Javi
Post-doc at the @wilflinglab.bsky.social in @mpibp.bsky.social
Previously EMBL Hamburg
#StructuralBiology under liquid Nitrogen #cryoEM / #cryoET
Mountain-lover
He/him
- Reposted by JaviPlease share! My group at @zmbp-tuebingen.bsky.social is offering a post-doctoral position (4 years). We look for a structural biologist with experience in Cryo-EM/Cryo-ET to investigate the mechanisms of host invasion by pathogenic fungi. Deadline February 28th! uni-tuebingen.de/universitaet...
- Reposted by JaviLLOMe has long been used to study lysosomal damage, yet how it works has remained a mystery. Using cryo-electron tomography, we show it forms amyloid structures inside lysosomes that mechanically rupture membranes – revealing a new paradigm for lysosomal failure. 🔗 doi.org/10.64898/202... #CryoET
- New preprint from the lab! 🆕 We combined in situ correlative cryo-ET 🥽🔬with multiscale simulations 🖥️⌨️ to study condensates inside yeast cells 🥼🧪 Link below 👇
- We are excited to share our new preprint which is now available to read on biorXiv: doi.org/10.64898/202... 🎉🎉🎉
- Reposted by JaviProhibitins aren’t hanging out just anywhere in the membrane — they prefer the 💁♀️💎✨VIP section💅🪩🥂 Lab all-star @mmedina300kv.bsky.social maps these microdomains using cryo-ET + surface morphometrics. s/o to #teamtomo #cryoET co-authors @hamid13r.bsky.social @attychang.bsky.social @baradlab.com
- Prohibitin complexes associate with unique membrane microdomains in cells biorxiv.org/content/10.1101/202…
- Reposted by JaviJust published! We share an open-source workflow to measure membrane thickness from tomograms, including a tutorial with 3D visualizations. We analyze thickness variations across organelles and reflect on where to define a membrane boundary. @becklab.bsky.social #teamtomo rupress.org/jcb/article/...
- Now that it’s November and Halloween is over, is it okay to put up the Christmas tree yet?
- Reposted by JaviHave you registered to the next EMBO Practical Course on In-situ structural biology by Cryo-FIB and Cryo-ET? 🧊 Join us in Frankfurt for hands-on training on cryo-techniques and networking with experts! 🔗 Apply by Dec 8, 2025: meetings.embo.org/event/26-in-... 📍 Frankfurt | 📆 April 12–20, 2026
- Reposted by JaviCheck out our preprint! With new molecular mechanisms, 140 subtomogram averages, and ~600 annotated cells under different conditions, we @embl.org were able to describe bacterial populations with in-cell #cryoET. And there’s a surprise at the end 🕵️ www.biorxiv.org/content/10.1... #teamtomo
- Reposted by JaviAre you ready to lead ground-breaking research in Infection Biochemistry? We are recruiting outstanding scientists to establish research groups based at @cssbhamburg.bsky.social tackling fundamental questions in molecular mechanisms of infection. embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
- Reposted by JaviResearchers from CSSB & @mpi-nat.bsky.social have generated a highly potent nanobody that neutralizes a protein essential for the herpes virus infection. Published in @nature.com, the findings promise new therapies to treat & prevent infections @leibnizliv.bsky.social @uni-hamburg.de t1p.de/cxt7a
- Reposted by JaviSub-cellular chemical mapping in bacteria using correlated cryogenic electron and mass spectrometry imaging Congrats Hannah Ochner and authors on this important paper! Strong collaboration with @kiranrpatil.bsky.social www.biorxiv.org/cgi/content/... @mrclmb.bsky.social @wellcometrust.bsky.social
- Reposted by JaviMore great cryo-ET benchmarking work from my colleagues Maarten Tuijtel, Tomáš Majtner, Beata Turoňová, & @becklab.bsky.social: Systematic study of how tilt increment choice affects downstream TM & STA. Preprint has the optimally balanced tilt increment. #TeamTomo www.biorxiv.org/content/10.1...
- Reposted by JaviWe’re hosting the @embo.org Practical Course on In-situ structural biology by CryoFIB and CryoET in April 2026! 🧬❄️ You can expect hands-on training, cutting-edge methods, and a chance to work alongside leading experts in structural biology. 🔗 Apply by Dec 8, 2025: meetings.embo.org/event/26-in-...
- New luminescent animal unlocked!
- Reposted by JaviProud to share our first lab pre-print: “SND3 is the membrane insertase within a fungal multipass translocon” where @tzujingyang.bsky.social solved the structure of a ribosome-associated SND3-translocon complex involved in ER membrane protein insertion ➡️ doi.org/10.1101/2025...
- Reposted by JaviSpeak up to prevent a major loss for the field. CASP, which helped shaping structural biology including AlphaFold is on the verge of shutting down. NIH funding has lapsed, UC Davis support ends and the core team is being let go. Painfully shortsighted.
- Reposted by Javi[Not loaded yet]
- Reposted by Javi[Not loaded yet]
- Reposted by JaviA colder frontier in cryo-EM 🧪🔬 Chris Russo’s group, inc. Joshua Dickerson, adapted #cryoEM to work at liquid helium temperatures (13 kelvins), where every frame captured contains more information than the equivalent using liquid nitrogen (81 kelvins). Read more: tinyurl.com/mwwcunkc #LMBResearch
- Reposted by JaviExcited to share our preprint on the molecular architecture of heterochromatin in human cells 🧬🔬w/ @jpkreysing.bsky.social, @johannesbetz.bsky.social, @marinalusic.bsky.social, Turoňová lab, @hummerlab.bsky.social @becklab.bsky.social @mpibp.bsky.social 🔗 Preprint here tinyurl.com/3a74uanv
- Look at those nucleosomes! 🧬 Impressive work on chromatin architecture from our colleagues, check it out below! ⬇️
- New preprint on 3D heterochromatin architecture in human cells! Great collab with @sergiocruzleon.bsky.social & @johannesbetz.bsky.social from @hummerlab.bsky.social, @marinalusic.bsky.social & the Turoňová lab. Many thanks to my supervisor @becklab.bsky.social. bioRxiv: tinyurl.com/3a74uanv 🧵👇
- Reposted by Javi[Not loaded yet]
- Reposted by JaviThrilled to share these experiments on shaping focused ion beams to explore different ways of milling. Here, we explore using different beam geometries to generate cellular thin sections/lamellae. The video shows elongating the beam on a charging spot burn www.biorxiv.org/content/10.1...
- Reposted by JaviHey #teamtomo, if you often find yourself using the excellent membrain-seg from @lorenzlamm.bsky.social et al., you might find my napari plugin "napari-segselect" useful. Let's say your tomogram contains the edges of two bacterial cells, each with a membrane and cell wall:
- Reposted by JaviThrilled to share the structure of dimerised human PINK1 docked to an endogenous translocase array on the mitochondrial surface, composed of two TOM complexes, bridged by a VDAC2 dimer! Published today in Science www.science.org/doi/10.1126/... @wehi-research.bsky.social @komanderlab.bsky.social
- Interesting sample preparation method moving away from blotting
- Reposted by JaviHappy to share our manuscript on the in situ visualization of the copia retrotransposon in its final form today published in @cellcellpress.bsky.social www.cell.com/cell/fulltex.... What’s new?
- I will think of this paper next time I am there... 😀
- Reposted by JaviIn a great collaboration with @hummerlab.bsky.social and the Kräusslich lab: HIV capsid doesn't break at the NPC; instead, it cracks open the NPC itself! Details in Cell: authors.elsevier.com/sd/article/S... @mpibp.bsky.social @uniheidelberg.bsky.social A thread below:
- Reposted by Javi[Not loaded yet]
- Wondering about phase separation and its impact in selective autophagy? Check the latest publication from the lab! ⬇️
- Reposted by JaviLatest from Baumeister & @lottesogaard.bsky.social labs: The PomXYZ complex and its role in bacterial cell division. www.pnas.org/doi/10.1073/... #teamtomo #cryoET #cryoEM
- Reposted by Javi[Not loaded yet]
- Reposted by JaviCheck out our latest preprint if you want to find out what happens when capsid and NPC interact (spoiler: it doesn't seem to end well for the NPC) #teamtomo www.biorxiv.org/content/10.1...
- Reposted by JaviDo not miss our latest #cryoET work! 🕵️ Xing et al. present the dynamic architecture of TRiC in human cells! The study of this protein-folding chaperonin opens the door to understanding its dysfunction in diseases like cancer and neurodegeneration 🧠🧪 #teamTOMO @becklab.bsky.social
- Look at those cages 😍
- Reposted by JaviIs this not the finest lab crafted Christmas tree decoration you’ve ever seen? Courtesy of Amy Tooke!
- Reposted by Javi[Not loaded yet]
- Reposted by Javi[Not loaded yet]
- Reposted by Javi[Not loaded yet]
- Reposted by Javi[Not loaded yet]
- Sometimes I really feel I need a Rosetta stone for #SerialEM language and python.
- Reposted by Javi⚠️THREAD OF ALL SCIENCE-RELATED STARTER PACKS! ⚠️ 🔄Share to help people finding its topic/field - STRUCTURAL BIOLOGY Structural Biology 1: bsky.app/starter-pack... Structural Biology 2: bsky.app/starter-pack... Crystallography: bsky.app/starter-pack... Synchrotron&CryoEM: bsky.app/starter-pack...
