Lead-DBS
Open source toolbox to model deep brain stimulation electrodes in the human brain. www.lead-dbs.org - home at the @netstim.org
- Reposted by Lead-DBS🧠 Deep brain stimulation for Parkinson’s disease achieves its best results when a precisely defined brain network operating in the high beta frequency range is targeted. This was shown by a team @andreashorn.org @bahnebahners.bsky.social in both space and time for the first time.👇 uni.koeln/5LYV7
- Reposted by Lead-DBS🧠 Die Tiefe Hirnstimulation bei Parkinson zeigt ihre bestmögliche Wirkung, wenn ein präzises Gehirnnetzwerk im Beta-Frequenzbereich (20–35 Hz) stimuliert wird – das zeigt ein Team um @andreashorn.org @bahnebahners.bsky.social jetzt erstmals gleichzeitig räumlich und zeitlich👇 youtu.be/ZrREFuDI-as
- Reposted by Lead-DBSIt was a great joy to talk to Ludvic Zrinzo about DBS, lesioning and how it all may work: stimulatingbrains.org/74-ludwig-zr... Thanks to Niels Pacheco for producing the episode!
- Reposted by Lead-DBSWhat is the status of DBS for epilepsy? Find out in our new review/metaanalysis spearheaded by @laurenahart.bsky.social & Garance Meyer in JNNP: pubmed.ncbi.nlm.nih.gov/40666371/ A 🧵 — please RT for reach! 🙏
- Reposted by Lead-DBSSee you in Geneva! We have such an incredible line up of speakers this year! #optoDBS2026 – registration now open at www.optodbs.ch As last time, we are expanding scope way beyond just DBS and optogenetics – for instance including TMS and LIFU applications this year!
- From Adaptive DBS to Adaptive Circuit Targeting 👇👇
- In #DeepBrainStimulation the two major developments across the last decade have been 1. Adaptive DBS and 2. Connectomic DBS In a @natrevneurol.nature.com article with @julianneumann.bsky.social, we ask: Could the two be united into a common framework? www.nature.com/articles/s41... A 🧵
- Reposted by Lead-DBSNext steps ahead for DBS! 👇👇
- In #DeepBrainStimulation the two major developments across the last decade have been 1. Adaptive DBS and 2. Connectomic DBS In a @natrevneurol.nature.com article with @julianneumann.bsky.social, we ask: Could the two be united into a common framework? www.nature.com/articles/s41... A 🧵
- Reposted by Lead-DBSKonstantin Butenko compares four methods for mapping structural network activations in deep brain stimulation—two simple, two complex; some deterministic, some probabilistic—into @lead-dbs.org for direct use in the Fiber Filtering Explorer. See the methods paper below 👇👇
- How should we best model recruitment of axons by deep brain stimulation? Various concepts have been introduced and Konstantin Butenko just introduced a few more in a new publication at Brain Communications: academic.oup.com/braincomms/a...
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- How should we best model recruitment of axons by deep brain stimulation? Various concepts have been introduced and Konstantin Butenko just introduced a few more in a new publication at Brain Communications: academic.oup.com/braincomms/a...
- Should we use • Electric Field Magnitude • Electric Field projections onto fibers • Pathway Activation Modeling • probabilistic Pathway Activation Modeling?
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- Reposted by Lead-DBSWe had a wonderful time talking to @rolstonjohn.bsky.social, the Director of Epilepsy Surgery at Brigham & Women's Hospital. We talk about RNS for epilepsy, DBS for coma, traveling waves in the brain, stem cell therapy, closed loop DBS & more! Tune in 👇 stimulatingbrains.org/72-john-rols...
- Reposted by Lead-DBSHow may traveling waves in the brain impact seizure focus detection in functional neurosurgery? How does RNS for epilepsy really work? Are we ready for stem cell therapy in PD? DBS for disorders of consciousness? Find out in a conversation with the one and only @rolstonjohn.bsky.social 👇👇
- We had a wonderful time talking to @rolstonjohn.bsky.social, the Director of Epilepsy Surgery at Brigham & Women's Hospital. We talk about RNS for epilepsy, DBS for coma, traveling waves in the brain, stem cell therapy, closed loop DBS & more! Tune in 👇 stimulatingbrains.org/72-john-rols...
- Reposted by Lead-DBSMassive, Herculanean work by @laurenahart.bsky.social and Garance Meyer to compile and integrate findings from DBS for epilepsy (20 targets!) including meta-analytical evidence for optimal stimulation sites for the two main targets (ANT & CM). Preprint out now 👇👇
- 🧠 ⚡️ Preprint alert ⚡️ 🧠 I️n the most comprehensive review of DBS in epilepsy, with 124 studies, 1,210 patients, and 20 anatomical targets we map where stimulation works best and why. Deep Brain Stimulation for Epilepsy: Optimal Targeting and Clinical Outcomes www.researchgate.net/publication/...
- Reposted by Lead-DBS🧠 ⚡️ Preprint alert ⚡️ 🧠 I️n the most comprehensive review of DBS in epilepsy, with 124 studies, 1,210 patients, and 20 anatomical targets we map where stimulation works best and why. Deep Brain Stimulation for Epilepsy: Optimal Targeting and Clinical Outcomes www.researchgate.net/publication/...
- Reposted by Lead-DBSWe are actively looking for an administrative position to help lead the newly founded @netstim.org at the University of Cologne – please spread the word and/or let us know if you know somebody that could be interested! lnkd.in/eEbnXByJ
- Reposted by Lead-DBS@foxmdphd.bsky.social's legendary anticorrelation paper has now been cited over 10.000 times and this was reason for a dedicated PNAS cake. Congratulations again, Mike, for this unbelievable pioneering effort that opened up the then novel field of resting-state fMRI! @braincircuits.bsky.social
- What a number! 🔜 🎉🥳🎊🍾 @foxmdphd.bsky.social!
- Reposted by Lead-DBSHard to keep track about all the great things our labmembers have achieved recently:
- Reposted by Lead-DBSHappening today! We have two amazing speakers, Nicole Provenza and Martijn Figee who will share their thoughts on engineering for Neuromodulation and circuit based DBS for OCD respectively. Be sure to tune in on May 29th, 12 noon EST/6:00 PM CET Register here: partners.zoom.us/webinar/regi...
- Reposted by Lead-DBSAre we on the cusp of moving beyond the levodopa challenge test to predict the best candidates and response to DBS in Parkinson's disease? We’ve long relied on the levodopa challenge to decide who’s a good candidate for deep brain stimulation but what if that test is only part of the story?
- Reposted by Lead-DBSCan brain injury cause the loss of visual imagination? We studied #aphantasia due to brain injury. Lesions were in many different regions but 100% were connected to the fusiform imagery node - a region active during visual mental imagery @braincircuits.bsky.social www.medrxiv.org/content/10.1...
- Reposted by Lead-DBSIs there a shared brain circuit target for tremor that transcends diagnosis and DBS site? New work by @lukasgoede.bsky.social @andreashorn.org @braincircuits.bsky.social says YES
- Tremor is a common symptom across many neurological disorders. But is there a shared tremor circuit across disorders - one that could guide treatment, regardless of diagnosis? We think: yes. Our study is out now in @natcomms.nature.com: 🔗 www.nature.com/articles/s41... 🧵 A thread.
- Reposted by Lead-DBSNew research from @lukasgoede.bsky.social @andreashorn.org & colleagues provides a robust, cross-condition tremor network that may guide both invasive & noninvasive neuromodulation strategies for #Parkinsons & essential tremor www.nature.com/articles/s41...
- Reposted by Lead-DBSTremor is a common symptom across many neurological disorders. But is there a shared tremor circuit across disorders - one that could guide treatment, regardless of diagnosis? We think: yes. Our study is out now in @natcomms.nature.com: 🔗 www.nature.com/articles/s41... 🧵 A thread.
- Reposted by Lead-DBSCurious in an update on networks involved in treating tremor using neuromodulation? New study from the lab spearheaded by the one and only @lukasgoede.bsky.social out now at nature comms - nice summary thread below 👇👇
- Tremor is a common symptom across many neurological disorders. But is there a shared tremor circuit across disorders - one that could guide treatment, regardless of diagnosis? We think: yes. Our study is out now in @natcomms.nature.com: 🔗 www.nature.com/articles/s41... 🧵 A thread.
- Reposted by Lead-DBSPatient selection for Deep Brain Stimulation (DBS) is crucial. Are there ways to improve it? In our new study, we found hints that non-invasive brain stimulation might enhance the levodopa response - and serve as an additional marker for DBS outcomes. doi.org/10.1002/acn3... A thread. 🧵
- Reposted by Lead-DBSIs there a role for noninvasive "network" stimulation (multifocal tDCS) to evaluate candidates for deep brain stimulation? @lukasgoede.bsky.social says yes – new study here: onlinelibrary.wiley.com/doi/10.1002/... A 🧵 @netstim.org @braincircuits.bsky.social @lead-dbs.org
- First Fiber Filtering study using MRgFUS lesions (instead of DBS Stimulation Volumes)! 👇👇
- MR guided focused ultrasound surgery is an effective and uprising treatment option for Essential tremor. But where is the optimal site to sonicate? Which spots to avoid due to side-effects? @science.org @braincircuits.bsky.social @netstim.org – a thread🧵! www.science.org/doi/10.1126/...
- Reposted by Lead-DBSWhen modeling volumes of tissue activated in subthalamic DBS for clinical outcomes, does it matter whether we process data in native or template space? Julianna Pijar and Clemens Neudorfer say No in the Brain Stimulation Journal: doi.org/10.1016/j.br...
- Reposted by Lead-DBSTune in here for a fantastic primer on ECT – and so much more! Thank you Dr. Sackeim for joining me on @stimulatingbrains.org!
- It was a great honor to talk with the founding editor of Brain Stimulation, Dr. Harold Sackeim! Beyond the past, present and future of ECT, we covered the entire field of neuromodulation. Priceless insights from a key leader in the field! Tune in here 👇 stimulatingbrains.org/71-harold-sa...
- Reposted by Lead-DBSIt was a great honor to talk with the founding editor of Brain Stimulation, Dr. Harold Sackeim! Beyond the past, present and future of ECT, we covered the entire field of neuromodulation. Priceless insights from a key leader in the field! Tune in here 👇 stimulatingbrains.org/71-harold-sa...
- Reposted by Lead-DBSTruly inspiring episode about a life lived in neurosurgery across 🇨🇦 and the 🇺🇸, from ventriculography- & frame-based procedures including ablative lesions in neuro & psych to intraoperative MRI all the way to carrying out over 600 lesions using MR guided focused ultrasound. Tune in below 👇👇
- We had a truly inspiring and insightful conversation with Dr. Rees Cosgrove, Director of Epilepsy and Functional Neurosurgery at @brighamandwomens.bsky.social & Professor of Neurosurgery @harvardmed.bsky.social Rediscovering the lost art of brain lesions…! stimulatingbrains.org/70-rees-cosg...
- Reposted by Lead-DBSWe had a truly inspiring and insightful conversation with Dr. Rees Cosgrove, Director of Epilepsy and Functional Neurosurgery at @brighamandwomens.bsky.social & Professor of Neurosurgery @harvardmed.bsky.social Rediscovering the lost art of brain lesions…! stimulatingbrains.org/70-rees-cosg...
- Reposted by Lead-DBSProbably the most insightful and most important paper on physiomarkers of subthalamic DBS in a long while. Bravo @julianneumann.bsky.social @tsbinns.com and team!! Out at @natcomms.nature.com: www.nature.com/articles/s41...
- Reposted by Lead-DBSResearch defined the optimal DBS response network in STN-DBS for Parkinson’s Disease in a spatial domain. Other research defined physiomarkers for DBS response locally, in a temporal domain. However, nobody has analyzed these two concepts simultaneously. Enter @bahnebahners.bsky.social 👇👇
- 🚨 🥁 Preprint alert: The Deep Brain Stimulation Response Network in Parkinson’s Disease Operates in the High Beta Band ->> www.researchgate.net/publication/... <<--
- Reposted by Lead-DBS🚨 🥁 Preprint alert: The Deep Brain Stimulation Response Network in Parkinson’s Disease Operates in the High Beta Band ->> www.researchgate.net/publication/... <<--
- Reposted by Lead-DBSFollow this interesting study led by @bahnebahners.bsky.social and @andreashorn.org using MEG‑LFP data to investigate cortico‑subthalamic coupling in Parkinson’s disease. The study showed that the optimal DBS response network defined by fMRI operates in the high‑beta band. Happy to be part of it!
- 🚨 🥁 Preprint alert: The Deep Brain Stimulation Response Network in Parkinson’s Disease Operates in the High Beta Band ->> www.researchgate.net/publication/... <<--
- Lighting effects.. 🎉💥
- Reposted by Lead-DBSI learned so much from a very sharp mind in this conversation. Equipped w an undergrad mathematics at Harvard, Medschool at Harvard, PhD at MIT, Terry has begun deeply thinking about dystonia and neuromodulation early on and has come up with a very unique sEEG based approach to treat tough cases.
- We had a wonderful conversation with Dr. Terry Sanger from CHOC who is a very inspirational figure and innovator in the field of DBS – with a special focus on treating pediatric forms dystonia / cerebral palsy. Tune in here 👇👇 stimulatingbrains.org/69-terrence-...
- Reposted by Lead-DBSWe had a wonderful conversation with Dr. Terry Sanger from CHOC who is a very inspirational figure and innovator in the field of DBS – with a special focus on treating pediatric forms dystonia / cerebral palsy. Tune in here 👇👇 stimulatingbrains.org/69-terrence-...
- Reposted by Lead-DBSIs generalized epilepsy a seizure of the whole brain or a specific brain network? In our new paper out now in @naturecomms.bsky.social, we investigate this by combining brain abnormalities and DBS with the human connectome. Paper: nature.com/articles/s41... A 🧵 below:
- Reposted by Lead-DBSInterested in an update on connectomic and adaptive deep brain stimulation for obsessive compulsive disorder? Take a look at our summary of this exciting field and how things could be brought together out now in BPS: www.biologicalpsychiatryjournal.com/article/S000... A brief 🧵
- Reposted by Lead-DBSAdaptive DBS was recently approved by the FDA – in this episode, we talk with @toddherrington.bsky.social about the underlying ADAPT-PD trial, the mechanism of action of DBS, and the potential role of stem cell therapy in movement disorders. Tune in here 👇🎧👇🎧 stimulatingbrains.org/68-todd-herr...
- Reposted by Lead-DBSHad a really insightful conversation with @toddherrington.bsky.social, the director of the DBS program at @massgeneralbrigham.bsky.social MGH about adaptive DBS, stem cell research and novel forms of neuromodulation! Tune in here 👇🎧👇🎧
- Adaptive DBS was recently approved by the FDA – in this episode, we talk with @toddherrington.bsky.social about the underlying ADAPT-PD trial, the mechanism of action of DBS, and the potential role of stem cell therapy in movement disorders. Tune in here 👇🎧👇🎧 stimulatingbrains.org/68-todd-herr...
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- Lead-DBS v3.2 is out now – featuring Lead-Tutor, lots of code fixes and improvements, as well as some new atlases. Read all about it here: www.lead-dbs.org?na=view&id=31
- Ever wondered how well your Lead-DBS electrode localizations compare to expert solutions on the same data? Now, with Lead-Tutor, you can self-assess!
- Madan and Hart et al. introduce Lead-Tutor, an open-access educational resource that combines an imaging dataset of anonymized DBS cases with a software tool for self-teaching: doi.org/10.52294/001... @laurenahart.bsky.social @andreashorn.org @jordytasserie.bsky.social @ohbmofficial.bsky.social
- Reposted by Lead-DBSMadan and Hart et al. introduce Lead-Tutor, an open-access educational resource that combines an imaging dataset of anonymized DBS cases with a software tool for self-teaching: doi.org/10.52294/001... @laurenahart.bsky.social @andreashorn.org @jordytasserie.bsky.social @ohbmofficial.bsky.social
- Reposted by Lead-DBSWant to learn DBS electrode localization with @lead-dbs.org while being able to verify your results? This new tool from the @netstim.org lab lets you compare your performance against experts. Spearheaded by Savir Madan & @laurenahart.bsky.social
- Madan and Hart et al. introduce Lead-Tutor, an open-access educational resource that combines an imaging dataset of anonymized DBS cases with a software tool for self-teaching: doi.org/10.52294/001... @laurenahart.bsky.social @andreashorn.org @jordytasserie.bsky.social @ohbmofficial.bsky.social
- Want to learn Lead-DBS yourself? This is now possible thanks to a new dataset and tool extension created by Savir Madan & @laurenahart.bsky.social – out now in @apertureohbm.bsky.social 👇👇
- Madan and Hart et al. introduce Lead-Tutor, an open-access educational resource that combines an imaging dataset of anonymized DBS cases with a software tool for self-teaching: doi.org/10.52294/001... @laurenahart.bsky.social @andreashorn.org @jordytasserie.bsky.social @ohbmofficial.bsky.social
- Reposted by Lead-DBSVery excited by this paper led by Savir Madan & @laurenahart.bsky.social, which introduces the first self-train dataset for learning Lead-DBS and a nice tool to self-assess how well localizations compare to expert solutions.
- Madan and Hart et al. introduce Lead-Tutor, an open-access educational resource that combines an imaging dataset of anonymized DBS cases with a software tool for self-teaching: doi.org/10.52294/001... @laurenahart.bsky.social @andreashorn.org @jordytasserie.bsky.social @ohbmofficial.bsky.social
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- Reposted by Lead-DBSI am excited to announce that I will be founding an institute for network stimulation at the University Hospital Cologne – already this coming May!
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- Reposted by Lead-DBSDoes human creativity map to a specific brain circuit? Can damage to this brain circuit increase creativity? New paper by Julian Kutsche @isaiahneuro.bsky.social @braincircuits.bsky.social out today in JAMA Network says answer to both is YES. Paper is open access and great thread below:
- How can a brain disease increase creativity? We derive a brain circuit from creative tasks demonstrating they share reduced activity in the right frontal pole. Then we show that brain lesions & neurodegeneration that increase creativity are connected to this location jamanetwork.com/journals/jam...
- Reposted by Lead-DBSEver needed illustrations to visualize UPDRS-III exams? Well, @patriciazvarova.bsky.social just made some - free and open to use for anyone! Check them out below 👇👇
