Claudia Hemsley
Molecular Biologist | Microbiologist with an interest in gene-regulation and pathogenesis. Currently in Dundee 🏴 Favourite bugs are #Pseudomonas #Coxiella #Burkholderia #UPEC
Views are my own.
- Reposted by Claudia HemsleyIn our most recent work David Forrest has discovered a widespread mechanisms linking transcription initiation to DNA supercoiling... www.nature.com/articles/s41...
- Reposted by Claudia HemsleyFRED: a universal tool to generate FAIR metadata for omics experiments www.biorxiv.org/content/10.6... #jcampubs
- Reposted by Claudia HemsleyWhat does competition for iron look like for pathogens in different environments? We had the chance to contribute to this great paper looking at Salmonella in the gut with the Cunrath Lab (UoStrasbourg). Salmonella relies on siderophore exploitation at low pH url: academic.oup.com/microlife/ar...
- Reposted by Claudia HemsleyNew in JB: Bange, Dornes, et al. review the molecular basis for flagellar patterns and numbers across bacterial species. journals.asm.org/doi/10.1128/... @asm.org #JBacteriology
- Reposted by Claudia HemsleyMRC instructs grant review boards to slash funding rates. Boards asked to recommend just three applications for funding, as BBSRC also suspends calls. www.researchprofessionalnews.com/rr-news-uk-r...
- Reposted by Claudia HemsleyA paper in Nature presents AlphaGenome, a deep learning model that can predict the function of long DNA sequences, up to one million base pairs. The tool can predict how DNA sequence variations affect different biological processes. go.nature.com/4t5JQa7 🧬 🧪
- Reposted by Claudia Hemsley#NatMicroPicks A bacterial symbiont wraps its flagllar filaments around its cell body to propel itself through narrow gut passages in its stinkbug host and hook flexibility is key for this 🪲🦠 by Yoshitomo Kikuchi & co @natcomms.nature.com www.nature.com/articles/s41...
- Reposted by Claudia Hemsley
- Reposted by Claudia HemsleyTranscription Factor Promiscuity Drives Regulatory Rewiring and Evolvability in Gene Networks in Bacteria (=Pseudomonas fluorescens) Advanced Science, perspective by @taylorlabgroup.bsky.social & @alanrice.ie Uni Bath's 60th anniversary special issue advanced.onlinelibrary.wiley.com/doi/10.1002/...
- Reposted by Claudia HemsleyA quorum-sensing molecule from Pseudomonas aeruginosa induces defensive multicellularity in a coinfecting pathogen -in PNAS from @anukharelab.bsky.social www.pnas.org/doi/10.1073/...
- Reposted by Claudia HemsleyDual-functional quorum sensing signal synthases DspII and DspI coordinate virulence switch in Pseudomonas aeruginosa @natcomms.nature.com www.nature.com/articles/s41...
- Reposted by Claudia HemsleySalmonella relies on siderophore exploitation at low pH #microLife by @ferrytin.bsky.social et al from Olivier Cunrath academic.oup.com/microlife/ad...
- Reposted by Claudia Hemsley
- Bacteria are amazing! The abundant Dps protein binds and protects DNA in stationary-phase cells with minimal effect on chromosome accessibility, dynamics, and organization. Now in NAR doi.org/10.1093/nar/...; I'm really proud of our multidisciplinary team led by Lauren, Lindsay, and Xiaofeng, et al.
- Reposted by Claudia Hemsley
- Reposted by Claudia HemsleyBacteria sense the antibiotic rifampicin through a widespread dual-promoter based alarm system @narjournal.bsky.social from Libor Krasny academic.oup.com/nar/article/...
- Reposted by Claudia HemsleyImpact of databases on genomic survey of Salmonella antimicrobial resistance and virulence factor functional genes across the African continent biorxiv.org/content/10.64898/20…
- Reposted by Claudia HemsleyWant to get the data out of a PDF figure? As in, the actual data – not a rough trace-along-the-lines version? I made an app you might like: adamkucharski.github.io/pdf2plot/ It all started a few years ago... 🧵
- Reposted by Claudia HemsleyValuable data sets are often overlooked because they are difficult to locate. The NIAID Data Ecosystem Discovery Portal provides a centralized, searchable interface that empowers users with varying technical expertise to find and reuse data. #mSystems: asm.social/2Lo
- Reposted by Claudia HemsleyJB Editor's Choice: Bhattarai, Harshey et al. propose a new model for YcgR::c-di-GMP regulation of flagellar motility in Salmonella/E. coli. They provide evidence for the first part of their model. journals.asm.org/doi/10.1128/... @asm.org #JBacteriology
- Reposted by Claudia HemsleyEver wondered if your favorite bacteria 🧫🦠 produce exopolysaccharides? You can now easily check that with epsSMASH, our new bioinformatic tool built on the antiSMASH framework. It detects both known and novel exoPS BGCs. Check out and share the preprint! www.biorxiv.org/content/10.6...
- Reposted by Claudia HemsleyNLR-like immunity in bacteria A new study from the Alex Gao lab. The scope of this work is incredible!!! www.biorxiv.org/content/10.6...
- Reposted by Claudia HemsleyJB Editor's Choice: Ratnikava, Lamprecht & Sourjik explore the complex regulation of curli in Escherichia coli. journals.asm.org/doi/10.1128/... @asm.org #JBacteriology
- Reposted by Claudia HemsleyA prophage-encoded sRNA limits phage infection of adherent-invasive E. coli #PLoSPathogen from @prsecor.bsky.social journals.plos.org/plospathogen...
- Reposted by Claudia HemsleyCharacterizing Cell-Free Transcription and Translation Dynamics with Nucleic Acid–Based Assays doi.org/10.1021/acss...
- Reposted by Claudia Hemsley1/ Our new preprint is out on biorxiv on how antibiotics bind to bacterial 30S subunits, please repost. #ribosome #antibiotics #microsky #rnasky doi.org/10.64898/202...
- Reposted by Claudia HemsleyA scalable transposon mutagenesis system for non-model bacteria biorxiv.org/content/10.64898/20…
- Reposted by Claudia HemsleyWe believe that, as our future leaders in biology, it is vital to provide #ECRs with the right support during the early stages of your academic career. We offer a number of practical ways to help you meet the unique needs and challenges you may encounter: www.biologists.com/about-us/ear...
- Reposted by Claudia HemsleyWe’re excited to share our latest study that reshapes our understanding of Mycobacterium tuberculosis (Mtb) lipid composition, with major implications for drug discovery, immunity, and vaccine development. www.nature.com/articles/s41... A thread.
- Reposted by Claudia HemsleyOur recent paper in npj Antimicrobials and Resistance is a great example of scientific serendipity: after staring at thousands of bacterial growth curves over many studies, we started wondering whether the curve shapes themselves carry mechanistic information 1/9 🦠🧪 www.nature.com/articles/s44...
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- Reposted by Claudia HemsleyPete Greenberg's view in #JBacteriol: Pseudomonas aeruginosa, my model for research on quorum sensing, biofilms, and opportunistic infections journals.asm.org/doi/10.1128/...
- Reposted by Claudia HemsleyEverything is everywhere but Escherichia coli adapts to different niches -in #ISMEJournal academic.oup.com/ismej/advanc...
- Reposted by Claudia HemsleyNew in JB: Yachida, Nakamura et al. consider the question of glocose metabolism in natural environments and show that the functions required for L-glucose catabolism overlap with L-galactose catabolism. journals.asm.org/doi/10.1128/... @asm.org #JBacteriology
- Reposted by Claudia HemsleyNew in JB: Trottier, Déziel et al. show that despite the conservation of the PqsE sequence of P. aeruginosa and some key conserved functions, including and essential role for HAQ biosynthesis, this protein has different impacts across strains of Pa. journals.asm.org/doi/10.1128/...
- Reposted by Claudia HemsleyNew in JB: Salpadoru, Patrauchan et al. explore the mechanisms of Ca2+-dependent PMB resistance in P. aeruginosa, and show links to responses to elevated Ca2+ and Pi starvation. journals.asm.org/doi/10.1128/... @asm.org #JBacteriology
- Reposted by Claudia HemsleySpatial proximity dictates bacterial competition and expansion in microbial communities @natcomms.nature.com by @esimsek.bsky.social et al from @lingchongyou.bsky.social www.nature.com/articles/s41...
- Reposted by Claudia Hemsley😳 Reversible phenotypic resistance to phage infection via capsule downregulation in Klebsiella pneumoniae #phage #phageky www.cell.com/iscience/ful...
- Reposted by Claudia Hemsley
- Reposted by Claudia HemsleyNutrient limitation shapes functional traits of mycorrhizal fungi and phosphorus-cycling bacteria across an elevation gradient #mSystems by @hannahshulman.bsky.social et al journals.asm.org/doi/10.1128/...
- Reposted by Claudia Hemsley
- Reposted by Claudia HemsleyNew at Addgene! Photoswitchable HaloTag, enabling robust and selective labeling of HaloTag on the surface of living cells using visible-light activation. From the @clairedeo.bsky.social lab. Walterspiel et al. Angew. Chem. Int. Ed. 2025 twp.ai/4isOad
- Reposted by Claudia Hemsley
- Reposted by Claudia Hemsley🦠Insight into the resilient world of prokaryotes! Koch lab – @sfb1381.bsky.social – reveals that E.coli use small membrane proteins (YohP & YncL) to condense their DNA & slow down metabolism, helping them survive to stresses. 🧬 buff.ly/dMzcQsP
- Reposted by Claudia HemsleyImpact of Small RNA Sponges on Regulatory RNA Networks in Bacteria #microsky www.annualreviews.org/content/jour...
- Reposted by Claudia HemsleyRole of FlhF and its domains in the assembly of a polar flagellum in P. aeruginosa #JBacteriol from Deepti Jain journals.asm.org/doi/10.1128/...
- Reposted by Claudia HemsleyEvolutionary Flexibility of Ribosome Biogenesis in Bacteria | Molecular Biology and Evolution | Oxford Academic academic.oup.com/mbe/article/42/11/m…
- Reposted by Claudia HemsleyThe limitations of small molecule and genetic screening in phenotypic drug discovery
- Reposted by Claudia HemsleyIn a very interesting talk about training dogs to sniff out infection - including Pseudomonas aeruginosa in #CysticFibrosis Here’s a study link, from medicaldetectiondogs.org.uk with @janedaviescf.bsky.social & colleagues publications.ersnet.org/content/erj/5
- Reposted by Claudia HemsleyChemists have discovered a promising new antibiotic that shows activity against drug-resistant bacterial pathogens This discovery suggests a new paradigm for antibiotic discovery through identifying and testing intermediates in the pathways to diverse natural compounds #SomeGoodNews
- Reposted by Claudia Hemsley#microsky on the Type VI secretion system (T6SS) www.nature.com/articles/s41...
