Mcclelland lab
Investigating origins and vulnerabilities of cancer chromosomal instability at the Barts Cancer Institute, London UK. Www.Mcclellandlab.com
- Reposted by Mcclelland labWe are recruiting a Postdoc in computational biology, together with @mariasecrier.bsky.social 4yr, fully funded by @cancerresearchuk.org, ideal for Postdocs wanting to develop their independence Applications open now: www.imperial.ac.uk/jobs/search-...
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- 4 months ago I boasted of two papers accepted in two days. In the interests of transparency I should also post that this week we had two papers rejected (or stalled). I wish this process was a little less demoralising, it’s the most important thing we have to do!!! Be nice people!
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- Arriving at work. That’s the moon.
- Reposted by Mcclelland labSo proud to watch Jana turn a side quest into an entire research programme. Couldn’t imagine a more well-deserved outcome. 😍 The mighty yeast reveals what we believe are general principles of centromere evolution! Behind the curtain: communities.springernature.com/posts/counti... #MEvoSky 🧪🌎
- How do new centromeres evolve while staying compatible with the division machinery? Discover it in our new Nature paper! We show centromeres transition gradually via a mix of drift, selection, and sex, reaching new states that still work with the kinetochore. 👉 doi.org/10.1038/s41586-025-09779-1
- Reposted by Mcclelland labWe are recruiting a postdoctoral fellow to study mechanisms of DNA replication stress using single-molecule imaging tools. If you are excited about microscopy, replisome dynamics, and genome stability, we’d love to hear from you. Application deadline: 24 December www.crick.ac.uk/careers-stud...
- Reposted by Mcclelland labA new and fascinating story from @bencarty.bsky.social and the group, with crucial help from the teams of @naltemose.bsky.social, Simona Giunta, and @dfachinetti.bsky.social. Many thanks to all for a fantastic collaboration. www.nature.com/articles/s41...
- Reposted by Mcclelland labCheck out this beautiful paper by @richardcsilva.bsky.social et al., out now in @natcomms.nature.com. Great new DSB sensors to track DNA break formation and repair in real-time www.nature.com/articles/s41...
- Lab website has been updated including a very nice news section! Www.mcclellandlab.com/news
- Reposted by Mcclelland labReady to start your own independent research programme? We're inviting applications for early career group leaders in all areas of biology and biomedicine @crick.ac.uk Apply by 27 Nov 2025: www.crick.ac.uk/careers-stud... #EarlyCareerResearchers #GroupLeader #ScienceCareers
- We're now recruiting early career group leaders at the Crick to lead ambitious research programmes and explore bold scientific questions. Hear our Director, Edith Heard, explain why the Crick is a unique place for curiosity-driven research. Apply now ➡️ www.crick.ac.uk/careers-stud...
- Reposted by Mcclelland labWe are looking for a senior technician (can undertake PhD) at Uni of Birmingham (UK) to study chromatin replication and ubiquitylation using Xenopus egg extract. Deadline 28/10/25. Get in touch with me or @m-saponaro.bsky.social for informal inquiries. Please share. www.jobs.ac.uk/job/DOW912/s...
- Reposted by Mcclelland lab3-year technician position with a possibility of doing a PhD available to study chromatin replication and ubiquitylation using cell free system of Xenopus laevis egg extract. Closing date 28/10/25. Get in touch @agagambus.bsky.social or @m-saponaro.bsky.social for informal inquiries lnkd.in/etU3yydb
- Reposted by Mcclelland labShortlisted candidates will be invited to give a seminar at the Fellows Conference, which will be held on 10 March 2026. Candidates who win Fellowships will be offered a Tenure Track Group Leader position from the outset, initially for 5 years. Find out more: www.jic.ac.uk/training-car...
- Reposted by Mcclelland labAre you a future black leader in cancer? Come join @mirazrahman.bsky.social and my labs @qmbci.bsky.social @kingscollegelondon.bsky.social to work on turning defective cell cycle checkpoints into innovative cancer therapies! Get in touch for more details www.colcc.ac.uk/2026-blic-ph...
- Are you interested in doing a #PhD in #cancerresearch? 🧪👩🏿🔬🧫🦠🔬 Do you want to develop new #biotherapeutics? Are you of black heritage? Applications for our fully funded 4-year BLiC PhD programme starting in Autumn 2026 are open now! bit.ly/485QAga #uclcancer #QMBCI #KCLcancer_pharm #KCL #TheCrick
- We are looking for our next PhD student to join us 🤩 www.mcclellandlab.com to understand cancer radiation therapy's impact on DNA damage repair and chromosomal instability. Prestigious funding from CRUK RadNet. Please contact me informally - deadline 5th Nov! crukradnet.colcc.ac.uk/phd-students...
- Interested in carrying out research in cancer Radiotherapy and Radiobiology? Applications are open now for our PhD programme for 2026 intake! @kingscollegelondon.bsky.social @qmbci.bsky.social @crick.ac.uk @ucl.ac.uk crukradnet.colcc.ac.uk/phd-students...
- Reposted by Mcclelland labOur first Centre for Cancer Evolution PI retreat! A wonderful day at Goodenough House discussing science, strategy and forging new collaborations @qmbci.bsky.social
- Reposted by Mcclelland labLast day of the @theaacr.bsky.social Advances in Pancreatic Cancer Research Conference in Boston! Yesterday I presented my poster on genome evolution & chemoresistance in PDAC, from @mcclellandlab.bsky.social. Thanks for the great feedback — and to @pancreaticcanuk.bsky.social for the opportunity!
- Come and join us at the Barts Cancer Institute @qmbci.bsky.social ! Our medical school, part of Queen Mary University of London @qmulfmd.bsky.social is hiring 10 professors!! www.veredus.co.uk/job/job-747a/. Contact me for a chat if interested.
- Reposted by Mcclelland labDosage responses of aneuploid autosomal chromosomes biorxiv.org/content/10.1101/202…
- Reposted by Mcclelland lab@mariasecrier.bsky.social & I are looking for an enthusiastic & excellent data scientist for a 4-year postdoc to understand cell cycle dysregulation in cancer. Deadline 15th October. Get in touch if you have any questions. Please repost! More details: www.imperial.ac.uk/jobs/search-...
- Please visit our newly refreshed and updated website mcclellandlab.com We seem to be hard to find on Google for some reason, any tips from website savvy people?? 🙏
- Reposted by Mcclelland labCheckout our latest research in @natcomms.nature.com rdcu.be/eBqBI A high-resolution, nanopore-based artificial intelligence assay for DNA replication stress in human cancer cells. A collaboration with Mike Boemo’s team
- Reposted by Mcclelland labNow out! Led by @susana-sousa.bsky.social and Noa Amin, and thanks to our collaborators in the Harrington @icr.ac.uk and Stucki and Choudhary @jc4-jyoti.bsky.social labs www.cell.com/cell-reports...
- New preprint from the lab on ARID1A, G quadruplexes, and repair: www.biorxiv.org/content/10.1...
- Reposted by Mcclelland labAlex's highly complementary study and fantastic story here: www.nature.com/articles/s41...
- The ‘surprise baby’ of papers, we trained visiting lecturer from Thailand 🇹🇭 Raksawan, who co-led by @nadeemshaikh.bsky.social and @mollyguscott.bsky.social produced our first work investigating CIN in Cholangiocarcinoma (prevalent in Northern🇹🇭 ). Congrats to co-corr author @nadeemshaikh.bsky.social!
- @mcclellandlab.bsky.social hosted Prof Raksawan Deenonpoe from Thailand so she could collaborate with @mollyguscott.bsky.social & I to look for evidence of chromosomal instability in cholangiocarcinoma. Our work is now published in Journal of Pathology.
- Reposted by Mcclelland lab🎉 Join us in congratulating four BCI researchers who have been promoted! Promoted to Professor: 🔹Professor Angus Cameron 🔹Professor Jun Wang Promoted to Senior Lecturer: 🔹Dr Diu Nguyen Promoted to Reder: 🔹Dr Miguel Ganuza @qmul.bsky.social @qmulfmd.bsky.social @cruk-cityoflondon.bsky.social
- Exciting work from my colleague Ben @benjaminwerner.bsky.social and others!
- 📰Rogue DNA rings could provide early clues to brain cancer’s growth, according to new results co-led by Dr @benjaminwerner.bsky.social, as part of international @cancergrand.bsky.social collaboration @qmul.bsky.social | @crick.ac.uk | @stanford.edu | @aacrjournals.bsky.social | #medsky #oncosky 🧪
- Calling all non-scientists interested in asking questions about cancer research for our new podcast-in-making!!! Please message your questions or contact me for more details 🤩
- Reposted by Mcclelland labVery happy to share our work on signature SBS5. See Molly's thread for a short summary
- In these dark times, it comes as a rare pleasure to highlight @natanaels.bsky.social & @marcdemanuel.bsky.social's work on germline and somatic mutations in humans. 1/n www.biorxiv.org/cgi/content/...
- Reposted by Mcclelland lab#1 Centromeres are epigenetic loci defined by CENP-A, positioned in unmethylated DNA flanked by highly methylated regions. Our work, published in @natgenet.nature.com in collaboration with @naltemose.bsky.social investigates the role of DNAme at human centromeres www.nature.com/articles/s41...
- Reposted by Mcclelland labMy first post on bsky to share our latest research in @nature.com: “DNA2 enables growth by restricting recombination-restarted replication” - defines DNA2’s essential function & elucidates links with primordial dwarfism and cancer. Thanks to the lab, collaborators & @ukri.org @acmedsci.bsky.social
- Reposted by Mcclelland lab[This post could not be retrieved]
- Reposted by Mcclelland labNarozna et al @gorbskylab.bsky.social uncover a high-frequency, chromosome 12-specific mis-segregation error in iPSCs. Eroded 12p arms lead to bridging & micronucleation, enabling widespread trisomy 12. A slight growth advantage allows trisomic cells to persist & dominate rupress.org/jcb/article/...
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- Reposted by Mcclelland labI am excited, our collaborative work on tumours driven by ecDNA amplified MYCN and the underlying copy-number dependent fitness landscape just came out in Cancer Discovery @aacrjournals.bsky.social. @anton-henssen.bsky.social @cancergrand.bsky.social aacrjournals.org/cancerdiscov...
- Reposted by Mcclelland labWe are looking for a postdoctoral researcher to investigate the role of inflammation on therapy resistance in colorectal cancer using patient-derived organoids and single-cell multiomics. Please reach out if interested: www.jobs.ac.uk/job/DNX776/p...
- Reposted by Mcclelland labJoin the #LMS! Our institute is advertising for junior #GroupLeader positions in #Physiology and #Metabolism. Closing date for applications: August 31st!
- Reposted by Mcclelland labProf Claude Chelala and her team's research into the inequalities facing women with breast cancer from different ancestries is now featured on @natcomms.nature.com homepage! Learn more & watch our interview with Prof Chelala: www.bci.qmul.ac.uk/general-news... #medsky 🧪 #oncosky @qmul.bsky.social
- New featured image on our homepage! bit.ly/4kVZAY1 Related to this #OpenAccess article: The clinical and molecular landscape of #BreastCancer in women of African and South Asian ancestry bit.ly/4l3tN7G @qmbci.bsky.social Image credit: Niten Patel
- Reposted by Mcclelland lab📰Could a breath test detect blood cancer? New research from @richeslab.bsky.social funded by @bartscharity.bsky.social suggests molecules exhaled in the breath might enable development of a simple, low-cost test to diagnose lymphoma. @qmul.bsky.social @qmulfmd.bsky.social #medsky #oncosky 🧪
- Reposted by Mcclelland labNew preprint! We solve a mystery you didn't know existed. Mitotic cells lack new transcription but require ongoing translation. Interphase mRNA half life is only 2-4 hrs. So how do cells arrest in mitosis for hours without depleting their transcriptomes? www.biorxiv.org/content/10.1...
- Reposted by Mcclelland labWe're very proud that our recent PhD graduate (and now postdoc) Rosie Wilkins' study on RNase H2 overexpression in human cells has been published in Oncogene. www.nature.com/articles/s41...
- Reposted by Mcclelland labResearchers have significantly expanded the catalogue of known human genetic variation. Two studies in @nature.com resequenced data from the landmark 1000 Genomes Project with long-read tech, creating what may be the most complete overview of the human genome to date. www.nature.com/articles/s41...
- Two papers accepted in two days! I never thought I’d be one of those annoying people that says that kind of thing…..
- Reposted by Mcclelland labOur new review on how the initiation of DNA replication is coordinated with transcription is now online! Congratulations to @syedshahidmusvi.bsky.social! www.sciencedirect.com/science/arti...
- I had a wonderful day at the Dunn school Oxford last Friday, met so many great scientists and trainees and got fantastic questions after my talk, thanks so much @esashilab.bsky.social for the invite, and hope to see you at BCI in the new year :)
- Reposted by Mcclelland labThere are just 3 days left on our crowd-investment campaign, which ends on Monday morning. Would you like to help us to get to the next round number? Every investment will help us to continue to achieve our aims... www.crowdcube.com/companies/ho...
- Reposted by Mcclelland labExploring CDK4/6-Dependencies in ex vivo Ovarian Cancer Models biorxiv.org/content/10.1101/202…
- Reposted by Mcclelland labDelighted to share our latest work showing how cells that evade #senescence after CDK4/6 inhibition are primed to become aneuploid because of their increased size (due to defects in cohesion and the mitotic checkpoint). Great work by fab PhD student Aanchal Pareri 👏🧪 www.biorxiv.org/content/10.1...
- Reposted by Mcclelland labNew preprint from Kelsey Fryer in the lab using ChAR-seq to identify RNAs that are bound to human centromeres. Lots of surprises! #centromere #RNA www.biorxiv.org/content/10.1...
- Lab is quiet this week with 4 students/postdocs enjoying the science (and weather) at EACR in Lisbon!
- Not many people know that I grew up in a folk music instrument shop that my parents established and grew into an international business. Times are tough and my sister (now managing director) has launched crowdfunding to help keep our music shops alive!. If anyone wants to support we’re grateful!
- The funding page is now live, here: www.crowdcube.com/companies/ho... Don’t invest unless you’re prepared to lose all the money you invest. This is a high-risk investment and you are unlikely to be protected if something goes wrong
- Wonderful visit to the very beautiful ancient city of Salamanca, to give a seminar and meet with great friends Esther Castellano and @nuriaferrandiz.bsky.social
- Reposted by Mcclelland labHi all, my team institut-curie.org/team/fachine... @institutcurie.bsky.social is looking for a Bioinformatician. You can find more details about the position here: euraxess.ec.europa.eu/jobs/344508 Is anyone looking for a job in the lovely Paris?
- Reposted by Mcclelland labIncoming - new preprint alert from the Parkes lab led by @brunobeernaert.bsky.social Full bluetutorial follows! 1/ 11 www.biorxiv.org/content/10.1...
- Reposted by Mcclelland labNew Competition! In our latest competition, you can win a lovely set of Hobgoblin Music merchandise and a £25 gift voucher. hobgoblin.com/community/co...
- Reposted by Mcclelland labNow online in Cancer Discovery: Human Papillomavirus Integration Induces Oncogenic Host Gene Fusions in Oropharyngeal Cancers - by Nusrat Khan, Keiko Akagi, Shiming Jiang, Maura Gillison, and colleagues doi.org/10.1158/2159... @mdanderson.bsky.social
- Reposted by Mcclelland labREGISTER NOW! Spots are filling up for the first EMBO workshop on Single cell Lineage Tracing 2025!! Sept 18-21 in Girona, Spain. Tons of opportunities for talks (short and full length) still available!!! meetings.embo.org/event/25-lineage-tracing
- Reposted by Mcclelland labLia Skolariki (amazing clinical fellow), Rosie Clark (fantastic RA and incoming PhD to Cambridge) and I really enjoyed writing this commentary on dsRNA sensing in chromosomal instability febs.onlinelibrary.wiley.com/doi/10.1002/...
- Reposted by Mcclelland labWhat governs where DNA replication begins in human cells? Here, we show that origins of replication in human DNA are epigenetically specified and that crucially, this epigenetic mark is required for both DNA replication and cell proliferation! @narjournal.bsky.social academic.oup.com/nar/article/...
- Reposted by Mcclelland labCome and join us! We’re hiring a new Group Leader in Generative Biology at the @sangerinstitute.bsky.social Building AI models or the data to train them? Core funding of >$130M a year for a faculty of ~30. www.nature.com/naturecareer... acrobat.adobe.com/id/urn:aaid:... pls RT!
- Reposted by Mcclelland labnew out in Nature www.nature.com/articles/s41...
- Reposted by Mcclelland labBetter late than never! The Rendo Lab website is officially up and running 🧠 🧬 Read about our ongoing research and the wonderful team that makes it happen! rendolab.org
- I’m not sure if this meeting can be topped, I was honoured to be part of the organising team and had a wonderful time at every moment.
- The @embo.org #chromoploidy2025 is over. It was an amazing workshop organized by a perfect match of scientists and friends @mcclellandlab.bsky.social @bendavidlab.bsky.social @stesantaguida.bsky.social @foijer-lab.bsky.social, Elsa Logarinho, Caroline Audouin and myself
- Reposted by Mcclelland labThe Gulbenkian Institute of Molecular Medicine (GIMM) is one of the best research institutes in Portugal. It's currently recruiting for three Group Leaders (junior or senior) across different areas, including systems biology and bioinformatics. gimm.pt/jobs/open-ca...
