Max Koppers
Axonal mRNA trafficking and local translation | Group leader
FGA/CNCR/VU Amsterdam | father of two
- Reposted by Max KoppersActive transport of tRNAs facilitates distributed protein synthesis biorxiv.org/content/10.64898/20…
- Reposted by Max KoppersVery happy to share our new paper in #ScienceSignaling revealing that importin β1 isn’t just important for nuclear transport or neuronal growth. We now show it is key for presynaptic plasticity in the hippocampus, local translation, and memory! www.science.org/doi/10.1126/...
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- Dynamic subtype- and context-specific subcellular RNA regulation in growth cones of developing neurons in the cerebral cortex. rdcu.be/eXuwg
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- Reposted by Max KoppersI am thrilled to share our latest story led by the incredibly talented Brooke D’Arcy and Camila Musso. We discover a rich world of local gene expression in radial glia, essential neural and glial precursors, and develop a new method for sub-cellular mRNA manipulation. www.biorxiv.org/content/10.1...
- Reposted by Max Koppers🚀 Our new paper is out @natmethods.nature.com! Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells. 🔗 www.nature.com/articles/s41... 🧬 www.addgene.org/John_Ngo/
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- Reposted by Max Koppers✨ Post-doc opportunity in axon biology, funded by #ATIP-Avenir! 👀 We are looking for an enthusiastic post-doc to join our team at @ibdm.bsky.social to explore translation dynamics in axon regrowth, using live imaging approaches. Apply at: emploi.cnrs.fr/Offres/CDD/U... Thank you for sharing! 👋 🙏
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- Reposted by Max KoppersI'm thrilled to share our work from @weissmanlab.bsky.social (www.sciencedirect.com/science/arti...). We developed LOCL-TL, an optogenetic approach for monitoring localized translation in mammalian cells. LOCL-TL revealed two distinct strategies for mitochondrially localized translation.
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- Reposted by Max Koppers📢 For all HaloTag lovers💙💚💛❤️💜🩶 we are excited to share that our work, in which we developed a new biotin-HaloTag ligand, is now published in @jcb.org! Full link here: rupress.org/jcb/article-...
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- Neuronal potassium channel activity triggers initiation of mRNA translation through binding of translation regulators. www.science.org/doi/10.1126/...
- Programmable control of spatial transcriptome in live cells and neurons. www.nature.com/articles/s41...
- Reposted by Max KoppersA 🧵 to walk those interested through this paper...
- Online now at @cp-cell.bsky.social , the culmination of a 12-year effort. 🧵 to follow later this evening www.cell.com/cell/fulltex...
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- Reposted by Max KoppersWhat drives cytoplasmic mRNA organization? We created unbiased, genome-wide maps of mesoscale RNA-RNA spatial proximity, revealing impact of encoded protein function. Fantastic work from @lindsayabecker.bsky.social @sofiquinodoz.bsky.social @davidaknowles.bsky.social www.biorxiv.org/content/10.1...
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- Reposted by Max KoppersEver wondered how several individual RBPs cooperate to repress translation? Lead by @marcopayr.bsky.social and in great collaboration with @hennig-lab.bsky.social, we simultaneously tracked the binding of several proteins to single mRNA molecules in real-time! www.biorxiv.org/content/10.1...
- In a collaboration between the @hennig-lab.bsky.social and @olivierduss.bsky.social labs we revealed how proteins work together to control gene expression through mRNA translation repression! Using single-molecule microscopy, we watched individual molecules in action. doi.org/10.1101/2025... 🧵
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- Reposted by Max KoppersA nearly 9 year effort to design and implement new CLIP-based technologies to define multimeric protein assemblies on RNA. Enables ‘watching’ of RNP assemblies inside living cells Special congrats to Luca Ducoli, Brian Zarnegar, and Paul Khavari @nature.com www.nature.com/articles/s41...
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- The first review paper from our lab is out!! @viviennebauer.bsky.social discussed the rapidly emerging knowledge on (the interplay between multiple) organelles and neuronal mRNA localization. Hope you enjoy the read! www.sciencedirect.com/science/arti...
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- Reposted by Max Kopperswww.science.org/doi/10.1126/... Tour de force by Barna Lab
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- Reposted by Max KoppersSave the date for the next edition of this wonderful meeting. We look forward to seeing you in Portugal!!
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- So cool! rdcu.be/eboxL
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- Reposted by Max KoppersEverything you always wanted to know about the Axon Initial Segment might be here: authors.elsevier.com/sd/article/S...
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- Reposted by Max KoppersAmazing stuff from @marvintanenbaum.bsky.social! Long-term imaging of individual ribosomes reveals ribosome cooperativity in mRNA translation: Cell www.cell.com/cell/fulltex... #RNAsky #RNABiology
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