Pierfrancesco Pagella
Associate Professor in Bioengineering 🇮🇹@ Linköping University 🇸🇪
Bioengineering/Genomics/Development/3R/Teeth/HeavyMetal/Photography
- Reposted by Pierfrancesco PagellaHow do cells orchestrate themselves to achieve a directional movement as a group? Hi, I’m @sayukihirano.bsky.social. In this thread, I’ll highlight key mechanisms of how cells communicate with each other to perform directional collective migration.
- Fresh pre-print: our all-human, innervated & vascularized oral cancer-on-chip, all done with fully defined extracellular matrices with controlled enrichment and degradability! 🔥 www.biorxiv.org/content/10.6...
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- In press: our brief review about the efforts to emulate the dental pulp using organ-on-a-chip approaches ”Dental Pulp-On-Chip” Microfluidic Devices for Emulating Human Dental Pulp Tissue Physiology and Pathology - Journal of Endodontics www.jendodon.com/article/S009...
- A majestic tour-de-force by @szczotml.bsky.social lab at @liu.se - beautiful combination of function & transcriptional identity to understand how pain is encoded across the body 👇🏼👇🏼
- Mapping genome-wide binding AND protein partners of virtually any gene regulator , simultaneously, without transgenesis? YES 👇🏼👇🏼👇🏼👇🏼 Look at what @annanordin.bsky.social & @claudiocantu81.bsky.social cooked!!
- Can one map the genome-wide binding (1) and its protein partners (2) simultaneously from the same sample? Yes, one can. with CUT&ID ✂️🪪 Spearheaded — singlehandedly — by @annanordin.bsky.social No need of transgenesis, cloning and overexpression. Check it out, it's fast and its works.
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- Reposted by Pierfrancesco PagellaFunders must recognise that great discoveries often come from studies that seeks to advance knowledge for its own sake go.nature.com/47zrzYZ
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- Reposted by Pierfrancesco Pagella"Jane Goodall showed us what a life in science could look like: rigorous discovery paired with fierce advocacy for what you study. She gave the world six decades of groundbreaking research on chimpanzees and their habitats, then turned that knowledge into a global movement for conservation." (1/2)
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- Reposted by Pierfrancesco PagellaThrilled to share our new paper @cp-cell.bsky.social: “Microglia–astrocyte crosstalk regulates synapse remodeling via Wnt signaling.” This work demonstrates the necessity of glia–glia communication and coordination during synapse remodeling. 🔗 www.cell.com/cell/fulltex... Faust et al., Cell 2025
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- We are hiring! 2 years postdoctoral fellowship, to work on the generation of all-human, vascularized and innervated organ-on-chip systems & model infection & inflammation - in Sweden 🇸🇪 @liu.se Details in the link - please help me spreading the announcement! liu.se/en/organisat...
- Glad to share the latest effort to emulate dental tissues on-chip: an organ-on-chip design including human dental pulp stem cells & HUVECs, odontoblasts, and a dentin powder-containing compartment, all innervated by mouse trigeminal ganglia! 👇🏼 advanced.onlinelibrary.wiley.com/doi/10.1002/...
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- Reposted by Pierfrancesco PagellaOur work bridging enhancer-promoter proximity to phenotypic outcomes in vivo is out! Shout out to @olimpiabompadre.bsky.social, to Marie Kmita's lab, and to all the co-authors. www.nature.com/articles/s41...
- Reposted by Pierfrancesco PagellaCan using synthetic approaches to build biology help teach us the design principles of how embryos build themselves? 👷♀️🔧 If this is a question that interests you, come and share your thoughts at this Royal Society Workshop on Generative Biology royalsociety.org/science-even...
- Always a great pleasure to see high-level work on tooth 🦷& craniofacial development!
- Closed up the Wnt Signaling GRS/GRC - honoured for the possibility of serving as co-chair in this amazing event!
- Incredibly useful thread! Thank you @juliaeckert.bsky.social !!
- What do we see when looking at cells under the microscope? 👉Some are bigger than others, some are elongated and align with the neighbors & others seem to move. Cool, right? But wouldn't it be cooler to quantify these observations? I'm @juliaeckert.bsky.social. Let's explore some analysis software!
- Reposted by Pierfrancesco PagellaWhat is buckling, and why is it relevant in understanding epithelial morphogenesis? 🧐 I am @onenimesa.bsky.social and I will share some papers to understand this aspect of #EpithelialMechanics
- Reposted by Pierfrancesco PagellaModular integration of epithelial, microbial, and immune components to study human intestinal biology. Amazing team project with Rubén López-Sandoval, Marius F. Harter, Qianhui Yu, Matthias Lütolf, Mikhail Nikolaev, and Nikolche Gjorevski! biorxiv.org/content/10.1...
- Always amazed by the sheer amount of e-mail traffic wasted by hopeless academic spam: this time, "dear Prof. [NAME]", "any contribution", from a "MEGA Journal of Case Reports" - waiting for Giga, Tera, and more!
- Cannot thank you enough @neilshubin.bsky.social for such an amazing contribution 🦷!!
- New paper from the lab: Our teeth arose as sensory organs on the outside of the body of ancient jawless fish.!! Congrats to Yara Haridy and the team! Background and video: phys.org/news/2025-05... Open Access Paper: www.nature.com/articles/s41... News and Views: www.nature.com/articles/d41...
- Reposted by Pierfrancesco PagellaYAP, a protein known to help #cancer cells survive treatment, behaves very differently in cell culture models depending on how they are grown in the lab, highlighting the importance of mimicking tumour architecture to guide better drug strategies. buff.ly/KQ9bkLg
- Thank you @shuntaroyamada.bsky.social and @unibergen.bsky.social for inviting me to give a talk at such a stimulating event - MRCRM 3rd International Meeting on Regenerative Medicine 2025 in Bergen, Norway! www.helse-bergen.no/en/arrangeme... Looking forward to our continued collaboration!
- Fresh out of press: our new chapter on the TBX3/WNT liaison, and how it drives metastasis-related genes expression in colorectal cancer, out on @pnas.org Enjoy the “bluetorial” by @claudiocantu81.bsky.social below! 👇🏼 #WNT #CRC @liu.se www.pnas.org/doi/10.1073/...
- We had previously shown that TBX3 and #WNT cooperate in limb #DevBio We now have a shocking finding, just published in @pnas.org TBX3 physically engages with β-catenin to drive metastasis genes in #ColorectalCancer (CRC) www.pnas.org/doi/epub/10....
- Registration is still open for our upcoming Gordon Research Conference (GRC, June 22-27) and Seminar (GRS, June 21 -22) on Wnt Signaling in Maine, US PhD students and postdocs, the GRS is for you, still possible to get selected for a talk - apply here! 👇🏼👇🏼 lnkd.in/d6ii4vDE lnkd.in/dfZ_v3Qk
- Reposted by Pierfrancesco PagellaThe Gulbenkian Institute of Molecular Medicine (GIMM) is one of the best research institutes in Portugal. It's currently recruiting for three Group Leaders (junior or senior) across different areas, including systems biology and bioinformatics. gimm.pt/jobs/open-ca...
- Reposted by Pierfrancesco PagellaInterested in Developmental Mechanics??? We are organizing a mechanobiology workshop in Baeza, Spain, October 21-23, 2025. Come join us (and please help us spread the word)!!!
- Reposted by Pierfrancesco PagellaEGFR signalling in amygdala astrocytes mediates neuroimmune interactions associated with FEAR 😨 www.nature.com/articles/s41...
- Reposted by Pierfrancesco Pagella😱 A very hungry #PacManoid ate the original post 🍬🍬🍬 Here’s the 🧵 on our latest in @cp-cellstemcell.bsky.social again! Gastruloids w/ a sweet tooth better model natural embryos: doi.org/10.1016/j.st... Spearheaded by @cryaaa.bsky.social & Alba Villaronga-Luque @mpi-cbg.de @poldresden.bsky.social
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- Registration is still open for our upcoming Gordon Research Conference (GRC, June 22-27) and Seminar (GRS, June 21 -22) on Wnt Signaling in Maine, US We have slots for short talks to be filled at both the main conference and the seminar - apply here! 👇🏼👇🏼 lnkd.in/d6ii4vDE lnkd.in/dfZ_v3Qk
- Reposted by Pierfrancesco PagellaA tour de force study from Taipale&Yin labs. It expands the vocabulary of the Regulatory Code by adding 1131 TF:TF composite motifs that are different from the individual TF motifs. The new composite motifs are enriched in cell-type specific elements and active in vivo www.nature.com/articles/s41...
- Reposted by Pierfrancesco PagellaThrilled to share our new review article! “The role of extracellular matrix viscoelasticity in development and disease” written together with Olivia Courbot is now published in npj Biological Physics and Mechanics. www.nature.com/articles/s44... #ECM #Mechanobiology #DevelopmentalBiology
- Reposted by Pierfrancesco Pagella🔬 New from the Farnung Lab: We established a fully in vitro reconstituted chromatin replication system and report the first cryo-EM snapshots of the human replisome engaging nucleosomes. Brilliant work by @felixsteinruecke.bsky.social with support from @jonmarkert.bsky.social! tinyurl.com/replisome
- Reposted by Pierfrancesco PagellaWith a little help from my friends… New cool story from @mucosalimmunology.bsky.social labs show that oral vaccines work way better when friendly microbes step in to outcompete gut pathogens. Teamwork makes the immune dream work! 🦠🫂 www.science.org/doi/10.1126/...
- Reposted by Pierfrancesco PagellaHot off the press! 🧬🔬 We developed in utero nano-injection to label & trace the mouse neural plate and otic placode using next generation single cell lineage tracing. We couple progenitors to mature cell types in the CNS & resolve the lineages of cells in the hearing organ: doi.org/10.1126/scie...
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- Reposted by Pierfrancesco PagellaStriking new study from @archaeon-alex.bsky.social's lab just out in @science.org on multicellular development induced by compression in Archaea: www.science.org/doi/10.1126/...
- Reposted by Pierfrancesco PagellaCholinergic enteric neurons expressing Piezo1 sense mechanical forces to regulate gut motility and modulate intestinal inflammation. #MechanoSensing www.cell.com/cell/abstrac...
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- www.nature.com/articles/d41... There’s plenty to discover in every corner!
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- Reposted by Pierfrancesco PagellaRead our collaborative paper @longchrom.bsky.social and @molinalab.bsky.social showing that disruption of NuA4 and ATAC coactivator complexes cause gene-specific transcript buffering, suggesting that cells dynamically adjust RNA export/degradation to sustain cellular homeostasis.
- Neutrophils secrete ECM (!!!) as physical barrier against pathogens during wound healing 👇🏼
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- Evolution of ectodermal appendages at the highest level? YES ❤️👇🏼 Thank you @rorylcooper.bsky.social !
- Check out these feather buds on the chicken embryo's wing! Our latest study @plosbiology.org reveals that temporary inhibition of sonic hedgehog signalling transforms feathers into simple, protofeather-like structures—similar to those of their dinosaur ancestors🔬🦖🧪 journals.plos.org/plosbiology/...
- Sonostimulation of MSC? 🤯 Thank you @carmeloferrai.bsky.social for this beautiful piece!!
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- β-catenin in Cnidaria is a different deal: yes, it patterns oral-aboral axis BUT inhibits endomesoderm specification 👉🏻β-catenin-dependent endomesoderm specification was a bilaterian innovation Amazing work !by @tclebedeva.bsky.social @genikhovich.bsky.social @adameykolab.bsky.social #Wnt
- Tanya's @tclebedeva.bsky.social paper on endomesoderm specification in the beta-catenin-negative area of the Nematostella embryo is out! www.nature.com/articles/s41...
- Check out our first chapter of the Transcription Factor Binding (TFB)-OMICS during #DevBio out on Development! 👇🏼
- Reposted by Pierfrancesco PagellaLungfish xkcd.com/3064
- Reposted by Pierfrancesco PagellaThe public really needs to understand this. Every university system in the world rests on public funding, there has never been an alternative model at any time in history. We have universities for literally the same reason that we have roads and armies.
- Cancer cells swirling to align collagen fibers at the tumor stroma interface -> invasion!
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- Reposted by Pierfrancesco Pagella1/46 Hey folks, we have a new paper out on the MuLTEE. Strap in and I’ll tell you the story of how this “little paper on polyploidy” turned into the most data rich paper our lab has produced, largely thanks to the leadership and work ethic of @kaitong25.bsky.social. www.nature.com/articles/s41...
- Reposted by Pierfrancesco PagellaOrgan-specific sympathetic innervation defines visceral functions www.nature.com/articles/s41...
- Reposted by Pierfrancesco PagellaWe wrote a review article on modelling and design of transcriptional enhancers using sequence-to-function models. From conventional machine learning methods to CNNs and using models as oracles/generative AI for synthetic enhancer design! @natrevbioeng.bsky.social www.nature.com/articles/s44...
- Reposted by Pierfrancesco PagellaUnbelievable news. Pancreatic is one of the deadliest cancers. New paper shows personalized mRNA vaccines can induce durable T cells that attack pancreatic cancer, with 75% of patients cancer free at three years—far, far better than standard of care. www.nature.com/articles/s41...
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- Reposted by Pierfrancesco PagellaHere is the peer-reviewed version of our study showing how some TAD borders are essential for gene regulation and development. Loss of a single CTCF motif is sufficient to cause embryonic lethality. www.sciencedirect.com/science/arti...
- Hej everyone out there! The registration for this year’s Wnt Signaling Gordon Research Seminar (GRS) and Conference (GRC) is open! Looking forward to see the whole #WNT community with us in Maine this year! www.grc.org/wnt-signalin...
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- Reposted by Pierfrancesco PagellaThe Institut Pasteur is recruiting group leaders! Pasteur is an absolute incredible environment to start your lab. Surrounded by so many great scientists, in the beautiful city of Paris. Come eat 🥐 and conduct awesome science. Contact me if you want info ! research.pasteur.fr/en/call/call...
- Looking forward to be back, although for this time only online, to my Alma mater - Milano-Bicocca @btbsunimib.bsky.social !
- Came for the post and stayed for the discussion: interesting and important thread 👇🏼
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- Great great work!
