Kari Hoffman
neuroscientist @vanderbilt studying neural circuit+population rules for creating and deploying knowledge. computational neuroethology.
- Reposted by Kari HoffmanBichan Wu (@bichanw.bsky.social) & I wrote a tutorial paper on Reduced Rank Regression (RRR) — the statistical method underlying "communication subspaces" from Semedo et al 2019 — aimed at neuroscientists. arxiv.org/abs/2512.12467
- Reposted by Kari Hoffmanlet's talk in person! but fwiw I personally think that we talk about dimensionality! to me the important ideas within the neural manifold framework are: (1) manifolds reflect biological constraints, (2) capture population-wide functions/computations, (3) manifolds (may) have ontological power
- 🤩 + impressive answer 🧭🚕 @ 2:50 “Trust me, knowledge is power” 💀 This is my guy.
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- Reposted by Kari Hoffmanwww.science.org/doi/10.1126/... damn this is so very clever! "... we investigated how the brain categorizes stimuli that are not linearly separable in the physical world ... The sensory manifold was ... expanded into a seven-dimensional perceptual manifold..."
- Human multipatch L2/3 functional cell types. LFG. 🧠📈🧪
- 🥳Excited to share our latest human multipatch paper, now out in @natneuro.nature.com 🧠 We studied the cellular and synaptic physiology of human L2–3 pyramidal neurons and identified subtype-specific local connectivity rules across individuals. www.nature.com/articles/s41... Join us: penglab.de
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- Last day to register for the 50th anniversary meeting Jan 8-11: parkcitywinterconf.org/register/ Historical perspectives from Lynn Nadel, Os Steward, Jim McClelland, and topics from synaptic plasticity to neural circuit dynamics of learning and memory systems to aging and dementia. #neuroskyence
- 📣Register now for the 50th Anniversary Park City Winter Conference on the Neurobiology of Learning and Memory parkcitywinterconf.org/register/ Deadline tomorrow, Friday, the 12th! Spread the word. 🧠🔬👩🔬 ➡️Top 5 reasons to attend: 1/6
- Nice thread (and nice recognition for @trackingactions.bsky.social!)
- Reposted by Kari HoffmanWe give examples for less striking number of neurons here. For different species, tasks, and brain areas, it's always the same observation: PCA overestimates the dimensionality -except for one very simple task- and this overestimate gets worse w the number of neurons www.biorxiv.org/content/10.1...
- 📣Register now for the 50th Anniversary Park City Winter Conference on the Neurobiology of Learning and Memory parkcitywinterconf.org/register/ Deadline tomorrow, Friday, the 12th! Spread the word. 🧠🔬👩🔬 ➡️Top 5 reasons to attend: 1/6
- correction: he *is* reviewer #3
- Met an old pal at #SfN25, he's still waiting to hear back from reviewer #3
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- Happening now ss3 ss4 dentate spikes, beta, category learning in freely moving 🐒
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- Reposted by Kari HoffmanGood morning #SfN25! Looking for some posters to see this afternoon? Check out two by our lab: GG15 and HH1 🧠🧪👩🏻🔬
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- Reposted by Kari HoffmanHearing a rumor that NIH/HHS may now plan to retaliate against other Bethesda Declaration signers. I am one, but it’s not about me: we have been speaking out because of the ongoing damage to US medical research, cancer and Alzheimer’s research. As @jenna-m-norton.bsky.social put well: 1/
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- Reposted by Kari HoffmanBREAKING: In AAUP et al v. Trump (wall-to-wall union lawsuit challenging the administration’s unlawful use of TItle VI to reshape the University of California system), the faculty and staff of the UC system WON!!! We were granted our preliminary injunction! @aaup.org
- Reposted by Kari HoffmanGoing to #SFN2025. Check out the Costa Lab posters on Sunday and Monday afternoon!
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- He’s not kidding- I predict he’ll be putting the “special” in Presidential Special Lecture. Bring popcorn.🍿
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- Reposted by Kari HoffmanA bad thing is unfolding at NIH this week: It looks like the Trump administration is trying to replace key civil servant scientific leaders, the Institute Directors, with political hires. These directors control the NIH budget, tens of billions. A bit of a video explainer here: 1/ 🧪
- Reposted by Kari HoffmanThe Preston Lab will be at @sfn.org #SfN2025! Come see what we've been working on 🧠 We'll discuss how kids & adults remember when things happen, how memory changes impact reasoning & how we learn different actions have different consequences based on the setting. Find us Monday & Wednesday 🤘
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- Reposted by Kari Hoffman🚨New in @cellpress.bsky.social We discovered that hippocampal replays in natural-scale environments are highly fragmented, not full-length. doi.org/10.1016/j.ce... 👇🧵
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[Not loaded yet] - Signed. Read and spread:
- (5/5) 🚨 It’s time to flood the zone. NIH scientists just took a huge risk speaking out. Now it’s our turn. 📜 Read the Bethesda Declaration ✍️ Sign the Public Letter of Support 👯♀️Follow NIHers doing the work: @nihvigils.bsky.social Read and sign here 👉 www.standupforscience.net/bethesda-dec...
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- 📌New bio constrained ANN learning rule: ➡️dendritic target propagation⬅️ considers cell diversity, compartmentalization, FF FB inputs, more. 🧠📈🤖🧪
- Cellular and subcellular specialization enables biology-constrained deep learning www.biorxiv.org/content/10.1...
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- 👀Interesting take from @stephanie-theves.bsky.social linking general intelligence and abstraction. One to watch. 🧪🧠📈🧠🤖🧠👩🔬 _ ?(emoji analogies seemed fitting)
- Reposted by Kari Hoffman🚨New paper alert! 🚨 Inactivation of the nucleus reuniens causes relapse of extinguished fear. Here we show this “circuit-induced relapse” depends on hippocampal fear memories and is mediated by hippocampal engrams. Congrats to the team!
- Reposted by Kari HoffmanAmerica cannot long remain free, nor first among nations, if it becomes the kind of place where universities are dismantled because they don't align politically with the current head of the government.
- We agree. KenjiLee your data. @sabbaspoor.bsky.social's version uncovered surprisingly specific spike-field motifs and short latency spike timing interactions in macaque CA1: doi.org/10.1016/j.ce...
- Reposted by Kari HoffmanOn behalf of Nicole Carr: new preprint from the Chand/Moore labs! High-resolution laminar recordings reveal structure-function relationships in monkey V1. 1/4 www.biorxiv.org/content/10.1...
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- Do everyone a favor and read this. Then act. 🧠📈🧪
- Reposted by Kari Hoffman#preprint: We mapped the structure and function of olfactory bulb circuits with in vivo 2-photon microscopy and synchrotron #Xray holographic nanotomography. doi.org/10.1101/2025... @yuxinzhang.bsky.social @andreas-t-schaefer.bsky.social @apacureanu.bsky.social @crick.ac.uk @esrf.fr
- 👀Come for the 3D microscopy porn, stay for the ensemble coding principle. I will never not like the olfactory circuit organization. Here’s a punchline post in the thread:
- Stimulating vosstacular stim work, and another case of targeting lateral temporal lobe (not medial) for stim in humans. ❓🙋🏻♀️ to Joel/Jim: you did parietal stim before, so would you pick LTL or Par. for therapeutic target to address “MTL”ish memory impairment? Or neither? 🧠 📈 🧪
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- Reposted by Kari HoffmanMany processes from industry are not appropriate or overkill for an academic setting, but we can and should be doing better than we currently are. Our paper tries to give practical advice on how you can improve your scientific workflow, without being a coding guru. www.nature.com/articles/s44...
- Nice approach to “what happens in the wake of a ripple?”
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- Reposted by Kari HoffmanI wrote something up for AI people who want to get into bluesky and either couldn't assemble an exciting feed or gave up doomscrolling when their Following feed switched to talking politics 24/7.
- Did they really just go from freezing memories to frozen memories 🥶? @tjryan.bsky.social you need a trip to the tropics 🌴. Impressive study, broad implications for general physiology 🧪
- Excited to share our new study: "Cold memories control whole-body thermoregulatory responses" by @andreamunozz.bsky.social, @aaron-douglas.bsky.social & team at @tcddublin.bsky.social, in collaboration with @lydialynch.bsky.social & @drchristineannd.bsky.social www.nature.com/articles/s41...
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- Leaner and meaner than a transformer? B/c #BTSP? Ok correlation-based cognitive map learner (CCML), you have my attention. 🧠📈🤖
