Ruslan Rust
Asst Prof at @keckmedicineusc.bsky.social with interest in the #brain, #BBB, #stemcells and what can go wrong following #stroke & #AD. 🧠 🔬 Alumni of @ethzurich.bsky.social
- Neutrophil-neuronal crosstalk drives arthritis-induced pain www.researchhub.com/paper/106078...
- New study shows that TGFβ signaling is crucial for maintaining microglial resilience to myelin degeneration during aging. This highlights a previously unresolved checkpoint of TGFβ signaling with regional specificity and spatially restricted microglia–oligodendrocyte interactions.
- Check out the news article about our recent work on cell therapies for stroke by Drug Target Review: www.drugtargetreview.com/news/187869/... More info about the original study can be found here: www.nature.com/articles/s41...
- Electroacupuncture alleviates blood-brain barrier disruption and neuroinflammation via astrocytic MC4R in a mouse model of multiple sclerosis
- Eleven clinical trials that will shape medicine in 2026 Happy to see a lot of cell-based therapies!
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- CleLight: A scalable 3D histology pipeline for mappingneurodegenerative and psychiatric pathology in archivalhuman brains www.researchhub.com/paper/105900...
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- New in @natureportfolio.nature.com on microglial regulation in Alzheimer’s disease. The study shows that microglia with low PU.1 expression and surface CD28 reduce amyloid pathology and inflammation. It highlights immune co-stimulatory pathways as potential targets in AD. Very interesting!
- Great work 👏 mapping how brain endothelial cells communicate with astrocyte endfeet at the blood–brain barrier in @natureportfolio.nature.com The study identifies ligand–receptor pairs conserved in humans and altered in MS and Alzheimer’s. Makes me also wonder how many could be druggable targets.
- Interesting new work @natureportfolio.nature.com showing that a small molecule identified through in silico transcriptome matching (thiorphan) enhances corticospinal regeneration after spinal cord injury. Combined with neural stem cell grafts, it improved forelimb recovery and axonal growth.
- Interesting new work modeling human cholinergic circuitry! Researchers generated nbM organoids from hPSCs and fused them with cortical organoids to form functional nbM–cortical assembloids. This provides a platform to study deficits seen in Down syndrome. @cp-cellstemcell.bsky.social
- The brain neurovascular epigenome and its association with dementia @cp-neuron.bsky.social Great study that maps cell-type-specific regulomes showing that small vessel disease heritability spans the neurovascular unit, incl astrocytes. These findings link vascular risk and Alzheimer’s mechanisms.
- Pluripotent Cells Expressing APOE4 Exhibit a Pronounced Pro-Apoptotic Phenotype Accompanied by Markers of Hyperinflammation and a Blunted NF-κB Response www.mdpi.com/1422-0067/26...
- Important study shows that a new 3D method can efficiently produce dopamine neuron precursors from stem cells. The researchers also tracked how these cells grow and connect after transplantation, big step for Parkinson’s disease treatment! cell.com/cell-stem-ce...
- Great study dissecting molecular hallmarks of neuronal resilience in Alzheimer’s disease highlighting natural protective mechanisms that could help preserve cognition. x.com/rust_ruslan/...
- Can stem cells help to regain brain function after stroke? Our new study in NatureComms @natureportfolio.nature.com shows that they can and dissect the key mechanisms driving recovery. t.co/KRfAHfkNIH
- Effects of psilocybin and related compounds on neuroprotection in human stroke www.researchhub.com/fund/4261/ef...
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- Reposted by Ruslan RustIn @nature.com we describe the use of scalable #proteinengineering & #machinelearning to predict millions of bespoke CRISPR enzymes, offering safer & more efficient genome editing tools 🧬🖥️ @rachelsilverstein9.bsky.social @mgbresearch.bsky.social @harvardmed.bsky.social www.nature.com/articles/s41...
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- Interesting finding that neural stem cells exist outside the brain/spinal cord-in tissues like lung & tail-and share key properties with brain NSCs, challenging current dogma. Wonder if these NSCs exist in humans & can show similar therapeutic potential www.nature.com/articles/s41...
- New preprint🚨 We generated human brain pericytes from pluripotent stem cells. They show strong molecular & functional similarities to primary human brain pericytes Transplanted into pericyte-deficient mice, they formed hybrid human-mouse microvessels🐭 biorxiv.org/content/10.1...
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- A new review from our lab exploring how the blood-brain barrier (BBB) can be used as a treatment target for neurodegenerative disorders tandfonline.com/doi/10.1080/... TL;DR → Here are a few key highlights 👇
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- New review from our lab in @brain1878.bsky.social We explore how molecular blood-brain barrier (BBB) changes in aging, neurodegeneration and stroke affect disease progression, delivery of therapeutics, and much more! academic.oup.com/brain/advanc...
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- Stem cell therapies hold great potential for stroke recovery; but when is the optimal time for transplantation? 🧠💉⏲️ Our latest preprint shows that delaying NPC therapy by one week post-stroke increases long-term graft survival 20-fold. www.biorxiv.org/content/10.1...
- Reposted by Ruslan Rust1. Today the NIH director issued a new directive slashing overhead rates to 15%. I want to provide some context on what that means and why it matters. grants.nih.gov/grants/guide...
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- Thank you @castltrastondrs.bsky.social for highlighting our work!
- Cool work!
- For my first-ever bluesky post, I'm really excited to share our new preprint "Geometric influences on the regional organization of the mammalian brain" with @alexfornito.bsky.social and a superstar 17-person team! (1/n) www.biorxiv.org/content/10.1...
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