Rob Schneider
- New paper from my lab out in NAR. We found that young L1 elements are controlled by SETDB1 and H3K9me3 in human neural progenitor cells via a mechanism independent of HUSH and TRIM28/KZNFs. academic.oup.com/nar/article/...
- Lovely lab hike in Werribee Gorge to celebrate the EckMasLab’s 5th birthday 🎂
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- Precise control of transcription condensates across S phase balances linker histone expression with DNA replication, ensuring genome stability www.cell.com/molecular-ce...
- Terrific paper on a new chromosomal compartment where extensive loop extrusion isolates domains from other such domains
- How do compartmentalization & loop extrusion organize eukaryotic genomes beyond classical model organisms? Hi-C analysis of silkworm chromosomes by Drinnenberg, Muller, Mirny et al reveals new combination of these mechanisms, and a new, secluded “S” compartment link.springer.com/article/10.1...
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- Michal Gdula group leader at @uam-ibmib.bsky.social is saerching for a postdoc to work on the epigenetics of pancreatic cancer within colaborative OPUS-LAP funded by @ncn.gov.pl and @dfg.de - reach out! #3Dgenome #cancer #pancreas
- We’re recruiting! Three-year, fully funded #postdoc opportunity: pancreatic cancer #epigenetics & potential new treatments (funded by @ncn.gov.pl & @dfg.de ). Collaboration with @akispapantonis.bsky.social, University of Göttingen (OPUS-LAP). See the ad & contact me! drive.google.com/file/d/1vrFd...
- Exciting news! The lab is moving to Colorado at @cuanschutz.bsky.social 🎉 We’ll be recruiting at all levels—stay tuned!
- How do compartmentalization & loop extrusion organize eukaryotic genomes beyond classical model organisms? Hi-C analysis of silkworm chromosomes by Drinnenberg, Muller, Mirny et al reveals new combination of these mechanisms, and a new, secluded “S” compartment link.springer.com/article/10.1...
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- "AI is rapidly populating medical records with synthetic content, creating a feedback loop [that] drives a rapid erosion of pathological variability and diagnostic reliability...this renders AI generated documentation clinically useless after just two generations" www.medrxiv.org/content/10.6...
- I started offering career advice to two junior colleagues today in separate meetings, and both times I caught myself thinking that, if I'm honest, I don't have very good advice on navigating the current funding and job climate. I think it's important to say that no one does.
- www.nature.com/articles/s41... happy i could be a part of this paper from the Gilan lab out now. Along with many other things, it provides strong evidence of chromatin memory for gene activation, and suggests that DOT1L is the missing link balancing the fast and slow arms of the MLL/Polycomb axis
- pdb101.rcsb.org/motm/314 histones outside of the eukaryotic domain are the 'molecule of the month'! nice!
- The Epigenetics Community at #HelmholtzMunich, together with #Abcam, is hosting the 3rd #Chromatin #SummerSchool in Munich: 📆 17–29 August 2026 ⏰ Apply by March 29, 2026 👉 Applications & info: bit.ly/4oGDR8f @epihmgu.bsky.social @metorrespadilla.bsky.social @robertife.bsky.social
- Two new papers from the lab published in The EMBO Journal! link.springer.com/article/10.1... By Kai Walstein, @louisa-hill.bsky.social and others – On role of M18BP1 in CENP-A loading link.springer.com/article/10.1... By Arianna Esposito Verza and others – On mechanism of activation of PLK1
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- Check out our new findings showing BRD4's role in preventing the premature activation of developmental transcription factors via #Polycomb, providing new mechanistic insights into the pathogenesis of neurodevelopmental disorder #CdLS #NDDs, #chromatinopathies www.biorxiv.org/content/10.6...
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- Please repost and consider applying: we work in such a fantastic context, we ask so interesting questions, and we have such a collegial and best-willing atmosphere… CRBM = Happy & Good Science
- 🚨WE'RE RECRUITING AT @irbbarcelona.org !!!! --- ADVANCED GENOMICS FACILITY MANAGER --- An amazing opportunity to help us drive the fight against cancer and other aging-related diseases using Single-cell, Bulk and Spatial genomics!!!! APPLY NOW!!!! recruitment.irbbarcelona.org/jobs/7124180...
- Does the noncoding genome actually carry more genetic information than coding seqs? Motivated by this question we mutated every bp in the 10kb MYC locus. Results are even more exciting: Decoding the MYC locus reveals a druggable ultraconserved RNA element www.biorxiv.org/content/10.6...
- Is it just me, or has publishing become ultra slow in the last 5 years?
- It is finally out! If you are interested in TE-derived CREs, and newly described, but evolutionary old KZFP-TE mechanistic modalities, read it at www.cell.com/cell-reports.... Thankful to everyone who took part in this work, namely @orpsf.bsky.social and other @trono-lab.bsky.social members. 🫀🧬✨
- Latest preprint of the team, when Polycomb meets Lamin domains in mechanical stress regulation... www.biorxiv.org/content/10.1...
- Interested in direct tRNA-seq by Nanopore? We developed a new RNA-based barcoding aproach for seq parallelization; it is also cost-saving. Scripts available on github. #tRNA #Nanopore track.smtpsendmail.com/9032119/c?p=...
- “The transformation is astonishing. [Paris] has quietly—& quickly—become one of the most bike-friendly cities in the world. What started as a series of emergency ‘coronapistes’ or pop-up bike lanes, built during the pandemic has evolved into a permanent bike network spanning hundreds of kilometres.”
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- We wrote a protocol article detailing induction of dormancy in stem cells, embryos, and blastoids. We hope that it is useful to the community. As usual fun to work with @nicolasrivron.bsky.social, Heidar and Dhanur.
- Great to catch up with alumni @nchoy.bsky.social who stopped by to visit the lab. So great to hear about your internship adventures with @robertife.bsky.social and see you doing so well!
- We had a super interesting seminar by Giacomo Cavalli (@cnrs.fr | @umontpellier.bsky.social), today. 🤩 … with exciting data and results by the Cavalli on epigenetic memory of past events that get mediated by Polycomb components & #histone #acetylation. Thanks to @iovino-lab.bsky.social for hosting!
- The speed at which Oxford Nanopore is cancelling support for their devices is just mind boggling 😳 P2 solo will be decommissioned soon!!! This is not sustainable! @nanoporetech.com
- Sad to hear that Oxford Nanopore wants to discontinue the P2Solo later this year in favor of the P2i (the very pricey P2Solo that comes with a GPU to do the basecalling in it) It feels like such a big step in the wrong direction. They are a great sequencing company, not a great GPU upseller...
- ⚠️ The final work of two former PhD students Till @tschwammle.bsky.social and Verena @verenamutzel.bsky.social is out! ➡️⬅️ They dissect how memory can arise from antisense transcription using mathematical modelling 💻, genomics 🧬 and synthetic biology ⚒️! link.springer.com/article/10.1...
- 📢 One more week to go... exciting fully funded #PhD position for UK candidates to work across #ICR and #Imperial on novel mechanisms in genome stability and #CancerResearch. #PhDStudentship #LifeSciences #DNAReplication #CRISPR
- We are recruiting a PhD student to tackle a fundamental question in cancer biology: how DNA replication fails at centromeres and drives chromosomal instability (CIN) — a major driver of tumour evolution and therapy resistance. tiny.cc/vilw001 #PhD #CancerResearch #GenomeStability #Chromatin
- AlphaFold protein interaction modeling tutorial and workshop thenode.biologists.com/https-www-yo...
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- Nature research paper: A nowhere-to-hide mechanism ensures complete piRNA-directed DNA methylation go.nature.com/4pDVgPq
- A wonderful collaboration between Jess Tyler lab, @epicypher.bsky.social, @gcloner.bsky.social, James Kadonaga and our lab at PSU. In this article, we provide the significance of the nucleosome acidic patch. doi.org/10.64898/202...
"RNAPII clusters reflect local accumulations of transcriptionally engaged polymerases and do not form through higher-order mechanisms such as phase separation" 😬 www.biorxiv.org/content/10.1... by the @mirlab.bsky.social- I am excited to see what one can do with this - protein "sequencing" (at the moment, bar code read out) - at the single peptide (molecule by molecule) level - and there will be a point where the signal to noise in the squiggle is good enough to move to peptide identification from a database.
- Current protein analysis is costly, complex & risks damaging proteins. We’re developing a protein barcoding method that's scalable, accessible & protein-friendly. Find out more: bit.ly/4pzmIhI
- What happens when you suddenly remove half of an essential enzyme from cells? 🤔 We watched in real-time as cells deploy multiple backup strategies to buffer against changes in RNA Pol II abundance. Our lab's new preprint 👇 bit.ly/4pyPgax
- Congratulations Anja! Wonderful recognition of your ground-breaking discoveries!
- You can read more about Anja's award here: novonordiskfonden.dk/en/news/biom...
- Congratulations to @groth-anja.bsky.social on receiving the Novo Nordisk Foundation Jacobæus Prize 🏆 we’re proud to see Anja's mentorship, leadership, & pioneering work in epigenetic cell memory getting top recognition 👏 celebrating the contributions of past & present lab members to this work too 🥳
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