Hasan Yardimci
Group leader at the Francis Crick Institute. Studying DNA replication one molecule at a time.
- Reposted by Hasan Yardimci2nd postdoc job alert in the Crick Institute in London. Project will examine the role of motors & the cytoskeleton (actin, septins and microtubules) during vaccinia virus egress using biochemical, structural & cellular approaches + live cell imaging. spread the word. crick.ac.uk/WayPostdoc20...
- Reposted by Hasan YardimciDear Colleagues, Delighted to share that our first lab paper is now published in Nature.!!! 😊😊😊 We identify a previously concealed “safety limit” in DNA replication program: cells intrinsically rate-limit PCNA via PAF15, shaping strand-specific and global replication dynamics. 👉 rdcu.be/e1bBt
- Reposted by Hasan YardimciNew work published in @natcomms.nature.com has shone light on how a protein called geminin ensures DNA is only replicated once before cells divide, helping cells to maintain the integrity and accuracy of their DNA. This work was a collaboration between the LMS and @imperialchemistry.bsky.social
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- Reposted by Hasan YardimciCool work from Heath Murray's lab where they use Cas9 nickase to study how ssDNA breaks are repaired in Bacillus subtilis #MicroSky www.nature.com/articles/s41...
- We are recruiting a postdoctoral fellow to study mechanisms of DNA replication stress using single-molecule imaging tools. If you are excited about microscopy, replisome dynamics, and genome stability, we’d love to hear from you. Application deadline: 24 December www.crick.ac.uk/careers-stud...
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- Reposted by Hasan Yardimci📢 Excited to share that our study has just been published in Nature Communications! We uncover how CRL4-DCAF12 regulates the cellular levels of MCMBP, a chaperone essential for assembling nascent MCM2-7 complexes, to ensure accurate and error-free genome duplication.
- Reposted by Hasan YardimciWe are looking for a senior technician (can undertake PhD) at Uni of Birmingham (UK) to study chromatin replication and ubiquitylation using Xenopus egg extract. Deadline 28/10/25. Get in touch with me or @m-saponaro.bsky.social for informal inquiries. Please share. www.jobs.ac.uk/job/DOW912/s...
- Reposted by Hasan YardimciAre you interested in working on related projects? 🌱 The Knipscheer lab at the Hubrecht Institute (Utrecht, the Netherlands) has openings for a postdoc and a PhD position. Apply here: www.hubrecht.eu/jobs
- Excited our paper is out! G-quadruplex (G4) unwinding via an intricate G-loop assembly and disassembly mechanism maintains genome integrity. Pioneered by Koichi Sato with great collaborators Jing Lyu and @simonelsasser.bsky.social Check it out: www.science.org/doi/10.1126/science.adr0493 🧵(1/4)
- Reposted by Hasan YardimciIt is not always safe to repair DNA Damage. Sometimes, cells "just bypass it". During DNA replication, repair of lesions on DNA can be dangerous. Cells instead "tolerate" DNA damage and focus on finishing replication. Read our review and find out why and how: doi.org/10.1016/j.ti...
- Reposted by Hasan Yardimci📢 For all HaloTag lovers💙💚💛❤️💜🩶 we are excited to share that our work, in which we developed a new biotin-HaloTag ligand, is now published in @jcb.org! Full link here: rupress.org/jcb/article-...
- Reposted by Hasan YardimciYadav, Jadhav, @hanasedlackova.bsky.social et al present a novel cell-permeable biotin-HaloTag ligand. The reported ligand expands the HaloTag toolbox by enabling in vivo labeling & providing capabilities for efficient affinity capture of protein variants from live cells rupress.org/jcb/article/...
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- Reposted by Hasan YardimciExcited our paper is out! G-quadruplex (G4) unwinding via an intricate G-loop assembly and disassembly mechanism maintains genome integrity. Pioneered by Koichi Sato with great collaborators Jing Lyu and @simonelsasser.bsky.social Check it out: www.science.org/doi/10.1126/science.adr0493 🧵(1/4)
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- Reposted by Hasan YardimciWe’re #hiring, please share! A fully funded #postdoc position is available in my lab to work on DNA damage response mechanisms. Please get in touch with your CV if you are interested; closing date: 27th June 2025. More details here: candidate.hr-manager.net/ApplicationI...
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- Reposted by Hasan Yardimci📢 For all DNA fiber enthusiasts! 🟥🟩 We are thrilled to announce the release of our long-awaited AI-based workflow for the automated and quantitative analysis of DNA fibers. It's an exciting step forward—check it out on bioRxiv! lnkd.in/dQWUPtsP
- Reposted by Hasan YardimciScience under siege: protecting scientific progress in turbulent times journals.biologists.com/dev/article/...
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- Reposted by Hasan YardimciHow do replisomes walk on DNA? And what happens when they run into a G-quadruplex? @sahilbatra.bsky.social and @benallwein.bsky.social provide unexpected insight in our latest paper with Richard Hite @mskcancercenter.bsky.social @science.org www.science.org/doi/10.1126/.... Congrats to all authors!
- In our latest preprint, we uncover how CMG helicase overcomes covalent DNA-protein crosslinks. Check out our findings here: www.biorxiv.org/content/10.1...
- A new PhD position is available in my lab to explore DNA replication mechanisms using single-molecule approaches. Apply by 19th of March: www.crick.ac.uk/careers-stud...
- Reposted by Hasan YardimciSAVE THE DATE! The next EMBO | EMBL Symposium on 'DNA replication and genome maintenance: from basic biology to disease' will be held October 20-23, 2026. Organized by Helle Ulrich (IMB), Johannes Walter (Harvard) and Anja Groth (Danish Cancer Institute). www.embl.org/about/info/c...
- Reposted by Hasan YardimciVery excited to share that my thesis work is out in Molecular Cell! We trained a Structure and Omics informed Classifier (SPOC) to score binary AlphaFold multimer (AF-M) predictions by structural quality and consistency with experimental omics datasets. www.cell.com/molecular-ce...
- Reposted by Hasan YardimciOur spring round of PhD recruitment is now open! We’re looking for researchers of any nationality with backgrounds in biological or biomedical sciences, physics, chemistry, maths or computer science. Find out more and apply by midday, 19 March: www.crick.ac.uk/careers-stud...
- Reposted by Hasan Yardimci4-year PhD studentship available in my lab to study helper helicase function in eukaryotic DNA replication. Happy to receive any enquiries directly to me. Come join us and add your figure to the lab lego collection! institute-genetics-cancer.ed.ac.uk/igc-graduate...
- Reposted by Hasan YardimciPlease share: Still plenty of time to apply for PhD projects in my lab using single-molecule methods to look at disordered regions and condensin complexes! Contact me at e.cutts@sheffield.ac.uk For details on how to apply: www.findaphd.com/phds/project...
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- Reposted by Hasan YardimciThe first paper from our lab is online! A wonderful collaboration with @scottbscience.bsky.social lab. We discover that Pol II is extensively regulated by Ubiquitin at the beginning of the transcription cycle! www.cell.com/molecular-ce...
- Reposted by Hasan YardimciI have received a Wellcome Discovery Award to study the initiation of eukaryotic DNA replication, with 8 years of funding at the Francis Crick Institute. Looking for a postdoc in molecular mechanisms, cryo-EM, cryo-FIB and in situ structure? Contact me now! 3 postdoc positions advertised soon.
- Reposted by Hasan Yardimci📢 Happy to share our bioRxiv preprint on how CRL4-DCAF12 regulates the cellular level of MCMBP, a chaperone of nascent MCM2-7 complexes, to ensure error-free genome duplication. The full story can be found here: lnkd.in/eCjVNQks
- Reposted by Hasan YardimciTwo fully funded PhD opportunities in our lab. Interdisciplinary, DNA replication, cancer research, structural biology… deadlines in early Jan. Open to international students. t.co/WEJJIU4zU4 www.findaphd.com/phds/project...
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