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Do immortalized cells have a different RNA modification profile compared to primary cells? 🤔
@sashafanari.bsky.social @wanunupore.bsky.social @srouhanifard.bsky.social assess the most abundant RNA modification, pseudouridine, in primary and immortalized human T cells
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doi.org/10.1101/2025...
Direct RNA sequencing of primary human T cells reveals the impact of immortalization on mRNA pseudouridine modifications.
Immortalized cell lines are commonly used as proxies for primary cells in human biology research. For example, Jurkat leukemic T cells fundamentally contributed to uncovering T cell signaling, activat...
