Julian Stingele
Professor | Gene Center @ LMU Munich
Cellular responses to DNA and RNA damage
- Reposted by Julian StingeleCheck out the GRC for DNA damage and Cancer! Join us in Summy California for a week of DNA repair and Cancer! www.grc.org/dna-damage-m...
- Reposted by Julian StingeleHow to keep in step when your (protein) partner speeds up… Here we investigated the adaptive remodeling of a protein-protein interaction surface essential for telomere protection. Congrats to whole team! www.science.org/doi/10.1126/...
- Reposted by Julian StingeleRegistration is open!🧬 Join us at Egmond aan Zee (April 19–24, 2026) for the next DNA Repair Meeting. We have an amazing line-up of speakers. 📅 Deadline for early registration: Jan 10, 2026 🔗 dnarepairmeeting-egmond2026.com
- Reposted by Julian StingeleAre you interested in working on related projects? 🌱 The Knipscheer lab at the Hubrecht Institute (Utrecht, the Netherlands) has openings for a postdoc and a PhD position. Apply here: www.hubrecht.eu/jobs
- Excited our paper is out! G-quadruplex (G4) unwinding via an intricate G-loop assembly and disassembly mechanism maintains genome integrity. Pioneered by Koichi Sato with great collaborators Jing Lyu and @simonelsasser.bsky.social Check it out: www.science.org/doi/10.1126/science.adr0493 🧵(1/4)
- Reposted by Julian StingeleThrilled that our work is now finally out in Nature Comms! rdcu.be/eG3vP We reveal cryo-EM structures of the MRN complex bound to DNA & TRF2 - showing how DNA breaks are sensed and regulated at telomeres. Fantastic work by first authors @yilanfan.bsky.social @filizkuybu.bsky.social & Hengjun!
- Reposted by Julian StingeleJOB ALERT 🚨 We are hiring TWO principal investigators in cell, molecular, systems, or chemical biology in Toronto, Canada at @sinaihealth.bsky.social. We provide a generous startup, fully funded salary and academic appointment at U of Toronto. www.nature.com/naturecareer... Please repost!
- Reposted by Julian StingeleWould you like to do some unique experiments in cancer genomics and mutagenesis, in beautiful Munich? Well then apply for this PhD position: jobs.dkfz.de/en/jobs/1679... You'll learn a lot and it'll be fun and interesting! #DKTK @dkfz.bsky.social @lmumuenchen.bsky.social
- Reposted by Julian StingeleI am very excited to share the newest paper of the lab, a huge amount of work led by our talented PhD student Maxime Galloy, in close collaboration with Andréanne Blondeau, our dedicated research assistant for 10 years! 🙌 www.cell.com/molecular-ce...
- Now peer reviewed and in its final form @natcomms.nature.com www.nature.com/articles/s41...
- Reposted by Julian Stingele🥳Congratulations, Shubo! 🥂👏What a fantastic start to your scientific career! Shubo Zhao @jstingele.bsky.social receives Promotion Award from the Münchner Universitätsgesellschaft: www.genzentrum.uni-muenchen.de/news-events/... MUG prizes for LMU early-career researchers www.lmu.de/en/newsroom/...
- Reposted by Julian StingeleCytarabine has been the mainstay for AML treatment for over 50 years. This chemotherapy can lead to problems with movement and balance. Here we explain this neurotoxic side-effect. www.nature.com/articles/s41... Work led by Jia-Cheng Liu, Donpeng Wang and Elsa Callen and terrific collaborators!
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- Reposted by Julian StingeleDelighted to share that the results of my main postdoc project are now published in @nature.com 🔗 doi.org/10.1038/s415...
- Reposted by Julian StingeleA PhD position is open in my group here in Heidelberg. We'll use cool primary cell models of osteosarcoma and genetic screens to understand and overcome mechanisms of clinically acquired drug resistance. It'll be a blast! karriere.klinikum.uni-heidelberg.de/index.php?ac...
- Reposted by Julian StingeleA must for all DNA repair aficionados! Egmond DNA Repair Meeting → April 19–24, 2026 🇳🇱 ✔️ Confirmed top speakers ✔️ Ample opportunities for talks & posters Don’t miss it: dnarepairmeeting-egmond2026.com
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- Reposted by Julian StingeleSAVE THE DATE! The next EMBO | EMBL Symposium on 'DNA replication and genome maintenance: from basic biology to disease' will be held October 20-23, 2026. Organized by Helle Ulrich (IMB), Johannes Walter (Harvard) and Anja Groth (Danish Cancer Institute). www.embl.org/about/info/c...
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- Happy to share our review on the cellular responses to RNA damage 🥂 Congrats to joined first authors Jacqueline Cordes & @shubozhao.bsky.social www.cell.com/cell/fulltex...
- Reposted by Julian StingeleRegister now for The Ageing Genome: from Mechanisms to Disease conference. Amazing line-up of speakers and great opportunities for presenting your work and discussing with leaders in the field #EESAgeing @embl.org @cecad.bsky.social www.embl.org/about/info/c...
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- Our review on the recently discovered transcription-coupled DPC repair pathway is out in Trends in Cell Biology. Yet another wonderful collaboration with @cjcarnie.bsky.social and Steve Jackson.
- Happy to share a review written with the wonderful @jstingele.bsky.social on transcription-coupled DPC repair, featuring an overview of new methods, close comparison with TC-NER, comments on clinical implications and plenty of discussion of the unknowns. www.cell.com/trends/cell-...
- Happy to share our latest work🍾 🥳 PhD student Sophie Dürauer discovered together with many wonderful collaborators that the ubiquitylation of DNA-protein crosslinks promotes their cleavage by SPRTN more than 100-fold 🧬🔧
- Using in vitro reconstitution, MD simulations, NMR and cell biology we show that ubiquitin binds to a novel surface on SPRTN, stabilising an open, active conformation of the protease.
- Reposted by Julian StingeleHappy to share our new paper with Goran Kokic and the Svejstrup lab in Cell! We show that STK19 facilitates the clearance of lesion-stalled RNAPII during transcription-coupled DNA repair. Great teamwork by Diana, Marta and Paula! www.cell.com/cell/fulltex...
- Reposted by Julian StingeleThe peer-reviewed version of our paper is out! Thanks to all co-authors, editor and reviewers for the smooth process 🤓🎉 And don’t miss the chromatin haiku! www.cell.com/molecular-ce...
- Do you want to know what happens when cells stop assembling chromatin during DNA replication? Check out the latest pre-print from our lab! True team work with many essential collaborators.. feedback welcome! www.biorxiv.org/content/10.1...
- Reposted by Julian StingeleHi BlueSky! It's great to be here. Here's a handy Starter Pack of DNA repair & genome stability groups that I found so far go.bsky.app/NvFWKvLat://did:plc:7hf6kbzafr7afbbtuko2vnex/app.bsky.graph.starterpack/3lasx2s6js725
- Reposted by Julian StingeleFirst post here! New paper from the lab! Profound synthetic lethality between FANCM and SMARCAL1: www.cell.com/molecular-ce...
- Very pleased to share our new paper on the translation-coupled resolution of RNA-protein crosslinks @MolecularCell Our first adventure into the resolution of RNA damage was spearheaded by the brilliant Jackie Cordes and Shubo Zhao doi.org/10.1016/j.mo...
- Super interesting analysis of the evolutionary aspects of DNA-protein crosslink repair
