In a massive effort, Lauren compiled evidence from 124 studies, corresponding to 1210 patients and 20 distinct surgical targets – giving an unprecedented overview about how DBS to different targets works for different types of epilepsy.

What is special about this metaanalysis is that Lauren also compiled stimulation locations across studies. She shows metaanalytic evidence that in ANT-DBS, proximity of stimulation sites to the mamillothalamic tract is associated with optimal seizure reduction – both on a study and patient level.

For CM, localisation effects may be dependent on the form of epilepsy, with stimulation of the parvocellular CM being associated with better outcomes in generalised epilepsy.

If you are interested in these topics, be sure to also check out the supplementary material which features a massive database with all the data Lauren and Garance compiled. There's certainly data worth for a few more studies and analyses in that dataset.