The Gene Lay Institute of Immunology and Inflammation
Immunology-focused research in cancer & aging | understanding immune evasion & resilience | improving health outcomes. 🔗 genelayinstitute.org
#Brigham&WomensHospital #MassGeneralHospital @HarvardMed.bsky.social
Excited to share our latest study in Cell Genomics, combining single-nucleus RNA-seq, spatial transcriptomics, and histology to dissect the molecular determinants of lung fibrosis! www.cell.com/cell-genomic... #fibrosis #lung #ILD- TFR cells are a dynamic and plastic cell subset, the differentiation of which is controlled by intrinsic and extrinsic programs that work together to form a feedback loop to control humoral immunity @natimmunol.nature.com www.nature.com/articles/s41...
- By reprogramming the tumor microenvironment with an engineered virus, @quintanalabhms.bsky.social boost anti-tumor immunity against glioblastoma. @mgbresearch.bsky.social @broadinstitute.org @harvardmed.bsky.social www.massgeneralbrigham.org/en/about/new...
- Deciphering the Immune System Side by Side | vitaminrush.com/276337/deciphering-… Great things can happen when the right minds come together. The story of Gordon Freeman and Arlene Sharpe is an excellent example of this adage. The two US researchers …
- “At Harvard Medical School, immunologists Arlene Sharpe and Gordon Freeman helped identify a molecular switch in the PD-1 pathway that stops the immune system from attacking cancer cells - and discovered a way to flip it.”
- “The top-selling drug in the world last year was Keytruda, a cancer immunotherapy w $29.5B in sales. Initially approved in 2014 for advanced melanoma and now used aga a wide array of cancers, it is the best known… of drugs that unleash immune cells aga tumors.” www.washingtonpost.com/education/in...
- 🔔 New episode alert! Dr. Ana Anderson from Harvard Medical School talks about her work on #ImmuneRegulation in cancer. ▶️ bit.ly/4pJvw4u
- Join us next week for an episode with Dr. Ana Anderson from Harvard Medical School! Her research focuses on understanding the pathways and mechanisms that regulate the #AntiTumor immune response.
- Immune dysfunction in Alzheimer disease — a Review by Oleg Butovsky, Neta Rosenzweig, Kilian L. Kleemann, Mehdi Jorfi, Vijay K. Kuchroo, Rudolph E. Tanzi & Howard L. Weiner #neuroscience #neuroskyence www.nature.com/articles/s41...
- Review @natrevneuro.nature.com Immune dysfunction in Alzheimer disease www.nature.com/articles/s41...
- The most detailed roadmap to date of how the gut’s nervous system responds to different environmental challenges. Exciting new 🧪study from @thexavierlab.bsky.social @mgbresearch.bsky.social @broadinstitute.org @harvardmed.bsky.social | Science www.science.org/doi/10.1126/...
- Check out our new study in @ScienceMagazine! Using single-cell transcriptomics, we profile enteric nervous system responses to the microbiota and inflammation, identifying regulators of motor #neuron states and #gut transit time. www.science.org/doi/10.1126/...
- Great summary from the @mgbresearch.bsky.social team on our new Science paper about ENS–immune system interactions! Check it out: www.massgeneralbrigham.org/en/about/new...
- Regional encoding of enteric nervous system responses to microbiota and type 2 inflammation @science.org @thexavierlab.bsky.social @broadinstitute.org www.science.org/doi/10.1126/...
- Excited to share new work in @NatureMicrobio! Using metagenomics, we show how #HIV infection and treatment shape the gut microbiome across geographic regions & find ART-induced phageome changes linked to inflammation and atherosclerosis. www.nature.com/articles/s41...
- Another 🌏 #KuchrooLabReunion in Kyoto with Norio Chihara, VKK, & Kimitoshi Kimura 🇯🇵
- For those of you joining us for the editors panel at #RTN2025, please bring your questions! We have more editors than I've ever seen at a single meeting, so this is your chance to get answers to all of your burning questions! @genelayinstitute.bsky.social @rtnconference.bsky.social
- We are proud to sponsor #ReThink Neuroimmunology 2025. A conference focusing on the biggest discoveries and breakthroughs in neuroimmunology, single cell genomics, immunology & neuroscience. The Gene Lay Institute of Immunology and Inflammation #RTN2025 RTN Conference Beth Stevens Jonathan Kipnis
- Looking forward to #RTN2025 today! Excited for some #neuroimmunology! If you'll be there, please look for me and say hello! @genelayinstitute.bsky.social @rtnconference.bsky.social genelayinstitute.org/rtn/#program
- Hou, Sun et al from @kuchroolab.bsky.social 2024 in @natureportfolio.nature.com "Neuropeptide signalling orchestrates T cell differentiation" www.nature.com/articles/s41...
- We're less than a week away from #ReThinkNeuroimmunology — a groundbreaking conference hosted by the @genelayinstitute.bsky.social! We’re thrilled to welcome experts, ignite new ideas, & push the field forward. Huge thanks to our incredible sponsors for making #RTN2025 possible! 🧵👇
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- The @genelayinstitute.bsky.social is excited to host its third #ReThinkNeuroimmunology meeting from October 14-16th, 2025. This year will focus on discussing major discoveries & breakthroughs in neuroimmunology, single cell genomics, immunology, & neuroscience. genelayinstitute.org/rtn/
- Our latest effort to translate genetic risk variants to disease mechanisms revealed that the R448G missense mutation in nuclear receptor coregulator NRIP1 promotes tissue inflammation via inefficient repression of a retinoic acid-mediated T cell gut-homing program. www.pnas.org/doi/10.1073/...
- ANKRD55 is associated with risk for multiple autoimmune diseases, but without a clear mechanism. In a new @jem.org study, we show that ANKRD55 promotes differentiation of inflammatory T cells via mitochondrial regulation, suggesting a new target for autoimmunity: rupress.org/jem/article-...
- Antibiotics unleash #neuroinflammation. Jessica Kenison and Francisco Quintana (@quintanalabhms.bsky.social) @genelayinstitute.bsky.social @broadinstitute.org discuss new work from Chatterjee et al. (doi.org/10.1084/jem....) in Insights: rupress.org/jem/article/... #Microbiome
- New insights from @quintanalabhms.bsky.social @jem.org
- In @jem.org, Kenison and Quintana @harvardmed.bsky.social discuss work by Chatterjee et al. (doi.org/10.1084/jem....) demonstrating that disruption of the gut microbiota promotes #neuroinflammation and cognitive decline through the loss of #microbiome-derived metabolites. rupress.org/jem/article/...
- #ReThinkNeuroimmunology! 3 days 27 speakers 7 selected talks 2 panel discussions >400 registered Submit your abstract by August 28th for #RTN2025. 🔗 genelayinstitute.org/rtn/ 🧪 @quintanalabhms.bsky.social @bethstevenslab.bsky.social @jonykipnis.bsky.social @idoamitlab.bsky.social #RejaneRua
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- Blockade of STUB1 in T cells boosts anti-tumor immunity. Study from the #SharpeLab led by @martinlafleur.bsky.social & #LaurenMilling @natimmunol.nature.com. @genelayinstitute.bsky.social @harvardmed.bsky.social @broadinstitute.org hms.harvard.edu/news/researc... www.nature.com/articles/s41...
- Excited to share our paper in @natimmunol.nature.com! Using in vivo #CRISPR screens we identify the E3 ligase STUB1 as a new cancer immunotherapy target in CD8 T cells. STUB1 is a dual function target: STUB1 KO promotes CD8 responses and STUB1 KO hinders tumor cells. www.nature.com/articles/s41...
- REV-ERBα & REV-ERBβ, which control clock gene expression, also maintain ILC3 in a state that facilitates the maintenance of a balanced and healthy intestine @natimmunol.nature.com #ColonnaLab www.nature.com/articles/s41... preview @theonlylabever.bsky.social www.nature.com/articles/s41...
- Cellular & spatial profiling of fibrosis in Crohn's disease provides new insights into the mechanisms involved. From the lab of our Vice Director @thexavierlab.bsky.social in collaboration with #SmillieLab. Study led by #LingjiaKong @broadinstitute.org
- 📢ONLINE @natgenet.nature.com 📰Single-cell and spatial transcriptomics of stricturing #Crohn’s disease highlights a fibrosis-associated network. By Lingjia Kong, @thexavierlab.bsky.social and colleagues. ⬇️ www.nature.com/articles/s41...
- Dr. Ramnik Xavier and Dr. Christopher Smillie from the @broadinstitute.org analyzed individual cells from the intestinal tissue of #Crohns disease patients, measuring gene activity and mapping the cells’ location: bit.ly/4nwuf0s 📃 @natgenet.nature.com: go.nature.com/45UEWDH
- Single-cell and spatial transcriptomics of stricturing Crohn’s disease highlights a fibrosis-associated network @natgenet.nature.com @thexavierlab.bsky.social www.nature.com/articles/s41...
- @kepauken.bsky.social, Markson, Sharpe et al. @harvardmed.bsky.social show that when PD-1–expressing and PD-1 knockout CD8+ T cells are within the same tumor microenvironment, both cell types exhibit similarly enhanced functions. rupress.org/jem/article/...
- 🚨 New study from the lab of our Vice Director, Arlene Sharpe, led by @kepauken.bsky.social & #SamuelMarkson in @jem.org. PD-1 regulates tumor-infiltrating CD8+ T cells in both a cell-intrinsic & a cell-extrinsic fashion🧪
- @kepauken.bsky.social, Markson, Sharpe et al. @harvardmed.bsky.social show that when PD-1–expressing and PD-1 knockout CD8+ T cells are within the same tumor microenvironment, both cell types exhibit similarly enhanced functions. rupress.org/jem/article/...
- Excited to announce that my final co-first author publication from my postdoctoral training with Dr. Arlene Sharpe was published in @jem.org today! Thank you to everyone involved! Check out our new findings on the importance of cell extrinsic consequences after PD1 loss! rupress.org/jem/article-...
- This finding suggests that molecular patterns could be more useful categories for microbiome-driven immune regulation than taxonomy. (2/2) Read the study in JACS – pubs.acs.org/doi/10.1021/... @broadinstitute.org @mgbresearch.bsky.social
- In our latest collab w/the Clardy Lab @HarvardMed to mine microbial metabolites for immunomodulators, we identified how Eggerthella lent—one of the most studied & least understood members of the human gut microbiome—upregulates inflammatory responses in a cell- & antigen- independent fashion. (1/2)
- Check out our recent work with John Rioux and the iGenoMed Consortium! Serum proteomic and metabolomic profiling in #IBD patients initiating vedolizumab identified pro-inflammatory analytes associated with treatment response. onlinelibrary.wiley.com/doi/10.1111/...
- Our annual symposium on Immunity & Inflammation in Disease & Tissue is on again on August 6th. 🎙️Looking forward to talks from #RafiAhmed, #RichardFlavell, @thefuchslab.bsky.social, #BanaJabri & #LawrenceSteinman. Joseph B. Martin Conference Center, Boston MA
- Our newest paper studying immunosuppressive astrocyte-GBM interactions using RABID-seq is out in @nature.com today! Congrats to Brian Andersen and Camilo Faust Akl! www.nature.com/articles/s41...
- Very excited to share our latest work in @NatureGenet with the Smillie lab: a spatial transcriptomics atlas of stricturing #Crohns disease that offers new insights into mechanisms driving fibrotic complications in chronic gut inflammation...(cont.) www.nature.com/articles/s41...
- Have you registered yet for #ReThinkNeuroimmunology in October? Speakers include @aleksdelab.bsky.social @labschaefer.bsky.social @annamolofskylab.bsky.social @itchdoctor.bsky.social @becherlab.bsky.social @gocastelobranco.bsky.social @miriammerad.bsky.social @kuchroolab.bsky.social & more
- #ReThinkNeuroimmunology 3 day think tank exploring the biggest discoveries & breakthroughs in neuroimmunology. Organized by @quintanalabhms.bsky.social @bethstevenslab.bsky.social @jonykipnis.bsky.social @idoamitlab.bsky.social #RejaneRua Registrations 🔗 genelayinstitute.org/rtn/
- New pre-print from our lab here: www.biorxiv.org/content/10.1...
- The glycolytic reaction PGAM restrains Th17 pathogenicity and Th17-dependent autoimmunity @cp-cellreports.bsky.social @kuchroolab.bsky.social www.cell.com/cell-reports...
- The glycolytic enzyme, phosphoglycerate mutase (PGAM), is a key metabolic regulator suppressing Th17 cell pathogenicity & autoimmunity. Led by Chao Wang, Allon Wagner & Johannes Fessler, with #Yoseflab, our study is now published @cp-cellreports.bsky.social 🔗 www.cell.com/cell-reports...
- Grad student, #RockyBarilla was responsible for driving this huge effort. Well done!
- 🚨New paper with @thexavierlab.bsky.social @science.org on the critical role of 🔄neuroimmune crosstalk in immune defense in the gut🪱🪱. 🧪@genelayinstitute.bsky.social @mgbresearch.bsky.social @harvardmed.bsky.social @broadinstitute.org www.science.org/doi/10.1126/...
- Bacterial sphingolipids delivered by outer membrane vesicles persist within mammalian immune cells and promote IL-10 secretion via the mevalonate pathway www.cell.com/cell-host-mi... @thexavierlab.bsky.social @cp-cellhostmicrobe.bsky.social
- (1/6) Our latest paper in @cp-cellhostmicrobe.bsky.social shows that sphingolipids in Bacteroides outer membrane vesicles (OMVs) induce a tolerogenic host cell response through the cholesterol biosynthesis pathway. www.cell.com/cell-host-mi...
