Rory Mulloy
PhDing in the @CorcoranLab, dabbles with RNA granules, viruses, and the outdoors
- Reposted by Rory MulloyEndogenous retroviruses synthesize heterologous chimeric RNAs to reinforce human early embryo development www.science.org/doi/10.1126/...
- Reposted by Rory MulloyRIP Catherine O'Hara, I have never not laughed at this
- Reposted by Rory MulloyThis one might be even better @barrlab.bsky.social
- Although using AI for science writing is spooky, I feel like now I’m allowed to write with more pizzazz (just to show im human)
- Reposted by Rory MulloyWriting is thinking "On the value of human-generated scientific writing in the age of large-language models." www.nature.com/articles/s44...
- Reposted by Rory Mulloy#Virology Herpesviruses exploit a cellular membrane protein, once thought to transport chloride, to escape the nucleus by tapping into an ancient membrane fusion process
- Reposted by Rory MulloyReview @natrevimmunol.nature.com @martint-babraham.bsky.social @babrahaminst.bsky.social RNA-binding proteins and ribonucleoproteins as determinants of immunity www.nature.com/articles/s41...
- Reposted by Rory MulloyOur new paper is out in Nature 🎉. We show that m1Ψ in mRNA vaccines doesn’t just quiet immunity, it also directly enhance translation by reshaping ribosome dynamics in a sequence-dependent way 🧬 Full paper : rdcu.be/eY5gx
- Reposted by Rory MulloyVery happy to share my latest preprint on clade IIb MPXV. After infection in a mouse model, the virus had highest titre in the testes with delayed clearance. This led to significant destruction in the testes and reduced sperm - what are the longterm implications? www.biorxiv.org/content/10.6...
- Christmas present to me! I won first place in the LCI/CMF Striking Image Competition! Thanks to the LCI and CMF teams!
- Reposted by Rory Mulloy
Two ancient humans, including famed ‘Iceman,’ had cancer-causing virus www.science.org/content/arti... - Reposted by Rory MulloyRecombination between strains fuels pervasive adaptive evolution among human gut commensal bacteria, and strongly implicate host diet and lifestyle as critical selection pressures @nature.com @nanditagarud.bsky.social www.nature.com/articles/s41...
- Reposted by Rory MulloyAnnouncing the 2026 edition of the EMBO workshop on RNA localization and local translation! This meeting will be held June 30 - July 4 near Porto, Portugal. Come for exciting updates in the field from both established investigators and trainees. See the link below for details!
- Reposted by Rory MulloyI am happy to share that my postdoctoral work in the @gerlichlab.bsky.social at @imbavienna.bsky.social is finally out 🎉! Our study reveals how cohesin guides focused and accurate homology search. Read more 👉 www.science.org/doi/10.1126/... Follow along for key insights and updates! 🧵
- Reposted by Rory MulloymRNA circularization is crucial for initiating codon-usage-dependent translation, whereas viral RNAs bypass this mechanism by blocking circularization, allowing efficient translation despite poor codon usage @nature.com #LiuLab www.nature.com/articles/s41...
- Reposted by Rory MulloyEnergy transitions can happen faster than we think: In 2000 almost 90% of Denmark's electricity was from fossil fuels. In 2024 less than 10% of Danish electricity was from fossil fuels.
- Reposted by Rory MulloyDo you want to image RNA in living cells? Check out our new live-cell Click labeling approach. An amazing collaboration with the Meier Lab at UHH and the Wagenknecht Lab at KIT! doi.org/10.1002/anie... Congratulations, especially to Doerte, Eileen, and Iven! Thanks to DFG CRC1648
- Reposted by Rory MulloyNovember is a big month for the lab with *two* new papers by @ehartenian.bsky.social and @alexandraboegli.bsky.social ++ co authors now online. www.embopress.org/doi/full/10....
- Reposted by Rory Mulloy“Someone with a 1-hr car commute needs to earn 40% more to be as happy as someone with a short walk to work. On the other hand, if someone shifts from a long commute to a walk, their happiness increases as much as if they’d fallen in love.” #CityMakingMath 50 reasons to want more walkable cities.
- Reposted by Rory MulloyPersistent mirusvirus infection in the marine protist Aurantiochytrium www.nature.com/articles/s41...
- Reposted by Rory MulloyMultiple rotavirus species encode fusion-associated small transmembrane (FAST) proteins with cell type-specific activity journals.asm.org/doi/10.1128/...
- Reposted by Rory MulloyCheck out the latest work from our lab, led by Arash Latifkar @ara-latifkar.bsky.social , www.biorxiv.org/content/10.1...
- Reposted by Rory MulloyOur new preprint is out 🥳🥳🥳 Henipaviruses, like Nipah and Hendra, package their genomes inside helical shells built by thousands of nucleoproteins. These nucleocapsids are essential to protect the viral RNA, but how do they ever let the polymerase in to read the sequence? 👇
- Reposted by Rory Mulloy1/ Excited to share our new study with @brumbaugh-lab.bsky.social, out in @natbiotech.nature.com! P-bodies selectively sequester RNAs encoding cell fate regulators, often from the preceding developmental stage. Releasing these RNAs can drive changes in cell identity. 🧵 www.nature.com/articles/s41...
- Reposted by Rory MulloyCongrats to the Blue Jays. I’m going to sulk for a few days but what an amazing season for the @mariners.com Proud of this team
- Reposted by Rory MulloyVirus driven Disruption of Transcription Termination (DoTT) generated cellular Z-RNAs are bona fide ZBP1 ligands driving cell death as a host response to counter viral disruption of the cellular transcriptional machinery @nature.com @foxchasecancer.bsky.social www.nature.com/articles/s41...
- Reposted by Rory Mulloy🧬 Exciting news from our lab 🧬 The Swiss National Science Foundation (SNSF) has approved our project studying KSHV and RNA decay: our first grant since re-launching the lab in Switzerland 🎉 We’re now looking for a Postdoc and a PhD student to join the team (start date January 2026) - please repost!
- Reposted by Rory MulloyI made a sign for the lab with our informal lab motto, inspired by this convo between @itaiyanai.bsky.social and Martin Lercher: nightscience.buzzsprout.com/1744020/epis.... A good reminder that talking is among the best forms of thinking!
- Reposted by Rory MulloyIn new study led by @bdadonaite.bsky.social, we measure how spike mutations affect function & antigenicity of spike of KP.3.1.1 strain of SARS-CoV-2. Sheds light on how key neutralizing epitopes are changing & importance of RBD up/down motion. www.biorxiv.org/content/10.1...
- Reposted by Rory MulloyCollaborative study with Kharpeskyy lab @dalhousieu.bsky.social + our lab @ulethbridge.ca (under review) shows: sequence features—not secondary structure—of 5′ UTRs give viral & cellular mRNAs resistance to SARS-CoV-2 Nsp1 host shutoff. www.biorxiv.org/content/10.1...
- Reposted by Rory Mulloyi love you hubble
- Reposted by Rory Mulloy
- Reposted by Rory MulloyGiant virus endogenization in Acanthamoeba we covered more in detail in a separate manuscript published some weeks ago in @bmc.springernature.com Biology, in a great collaboration with John Archibald's group at Dalhousie: bmcbiol.biomedcentral.com/articles/10..... 6/7
- Reposted by Rory MulloyCrab-like creatures are famed for having evolved five times in evolutionary history. But anteaters have evolved at least 12 times--in half the evolutionary span. Cool story by @jakebuehler.bsky.social for @science.org
- Reposted by Rory MulloyHuge congratulations to Dr. Emma LeBlanc on her successful PhD thesis defence yesterday! As my first PhD student, Emma was instrumental in getting my lab up and running, in the midst of a pandemic, while managing to be very productive and do some exciting science along the way! #proudPI
- Reposted by Rory Mulloy
- Reposted by Rory MulloyIt’s too late to save these lost young lives in Texas, but not too late to avert the next tragedy that could be fully avoided. It’s one thing to say you’re making things more efficient and quite another to gut something essential with no replacement. Turn the f’ing lights back on! /fin
- Reposted by Rory Mulloy'The myth of meritocracy in science collapses under the financial sacrifices expected at every career stage. From unpaid internships and self-funded conferences to underpaid graduate and postdoctoral positions, the hidden costs of ‘doing science’ are profound.' journals.plos.org/plosbiology/...
- Reposted by Rory Mulloy💥 Couldn’t be more stoked our study identifying a completely new CMV virion surface complex involved in cell entry is now published at Nature Micro 🦠 H/T @paramyxologist.bsky.social + Lauren Henderson, Erica Ollmann Saphire Chris Benedict @natmicrobiol.nature.com www.nature.com/articles/s41...
- Reposted by Rory MulloyNew CRISPR technology developed by @stanleyqilab.bsky.social, Mengting Han & team could pave the way for potential treatments for neurodegenerative diseases like ALS and spinal muscular dystrophy:
- Reposted by Rory MulloyNature research paper: Probing condensate microenvironments with a micropeptide killswitch go.nature.com/4mMlGyc
- Reposted by Rory Mulloy🚨🚨 News from the @castello-lab.bsky.social and @shabazlab.bsky.social. Our work, led by Louisa Iselin, reveals pervasive changes in the RNA-bound proteome induced by interferon. #RNA, #immunity, #interferon, #host-virus www.biorxiv.org/content/10.1...
- Reposted by Rory Mulloy2nd is the brilliant preprint of @corcoranlab.bsky.social & @rorymulloy.bsky.social. It’s a deep dive into all things N*, & every other paragraph drops some new, delightful discovery. www.biorxiv.org/content/10.1... 15/34
- Reposted by Rory Mulloy…prompted me to take a closer look, and for reasons I’ll describe below, I now believe rumors of N*’s death are exaggerated. First, XEC is in terminal decline, replaced by variants with full N* expression, so N* is back in fashion. 3/34 journals.plos.org/plosbiology/...
- Reposted by Rory MulloySGs can form as a response to dsRNA detection, but when Mulloy induced SG formation via a dsRNA-independent pathway, N* still stopped SGs. Mutation of two essential AA for dsRNA binding (K257, K261) showed that N*’s dsRNA binding was required for SG antagonism. 23/34
- Reposted by Rory MulloyAn awesome preprint on the novel, unsung SARS-CoV-2 N* protein came out recently, authored by @corcoranlab.bsky.social and @rorymulloy.bsky.social. I’ve previously written on N*’s demise in XEC, the top variant for several months, but… threadreaderapp.com/thread/18373... 1/34
- Reposted by Rory MulloyIf people of means are interested in establishing a 2025 “Institute for Advanced Study” for displaced/defunded biomedical scientists, I know many people who will help, including myself. @mcuban.bsky.social @arcadiascience.com @arcinstitute.org
- Reposted by Rory MulloyExcited to share our new paper on Nature - how Ku accommodates Alu expansion in primates by binding to dsRNA, providing a clue for both the high levels of Ku and its essentiality in human cells. Thank @chaolinzhang @hchung03 @LenaSteckelberg More to come www.nature.com/articles/s41...
- Reposted by Rory MulloyThe parasitic larvae of a wasp inject a virus into their caterpillar hosts that makes the caterpillars aggressive and even cannibalistic when food is scarce, increasing the odds that the parasites and their hosts will survive. In PNAS: www.pnas.org/doi/10.1073/...
- Reposted by Rory MulloyNon-spike protein mutations in #SARSCoV2, likely to impact viral properties, are understudied. @brucelab.bsky.social show that a #nucleocapsid protein mutation in Delta variant enhances viral growth in vitro & in vivo by increasing viral genome #encapsidation @plosbiology.org 🧪 plos.io/4iBYsaI
- Reposted by Rory MulloyAs new PhDs graduate, I'm reflecting on the below convocation address I delivered at my own PhD ceremony about science's most essential question: "How do we know that?" Equal parts #NightScience meditation and a call to action. Sometimes we need to hear from our younger selves. #StandUpForScience
- I realized the novel viral protein I study (SARS2 N*M210) was going extinct, which to a nerd is quite sad. HOWEVER, N*M210 is making a big comeback... R204 (yellow) mutation sequence enables N* synthesis. You can see N*-producing viruses are taking over (once again) Evolution in real time.
- We conducted the same experiment as nature is conducting and satisfyingly found the same results. N* gives SARS2 a selective advantage (blue makes heaps of N*)
- Reposted by Rory MulloyCongratulations to Mark Carney and the Liberal Party on their election victory. The bond between Europe and Canada is strong — and growing stronger.
