Lori L. Burrows
microbiologist, McMaster U 🇨🇦 • type IV pili, phages, biofilms, antibiotic resistance • equestrian🐴 • cancer survivor🎗️
- Reposted by Lori L. BurrowsSummer REU in biofilms! Pls share. www.binghamton.edu/centers/biof...
- Are you trying to kill #MRSA? The Burrows & the Pinho labs are too, and we found that an old anti-inflammatory compound can resensitize it to pen G and other beta lactams in a wall teichoic acid-dependent way, but unlike other WTA adjuvants. @mcmasteriidr.bsky.social www.biorxiv.org/cgi/content/...
- Now available - PhD student Veronica Tran reviews the importance of identifying & reporting #phage receptors to build better therapeutic cocktails with diverse #bacteriophages for tough pathogens like #Pseudomonas journals.asm.org/doi/epub/10.... @mcmasteriidr.bsky.social @mcmasternexus.bsky.social
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- New paper alert! PhD candidate Veronica Tran asked what types of resistance mutations were selected in #Pseudomonas by type IV pilus-specific #phages & whether they were reversible, Qs relevant to #phagetherapy - she got some interesting answers! Read the paper here: www.biorxiv.org/cgi/content/...
- New paper alert! We used our fav technique, genetic suppression, to understand how FimX controls function of the T4P PilB motor ATPase in Pseudomonas aeruginosa. Great collab with the Ellison lab at U Georgia who helped with some fancy microscopy to capture pilus dynamics! doi.org/10.1371/jour...
- New paper! Specific PilA and PilY1 sequences make PilU dispensable for T4P-dependent twitching motility in P. aeruginosa. However, most suppressors still had high cAMP levels from loss of PilU, showing that motility and surface sensing responses can be uncoupled.🧐 ⏩ journals.asm.org/doi/10.1128/...
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- Reposted by Lori L. BurrowsSuch a fun project & massive team effort. We sampled tree cores my 1st yr of grad school then took a year to figure out how to grind wood… ! But we were amazed to find such a complex & unexpected ecosystem inside trees. And we’ve just scratched the surface! We explored 150 trees— 3 trillion to go!
- #NatMicroPicks Hidden microbial world in trees🌳 Living wood hosts trillions of bacteria making trees a complex ecosystems with major roles in forest health and function. #PlantMicro #MicroSky www.nature.com/articles/s41...
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- New paper alert! PhD candidate Nathan Roberge is studying regulation of the #T4P assembly ATPase PilB and identified suppressors of FimX with enhanced motility. Where did they map? Find out here: www.biorxiv.org/content/10.1...
- Lovely work by @ianyyen.bsky.social and @gregwhitfield99.bsky.social on the bifunctional ATPase that powers assembly and disassembly of #T4cP type IV pili! www.nature.com/articles/s41...
- Nifty - circular pilins! Cryo-EM structure of the conjugation H-pilus reveals the cyclic nature of the TrhA pilin | PNAS www.pnas.org/doi/10.1073/...
- While I watch chaotic dismantling efforts in the name of efficiency: 'Few humans on their deathbed have celebrated their achievement of “Inbox Zero.”' www.forkingpaths.co/p/against-op...
- If I was 30 years younger...awesome lab!
- Would you like to do a post-doc in the Bowdish lab? Interested in human immunology? Want to discover age-related differences in immune responses to SARS-CoV-2/COVID-19 vaccinations and infections? Check us out! (Please share broadly)👩🔬🧪 #immunosky #IDsky www.bowdish.ca www.bowdish.ca/lab/wp-conte...
- Reposted by Lori L. BurrowsPlease repost!!!!! Abstraction submission for the next Great Wall Symposium is now open! Come to Sicily in September and learn the latest on bacterial cell wall biology. thegreatwall-symposium.org/abstract-sub...
- Great week at BLAST XVIII in Cancún - terrific science and conversations with smart people, plus no polar vortex!
- Reposted by Lori L. BurrowsDistribution of the four type VI secretion systems in Pseudomonas aeruginosa and classification of their core and accessory effectors @naturecomms.bsky.social from Daniel Unterweger www.nature.com/articles/s41...
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- 🤯
- What is the diversity of antiphage systems out there ? We used protein and genomic language models (and defense score!) to start bringing some answers: >45 000 protein families. Leb by E. Mordret. www.biorxiv.org/content/10.1... Interactive UMAP to have fun mdmparis.github.io/antiphage-la...
- Reposted by Lori L. BurrowsAnother newly discovered mechanism of bacteria inhibiting competitors - increasing their sensitivity to phages - fascinating www.nature.com/articles/s41...
- Trojan horse peptide conjugates remodel the activity spectrum of clinical antibiotics doi.org/10.1073/pnas...
- Reposted by Lori L. BurrowsWe found that many bacterial species use exogenous peptidoglycan fragments - released by lysis of neighboring cells - as a general danger signal, triggering a danger response that protects bacteria against many dangers: biofilm formation. Details here 👇 www.nature.com/articles/s41...
- Reposted by Lori L. BurrowsPeptidoglycan as danger signal promotes biofilm formation - great article by the Drescher lab www.nature.com/articles/s41...
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- Cool octopus or elephant vibes.
- SpiRobs: Logarithmic Spiral-shaped Robots for Versatile Grasping Across Scales "They are actuated by cables, which allows for fast and life-like movements. Besides, a single robot can handle a wide variety of objects (in terms of size, shape, and weight)." Open Access www.cell.com/device/pdf/S...
- Antibiotic emergency ‘could claim 40 million lives in next 25 years’
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- Reposted by Lori L. BurrowsStructure of the Pseudomonas aeruginosa PAO1 Type IV pilus Finally out in PLOS Pathogens. Congrats Hannah Ochner and co-authors. @mrclmb.bsky.social journals.plos.org/plospathogen...
- Reposted by Lori L. Burrows#ASMBiofilms Mark your calendars - This is shaping up to be a fantastic conference in Fall of 2025 in Portland, Oregon
- 2025 10th ASM Conference on Biofilms Nov. 9-13, 2025, Portland, Oregon Pre-conference Early Career Scientist Symposium (Nov. 9) asm.org/Events/ASM-B...
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- Cool!
- Check out this bombshell publication by Michael Fischbach @mfgrp.bsky.social and coworkers @stanford-chemh.bsky.social @stanfordmedicine.bsky.social, imagine a cancer immune therapy/vaccine where treatment begins and ends with a painless topical skin treatment! 🤯 www.nature.com/articles/s41...
- Reposted by Lori L. BurrowsAre you working on natural products? We’ve just released version 4.0 of the MIBiG data standard and repository! It now includes 3059 biosynthetic gene clusters, thanks to the combined efforts of 288 expert contributors. A thread: (1/8) academic.oup.com/nar/advance-...
- Reposted by Lori L. BurrowsIf an #H5N1 pandemic starts tomorrow or in three months, there will be little mystery as to how it happened. The conditions are all there. They have been for a while. So in some ways the more interesting question to me at the moment is: Why aren’t we in a pandemic yet? Story here, 🧵 to come: 🧪#IDSky
- Small but mighty - #phages are so interesting and potential lifesavers! nautil.us/medicine-is-...
- Really scary - NDM-1-producing #Klebsiella pneumoniae and other essentially untreatable XDR pathogens are infecting injured soldiers. New antibiotics can't come fast enough. www.science.org/content/arti... #AMR
- Hoo boy. Not loving the Venn diagram where 'single mutation allows for human infection by #H5N1' meets 'let's make major changes to healthcare in the US'. 🫣
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- "AI will not replace people anytime soon, but people who use AI might replace those who don’t." doi.org/10.1038/d415...
- Reposted by Lori L. BurrowsI'm recruiting a Research Fellow/Postdoc to join my team at #SCELSE to work on food chain biofilms to find new ways to extend food shelf life and reduce food waste. If you have skills in #microbiology and #biofilms apply via Workday: tinyurl.com/3468xm34 or MCF: tinyurl.com/5fyy6hdd. Share widely!
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- Reposted by Lori L. BurrowsI'm pumped to finally share our lab's first publication! Microbiology and cancer are deeply intertwined, and this is our first foray into the cancer field. We asked: how do bacteria activate innate immunity in tumors to elicit anti-cancer responses? www.sciencedirect.com/science/arti...
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- Reposted by Lori L. Burrows@kellygoldlust.bsky.social glad to see you here, kelly 😊 you might have noticed that we featured your paper in STC > schaechter.asmblog.org/schaechter/2...
- Reposted by Lori L. BurrowsExcited to share our latest, "Biofilm dispersal patterns revealed using far-red fluorogenic probes." @plos.bsky.social We developed a cell-labeling strategy using far-red dyes to image dense microbial communities (where fluorescent proteins often do not work well) journals.plos.org/plosbiology/...
- Looking for Biorender alternatives?
- Reposted by Lori L. BurrowsCrazy stuff in PNAS dental plaque bacterium 𝘊𝘰𝘳𝘺𝘯𝘦𝘣𝘢𝘤𝘵𝘦𝘳𝘪𝘶𝘮 𝘮𝘢𝘵𝘳𝘶𝘤𝘩𝘰𝘵𝘪𝘪 can divide into an unprecedented 14 daughter cells at once—then each daughter cell starts growing immediately in a rare process called multiple fission, achieving 0.5 mm per day of expansion www.snexplores.org/article/bact...
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- Congratulations to Dr. Victoria Coles - she's continuing her fight against #AMR from the policy side with her new role at CIHR's Institute of Infection and Immunity 🦠🎓
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- Reposted by Lori L. BurrowsHow do secreted and membrane-localized enzymes get appropriately metalated? ... Bixi He and I tackled this question, with a focus on the cell envelope... Metalation of Extracytoplasmic Proteins and Bacterial Cell Envelope Homeostasis | Annual Reviews - go.shr.lc/3V0lM92
- Now ordering a box of festive N95s for those upcoming holiday get togethers….
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- Reposted by Lori L. BurrowsOur recent report on #AntimicrobialResistance & the need for improved surveillance, testing, infection control, #antibiotic stewardship, funding & global commitments for #AMR solutions in humanitarian settings. #WAAW2024 #MedSky msfaccess.org/broken-lens-...
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The blue plaque which commemorates the celebration of the discovery of the structure of DNA has finally been updated to acknowledge Rosalind Franklin. #womeninSTEM 😍 newn.cam.ac.uk/newnham-news... - Reposted by Lori L. Burrows[Not loaded yet]
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- Just in time for #WAAW - new collab paper with the Strynadka lab at UBC on structure/function of #peptidoglycan fragment recycling transporter AmpG involved in AmpC-related beta lactam resistance. www.nature.com/articles/s41... @yaegerluke.bsky.social
