Miranda
PhD student working on avian influenza | Interested in all things viruses & antiviral immunity | she/her 🔬🧬🦠
- Reposted by MirandaNature research paper: PtdIns(3,5)P2 is an endogenous ligand of STING in innate immune signalling go.nature.com/4klvMp1
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- Reposted by Miranda🦅 What’s driving the spread of highly pathogenic avian influenza (H5N1) across Europe? Using machine learning and wild bird ecology, a new study from @L_Brierley & colleagues reveals a shift towards year-round risk in cold, low-lying regions of NW Europe. www.nature.com/articles/s41...
- Reposted by MirandaBoth MRC and BBSRC responsive modes now withdrawn until further notice. Existing applications unlikely to succeed (late 2025 round expecting 1-5% success rate). Listen, I get that UKRI wants to pivot. But killing both at once is devastating. Let's hope at least one opens by summer... #AcademicSky
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Mechanistic insights into the impact of prenatal viral infections on maternal and offspring immunity www.nature.com/articles/s44... - Reposted by Miranda[Not loaded yet]
- Reposted by MirandaNow out in Nature! We visualize infection of the RNA virus RSV in real-time with single-vRNP resolution to understand how RSV establishes viral factories, biomolecular condensates that act as sites of viral replication. A huge collaborative effort led by Dhanushika Ratnayake! rdcu.be/e1bBW
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- Reposted by Miranda🚨New Pre-Print🚨 Although H3N2 subclade K has multiple mutations in HA, neutralisation assays with pre-epidemic human sera show only moderate antigenic drift, and vaccines used in the 2024/2025 flu season induced cross-neutralising immunity www.medrxiv.org/content/10.6...
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- Reposted by MirandaExcited to share our work on #AncientRNA from alcohol-preserved lungs, recovering the oldest human RNA virus genome (an 18th-century rhinovirus). Our study shows that viral RNA remnants persist in centuries-old tissue, opening new ways to study virus evolution and historical disease #Paleovirology🫁🦠
- Reposted by MirandaInteresting paper. Flu A transmits shortly before people become symptomatic in about 10% of cases. Doesn't seem to happen for flu B. Pre-symptomatic transmission in up to 65% of SC2 Omicron cases! www.nature.com/articles/s44...
- Reposted by MirandaPrenatal Zika virus exposure disrupts social-emotional development and cortical visual function in infant macaques www.nature.com/articles/s41...
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- Reposted by MirandaFrequent presymptomatic household transmission of influenza A but not influenza B virus www.nature.com/articles/s44...
- Reposted by MirandaJoin us tomorrow at the #SystemsVirologyJournalClub. @lauraluebbert.com will present her work with @lpachter.bsky.social on detecting viruses at single-cell resolution and uncovering associated changes in host gene expression. Paper: pubmed.ncbi.nlm.nih.gov/40263451/
- 🚨 Systems Virology Journal Club – 8th Series! 🚨 #BillSchneider and I are delighted to announce another round of cutting-edge talks in #SystemsVirology! 🦠💡 Join us and an outstanding lineup of speakers, starting Oct 30. Free registration: shiraweingartengabbay.com/systems-viro... 🔬✨
- Reposted by MirandaNew Publication: DNAJC14 gene-edited pigs are resistant to classical pestiviruses @roslininstitute.bsky.social @thedickvet.bsky.social #pestivirus #CRISPR www.sciencedirect.com/science/arti...
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- Reposted by MirandaOur third installment on prefusion stabilization of herpesvirus gB proteins is available as a preprint: doi.org/10.64898/202.... A great collaboration with colleagues at Merck. Our prefusion HSV-2 gB protein adopts a more closed conformation than has been observed for HSV-1 gB in recent papers.
- Reposted by MirandaOut Now! Genomic features associated with sustained mammalian transmission of avian influenza A viruses #MicroSky
- Reposted by MirandaOur newest paper is out where we investigate how exogenous RNA triggers innate immune responses, such as PKR activation and stress granule assembly. rnajournal.cshlp.org/content/earl...
- Reposted by MirandaBovine-derived influenza A virus (H5N1) shows efficient replication in well-differentiated human nasal epithelial cells without requiring genetic adaptation www.biorxiv.org/content/10.6...
- Reposted by MirandaGenomic features associated with sustained mammalian transmission of avian influenza A viruses www.nature.com/articles/s41...
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- Reposted by MirandaJust out @natrevimmunol.nature.com RNA-binding proteins and ribonucleoproteins as determinants of immunity www.nature.com/articles/s41... gives our perspective on this growing area of research. Special thanks to the editor Alexandra, for streamlining the manuscript.
- Reposted by MirandaLost in translation? Not with this host protein on the job 🧬 See how reovirus translates poly(A)-less RNAs (www.nature.com/articles/s41...) —now an Editor’s Highlight in Nature Communications! Primary author: Xay www.linkedin.com/in/somoulayx
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- Reposted by MirandaThis has been on the horizon for some time. It's the culmination of Wakefield and weaponisation of mRNA vaccines by RFK Jr, Malhotra, Malone etc etc... @independentsage.bsky.social put this out last year. We hope it helps. Please, vaccinate your kids 🙏 independentsage.org/wp-content/u...
- UKHSA responds to the confirmation from @WHO that the UK has lost its measles elimination status. Read more from WHO here: bit.ly/3YZuOFa
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- Reposted by MirandaWife and I in tears reading this…
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- Reposted by MirandaCryo-EM structure reveals how influenza A virus NEP binds the viral polymerase at a regulatory hotspot, coordinating RNA synthesis and nuclear export. Fantastic collaboration with @loiccarrique.bsky.social and Jon Grimes. www.science.org/doi/10.1126/...
- Reposted by MirandaThis first probable case of highly pathogenic avian influenza in a dairy cow in Europe raises two points. First, it suggests that virus incursion is possible in the Dutch housing system, which differs from that in the southern U.S., where cows were first infectted. www.science.org/content/arti...
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- Reposted by MirandaBeautiful work from @efodor.bsky.social and Jonathan Grimes' labs - the first full structure of the influenza A virus NEP protein, and a clear indication that its role in viral replication is more nuanced that first thought www.science.org/doi/10.1126/...
