Yuxin Zhang
PhD at the Francis Crick Institute. Mouse olfaction; systems neuroscience; connectomics; correlative 2P, X-ray and EM.
- Reposted by Yuxin ZhangJoin us *next Monday*! #CrickXrays25 X-ray #nanoimaging of biological tissues 🇬🇧🌐 @crick.ac.uk & online tinyurl.com/crickxrays25 Sponsored by @dectris.bsky.social, @webknossos.org and @biologists.bsky.social and backed by @brukercorporation.bsky.social and Histomography
- #Nanoimaging symposium @crick.ac.uk! At #CrickXrays25 we'll tackle: 💫synchrotron upgrades 📈current limits in throughput, volume, resolution 🧪sample preparation for X-ray PC imaging 🧠♥️applications in neuroscience and tissue life science 🗓️13th October 2025 🇬🇧🌐 London & online tinyurl.com/crickxrays25
- Reposted by Yuxin ZhangOur pre-print is out! Critical point drying of brain tissue for x-ray phase contrast imaging. @apeart.bsky.social @yuxinzhang.bsky.social @jkbrmn.bsky.social @apacureanu.bsky.social @andreas-t-schaefer.bsky.social @carlesbosch.bsky.social @esrf.fr @crick.ac.uk bioarXiv: doi.org/10.1101/2025...
- Reposted by Yuxin Zhang#Nanoimaging symposium @crick.ac.uk! At #CrickXrays25 we'll tackle: 💫synchrotron upgrades 📈current limits in throughput, volume, resolution 🧪sample preparation for X-ray PC imaging 🧠♥️applications in neuroscience and tissue life science 🗓️13th October 2025 🇬🇧🌐 London & online tinyurl.com/crickxrays25
- Reposted by Yuxin Zhang#preprint: We mapped the structure and function of olfactory bulb circuits with in vivo 2-photon microscopy and synchrotron #Xray holographic nanotomography. doi.org/10.1101/2025... @yuxinzhang.bsky.social @andreas-t-schaefer.bsky.social @apacureanu.bsky.social @crick.ac.uk @esrf.fr
- Reposted by Yuxin ZhangBig congrats @yuxinzhang.bsky.social @carlesbosch.bsky.social @andreas-t-schaefer.bsky.social for completing this adventurous journey 🙌🏅! Three replicas of aligned 3D functional (2P) and structural (X-ray nanotomography) data to peer inside olfactory neural circuits 🐭🧀.
- My PhD project is out as a preprint! We combined 2P and synchrotron X-ray to understand mouse olfactory bulb circuits, linking physiology to structure in 3 animals! doi.org/10.1101/2025... 🙌 @carlesbosch.bsky.social, @apacureanu.bsky.social, @andreas-t-schaefer.bsky.social, @esrf.fr, @crick.ac.uk
- Reposted by Yuxin ZhangLinking function and structure at scale with X-rays - and several times over. Massive congratulations to the team @yuxinzhang.bsky.social, @carlesbosch.bsky.social, @apacureanu.bsky.social @esrf.fr, @crick.ac.uk and all our collaborators.
- My PhD project is out as a preprint! We combined 2P and synchrotron X-ray to understand mouse olfactory bulb circuits, linking physiology to structure in 3 animals! doi.org/10.1101/2025... 🙌 @carlesbosch.bsky.social, @apacureanu.bsky.social, @andreas-t-schaefer.bsky.social, @esrf.fr, @crick.ac.uk
- My PhD project is out as a preprint! We combined 2P and synchrotron X-ray to understand mouse olfactory bulb circuits, linking physiology to structure in 3 animals! doi.org/10.1101/2025... 🙌 @carlesbosch.bsky.social, @apacureanu.bsky.social, @andreas-t-schaefer.bsky.social, @esrf.fr, @crick.ac.uk
- In mice, olfactory sensory neurons expressing the same olfactory receptor converge to ~2 glomeruli per bulb. The circuit then diverges, with a few 10s of sister mitral/tufted cells receiving inputs from each glomerulus. Why does the circuit diverge? Are sister cells redundant or functional?
- This long-standing question had been studied with pioneering approaches by Tan 2010 doi.org/10.1016/j.ne... Dhawale 2010 doi.org/10.1038/nn.2... Kikuta 2013 doi.org/10.1016/j.ne... Arneodo 2018 doi.org/10.1038/s414... But sister cell identification remained a key challenge and the yield was low.
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View full thread🙌 Kudos to Carsten from @zeiss-microscopy.bsky.social who helped fs-laser milling of the sample, and Manuel, Andrea and @normanrz.com from @webknossos.org for help with large data storage, viewing, tracing and segmentation. It has been an honour for me to work with you all together on this project!
