Manuel Mendoza
Nuclear pore complexes and RNA export, Chromosomes and cytokinesis @igbmc.bsky.social Strasbourg. Who took the Bomp from the Bompalompalomp? Who took the Ram from the Ramalamading-dong? 🇻🇪 🇪🇸 🇫🇷
- Reposted by Manuel Mendoza🧬 #Yeast condensin does more than organize chromosomes. New study shows it acts as a transient crosslinker in entangled DNA, stabilizing entanglements rather than resolving them. This challenges current models of chromosome organizing proteins. #YeastResearch #SGD www.yeastgenome.org/reference/S1...
- Reposted by Manuel MendozaThe Muppet Show on Disney+ is glorious. They haven't tried to update it, or twist it in any way. It's just The Muppet Show you watched when you were a kid.
- Reposted by Manuel MendozaHi all- we are searching for a new manager/operator to run and develop KCL's Cryo-EM Structural Discovery Facility: a JEOL cryoARM200 + k3 and sample preparation equipment. This 200kV set up recently achieved a 1.2 Å apoferritin! www.biorxiv.org/content/10.6... www.kcl.ac.uk/jobs/137165-...
- Reposted by Manuel MendozaSo much here that I just cannot wrap my head around... "Asked about the shooting of Ms. Good, more than half of Republicans said it was a necessary use of force. Asked about Mr. Pretti, just 33 percent said it was a necessary use of force. A large share, 43 percent, said they were not sure."
- Reposted by Manuel MendozaPlease repost and consider applying: we work in such a fantastic context, we ask so interesting questions, and we have such a collegial and best-willing atmosphere… CRBM = Happy & Good Science
- Reposted by Manuel MendozaMelike Lakadamyali @melikel.bsky.social, Jérôme Solon and Manuel Mendoza @longchrom.bsky.social share the behind the paper story of their research interrogating how chromosome compaction scales with cell size using a combination of live confocal microscopy and 3D STORM.
- Reposted by Manuel MendozaMitosis has a timing system. If chromosomes attach properly, cells divide on schedule and keep proliferating. If attachment is slow or incomplete, the delay is recorded — and daughter cells stop dividing. We explore this link in our new preprint. 🔗 www.biorxiv.org/content/10.6...
- Reposted by Manuel MendozaI wrote this song on Saturday, recorded it yesterday and released it to you today in response to the state terror being visited on the city of Minneapolis. It’s dedicated to the people of Minneapolis, our innocent immigrant neighbors and in memory of Alex Pretti and Renee Good. Stay free
- Thanks to @focalplane.bsky.social for the invitation to highlight our recent @biophysj.bsky.social paper! With @melikel.bsky.social and Jérôme Solon, we combined super-resolution and live imaging to connect interphase chromatin organisation to mitotic chromosome compaction across cell sizes.
- Reposted by Manuel MendozaI’ll soon share a call for a postdoc at Institut Jacques Monod (Paris) on fundamental mechanisms of membrane traffic and protein/collagen secretion in health and disease. Please get in touch if interested.
- “A student joining a lab is often presented with a hypothesis to work on and may see science as a hypothesis-testing endeavor. Many young postdocs have been told that as a PhD student their job was to answer questions—now they have to discover their own unknown unknowns.”
- A great read! link.springer.com/article/10.1...
- Reposted by Manuel MendozaComme promis, un texte où je persiste et signe : le film "Le mage du Kremlin" est dangereux, car il se met au service du pouvoir russe en diffusant une vision du pays exactement conforme à ce que le Kremlin veut nous faire penser. colinlebedev.fr/2026/01/22/h...
- Reposted by Manuel Mendoza
- Reposted by Manuel MendozaWe are looking for a postdoc to work on mechanisms of #RNA decay in cancer using #cryoEM with #nanobodies and #minibinders! Please RT
- Reposted by Manuel MendozaThis photo was taken in 1911 using glass plate technology by Herbert Ponting who was part of Scott's Antarctic expedition, The composition and detail are exquisite with the band of white snow/ice creating a perfect frame around the two people and the ship in the distance Iconic imo
- Who’s behind this? The answer will not surprise you www.cidrap.umn.edu/childhood-va...
- This is nuts
- Histoire assez dingue : un essai clinique sur un vaccin contre l’hépatite B en Guinée-Bissau, financé par les États-Unis, prévoit de priver la moitié du groupe (soit 7 000 bébés !) du vaccin à la naissance. C'est "inacceptable"... et l'essai est suspendu. www.cidrap.umn.edu/c...
- Reposted by Manuel Mendoza
- Reposted by Manuel Mendoza0/10 🥳 our #exocyst paper out in @cp-cell.bsky.social, led by Marta, Sebas & @sasmeek.bsky.social in collab with @jonasries.bsky.social, @cmanzo.bsky.social & Castaño-Díez labs #Quantitative_Cell_Biology Continuum architecture dynamics of vesicle tethering in exocytosis www.cell.com/cell/fulltex...
- Reposted by Manuel Mendoza@science.org Scientists turn cells’ most mysterious structures into spies on genetic activity | Science | AAAS www.science.org/content/arti...
- Reposted by Manuel MendozaHappy to share that the our manuscript "Cyclin CLB2 mRNA localization and protein synthesis link cell cycle progression to bud growth" is now finally out in its final form @natcomms.nature.com www.nature.com/articles/s41... Below a short🧵 with the key findings!
- Reposted by Manuel MendozaTrump trying to conquer a foreign country. ICE killing someone and lying about it. We're not even a year into this Trump term and we're already here.
- Reposted by Manuel MendozaThis is basically the view of the world that Plato sets out to refute in the Republic. One of the core questions asked therein is: why do powerful people think the mere fact of them exercising dominion makes it good for them to do so? Sure, you *can* get away with stuff if you're powerful - so what?
- Reposted by Manuel Mendoza📢 Open PhD position Phasing polyploid genomes to decipher their phenotypic & adaptive potential 📍 IGBMC - Strasbourg ⏰ Start: Spring 🔍 Profile: MSc in bioinformatics, Python/Bash, R, sequencing data experience a plus. 📩 Application: see below
- A las barricadas compañeros, a trabajar conjuntamente en una agenda de cooperación
- Reposted by Manuel MendozaSo much for revolutionary fervor
- My sophisticated take on this is that when Trump said he was going to “run Venezuela” he was, in fact, full of shit
- Party like it’s the 1970s
- Reposted by Manuel MendozaSome people were angry I was preaching caution in #Venezuela instead of celebrating. Yes, Maduro out is a relief; but Delcy & Gang with wartime powers to suspend rights is a terrifying perspective. I wasn't doing cartwheels because I fear we Venezuelans will be off worse.
- “Maduro is gone. It’s tempting to think that, without him, the regime will implode. But Maduro’s system was always a team effort; the kind of regime that could very well survive decapitation. And if it does, Venezuelans will get the worst of it.”
- Welcome to 2026, the year of the Putinisation of American foreign policy
- Reposted by Manuel MendozaThere is of course zero internal logic. Former Honduran President Hernandez was extradited, convicted and sentenced to 45 years of prison for exactly the type of crimes Maduro is accused of - and Trump pardoned him. It's power, money and oil all the way down...
- Reposted by Manuel MendozaBardella and Le Pen are being clever, but hypocritical. The French far right has always been anti American, even during the Cold War. But they have been less wholehearted in their condemnation of Russian expansionism/imperialism
- Reposted by Manuel MendozaRemember that there is a legitimately elected president of Venezuela: Edmundo Gonzalez. He won the election in 2024.
- Reposted by Manuel MendozaBang on.
- Reposted by Manuel MendozaRead our new preprint where we uncover a hierarchy in human PIC assembly and establish a quantitative framework that connects factor exchange kinetics to the regulation of Pol II activity in living human cells. doi: doi.org/10.64898/202... By A. Oravecz and our collaborators @molinalab.bsky.social
- Reposted by Manuel MendozaAn in vivo imaging technique can track the way molecules move through the nuclear pore complex go.nature.com/3KODM4A
- Reposted by Manuel MendozaHierarchical buffering of cellular RNA polymerase II pools maintains transcriptional homeostasis biorxiv.org/content/10.64898/20…
- Reposted by Manuel MendozaHappy holiday ❄️⛄🎅! Global protein synthesis rates can fluctuate dramatically as a function of food intake, infections, energy resources, etc. Wondering whether/how protein elimination routes adapt to these changes to maintain proteome homeostasis ? Find out here: www.cell.com/cell-systems....
- Reposted by Manuel MendozaIn case any other Early-career scientist is interested in the call, I am based in Italy and we work on Transcription Factors cooperativity and their activation domains, co-translational assembly, promoter architecture (human cells). Very open to ideas! #HFSP #EarlyCareer
- Attention scientists from all over the world🙃 The Call for Letters of Intent for #HFSPResearchGrants 2027 is now open! 🧪 Get your international & interdisciplinary team. It's time to put your bold research idea into practice! 🔗https://bit.ly/48VsGCG 📅 15 Dec 2025–26 Mar 2026 #sts #LifeSciences
- Reposted by Manuel MendozaThanks @jcellsci.bsky.social for this opportunity to contribute to your centenary collection with our take on the state of the field - 10 years after its modern reincarnation 🧪🌍 W/ @alebenoit.bsky.social @eelcotromer.bsky.social @fritzlaylin.bsky.social journals.biologists.com/jcs/article/...
- Reposted by Manuel MendozaMy lab is hiring a postdoc (ERC funded)! If you're interested, get in touch!
- Reposted by Manuel MendozaFellow yeast enthusiasts, does anyone have the genomic or amino-acid substitution for the cdc20-1 ts mutant - thanks!
- Reposted by Manuel MendozaPostdoc position available in our lab @igbmc.bsky.social We have an exciting project aimed at re-visiting the (epi-)genomic functions of AT-binding proteins using state-of-the-art technologies: www.igbmc.fr/en/igbmc/lif... Expected start: from March 2026 Please share 📢
- Reposted by Manuel Mendoza🗞️ New preprint from the lab, led by our postdoc Ana Garoña (not on here) in collab with @andreagiometto.bsky.social: “Experimental evolution of cellular miniaturization reveals a mechanism for cell size evolution”, aka: “honey, we shrank the yeasts!” 🎥 www.biorxiv.org/content/10.6...
- Reposted by Manuel MendozaExperimental evolution of cellular miniaturization reveals a mechanism for cell size evolution biorxiv.org/content/10.64898/20…
- Reposted by Manuel MendozaThis entire story is just… 🤯 #giftarticle www.nytimes.com/2025/12/07/u...
- Reposted by Manuel MendozaThe next big electoral crunch in the EU will be the presidential election in France in April-May 2027. If the Far Right, already in poll position, conquers France, it will be a dagger to the belly of the European Union. 11/
- Reposted by Manuel MendozaThe US is now officially committed (alongside Moscow) to interfering in European electoral politics to promote nationalist and anti-EU parties of the Far Right, from Reform in the UK to Marine Le Pen’s Rassemblement National in France to the xenophobic AFD in Germany. 5/
- Reposted by Manuel MendozaNice work! #mRNP #Condensation #Stress #Yeast Transcriptome-wide mRNP condensation precedes stress granule formation and excludes new mRNAs: Molecular Cell www.cell.com/molecular-ce...
- Reposted by Manuel MendozaOf course it does. The paper is indeed very nice. No need to invoke LLPS though. It is the explanation that is pure fantasy. And Angus Lamond, Ted Salmon and others had already shown liquid-like and dynamic behavior
- Reposted by Manuel MendozaYour periodic reminder that science is not done by a few selected "stars scientists". Science is done by hundred of thousands. Siloed money mean a few flashy discoveries and a lot of waste. Want to change things? Make funding accessible and stop funding calls with less than 2% success rate.
- · #AcademicSky · The European Research Council is launching €7m Plus Grants for ambitious, long‑term research — open to researchers at any career stage but limited to about 30 awards; current ERC grantees and applicants are ineligible, reports @clanicholson.bsky.social.
- Reposted by Manuel Mendoza🚨 PhD opportunity in Strasbourg! 🚨 We’re looking for a motivated PhD student to join the @haploteam within the IMCBio program (PhD-2026-17). 🔗 imcbio-phdprogram.unistra.fr Please spread the word or contact me if you’re interested!
- Reposted by Manuel Mendoza[This post could not be retrieved]
- Reposted by Manuel MendozaThese image generators add invisible marks to AI generated content. Publishers need to quickly integrate the detectors into their publishing platforms to flag AI generated images.
- Reposted by Manuel MendozaFrench authorities are taking X to court because Grok is now doing straight up holocaust denial. Gas chambers intended for disinfection, cyanide residue tiny, ‘story’ persists because of taboo against critical examination. (Full translation in alt text)
- Reposted by Manuel MendozaPublished in Science Advances! Looking forward to discussing the implications of our results and their applications with many researchers. www.science.org/doi/10.1126/...
- Reposted by Manuel MendozaThe bottom line: the scaffold–client model collapses because the scaffold cannot exist. And once you remove it, LLPS is no longer needed to explain condensates. Biology becomes simpler, not more mysterious.
- Reposted by Manuel MendozaBLOOMBERG REPORTER: “If there’s nothing incriminating in the Epstein files why not…?” TRUMP: “Quiet. Quiet, Piggy.” 😕
