Gabriel Victora
- Reposted by Gabriel VictoraA study from @danmucida.bsky.social and @victora.bsky.social showed how immune cells in the gut distinguish between food and harmful pathogens, shedding light on the origins of #foodallergies. #RockefellerScience #YearInReview 🔗: bit.ly/4hyS18b
- Zincfinger
- Reposted by Gabriel VictoraIn @natureportfolio.nature.com: Researchers, including Rockefeller's own Gabriel Victora (@victora.bsky.social), are striving to understand the impact a phenomenon known as original antigenic sin has on immunity to the virus that causes the flu.
- Congrats on a very important paper!
- I am excited to share that our work, in which we have dissected the signals driven by the nucleoside-modified mRNA and LNP components of mRNA vaccines that regulate germinal center (GC) responses, is now published in Cell! www.cell.com/cell/fulltex...
- Secret to great science: find the absolute best collaborators 👇👇
Over the past 5+ years I've had the honor of working with @wsdewitt.github.io @victora.bsky.social and many others on a project to "replay" affinity maturation evolution from a fixed starting point. matsen.group/general/2025...
- Reposted by Gabriel VictoraCalling all rising juniors & seniors: Interested in biological or biomedical research? Applications for our ’26 Summer Undergraduate Research Experience Program are now open! Nine weeks, hands-on research, & mentorship from some of the nation’s top scientists — learn more: bit.ly/CechFellows
- Check out our latest preprint on the effects of antibody-mediated feedback on ongoing germinal center reactions, led by Alex Barbulescu and @janabilanovic.bsky.social www.biorxiv.org/content/10.1...
- Long story short, antibodies can modulate the balance between B cells of different epitope specificities, countering excessive expansion of dominant clones
- One more piece for the very interesting puzzle of how antibodies feed back onto B cell responses in an epitope-specific manner. Lots more still to learn!
- Reposted by Gabriel Victora@biorxiv-immuno.bsky.social Identification of distinct cDC2 subpopulations that direct microbiota-specific T cell differentiation www.biorxiv.org/content/10.1... @ucberkeleyofficial.bsky.social
- Reposted by Gabriel Victora@biorxivpreprint.bsky.social Lymphatic constraint of germinal centers optimizes protective antibody responses www.biorxiv.org/content/10.1... @thelundlab.bsky.social @nyulangone.bsky.social @carlanowosad.bsky.social
- Reposted by Gabriel VictoraOur B cell Keystone is getting closer! Short talk abstracts and scholarship applications are due on November 13 - get to it! www.keystonesymposia.org/conferences/...
- Renewing my yearly bet on Cooper/Miller for the Nobels. One might think that I would learn after being wrong so many times, but one would be mistaken. laskerfoundation.org/winners/b-an...
- @cyrilpedia.bsky.social is biased, I’ve grilled him too many steaks
- If you want to deep dive in to immunology you could do worse than Gabriel's evolutionary landscaping www.biorxiv.org/content/10.1...
- Reposted by Gabriel VictoraCongratulations to all, especially Rockefeller's @veenapadmanaban.bsky.social, a research associate in @sohailtavazoie.bsky.social's lab, and Maria Cecilia Campos Canesso, formerly a postdoc in @danmucida.bsky.social and @victora.bsky.social’s labs. A very well-deserved recognition!
- Reposted by Gabriel Victora2/ Did adaptive immune cells learn to cooperate before the modern immune system existed? Awardee @affinityborn.bsky.social may redefine what's essential for immune memory & enable alternative immune architectures. 🥳 Congrats Dr. Wesemann! @harvardmed.bsky.social 🙏 #HFScout @victora.bsky.social
- Reposted by Gabriel VictoraIn a new preprint we use deep learning on lineage trees to infer the functional form of the relationship between affinity and fitness that controls antibody evolution in germinal centers: arxiv.org/abs/2508.09871 🧵
- Reposted by Gabriel VictoraIn the minority here, but I think it would be refreshing and I'd appreciate reading a piece like "On the value of reductionist science". While *incredibly* valuable, not everything *needs* -omics and the like, let alone when only done because it _can_ be done, with an illusion of mechanism.
- Reposted by Gabriel VictoraOslo University's Johanne Tracey Jacobsen visited CCII this week & shared exciting progress in the application of cutting edge imaging techniques to decode dynamic T-B interactions in the Germinal Center. #Immunology #GerminalCenter www.jjacobsenlab.com
- Reposted by Gabriel VictoraCheck it out, a great opportunity for people looking to start their own lab in Japan 👇 www.ccii.med.kyoto-u.ac.jp/en/careers-e...
- Reposted by Gabriel VictoraGerminal center clonal diversity trees as a musical score, a great image to start @victora.bsky.social's CCII seminar, "Replaying germinal center evolution on a quantified affinity landscape" #GerminalCenter #Immunology www.ccii.med.kyoto-u.ac.jp/en/event/the...
- Reposted by Gabriel VictoraFollowing Daniel @danmucida.bsky.social's session, Angelina Bilate @rockefelleruniv.bsky.social discussed strategies to identify antigen specific T cells. www.science.org/doi/10.1126/...
- With a little help from my friend
- Day 2. Gabriel Victora @victora.bsky.social discussing with students and postdocs the long & winding road to developing LIPSTIC, the tool his lab created to track cell-cell interactions in vivo www.nature.com/articles/s41...
- Reposted by Gabriel VictoraA great start to a 3-day workshop: Daniel & Angelina Bilate discussing with students & postdocs at @ccii-kyoto.bsky.social all the obstacles faced & strategies to overcome them (or, more drastically, the thorny topic of when to pull the plug on a project). www.ccii.med.kyoto-u.ac.jp/en/event/wor...
- Reposted by Gabriel VictoraOur streamlined Junior PI application process asks you to submit: a cover letter; a research plan; a current curriculum vitae; brief narrative summary of your main research achievements; Contact information for three references #Immunology #Immunotherapy www.ccii.med.kyoto-u.ac.jp/en/careers-e...
- The Center for Cancer #Immunotherapy and #Immunobiology in Kyoto has opened a call for three Junior faculty positions. Applications are open until July 31st. #ScienceJobs #Immunology #Immunosky www.ccii.med.kyoto-u.ac.jp/en/careers-e...
- Great to be back for the last iteration of this great symposium. It will be missed!
- I am so delighted to be in #Japan for this year's RIKEN IMS–JSI International Symposium on #Immunology! 🇯🇵 温かく迎えてくれた主催者に感謝する！
- Reposted by Gabriel VictoraI'm stoked to have this long-term and highly collaborative effort out in the wild. We present an experimental evolution system to quantitatively study the rapid evolutionary dynamics of B-cell affinity maturation. These evolutionary mechanisms underpin antibody responses and immune memory formation.
- Wanted to highlight our latest preprint--a huge effort by multiple people and labs, but led primarily by @wsdewitt.github.io, Tatsuya Araki, and Ashni Vora, in a very close wet-dry collaboration with @matsen.bsky.social’s lab at the Hutch www.biorxiv.org/content/10.1...
- Reposted by Gabriel VictoraAnother tour de force by the Victora lab. A must read for germinal center aficionados. There goes the weekend!
- Wanted to highlight our latest preprint--a huge effort by multiple people and labs, but led primarily by @wsdewitt.github.io, Tatsuya Araki, and Ashni Vora, in a very close wet-dry collaboration with @matsen.bsky.social’s lab at the Hutch www.biorxiv.org/content/10.1...
- Wanted to highlight our latest preprint--a huge effort by multiple people and labs, but led primarily by @wsdewitt.github.io, Tatsuya Araki, and Ashni Vora, in a very close wet-dry collaboration with @matsen.bsky.social’s lab at the Hutch www.biorxiv.org/content/10.1...
- In his book Wonderful Life, Stephen Jay Gould proposes a thought experiment where one would replay evolution on Earth many times from the beginning, so as to find out what features would emerge reproducibly and which ones were contingent on historical accidents
- We took this idea seriously and applied it to germinal centers, evolving the same reaction over 100 times. No spoilers here, though I can tell you that the amount of data is huge, and some of the findings were pretty surprising. Please check out the preprint!
- Additional credit to multiple members of the Matsen, Victora, and other labs, especially Jared Galloway for coding; @tylernstarr.bsky.social and @jbloomlab.bsky.social for deep mutational scanning; Ward lab for cryo-EM; and @thearmita.bsky.social and @yun-s-song.bsky.social for help with modeling
- Reposted by Gabriel Victora”replication crisis” has always been hyperbole. Scientists ALWAYS argued, called each other frauds, and eventually land on consensus. A lot of what van Leeuwenhoek observed in the late 1600s was NOT REPRODUCIBLE because nobody could make lenses like him. But he was right, about cells, and bacteria.
- Dear uLIPSTIC users, We have been getting reports that, under some more inflammatory settings like TB or chronic LCMV infection, uLIPSTIC-expressing lymphocytes adoptively transferred into cre-negative uLIPSTIC hosts may be rejected at later timepoints (>1 wk).
- This doesn't seem to be a problem for studying physiological settings or in short-term infection experiments (we never saw it ourselves in any of our own studies).
- In any case, an emerging solution seems to be to cross the host uLIPSTIC mouse to a cre line that is expressed in the thymus, such as Pou2F3-cre or Foxn1-cre, to enforce tolerance. (though beware that such cre lines may also recombine in other tissues, eg tuft cells and lung epithelium).
- thanks to @danmucida.bsky.social, @kamphorstlab.bsky.social and Joel Ernst (UCSF) for reporting these problems and coming up with the solution!
- Reposted by Gabriel VictoraA collaborative study between the labs of @danmucida.bsky.social and @victora.bsky.social earlier this year showed how immune cells in the gut distinguish between food and harmful pathogens, shedding light on the origins of food allergies: bit.ly/4hyS18b #FoodAllergyAwarenessWeek
- Reposted by Gabriel VictoraNew imaging from @victora.bsky.social's lab reveals a built-in safeguard that allows B cell populations to rapidly expand in germinal centers without introducing deleterious mutations. #RockefellerScience
- Cool germinal center acrobatics from Juhee Pae et al, check it out! www.nature.com/articles/s41...
- Reposted by Gabriel VictoraGreat to have our latest review "The cellular factors that impair the germinal center in advanced age" out @jimmunol.bsky.social. Work led by @wsfoster.bsky.social and Edith Marcial-Juárez. With @sanmarti92.bsky.social creating the beautiful GC images in figure 2. doi.org/10.1093/jimm...
- Reposted by Gabriel VictoraICYMI by First release - now in print @science.org Identification of APCs in the gut that promote Treg differentiation and how tolerance to food antigens is influenced by helminth infection. buff.ly/3DjNQ1e By @cicacanesso.bsky.social @danmucida.bsky.social @victora.bsky.social et al
- Reposted by Gabriel VictoraIn 2024, we reached out to 50 scientists who are doing innovative research around the world. 🧵 You can read our interviews with them in our #50ScientistsThatInspire collection: www.cell.com/topic/cell-d...
- Reposted by Gabriel VictoraRockefeller hearts science! This heart-shaped germinal center comes from the @victora.bsky.social lab, which studies how antibodies are generated in response to infection and immunization. Happy Valentine’s Day! 📷: Carla Nowosad
- Reposted by Gabriel VictoraRockefeller's @cicacanesso.bsky.social talks to The Scientist about her recent work with @danmucida.bsky.social and @victora.bsky.social on how cell-cell interactions help drive tolerogenic or inflammatory responses to the maelstrom of antigens passing through the gut.
- Reposted by Gabriel VictoraNew research from AAI members @danmucida.bsky.social and @victora.bsky.social @rockefelleruniv.bsky.social unlocked new clues on the mechanism behind food tolerance. Their findings show the delicate balance between tolerating food and defending against infections. Read more: ow.ly/LaP550UQwFJ.
- Reposted by Gabriel VictoraA study from @victora.bsky.social and @danmucida.bsky.social in @science.org reveals how immune cells in the gut distinguish between food and harmful pathogens, shedding light on the origins of both food allergies and intestinal diseases. #RockefellerScience bit.ly/4hyS18b
- we all have an emotional support dead famous guy and who he is says a lot about you
- Reposted by Gabriel VictoraI hate the direction lab equipment design has gone in recent years. I don't want touchscreens, I don't want wifi integration, I don't want centrifuges demanding to know what time zone they're in. I just want reliable instruments - with physical buttons - that do the one task they were made for.
- Reposted by Gabriel VictoraI am excited to share our study showing how the immune system strikes a delicate balance between tolerating food and defending against helminth infections. www.science.org/doi/10.1126/....
- Glad to see our work with @danmucida.bsky.social and @cicacanesso.bsky.social finally out!
- #Immunology by First release now @science.org Identification of APCs in the gut that promote Treg differentiation and how tolerance to food antigens is influenced by helminth infection buff.ly/3DjNQ1e By Maria Canesso, @danmucida.bsky.social , @victora.bsky.social and colleagues.
- Reposted by Gabriel VictoraCheck out our last pub. from @mfgrp.bsky.social al lab! We discovered that skin commensal microbes induce systemic and local B cell responses upon colonization and took advantage of this knowledge to create topical vaccines using engineered skin microbes. Please read the thread for details.
- Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @djenetbousbaine.bsky.social led the charge... @natureportfolio.bsky.social 1/55
- Thank you @cellpress.bsky.social for highlighting our work! www.cell.com/news-do/50-i...
- Reposted by Gabriel VictoraB CELL FUN FACT: Secrets of the GC #1 Walther Flemming described GCs in 1885 paper "Studies in Tissue Regeneration". He mistakenly thought they were sites of cell birth (hence name) & tingible bodies ("tingiblen Körper") were daughter cells about to be born! link.springer.com/article/10.1...
- Reposted by Gabriel VictoraMax deserves a Nobel. In the meantime, you can nominate someone for the Max Cooper Prize, deadline is April 1st. "Nomination letters of up to 3 pages must articulate how their research has led to advances in immunology research that will have a lasting impact." #Immunology
- Reposted by Gabriel VictoraI feel like this card is attacking me 😭 🧪
- Another beautiful example of @victora.bsky.social 's LIPSTIC ("labeling immune partnerships by sorTagging intercellular contacts") technique in action!
