David McQuarrie
Postdoc in the Jaffrey lab at @WeillCornell.bsky.social @CornellUniversity.bsky.social former PhD in the Soller lab interested in RNA-binding proteins and RNA modifications; #RNA #RNAmodifications #Genetics 🧫🪰 #MolecularBiology #Evolution
- Reposted by David McQuarrie🧬🌉Online @science.org Programmable genome editing in human cells using RNA-guided bridge recombinases | Science www.science.org/doi/10.1126/...
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- Reposted by David McQuarrieNew research in #GENETICS identifies chromosome number and mean chromosome size as practical proxies for genome-wide recombination rate by analyzing genetic map data from 73 insect species and 157 monocentric flowering plants. buff.ly/L4O68V5
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- Reposted by David McQuarrieSWARM is an AI framework for nanopore direct RNA sequencing that detects m6A, pseudouridine (Ψ), and m5C mods at single-nucleotide & single-molecule resolution. Key innovation: Crosstalk-aware training with non-target mods & validated cellular signals to reduce false positives. 2/6
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- Reposted by David McQuarrieOur newest paper is out where we investigate how exogenous RNA triggers innate immune responses, such as PKR activation and stress granule assembly. rnajournal.cshlp.org/content/earl...
- Reposted by David McQuarrieDoes the noncoding genome actually carry more genetic information than coding seqs? Motivated by this question we mutated every bp in the 10kb MYC locus. Results are even more exciting: Decoding the MYC locus reveals a druggable ultraconserved RNA element www.biorxiv.org/content/10.6...
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- Reposted by David McQuarrieTransposons contribute to splice-isoform diversity in the Drosophila brain biorxiv.org/content/10.64898/20…
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- Reposted by David McQuarrieNew lab paper!! We develop a technology for real-time, single-molecule visualization of proteasomal substrate degradation in cells. We find that the site of substrate engagement by the proteasome determines decay kinetics, efficiency and co-factor requirement. www.biorxiv.org/content/10.6...
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- Reposted by David McQuarriePolyamine-dependent metabolic shielding regulates alternative splicing www.nature.com/articles/s41...
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- Reposted by David McQuarrieSo cool - someone finally hacked 'the vault'. www.science.org/doi/10.1126/...
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- Reposted by David McQuarrie📣First preprint of the lab📣 Did that really happen?😅 Enteric neurons, aka somatic postmitotic cells, must hold on to their sex identity tight, to deliver a tuned response to signals from the ovary that instruct the animal to engage sex-matched behavioural programmes. www.biorxiv.org/content/10.6...
- Reposted by David McQuarrieIn 2024, researchers in #ScienceRobotics followed up on their development of Third Thumb—a robotic appendage that, when trialed by members of the general public, was a big hit. Learn more: scim.ag/3LmQ9oL #ScienceMagArchives
- Reposted by David McQuarrieKudos to Dana Kennedy, for making this lovely, pressed flower cover image for her paper. "Pressed-flower art representing heterochromatin gene silencing in Schizosaccharomyces pombe. Each distinct flower symbolizes HP1/Swi6, Clr4, nucleosomes, and post-translational modifications (cont)
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- Reposted by David McQuarrieSHH exosomes surfing along the OUTSIDE of mesenchymal cell cytonemes - check it out! www.biorxiv.org/content/10.6...
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- Reposted by David McQuarrieHappy to share with you our work on how the interferon response impacts embryonic development 🦠Mammalian embryos contain endogenous dsRNAs that resemble viruses and can be misrecognised by the dsRNA sensor MDA5. Thanks to all collaborators, we could not have done it without you 🤩 rdcu.be/eWMfA
- Reposted by David McQuarrieNeed a bit of escapism? Not exactly Lord of the Rings, but in similar vein: doi.org/10.1038/s443...
- Reposted by David McQuarrieCorrelated Gene Copy Number Changes in a Seminal Fluid Protein Network in Drosophila biorxiv.org/content/10.1101/202…
- Reposted by David McQuarrieDoes predictability matter for adaptation? In fruit flies, predictable thermal variation favors evolved longevity, while unpredictable environments impose survival and reproductive costs—revealing distinct routes to adaptation under climate change. Image: Wikimedia academic.oup.com/evlett/advan...
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- Reposted by David McQuarrieHow are RNAs sorted for export vs. degradation in the nucleus? In collaboration with @heick.bsky.social’s lab we (@clemensplaschka.bsky.social and @juliusbrennecke.bsky.social labs) discovered a direct mechanistic link between the export and decay machineries: www.biorxiv.org/content/10.1... (1/x)
- Reposted by David McQuarrieI'm excited to share that our preprint is now available on bioRxiv! Our study challenges the widespread use of molecular genetic diversity as a predictor adaptive potential, with important implications for how genetic data is used to inform conservation decisions. www.biorxiv.org/content/10.6...
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- Reposted by David McQuarrie☕Earl Grey v7.0.0 brewed fresh☕ Nested TEs finally get the treatment they deserve: iterative detection of deep nesting, cleaner GFF annotations, and coverage stats that don’t double-count genomic space + a RepeatCraft edge-case fix. Happy new year to the TE folks! 🧬 github.com/TobyBaril/Ea...
- Reposted by David McQuarrieDynamic subtype- and context-specific subcellular RNA regulation in growth cones of developing neurons in the cerebral cortex. rdcu.be/eXuwg
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