Scott Berry
Group leader at Single Molecule Science and UNSW RNA Institute at the University of New South Wales, Sydney. Interested in quantitative regulation of gene expression in single cells. Views my own. @scottbscience https://berrygroup.github.io
- What happens when you suddenly remove half of an essential enzyme from cells? 🤔 We watched in real-time as cells deploy multiple backup strategies to buffer against changes in RNA Pol II abundance. Our lab's new preprint 👇 bit.ly/4pyPgax
- This fun project was driven by the talented and rigorous Alex Gillis @cftbla.bsky.social, in wonderful collaboration with Ana Tufegdžić Vidaković's @anatv.bsky.social lab! @singmolsci.bsky.social @unswrna.bsky.social
- Reposted by Scott BerryHappy to share a new preprint from our lab, uncovering "spooky action at a distance" - for RNA Polymerase II: www.biorxiv.org/content/10.6...
- Reposted by Scott Berry🎉 𝙒𝙝𝙖𝙩 𝙖 𝙙𝙖𝙮! 🎉 On Thursday we held our inaugural EMCR Mini Symposium, bringing together six in-person nodes plus online attendees from across Australasia. It was fantastic to see our community come together to share science, build connections, and finish 2025 strong. #EMCR #AEpiA #epigenetics
- Reposted by Scott BerryOptimised nanobody-based quenchbodies are developed through rational design and in vitro evolution, enabling improved protein detection with up to 2.4-fold fluorescence increase @haiboyu.bsky.social @lisannes.bsky.social @molecularhorizons.bsky.social www.nature.com/articles/s42...
- Reposted by Scott Berry🌟 𝐈𝐧𝐭𝐫𝐨𝐝𝐮𝐜𝐢𝐧𝐠 𝐄𝐌𝐂𝐑 𝐌𝐢𝐧𝐢 𝐒𝐲𝐦𝐩𝐨𝐬𝐢𝐮𝐦 𝐂𝐚𝐫𝐞𝐞𝐫 𝐏𝐚𝐧𝐞𝐥𝐥𝐢𝐬𝐭 – 𝐃𝐫 𝐋𝐮𝐤𝐞 𝐈𝐬𝐛𝐞𝐥 🌟 We’re excited to spotlight Dr Luke Isbel, one of our inspiring career development panellists for the upcoming Australasian Epigenetics Alliance 𝐄𝐌𝐂𝐑 𝐌𝐢𝐧𝐢 𝐒𝐲𝐦𝐩𝐨𝐬𝐢𝐮𝐦! aepia.org.au/emcr-symposium
- Reposted by Scott BerryA purpose built solution to Australia’s biomedical funding crisis….. release the #MRFF = invest in our future scientists & their discoveries. #DiscoveriesNeedDollars www.smh.com.au/politics/fed...
- Reposted by Scott BerryThe Asia RNA Club Symposium will be happening in Seoul in Nov 3-5, bringing together RNA scientists from the Asia-Pacific region. Excellent speakers and a great opportunity to connect! Abstract submission by Sept 5 asiarnaclub.org
- Reposted by Scott BerryWe have some news to share: The Kueh lab is moving to Yale this fall! We will be joining the Yale Center for Systems and Engineering Immunology @yalecsei.bsky.social and the Department of Immunobiology. medicine.yale.edu/systems-engi...
- Reposted by Scott BerryOur #AI #research @natcomms.nature.com uses #multiomics data integration concepts to fuse 4-channel imaging data into unlimitedly multiplexed image datasets via generative deep learning to interrogate complex cell biology, like #EMT. Multiplexing made easy! rdcu.be/emtBc @singmolsci.bsky.social
- Reposted by Scott BerryFantastic to see this short film about A/Prof Lawrence Lee who is a Group Leader in UNSW Single Molecule Science and the founding CEO of the exciting startup, SWAN Genomics 🧬🔬
- 🚀 Meet Our Centre Startups: SWAN Genomics with Associate Professor Lawrence Lee SWAN Genomics is changing the way we sequence #DNA with a new approach that goes beyond today’s short-read and long-read methods. #Startup #SyntheticBiology #Biotechnology youtu.be/WCT3sA2-jtY?...
- Reposted by Scott BerryJoin our group (www.luginbuehllab.com) at @camplantsci.bsky.social! Are you excited about mycorrhiza, (single-cell) transcriptomics, carbon physiology, and the model crop rice? We have a 2-year postdoc position available, starting ASAP. Closing date 23rd May 2025! www.jobs.cam.ac.uk/job/51214/
- Reposted by Scott BerryWe have had multiple discussions about why people have not previously observed the very dramatic reduction in transcription upon PNUTS depletion. So I looked at our own TT-seq data and analysed it without including the spike-in. The numbers speak for themselves! Spike-in calibration is important!
- Reposted by Scott BerryMechanism of quality control of gene expression revealed by @anatv.bsky.social & @scottbscience.bsky.social’s groups in study of Pol II molecules. Read more about the work, led by Roberta Cacioppo, Alexander Gillis, Iván Shlamovitz & Andrew Zeller: www2.mrc-lmb.cam.ac.uk/newly-identi... #LMBResearch
- Was a pleasure working with @anatv.bsky.social on this!
- The first paper from our lab is online! A wonderful collaboration with @scottbscience.bsky.social lab. We discover that Pol II is extensively regulated by Ubiquitin at the beginning of the transcription cycle! www.cell.com/molecular-ce...
- 📣 New paper from the lab! In a fantastic new collaboration with @anatv.bsky.social lab, we characterise a major Pol II homeostasis pathway in human cells. Congratulations Roberta, Alex, Ivan, and Andrew. www.cell.com/molecular-ce...
- Building on our previous work on RNA concentration homeostasis doi.org/10.1016/j.ce..., we were interested to understand how global levels of Pol II are controlled. We teamed up with @anatv.bsky.social's lab who delve deep into mechanisms of ubiquitin-mediated regulation of the transcription cycle.
- It has long been known that Pol II is degraded when transcription is inhibited - either with small molecules or if specific cofactors are depleted. We now know the ubiquitin ligase responsible is CUL3-ARMC5. When we remove ARMC5, Pol II is no longer lost upon inhibition.
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View full threadAlso take a look at complementary work from Jesper Svejstrup's lab: sciencedirect.com/science/arti...
