Filipe Carvalho
Postdoc @ EpiMiC lab (UMR1319 Micalis, INRAE, Jouy-en-Josas 🇨🇵).
Previously @ Cossart lab (Institut Pasteur, Paris 🇨🇵), @ Cabanes lab (i3S, Porto 🇵🇹).
Molecular microbiology, host-pathogen interactions, bacterial dormancy and environmental persistence
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- Reposted by Filipe CarvalhoMany spores from the Firmicutes group are decorated with hair-like structures. Since the 60s, they remained a mystery. @remaut-lab.bsky.social named these fibres ENdospore Appendages (ENAs). Using Cryo-ID, we report the identity, structure and function of F-ENA. www.nature.com/articles/s41...
- RagB stimulates the activity of the peptidoglycan polymerase RodA in Bacillus subtilis [RagB = YrrS] @emboreports.org by Frédérique Pompeo et al www.embopress.org/doi/full/10....
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- New review from our lab! Compartmentalization during bacterial spore formation. Focusing on latest discoveries in Bacillus subtilis #subtiwiki www.sciencedirect.com/science/arti...
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- Reposted by Filipe CarvalhoOur new paper on FtsN is out! Now there are three tracks for organized cell wall constriction-- the old, boring E. coli always manages to surprise us. A special shout-out to all the people who made this work possible, especially Dr. Jason Lyu, and Dr. David Weiss. www.nature.com/articles/s41...
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- Reposted by Filipe CarvalhoHow do intracellular #bacteria breach vacuoles to enter the host cytosol? @leaswistak.bsky.social @matthijnvos.bsky.social @enningalab.bsky.social &co show that #Shigella uses its T3SS system to damage endomembranes via mechanoporation to initiate cytosolic access @plosbiology.org 🧪 plos.io/4jXrr9Z
- Reposted by Filipe CarvalhoOut in Nature today: A new immune signaling molecule, His-ADPR, is produced by defensive TIR domain proteins in bacteria to protect from phage Joint work with the Tamulaitienė and Kranzusch labs www.nature.com/articles/s41... Congrats Carmel Avraham, Dziugas Sabonis, Renee Chang and co-authors!
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- Reposted by Filipe CarvalhoCheck it out - amazing new work by @raflynn5.bsky.social and Kostas Tzelepis labs, discovery of a cell surface RNA/glycoRNA binding protein that is also a cancer antigen, new target for antibody therapy! www.nature.com/articles/s41...
- Happy Freedom Day and 51st anniversary of the Carnation Revolution! 🇵🇹
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- Reposted by Filipe CarvalhoCell division in rod-shaped bacteria is well studied (think "Min system"), but how do round bacteria find their middle? @felixrl.bsky.social 's new review article covers how #Staph aureus, Streptococci, and others figure out how to perform binary fission. portlandpress.com/biochemsoctr...
- Reposted by Filipe CarvalhoA huge, new resource for plasmid research - PlasmidScope is a database of 852,000 #plasmid sequences with a rich set of annotations, automated online analysis and interactive visualisation academic.oup.com/nar/article/...
- 🦠 Dreaming of tracking real-time colony growth? SelinaRust, RandauLab built SMARTIS for you: a remote-controlled, smartphone-based time-lapse imaging system. 🔬📱 Early heterogeneity spotted within hours for cells with Type IV-A1 CRISPR-Cas activity! @unimarburg.bsky.social buff.ly/BBzh7cY
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- Feeling weirdly guilty to have watched "Conclave" last night. R.I.P. #PopeFrancis 🤍
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- New postdoc position in our lab (2 y+): evolutionary genomics of integrons and MGEs with focus on vibrio-phage interactions. Great environment @pasteur.fr for science, career building. Super collaborators @celineloot.bsky.social @amazeld.bsky.social @fredoleroux.bsky.social 3 weeks to apply!
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- 👏👏👏 #MicroSky
- Proteolytically activated antibacterial toxins inhibit the growth of diverse Gram-positive bacteria biorxiv.org/content/10.1101/202…
- Host AAA-ATPase VCP/p97 lyses ubiquitinated intracellular bacteria as an innate antimicrobial defence www.nature.com/articles/s41... #MicroSky
- Reposted by Filipe CarvalhoNew genome-based predictions 🧬🖥️ generated using a deepG GenomeNet model were recently added to BacDive 🦠. 33,913 predictions for Gram stain, motility, oxygen tolerance and spore formation with high confidence could be fully integrated into the strain data. 👉 bacdive.dsmz.de/news 👉 deepg.de
- RNF213, a host E3 ligase, ubiquitylates LPS to mark cytosol-invading bacteria for autophagy. But how do cytosol-adapted bacteria escape? We found that Shigella's E3 ligase IpaH1.4 blocks LPS ubiquitylation by degrading RNF213 via the proteasome. www.nature.com/articles/s41...
- Subpopulations in clinical samples of M. tuberculosis can give rise to rifampicin resistance and shed light on how resistance is acquired biorxiv.org/content/10.1101/202…
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- Fantastic new preprint of Vaughn Cooper's lab @vscooper.micropopbio.org - filamentous phages can get cancer and it's contagious. 🔥👇🏼 www.biorxiv.org/content/10.1...
