Esashi Lab
Sir William Dunn School, University of Oxford, Interested in genome stability, homologous recombination, chromosome, centromeres
esashilab.wordpress.com
- Absolutely fascinating work! 🔥 The more you think, the more intrigued. We featured it in our highlight 🔗 rdcu.be/eyOGc - such a cool twist in the host–virus warfare. Many congrats to @manellab.bsky.social
- Thrilled to share our latest @cp-cell.bsky.social. We present VICAR (VIral-induced Centromeric DNA Amplification and Recognition), a new defense system to detect viruses in the nucleus based on nuclear cGAS. www.cell.com/cell/abstrac...
- We are delighted to share our latest work, characterising the role of BRCA2 and its binding partner PALB2 at centromeres, just out in the latest issue of Cell Reports. ⬇️ www.cell.com/cell-reports...
- Note that the phenotype varies between cell lines (HCT116 vs RPE1), but in the big picture, we propose that homologous recombination and mismatch repair factors engage in a ‘tug of war’ at centromeres to maintain their functional resilience.
- This study, conceived eight years ago, was made possible by a global collaboration across the UK, USA, Japan and Turkey. The dedicated team efforts of Emily and Lucia, relayed by Brian, Jacob, Emoke and Ramazan, and invaluable assistance from many others, brought this research to life.
- Huge thanks to everyone involved and for the incredible support from the community. This is our very first post on this platform, and we're looking forward to continuing to connect with you all!
