Stephen Garrett
EMBO Postdoctiral Fellow in the Whitney lab at McMaster University, working on interbacterial warfare and phage defense
- Reposted by Stephen Garrett🚨 Hiring Alert! 🚨My lab at Institut Pasteur is recruiting several Postdocs! We have exciting open projects in: 🦠 Synthetic Biology and🛡️ Bacterial Immunity. Come do great science with us in the middle of Paris! 🇫🇷🥐 research.pasteur.fr/en/job/postd...
- Reposted by Stephen GarrettIt was great to play a part in this study, using all of the work on alphaproteobacterial GTAs to help inform and identify key tell-tale patterns of GTAs in the human gut microbiome. I'm sure there will be many great followup studies on these fascinating particles. www.nature.com/articles/s41...
- Reposted by Stephen GarrettE. coli is the leading bacterium causing death from AMR infections worldwide. If you'd like to explore approaches to exploit the DNA damage response as alternative antimicrobial, please apply to the following PhD studentship available in my lab starting October 2026: www.findaphd.com/phds/project...
- Reposted by Stephen GarrettPhD position available in our team to study how UPEC exploits metals to successfully colonise the host gut. Cool collaboration with @thecopperdoctor.bsky.social and @banzhaflab.bsky.social Please share and get in touch for more details
- Reposted by Stephen Garrett
- Reposted by Stephen GarrettIf you or someone you know is looking for a post-doctoral position working on mycobacterial envelope biology, please get in touch. I am recruiting here at the University of Western Ontario in London, Ontario, Canada.
- Very happy to have been part of this work from the Mariano lab, identifying 11 hotspots enriched in phage defence systems in Pseudomonas aeruginosa. It was great to get the chance to collaborate with @giusym1990.bsky.social again! academic.oup.com/nargab/artic...
- Reposted by Stephen GarrettExcited to share our new study! Great fun working again with my good friend @stephenrgarrett.bsky.social — always a highlight! Huge thanks to fantastic co-authors @samkaytucker.bsky.social, @drandyjroe.bsky.social and our star technician Vojtech Pavelka. academic.oup.com/nargab/artic...
- Reposted by Stephen GarrettOur latest T7SS study is now out in Science Advances! We solved the cryoEM structure of the T7SSb core unit (T7bCU) composed of YukB, YukC, and YukD from Bacillus subtilis, revealing how these components assemble within the secretion machinery. www.science.org/doi/10.1126/...
- Reposted by Stephen GarrettThere's just over 2 weeks left to apply for a fully funded PhD studentship with us working on C. difficile vancomycin resistance. Two more studentships - linked in the thread below - close in early January
- Reposted by Stephen Garrett#microsky #phagesky Intriguing instance of a reversible type of mutation from #phage exposure www.biorxiv.org/content/10.1...
- Reposted by Stephen GarrettPhD opportunity (unfortunately UK home students only) to work on nanoparticles to combat AMR with @forganross.bsky.social and me in UoG. If you have a microbiology background and an interest in chemistry this would be a perfect project for you! Please share!
- Reposted by Stephen Garrett🚨 PhD opportunity! 🚨 Join us at St Andrews to study how multiple prophages shape bacterial behaviour & AMR. Co-supervised with @tatianadimitriu.bsky.social This is a competition-based EASTBIO PhD. Full details and the application link are in the advert 👇 www.findaphd.com/phds/project...
- Reposted by Stephen GarrettA fantastic opportunity with two amazing supervisors!
- 🚨 PhD Opportunity 🚨 Interested in microbiology, phages & water security? Join me and Prof Cindy Smith to test phages as a sustainable alternative to chlorine in drinking-water biofilters. Metagenomics, phage discovery & ecology — all in one exciting project! Apply: www.gla.ac.uk/colleges/mvl...
- Reposted by Stephen GarrettPhD opportunity in the lab of a young PI who’s simply going stratospheric, on using #phage for water treatment. What’s not to like? You can’t miss this chance. #microsky #phagesky
- 🚨 PhD Opportunity 🚨 Interested in microbiology, phages & water security? Join me and Prof Cindy Smith to test phages as a sustainable alternative to chlorine in drinking-water biofilters. Metagenomics, phage discovery & ecology — all in one exciting project! Apply: www.gla.ac.uk/colleges/mvl...
- Reposted by Stephen Garrett🚨 PhD Opportunity 🚨 Interested in microbiology, phages & water security? Join me and Prof Cindy Smith to test phages as a sustainable alternative to chlorine in drinking-water biofilters. Metagenomics, phage discovery & ecology — all in one exciting project! Apply: www.gla.ac.uk/colleges/mvl...
- Reposted by Stephen GarrettHappy to share the last paper form the lab: Specialized shuttle proteins recognize T9SS signals and target effectors to their final destinations. Great work by @maellepllt.bsky.social, led by @thicoz.bsky.social in collaboration with @audebertstephane.bsky.social www.nature.com/articles/s42...
- Reposted by Stephen GarrettBacteria export alarmone synthetases that produce (p)ppApp and (p)ppGpp 🦠🤯 From Boyuan Wang and John Whitney journals.asm.org/doi/10.1128/...
- Reposted by Stephen GarrettPlease RT. Post-doc opportunity alert! 💥 closing 10th December.. Come join our team (www.thelowlab.org) at Imperial, London, working on the structure and mechanism of bacterial secretion systems. For more details and to apply please see www.imperial.ac.uk/jobs/search-...
- Reposted by Stephen GarrettHi everyone, a few years ago, we started a list of labs studying bacterial immunty for students, editors, conference organizers... (currently n=79). Update time ! Send me a message to 1) add your lab or others 2) Correct info docs.google.com/spreadsheets... #Phagesky #Microsky
- Reposted by Stephen GarrettRemarkable increase in vancomycin resistance among clinical Enterococcus faecium isolates in Italy (from 11.5% in 2015 to 32.4% in 2023). aricjournal.biomedcentral.com/articles/10....
- Reposted by Stephen GarrettNew paper alert! We used our fav technique, genetic suppression, to understand how FimX controls function of the T4P PilB motor ATPase in Pseudomonas aeruginosa. Great collab with the Ellison lab at U Georgia who helped with some fancy microscopy to capture pilus dynamics! doi.org/10.1371/jour...
- Some really cool work from @shelbyeandersen.bsky.social in the @duerkoplab.bsky.social using a new approach to identify novel phage defence systems.
- Serine recombinases are conserved genetic markers of antiphage defense systems biorxiv.org/content/10.1101/202…
- Reposted by Stephen Garrett🚨PhD Opportunity Alert🚨 Join me, @suzieh.bsky.social and @walllabuoglasgow.bsky.social to investigate how environment shapes anti-phage defences & prophage–prophage conflict in Pseudomonas aeruginosa. Apply here: www.gla.ac.uk/postgraduate...
- Reposted by Stephen GarrettPhD opportunity to come and work in Glasgow, developing advanced tissue culture models to study Staphylococcus aureus colonisation and infection #microsky #PhD #DTPprogram Enquiries from potential applicants are welcome. www.gla.ac.uk/postgraduate... www.findaphd.com/phds/program...
- Really excited to share my first paper from the Whitney lab, alongside an amazing grad student, Polina. Here we identify a chaperone family required for the folding of a central domain of T7SS toxins, and solve the structure of the chaperone-toxin complex. www.pnas.org/doi/10.1073/...
- Reposted by Stephen GarrettIn our new article, we show how P. aeruginosa, a major cause of chronic respiratory infections in #cysticfibrosis (CF), uses the Type VI Secretion System #T6SS and specific #toxins to eliminate competing bacteria www.cell.com/cell-reports... #cryoEM @dshatskiy.bsky.social @jakecolautti.bsky.social
- Reposted by Stephen GarrettThrilled to share our two latest papers with the @tcostalab.bsky.social lab! In the first, we uncover a new mechanism of satellite transfer: cf-PICIs hijack tails from diverse phages to spread across species. @imperialcollegeldn.bsky.social www.cell.com/cell/fulltex...
- Reposted by Stephen GarrettExcited to share that my work in the @aaronwhiteley.bsky.social lab describing chaperone-mediated phage sensing by a bacterial NLR-related protein is out in @plosbiology.org!
- Bacteria encode homologs of the human NACHT proteins that form inflammasomes and use them to defend against phage #infection. @amyconte.bsky.social @aaronwhiteley.bsky.social &co show that bNACHT25 detects diverse phages indirectly through interaction with the host chaperone DnaJ. 🧪 plos.io/4koXP60
- Reposted by Stephen GarrettExcited to share my PhD work in the Kranzusch Lab published in @nature.com! Two key discoveries: - Nucleotides can act as negative regulators of antiviral immunity - Ion channel activation is gated by DNA Thank you to our all collaborators! @soreklab.bsky.social www.nature.com/articles/s41...
- Reposted by Stephen GarrettOut in Nature today: A new immune signaling molecule, His-ADPR, is produced by defensive TIR domain proteins in bacteria to protect from phage Joint work with the Tamulaitienė and Kranzusch labs www.nature.com/articles/s41... Congrats Carmel Avraham, Dziugas Sabonis, Renee Chang and co-authors!
- Reposted by Stephen GarrettJoin the Blokesch lab (@EPFL) as a postdoc in Molecular Microbiology 🤩 Study Vibrio cholerae defense systems (phage/plasmid) in a dynamic, collaborative environment in Lausanne close to Lake Geneva in 🇨🇭! Please visit my lab's webpage for details about the position and how to formally apply.
- Reposted by Stephen GarrettPostdoctoral Fellow position–Investigating the Escherichia coli efflux network and cell envelope to advance next-generation antimicrobial development in the Cox lab, Department of Molecular and Cellular Biology, UoG, Canada. Please share! www.coxlab.ca/job-opportun... @uofguelph.bsky.social
- Reposted by Stephen GarrettNew postdoc position in our lab (2 y+): evolutionary genomics of integrons and MGEs with focus on vibrio-phage interactions. Great environment @pasteur.fr for science, career building. Super collaborators @celineloot.bsky.social @amazeld.bsky.social @fredoleroux.bsky.social 3 weeks to apply!
- Reposted by Stephen GarrettThe BASEL collection of E. coli #phages is limited by its host strain. @humollidorentina.bsky.social @damienpiel.bsky.social @aharms485.bsky.social &co use a modified host to add 36 new phages, revealing roles of O-antigen in recognition & R-M systems in immunity @plosbiology.org 🧪 plos.io/4jirGvX
- Really excited to share this story from Jake in the lab! We have found bacterial protein toxins that can enter Gram positive bacterial cells without the need for a receptor resulting in broad spectrum antibacterial activity.
- Proteolytically activated antibacterial toxins inhibit the growth of diverse Gram-positive bacteria biorxiv.org/content/10.1101/202…
- Reposted by Stephen GarrettIf you are interested in phage satellites, we hope you'll enjoy this. Fun collaboration with the Rocha, Seed, Bikard, and Chen labs! rdcu.be/efkvG
- Reposted by Stephen GarrettNew online! Genetics, ecology and evolution of phage satellites
- Reposted by Stephen GarrettExcited to share with you the story that enabled me to start my own lab: what happens when the bacterial DNA replication machinery encounters single-strand discontinuities on template DNA? What is required for break repair and replication restart? www.biorxiv.org/content/10.1...
- Reposted by Stephen GarrettFirst senior-author paper is out today in the Journal of Microscopy! 🧪🔬 We present the first 3D printed microscope where both the optics & frame are entirely 3D printed - a low-cost, accessible, and reproducible tool for histological imaging! onlinelibrary.wiley.com/doi/full/10.1111/jmi.13398
- Reposted by Stephen Garrett📣Just 1 week left to apply for 2x 5-year researcher posts in experimental evolution #mevosky #microsky in @mermanchester.bsky.social @official-uom.bsky.social + 3-year research tech post www.jobs.manchester.ac.uk/Job/JobDetai... ERC project: how MGEs and defence systems control genome evoluton
- ☎️ Calling #MEvoSky ☎️ 2x 5-year research associate / research assistant positions in experimental evolution ERC-funded project: How do mobile genetic elements and defence systems shape bacterial genome evolution? Join the friendly and exciting @mermanchester.bsky.social community in Manchester!
- Reposted by Stephen Garrett🚨We are hiring! A MRC-funded PDRA position to study novel anti-phage systems & their evolutionary dynamics in P. aeruginosa, in collaboration with @friendlymicrobe. If you are passionate about phage-bacteria interactions & evolution, apply now ! tinyurl.com/bddz4z44
- Reposted by Stephen Garrett🚨 #PhD opportunity 🚨 Interested in the environmental persistence of bacterial pathogens 🦠 & quantifying the role of climate change in virulence and #AMR? Come and join us! @uofglasgow.bsky.social @sbohvm.gla.ac.uk www.findaphd.com/phds/projectdetails.aspx?PJID=182832 Please share!
- Reposted by Stephen Garrett📌 WE ARE HIRING! @uofgsii.bsky.social is seeking to appoint a Research Associate in Molecular Microbiology. ⏺️ Vacancy Ref: 164773 ⌛️ Closing date: 24 Feb 2025 📧 Informal Enquiries: Dr @giusym1990.bsky.social Giusy.Mariano@glasgow.ac.uk More Info | How To Apply: www.jobs.gla.ac.uk/job/research...
- Reposted by Stephen GarrettNew version of DefenseFinder available defensefinder.mdmlab.fr (& cli) Now encompassing 263 systems (+111 this year..!). Thanks @ftesson.bsky.social, DefenseFinder grandmaster. Full list of systems here: defense-finder-models/List_system_article.md at master · mdmparis/defense-finder-models
- It’s not too late to apply for a postdoc position with Giusy in Glasgow! Super supportive lab doing some really exciting science!
- Reposted by Stephen GarrettNow over 900 signatures. Please keep signing and sharing to send a clear message to the Royal Society that we want them to stand up for values that we all hold dear: docs.google.com/forms/d/e/1F...
- Reposted by Stephen GarrettNew mechanism of gene transfer! With @tcostalab.bsky.social @imperialcollegeldn.bsky.social, we discovered that cf-PICIs form tail-less elements that, once released, spread among different bacterial species by hijacking tails from various phages. More exciting news soon! shorturl.at/kRJqE
- Reposted by Stephen GarrettLove phage-bacteria interactions, anti-phage systems, and a sprinkle of evolutionary biology? There’s still time to apply and join our team in Glasgow at @uofgsii.bsky.social !
- 🚨We are hiring! A MRC-funded PDRA position to study novel anti-phage systems & their evolutionary dynamics in P. aeruginosa, in collaboration with @friendlymicrobe. If you are passionate about phage-bacteria interactions & evolution, apply now ! tinyurl.com/bddz4z44
- Reposted by Stephen Garrett🚨 #PhD opportunity! 🚨 Come and work with @evaheinz7.bsky.social and me at the University of Strathclyde (Glasgow) on an exciting project investigating the roles that #bacteriophages play in the evolution and virulence of #enterococci. 🧫🧬 Details here: www.strath.ac.uk/studywithus/...
- And another #PhD, again @unistrathclyde.bsky.social in the very friendly, open-minded and diverse Glasgow! #Enterococcal #phages and their role in infections - how much do they contribute to success of nosocomial pathogens? Details here, led by Suzie Humphrey 😊 www.strath.ac.uk/studywithus/...
- Reposted by Stephen GarrettThe Howard Hughes Medical Institute, the nation’s largest private funder of biomedical research, yesterday killed a $60 million program aimed at making universities’ STEM education more inclusive. scim.ag/3EtS0US
- Reposted by Stephen GarrettCome and meet with fellow queer microbiologists at our LGBTQ+ Networking Event on Tuesday 1 April 20:30 GMT, with a Trans and Nonbinary pre-meet. For further information and to secure your place, visit our website: microb.io/Microbio25 #Microbio25
- Reposted by Stephen GarrettDid you know, the Black Microbiologist's Association is a non-profit society that supports underrepresented scientists? I made a donation. What good cause can you support (if you have the means?) blackinmicrobiology.org
- Reposted by Stephen GarrettThe 2nd round of our Yorkshire Biosciences PhD programme is now open for applications - deadline March 14th. Both of our C. diff phage projects are also available in this round - details in the thread below. More info and expressions of interest here: app.onlinesurveys.jisc.ac.uk/s/leeds/ybdt...
- Reposted by Stephen GarrettA fun collaboration with the Whitney, Prehna, and Bosis labs, in which we reveal the role of DUF2169 proteins: assisting PAAR-like domains in forming spike complexes and #T6SS assembly. 🦠 search.app/jDxaUi5yJK9B...
