Armita Nourmohammad
physicist, interested in biology --- Assoc. Prof. of physics @UW
(Seattle)
- excited to announce that this January we are relocating to Yale to start a theory initiative at the Center for Systems and Engineering Immunology (CSEI): @yalecsei.bsky.social looking to hire 2 postdocs to join us in this endeavor. more details can be found here: sites.google.com/uw.edu/statp...
- Topics of interest: (1) Physics-inspired machine learning for molecular immune-pathogen recognition. (2) Modeling cell-fate decisions in dynamic environments to build predictive, controllable models of immune responses across cellular and tissue conditions.
- some relevant recent publications from the group: Protein structure modeling with symmetry-aware neural nets: www.pnas.org/doi/10.1073/... designing T-cell antigens w/ our protein models: www.pnas.org/doi/10.1073/... Design principles of T-cell responses: arxiv.org/abs/2509.22997
- Reposted by Armita Nourmohammad
The Mahan postdoctoral fellowship offers 21 months of support to develop your own research with Fred Hutch computational biology faculty-- lots of excellent labs to choose from! Apply: apply.interfolio.com/172697 Faculty: www.fredhutch.org/en/research... - excited that this paper is finally out in @pnas.org : www.pnas.org/doi/10.1073/... Led by Gian Marco Visani (effort initiated by Michael Pun), fantastic collaboration with @pgtimmune.bsky.social @asya-minervina.bsky.social and Phil Bradley.
- check out our new manuscript (led by Gian Marco Visani): structure-based machine learning model for TCR-pMHC complexes, predicting T-cell affinity to peptide-MHC complexes, quantifying T-cell receptor specificity, and designing de-novo immunogenic peptides: arxiv.org/abs/2503.00648
- check out our manuscript (led by Obinna Ukogu) on Design principles of cytotoxic T-cell response: www.biorxiv.org/content/10.1...
- By exploring an ensemble of feedback control immune designs, we quantified trade-offs between effective pathogen clearance and immunopathology. We identified genetic signal-processing perturbations that could improve efficacy while limiting toxicity of T-cell immunotherapies against cancer.
- Reposted by Armita NourmohammadWanted to highlight our latest preprint--a huge effort by multiple people and labs, but led primarily by @wsdewitt.github.io, Tatsuya Araki, and Ashni Vora, in a very close wet-dry collaboration with @matsen.bsky.social’s lab at the Hutch www.biorxiv.org/content/10.1...
- Reposted by Armita NourmohammadRecasting the perils of phylodynamic non-identifiability as a feature not a bug, we show that a unique forward-equivalent process enables exact and efficient simulation from arbitrarily large populations. With M Celentano, S Prillo, @yun-s-song.bsky.social www.pnas.org/doi/10.1073/pnas.2412978122
