GenomeTDCC
Technology Development Coordinating Center at NHGRI. Advancing innovation in genomic technology development through collaboration, promoting standards, and outreach in conjunction with The Jackson Laboratory 🧬💻🧪
- Captify: A new platform to study chromatin readers in the nucleosome context 🧪💻🧬 Recently published in Nucleic Acids Research @narjournal.bsky.social, the folks at @epicypher.bsky.social discuss development & integration of these easily adoptable biochemical and genomic tools doi.org/10.1093/nar/...
- 🧪🧬💻 Congratulations on the recent publication from @jshendure.bsky.social, @troymcdiarmid.bsky.social, @uwgenome.bsky.social and colleagues! 👇 www.nature.com/articles/s41...
- A parts list of promoters and gRNA scaffolds for mammalian genome engineering and molecular recording - @jshendure.bsky.social @troymcdiarmid.bsky.social @uwgenome.bsky.social go.nature.com/49eTPCu
- New highlight video! 🧪🧬💻 RAEFISH from Steven Wang at Yale unlocks whole-transcriptome imaging at single-molecule resolution. See 20,000+ RNAs light up in cells and tissues. Plus get direct gRNA detection in high-content CRISPR screens. Spatial biology just leveled up www.youtube.com/watch?v=P2j6...
- 👀 Read all the details - recently published in @cellpress.bsky.social www.cell.com/cell/fulltex...
- New video! Discover how transcription factors find their way through tightly packed DNA. 🧪🧬💻👩🔬 www.youtube.com/watch?v=gOta... Luca Mariani & Martha Bulyk introduce PIONEAR-seq, revealing how DNA flexibility shapes gene regulation. Recently published in @natsmb.nature.com
- SO many great talks from leading scientists who develop and use various genomic technologies. 🧪🧬💻👩🔬 Genome architecture, RNA regulation + modification identification, nanopores, DNA writing, statistics, sequencing! It's all there on the GenomeTDCC YouTube channel! www.youtube.com/playlist?lis...
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- Don't miss hearing from Shubham Khetan and Martha Bulyk in this publication highlight video where they discuss their work developing PADIT-seq. 🧪 youtu.be/45hdZ6R9fX4
- Martha Bulyk & Shubham Khetan just dropped a @nature.com paper redefining how we think about transcription factor binding, noncoding variants, and disease. PADIT-seq, reveals that multiple overlapping binding sites drive TF occupancy and gene expression 🧪🧬💻👩🔬 Highlight 📽️https://youtu.be/45hdZ6R9fX4
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- Join us Oct. 2, 2025, for this year's Biotech Innovation Summit—featuring keynotes, fireside chats and one-on-one networking with investigators pioneering early-stage breakthroughs. Spots are limited! Register now: ow.ly/rcGM50WN8Uc or contact biotechsummit@scripps.edu for more info.
- What if doing something poorly could lead to something great? Rob Mitra, @washugenetics.bsky.social, dives into the evolution of genome tech, short-read sequencing, and how his lab is fighting rising drug costs with innovation. 🧪🧬💻 #STS 📺 Watch the keynote: youtu.be/C8U5WDA9ri4 #genomics #Biotech
- What if DNA didn’t use ACGT, but had PZSB instead? UW and FfAME researchers describe how they were able to sequence a synthetic DNA molecule made from 4 artificial bases in @natcomms.nature.com 🧪🧬🖥️ Check out the publication highlight on “ALIEN DNA” 👇 www.youtube.com/watch?v=S6tE...
- RNA isn’t just a messenger. It’s a modified masterpiece! 🧪 Over 10,000 sites in mRNA are chemically tagged, and we’re only beginning to understand why. Kristin Koutmou @umich.edu explores the tools that reveal this hidden layer of gene regulation. Must-watch! 🎥👇 www.youtube.com/watch?v=s5Bt... 👩🔬🧬🖥️
- DNA beyond ACGT? But how do you sequence? 🧬 🖥️ youtu.be/GN6_Hc9tYow Andrew Laszlo explains how #nanopore sequencing reads modified and synthetic bases like Z, P, B, and S by measuring ion current shifts instead of chemical pairing. This technology could reshape synthetic biology and epigenetics. 🧪
- Winston Timp @timp0.bsky.social explains how single-molecule seq is transforming our understanding of gene regulation and epigenetic complexity 🧪🖥️🧬 www.youtube.com/watch?v=fj1_... Direct detection of 5mC and 5hmC, supports cell-type deconvolution, and reveals tissue-specific regulatory features
- DNA has become programmable. 🧬🖥️ Sasha Levy (BacStitch DNA) discusses how #DNA engineering has evolved from basic cut-and-paste to programmable systems. Learn how enzymatic synthesis and in vivo assembly are shaping the future of synthetic biology 🧪 #STS youtu.be/kSAm-2FbNus
- Jingyi Jessica Li @jsb-ucla.bsky.social (@fredhutch.bsky.social) (formerly @ UCLA) explains how statistics can make genomics more reliable From RNAseq to single-cell data, she shows how permutation testing reveals flaws in popular methods and can help make better decisions 🧪🖥️🧬👩🔬 youtu.be/t2pxOsJ9mgE
- Not that kind of Alien!👽 De novo #nanopore sequencing of ALIEN (ALternative Isoinformational ENgineered) #DNA. Direct, label-free, single-molecule sequencing. @natcomms.nature.com www.nature.com/articles/s41... Funded in part by an NHGRI Opportunity Fund (genometdcc.org/opportunity-...) 🧪🧬🖥️ #STS
- RNA is never naked 🧪🖥️🧬 Gene Yeo @ucsandiego.bsky.social reveals how RNA-binding proteins (RBPs) shape gene expression, drive disease, and can unlock new therapies. From splicing to synthetic RBPs, this talk is packed with insights youtu.be/AnhbGp-pA-w #RNA #AcademicSky @sanfordstemcell.bsky.social
- 📢Job Opening! 🧪🖥️🧬👩🔬 Ready to hire qualified candidates to map #RNA modifications in human transcriptomes using #nanopore direct sequencing. Dr. Ya-Ming Hou at Thomas Jefferson University houlaboratory.com/research #HigherEd #EDUSky #AcademicSky #STS
- Happy #RNADay! What happens to RNA after transcription? @stirlingchurchman.bsky.social tracks RNA flow through the cell, revealing key insights into gene regulation, nuclear degradation & RNA kinetics. A fascinating look into #RNA biology! 🧪🧬🖥️👩🔬 youtu.be/XAKMASk_fc4
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- In this interview, I explain how university research, when funded by independent #NIH #NSF federal grants, brings oversight to biotech to fuel innovation while keeping science transparent, reliable, and in service of the public good: hub.jhu.edu/2025/07/30/j... #ResearchMatters
- How does 6ft of #DNA fit inside a cell only 10 microns wide? @sstevenwang.bsky.social provides a brief history of contemporary 3D #genomics technologies. Learn how spatial organization of DNA plays a vital role in gene regulation, development, and disease. 🧬🖥️🧪 #STS www.youtube.com/watch?v=gXCO...
- 📅 June 9 - Genomic Technologies Open Science Day at @washu.bsky.social and online www.jax.org/scienceday25 Register for Free by: May 30: In-Person June 8: Virtual Learn how emerging tech is used to manipulate RNA & DNA, study genome function and structure, and navigate multi-omic analysis 🧪👩🔬🧬🖥️
- HAPPY DNA DAY! 🧬🧪 Genomics research has provided humanity with a transformative understand of life at the molecular level leading to a wide range of benefits in medical advancements, synthetic biology, biotechnology, infectious disease, agriculture, and evolution. We are connected by ATGC
- From @nickingolia.bsky.social at @ucberkeleyofficial.bsky.social 🧪🧬🖥️ Disordered protein regions hold powerful sway over gene expression, as this new large-scale study reveals how they regulate mRNA stability and translation without a fixed structure. Published in @nature.com doi.org/10.1038/s415...
- 🚨PRE-PRINT 🧪🧬🖥️👩🔬 Long-range massively parallel reporter assay reveals rules of distal enhancer-promoter interactions From Barak Cohen's lab at @washu.bsky.social Read the pre-print 👇 doi.org/10.1101/2025... Learn more about the research from the Cohen lab: bclab.wustl.edu
- 📅 Genomic Technologies Open Science Day - June 9 FREE event featuring expert developers and users! Register: www.jax.org/scienceday25/ Happening in person at @washu.bsky.social and online in partnership with NHGRI and @jacksonlab.bsky.social 🧪🧬🖥️👩🔬 #STS Learn more at genometdcc.org#outreachevents
- Single Cell Genomics Day! 🧪🧬🖥️ Friday April 25 (10:00 AM to 5:00 PM EDT) Watch the event live satijalab.org/scgd25/ The Rahul Satija Lab at @nygenome.org and NYU is hosting the annual SINGLE-CELL GENOMICS DAY on #DNADay
- Check out the 🧵 by @stanleyqilab.bsky.social on their recent publication. 🧪🧬💻 #3Dgenome
- Thrilled to share our paper, led by Dr. Yanyu Zhu @yanyuzhu.bsky.social in collaboration with Prof. W.E. Moerner and Prof. Andrew J. Spakowitz, on developing Oligo-LiveFISH technology, in Cell @cellcellpress.bsky.social. A🧵 @stanford-chemh.bsky.social @bioe-stanford.bsky.social
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- A tool to dissect regulatory DNA in its endogenous context enables the identification of designed small edits (<10 bp) that fine-tune gene expression, with potential therapeutic implications #NBThighlight www.cell.com/cell/abstrac...
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- You can hear from the authors in this Publication Highlight video as they discuss the development of Perturb-tracing and some of their results. youtu.be/oR63uI8feWs?...
- DYK www.youtube.com/@genometdcc has videos on the latest genomic technology being developed by researchers supported by NHGRI? 👩🔬 🧪🧬🖥️ #STS Highlighting new research pubs and #educational videos discussing innovations in synthetic biology, nucleic acid and protein seq, large-scale genomics, and more!
- Postdoc Position Available 🧪 Interested in #Nanopore Direct Sequencing of #RNA? Ya-Ming Hou at Thomas Jefferson University 👩🔬 houlaboratory.com/research Seeking candidates with #bioinformatics skills Send cover letter, CV, and references For contact information, visit houlaboratory.com/contact
- Newly published in @nature.com. Supported in part by the NHGRI Genome Technology Development Opportunity Fund. Check out the🧵 by @cfell.bsky.social below for more details about the paper. Learn more about this and other work supported by the Opportunity Fund genometdcc.org/opportunity-... 🧪🖥️🧬 #STS
- So excited to share our new paper out today in @nature.com. We repurposed R2 retrotransposons to create STITCHR, a tool that can make virtually any kind of edit in mammalian genomes including the scarless multi-kilobase scale insertions 🧵 www.nature.com/articles/s41...
- Fresh off the press in @naturemethods.bsky.social In this highlight video, Siyuan Wang and Yubao Cheng at @yale.edu unveil a new image-based high-content screening platform, Perturb-tracing, to screen for new regulators of chromatin organization at multiple length scales. 🧪🧬🖥️ youtu.be/oR63uI8feWs
- You can read their article "Perturb-tracing enables high-content screening of multi-scale 3D genome regulators" in @naturemethods.bsky.social 👇 www.nature.com/articles/s41...
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- New #research from the @juliazeitlinger.bsky.social Lab uses #AI to decipher how cells respond to developmental cues, potentially paving the way for personalized #medicine + original artwork from the lab was selected for the cover of Cell Genomics (@cellpress.bsky.social). Read more: bit.ly/426OoSg
- 📅 April 10-11: FREE VIRTUAL SYMPOSIUM Don't miss out on this opportunity to hear from leading experts in #RNA research View the agenda and register TODAY: www.rnaepicenter.com/educationand... 🧪👩🔬🧬🖥️
- FREE VIRTUAL SYMPOSIUM Featuring experts in RNA mass spectrometry, sharing the latest research and innovations in RNA modifications and sequencing. April 10 - 11 Register: tinyurl.com/43kkxvp7 Hosted by the Center for Genomic Information Encoded by RNA Nucleotide Modifications 🧬🧪🖥️ #STS #RNA
- 🎉Congratulations to @ceesdekker.bsky.social! Learn more about the amazing work coming from this lab at ceesdekkerlab.nl 🧪🧬🖥️ #STS #nanopore
- The 2026 Biochemical Society Award for Significant Breakthrough or Achievement is presented to Cees Dekker @ceesdekker.bsky.social! Celebrating his ground-breaking contributions to nanotechnology, Cees has pioneered research on solid-state nanopores and nanopore-based DNA sequencing.
- A new spatial transcriptomics approach eliminates the need for time-intensive imaging with specialized equipment, making the technique accessible to more researchers around the world. @naturebiotech.bsky.social
- Hear from Fei Chen and @chenleihu.bsky.social in this Publication Highlight video as they discuss this new imaging-free method. 🧪🧬🖥️👩🔬 youtu.be/dVEmk8L8ufI
- Imaging-free Spatial Transcriptomics! Computational reconstruction of spatial barcode locations using molecular diffusion + dimensionality reduction. Fei Chen and Chenlei Hu at @broadinstitute.org discuss 👇📽️ Published in @naturebiotech.bsky.social 🧪🧬🖥️👩🔬 #STS www.youtube.com/watch?v=dVEm...
- Read the article www.nature.com/articles/s41...
- FREE VIRTUAL SYMPOSIUM Featuring experts in RNA mass spectrometry, sharing the latest research and innovations in RNA modifications and sequencing. April 10 - 11 Register: tinyurl.com/43kkxvp7 Hosted by the Center for Genomic Information Encoded by RNA Nucleotide Modifications 🧬🧪🖥️ #STS #RNA
- Check out the🧵 from @kaiamattioli.bsky.social on Widespread variation in molecular interactions and regulatory properties among transcription factor isoforms 🧪 👩🔬🧬🖥️ #GeneSky Publication link 👇 www.sciencedirect.com/science/arti...
- our work on the molecular differences between transcription factor isoforms is out now in Molecular Cell! key point: 2/3rds of TF isos differ in properties like DNA binding & transcriptional activity many are "negative regulators" & misexpressed in cancer www.sciencedirect.com/science/arti...
- Check out the thread 🧵 from @srouhanifard.bsky.social on dynamic response of pseudouridine (Ψ) to cell state. 👇 🧪🖥️🧬👩🔬 #nanopore #RNA #STS
- 1/6 🧬New paper at @cp-cellsystems.bsky.social led by @sashafanari.bsky.social! Does pseudouridine (Ψ) dynamically respond to cell state? We used nanopore DRS + Mod-p ID to map Ψ in neuron-like cells under “normal” and “perturbed” conditions (healthy differentiation and unhealthy Pb2+ poisoning).
- Single-molecule protein sequencing using nanopores - A perspective article in @naturebiotech.bsky.social from Giovanni Maglia and colleagues at @unigroningen.bsky.social 🧪🖥️🧬 #STS Great discussion on current approaches and the challenges to sequencing #proteins www.nature.com/articles/s41...
- Eric Green is out as head of National Human Genome Research Institute 🧪🧬🖥️ www.statnews.com/2025/03/17/t... #genomics #NIH #NHGRI
- 🚨Pre-Print Tired of losing valuable DNA-protein interaction information from your long-read seq data during wash steps? New wash-free, one tube DiMeLo-cito protocol from @naltemose.bsky.social @astraight.bsky.social @ngamarra.bsky.social for max quality + yield! 🧪🖥️🧬 #STS 👇 doi.org/10.1101/2025...
- Celebrate Pi day by embracing creativity, curiosity, and innovation (and 🥧) Science, Technology, Engineering, and Mathematics make our world safer, united, and healthier. Explore the innovations being advanced from the NHGRI Genome Technology program at genometdcc.org 🧪🧬🖥️👩🔬 #STS
- 🧪🧬👩🔬🖥️ Do immortalized cells have a different RNA modification profile compared to primary cells? 🤔 @sashafanari.bsky.social @wanunupore.bsky.social @srouhanifard.bsky.social assess the most abundant RNA modification, pseudouridine, in primary and immortalized human T cells 👇 doi.org/10.1101/2025...
