Leon Smyth
CNS immunology, stroma, and barriers | Lab head @Monash | former postdoc in @kipnislab @WUSTL | Kiwi 🥝 🇳🇿
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[Not loaded yet] - Reposted by Leon SmythCell is hiring! Do you have a background in #neuroscience or #immunology? Better still, #neuroimmunology? Cell has an opening for a full-time scientific editor. Role will be based out of any one of our offices in Medford, MA, UK, Spain, Netherlands, China tinyurl.com/4ma236xn @cp-cell.bsky.social
- Reposted by Leon Smyth🙏🙏 to entire team esp co-lead Tim Bartels. So proud of @seppedeschepper.bsky.social brilliant first postdoc who now leads his own at VIB. 🙏🙏🙏to @chanzuckerberg.bsky.social for supporting the project from early pilot phase. Contact us if u want to explore next steps in PD gut/brain neuroimmunology!
- Could targeting the gut's immune system tackle the early stages of Parkinson's? 🧠 A new study from @soyonhonglab.bsky.social & Tim Bartels (UK DRI at UCL) has revealed how Parkinson’s spreads from the gut to the brain - with the help of immune cells. Read more 👉 www.ukdri.ac.uk/news-and-eve...
- Reposted by Leon SmythClonal CD8+ T cells populate the leptomeninges and coordinate with immune cells in human degenerative brain diseases www.nature.com/articles/s41...
- Reposted by Leon SmythWe’re delighted to see this out today! Latest work from the lab reveals insights into the evolution of brain immunity and the developmental and evolutionary plasticity of lymphatic endothelial cells. www.nature.com/articles/s41...
- Reposted by Leon SmythFibroblastic reticular cells direct the initiation of T cell responses via CD44 @nature.com @the-de-lab.bsky.social www.nature.com/articles/s41...
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- Reposted by Leon Smyth3 papers in Cell @cellpress.bsky.social today exploring the mechanistic connection between Epstein-Barr virus and multiple sclerosis #MultipleSclerosis cell.com/cell/fulltex... cell.com/cell/fulltex... www.cell.com/cell/fulltex...
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- Beautiful preprint by Maria Lehtinen's group on the impact of aging and Alzheimer's disease on the choroid plexus. www.biorxiv.org/content/10.6...
- Reposted by Leon SmythThrilled to share our new paper on reactive microglial plasticity! Using long-term fate mapping and epigenetic profiling, we uncover the remarkable plasticity of reactive microglia across the lifespan and the enhancers and associated TFs that govern state transitions.
- WE ARE HIRING! The Smyth Lab at Monash University is looking for a postdoc to join our team! Come join us if you are excited about neuroimmunology and the meninges. 📍 Melbourne, Australia 🇦🇺 Apply now: careers.pageuppeople.com/513/cw/en/jo... #Neuroimmunology #Meninges #PostdocJobs
- Reposted by Leon SmythSo excited to share with you our latest work, result of my PhD with Dr.Rejane Rua at the @ciml.bsky.social! 🍾 If you want to brainstorm about bone channels and skull’s contribution to meningeal immunity, have a look! 🔬🧠
- Reposted by Leon SmythRemodeling of skull bone channels regulates immune infiltration into the meninges during neuroinflammation: Immunity www.cell.com/immunity/ful...
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- Reposted by Leon SmythSmyth, Mehta, @jonykipnis.bsky.social et al. show that bridging veins accumulate amyloid in mouse models of #Alzheimers disease and human Alzheimer’s disease specimens, associated with impaired cerebrospinal fluid efflux. rupress.org/jem/article/... 🎥 See video summary: youtu.be/FsM6ontxHEI
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- Thank you very much to Maiken and her team for writing this news and views article about our recent work on bridging vein amyloidosis! doi.org/10.1084/jem....
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- Reposted by Leon SmythAmyloidosis of bridging veins in AD mouse models and humans - clogged CSF exit routes. New from Smyth, Mehta, @jonykipnis.bsky.social @washumedicine.bsky.social and colleagues: rupress.org/jem/article/... #Neuroinflammation #Alzheimers
- Reposted by Leon SmythAmyloidosis of bridging veins in AD mouse models and humans - clogged CSF exit routes. New in @jem.org from Smyth, Mehta, @jonykipnis.bsky.social @washumedicine.bsky.social and colleagues: rupress.org/jem/article/... #Neuroinflammation #Alzheimers
- Reposted by Leon SmythExcited to share our new preprint: “Local B cell maturation and mast cell regulation of choroid plexus function in early life” www.biorxiv.org/content/10.1... , initiated in the lab by Laetitia Travier and led by the one and only @fakesamir.bsky.social
- Excited to share my final postdoc project published. We looked into the striking amyloidosis of important brain waste clearance sites (bridging veins) in mouse and human. A great collaborative project with Rupal Mehta at Rush who did all the human studies. Thanks to everyone who contributed!
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- Beautiful work on postnatal meningeal B cell proliferation and instruction by local fibroblasts!
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- Reposted by Leon SmythMicroglial CLEC7A restrains amyloid beta plaque pathology in a mouse model of Alzheimer's disease alz-journals.onlinelibrary.wiley.com/doi/10.1002/... @alzdemjournals.bsky.social
- Reposted by Leon SmythI'm hiring! Come and work with me at UCL to try and understand how the brain's blood vessels go wrong and promote dementia: www.ucl.ac.uk/work-at-ucl/...
- Reposted by Leon SmythResolving the mysteries of brain clearance and immune surveillance: @cp-neuron.bsky.social www.cell.com/neuron/fullt...
- Reposted by Leon SmythNice overview on the knowns and unknowns about pathways and mechanisms governing brain immunity and clearance. 🫶🏻😃 “Resolving the mysteries of brain clearance and immune surveillance” Check it out 👇🏻 authors.elsevier.com/sd/article/S...
- A great consensus review on brain washing from the groups doing some of the most important work in the field summarizing areas of agreement and open questions. www.cell.com/neuron/fullt...
- Reposted by Leon SmythWonderful to see our work so clearly and professionally presented at #AIC2025 by co–first author and graduate student Kevin Telfer. www.nature.com/articles/s42...
- Reposted by Leon SmythThrilled to share this last little bit of my thesis work w/ @siegenthalerlab.bsky.social! 🐭🧠 Generating the PDGFRa cKO line we use in this paper was no trivial task, spanning multiple years (& a pandemic!) We were extremely excited to see this phenotype & even more excited to share it with everyone!
- Our work out in @devbiol.bsky.social, PDGFra is needed for 🧠 perivascular fibroblast development... ⬇️ perivascular fibroblast = ⬇️ perivascular macrophage...cross-talk? 👀 Led by Hannah Jones @hejcell.bsky.social w/ Kelsey Abrams, Sophia Kim, excited for more projects w/ @fantauzzolab.bsky.social!
- Reposted by Leon SmythOur work out in @devbiol.bsky.social, PDGFra is needed for 🧠 perivascular fibroblast development... ⬇️ perivascular fibroblast = ⬇️ perivascular macrophage...cross-talk? 👀 Led by Hannah Jones @hejcell.bsky.social w/ Kelsey Abrams, Sophia Kim, excited for more projects w/ @fantauzzolab.bsky.social!
- PDGFRα is required for postnatal cerebral perivascular fibroblast development. Congrats @siegenthalerlab.bsky.social ! #cerebrovascular #fibroblasts #development
- Reposted by Leon SmythPDGFRα is required for postnatal cerebral perivascular fibroblast development. Congrats @siegenthalerlab.bsky.social ! #cerebrovascular #fibroblasts #development
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- Reposted by Leon SmythCheck out our recent preprint, "Live longitudinal imaging of meningeal cerebrovascular injury and its sequelae in adult zebrafish." lnkd.in/gN7z6th4
- Reposted by Leon SmythAustralia’s first Centre of Research Excellence in #Lymphoedema and Lymphatic Regeneration has launched, led by Prof @benjhogan.bsky.social and Prof Natasha Harvey, it's been dubbed a global “paradigm shift” and a major step forward. Read more: www.petermac.org/about-us/new...
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- Reposted by Leon SmythAttentional failures during wakefulness after sleep deprivation are tightly orchestrated in a series of brain–body changes, including neuronal shifts, pupil constriction and cerebrospinal fluid (CSF) flow pulsations @lauradata.bsky.social @ziy027.bsky.social www.nature.com/articles/s41...
- Reposted by Leon SmythOur B cell Keystone is getting closer! Short talk abstracts and scholarship applications are due on November 13 - get to it! www.keystonesymposia.org/conferences/...
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- Reposted by Leon SmythNEW STUDY! Building on pioneering work by Dr. Alison Goate, an international team of researchers, led by #IcahnMountSinai's Anne Schaefer, ID'd distinct population of neuroprotective #Microglia that may point to new therapeutic approach for #Alzheimers. @nature.com 👉 www.nature.com/articles/s41...
- Reposted by Leon SmythExcited to see the updated results from INDIGO confirming sustained benefit of mIDH inhibition for 1st line treatment in patients with G2 gliomas. Reduced seizure frequency aligns with our findings that mIDH inhibition modulates the glioma electrical microenvironment! 👇
- Reposted by Leon Smyth‼️Lymphatic Education&Research Network-GRC Scholarships‼️ LE&RN is awarding 10 × $1,000 scholarships to early investigators to attend 2026 Lymphatics GRC March 1 – March 6, 2026, Lucca (Barga), Italy. 🗓 Apply by Dec 8, 2025! form.jotform.com/LERN/2026-gr...
- Reposted by Leon SmythHappy to share our latest work led by @kevincziegler.bsky.social and Aydan Askarova, examining cell type contributions of vascular cell types to dementia risk. Many thanks to the donors, and for support from @ukdri.ac.uk and @alzassociation.bsky.social. www.cell.com/neuron/fullt...
- Reposted by Leon Smyth📣Registration is now open for the Gordon Research Seminar and Gordon Research Conference on Lymphatics 2026! Half of the talks will be selected from submitted abstracts. Don’t miss your chance to share your work! grc.org/lymphatics-g... grc.org/lymphatics-c...
- Reposted by Leon SmythOur paper on CSF, BOLD, pupil, and physiological measures in sleep deprivation and recovery sleep is finally out! 🎉 Congrats Zinong! www.nature.com/articles/s41...
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