A tool to dissect regulatory DNA in its endogenous context enables the identification of designed small edits (<10 bp) that fine-tune gene expression, with potential therapeutic implications
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Rewriting regulatory DNA to dissect and reprogram gene expression
Martyn and Montgomery et al. present Variant-EFFECTS, a high-throughput technology
developed to precisely measure the effects of CRISPR-mediated edits on gene expression.
Variant-EFFECTS is reproducib...
