tomography (cryo-ET) used for visualizing 3D structures of cells with sub-nanometer resolution. 🔬🧫 www.nature.com/articles/s43...
- Reposted by Zunlong KeIsoNet2 determines cellular structures at submolecular resolution without averaging biorxiv.org/content/10.64898/20…
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- IsoNet2 determines cellular structures at submolecular resolution without averaging biorxiv.org/content/10.64898/20…
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- Reposted by Zunlong KeProhibitins aren’t hanging out just anywhere in the membrane — they prefer the 💁♀️💎✨VIP section💅🪩🥂 Lab all-star @mmedina300kv.bsky.social maps these microdomains using cryo-ET + surface morphometrics. s/o to #teamtomo #cryoET co-authors @hamid13r.bsky.social @attychang.bsky.social @baradlab.com
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- Reposted by Zunlong KeExcited for Adam Klivans and my other colleagues at UT working in the AI space!
- Reposted by Zunlong KeAn Asgard archaeon with internal membrane compartments Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors! www.biorxiv.org/content/10.1...
- Reposted by Zunlong KeGlad to see our antibody design paper finally out in @nature.com (and congrats to lead authors and everyone involved )! At Xaira we are excited about pushing antibody design further to bind harder targets and make drugs for unmet medical needs. Paper: www.nature.com/articles/s41...
- Reposted by Zunlong KeLab’s first paper is out!! We show the first structures of #Asgard #chromatin by #cryo-EM 🧬❄️ Asgard histones form closed and open hypernucleosomes. Closed are conserved across #Archaea, while open resemble eukaryotic H3–H4 octasomes and are Asgard-specific. More here: www.cell.com/molecular-ce...
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- Just completed 100 miles at Austin rolling through Texas Hill Country. The event is 2025 LiveStrong Challenge to support cancer research. Feeling blessed!
- Reposted by Zunlong KeWe are looking for a computational postdoc to work with us on new optimisation algorithms to make #RELION even better. Join our bubbly team at the @mrclmb.bsky.social in Cambridge, UK. 🤗 RTs appreciated. mrc.tal.net/vx/appcentre...
- Reposted by Zunlong KeEver seen a pumpkin under a microscope? 🎃🔬 This Halloween, Raymond Wightman & Daniel Sparrow used @slcuplants.bsky.social’s powerful imaging tools to reveal: 🔬 Skin detail with the #Keyence microscope 💡 Beta-carotene via #Raman spectroscopy ❄️ Flash-frozen oval cells via cryo-SEM #HappyHalloween
- Reposted by Zunlong KeNew lab preprint! @zestytoast.bsky.social tagged a scarce mycobacterial protein in M. smegmatis with TwinStep but got… something? @kjamali.bsky.social's ModelAngelo built models & @martinsteinegger.bsky.social's FoldSeek IDed them as the biotin-containing MCC & LCC complexes 🧵 tinyurl.com/ukny4ptz
- The biophysics class I taught recently did kinesin walks hand-over-hand model (2004, Science), with reference to the inchworm model (2002,Science). Students discussed danced to mimic the two models, super fun! Thanks to the shortage of giant squid due to meteorological disturbance El Niño in 1983!
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- Reposted by Zunlong KeOur colleagues Vinith Kishore and Valentin Debarnot from the @ivandokmanic.bsky.social lab have come up with an amazing deep learning tool for denoising and filling the missing wedge in #cryoET data. I'm pleased to introduce Icecream🍧
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- Reposted by Zunlong KeExcited to share a new chapter of my scientific journey in Chris Russo's group — developing a way to freeze proteins faster than they diffuse, paving the way for cryo-EM without air–water interface damage.
- Chris Russo and Anastasiia Gusach have developed a new method to prepare #cryoEM samples that avoids protein damage during freezing Read more: www2.mrc-lmb.cam.ac.uk/a-new-method... #LMBResearch
- Reposted by Zunlong KeDuring these uncertain times, I’m very happy to see that my institution, @scripps.edu has an open tenure-track Assistant Professor position. Any field in Chemistry or Biology is welcome. I’d especially love to see fellow neuroscientists apply. Please repost! apply.interfolio.com/174756
- Reposted by Zunlong KeOur home department of Molecular Biology & Biochemistry at UC Irvine is looking to hire a new tenure-track assistant professor in the broad area of structural biology. Come be our colleague! recruit.ap.uci.edu/JPF09887 Please apply and/or share this post.
- Reposted by Zunlong KeHey folks! I got a tattoo of my beloved PIEZO ion channel on my arm! Now I can show how they activate (flatten) under pressure by flexing—Will add a bit of performance art to my science talks 🧪🧠.
- Reposted by Zunlong Ke🚀 Introducing fully automated data processing for repeat-target #cryoEM. Using new tools in #CryoSPARC, it is now possible to obtain resolutions & map quality equal to or better than manual processing, with zero user intervention. Preprint: www.biorxiv.org/content/10.1...
- Reposted by Zunlong KeYikes! In this paper the AlphaFold model of human plasminogen (PDB-8uq6) has been refined into noise (EMD-42462) using Phenix & ISOLDE. For some reason the authors even interpret side-chain interactions: #cryoEM
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- Reposted by Zunlong KeIt was wonderful to have Bijun with us @mpi-mp-potsdam.bsky.social & @incavirus.bsky.social to finally "use our microscope to its full potential" as our core-facility put it! 🔬 Congrats to all, esp. @bijuntang.bsky.social and @xanderjones.bsky.social ! Super happy to be a part of this great story!
- Salicylic acid biosensor, SalicS1, tracks the plant immune hormone salicylic acid in real time - revealing propagation of hormone surge during plant pathogen advance Latest biosensor from @xanderjones.bsky.social team In Science doi.org/10.1126/scie... Summary www.slcu.cam.ac.uk/news/new-bio...
