Sean Rudd
Group leader @ Karolinska Institutet & SciLifeLab in Stockholm, Sweden. Interested in understanding how cancer drugs work.
Lab site - seanruddlab.com
Genome stability | dNTP metabolism | Cancer therapy
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- Reposted by Sean RuddUnrepaired DNA-protein crosslinks cause a process that leads to premature aging and embryonic lethality in mice. The findings in Science reveal a previously unrecognized link between defective DNA repair and immune-driven inflammatory disease. scim.ag/4qdZWf9
- Reposted by Sean Rudd"authors also express frustration at the amount of work expected for a single publishable unit, a concern we share (while humbly noting that it may not be held by the same authors when they serve as reviewers of other work)" <-THAT www.nature.com/articles/s41... ht @ritastrack.bsky.social
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- Reposted by Sean RuddDear Colleagues, Delighted to share that our first lab paper is now published in Nature.!!! 😊😊😊 We identify a previously concealed “safety limit” in DNA replication program: cells intrinsically rate-limit PCNA via PAF15, shaping strand-specific and global replication dynamics. 👉 rdcu.be/e1bBt
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- Reposted by Sean RuddWant to get the data out of a PDF figure? As in, the actual data – not a rough trace-along-the-lines version? I made an app you might like: adamkucharski.github.io/pdf2plot/ It all started a few years ago... 🧵
- Reposted by Sean RuddDefending PhD student, looking over their thesis: “If I knew then what I know now, I could’ve done all of this in like 9 months.” A thread about my favorite pioneering cave explorers and why I don’t think AI will ever “solve” biology.
- Reposted by Sean Rudd@science.org Deep contrastive learning enables genome-wide virtual screening | Science www.science.org/doi/10.1126/...
- Reposted by Sean RuddI guess I should re-post from the Bird Site "The Rules For Academic Success here": I always get asked for advice about starting/surviving the tenure track. Here are the rules I've found useful. Thought I'd put it out there for the masses... This list gets longer all the time
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- Reposted by Sean RuddIt feels to me as if this is missing something about getting out of projects that are floundering with *something* to show for the effort and investment of funds.
- Blog post: Just quit Quitting projects in science is hard, but we should be doing a lot more of it. open.substack.com/pub/arjunraj...
- Reposted by Sean RuddBlog post: Just quit Quitting projects in science is hard, but we should be doing a lot more of it. open.substack.com/pub/arjunraj...
- Reposted by Sean RuddA new community-driven lab handbook for reducing conflict and creating more positive and equitable work environments gets strong support from a survey of 200 researchers. buff.ly/K7CGFLV
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- Reposted by Sean Rudd1/New paper from Zheng Wu, Phong Nguyen et al. @cri-utsw.bsky.social shows how cells balance the two pathways that produce purine nucleotides: de novo purine biosynthesis (DNPB) and purine salvage. The surprising mechanism involves NUDT5, a Nudix hydrolase www.science.org/doi/10.1126/...
- Reposted by Sean RuddNew preprint from the lab for any DNA repair or replication stress geeks out there! www.biorxiv.org/content/10.1...
- Reposted by Sean RuddPREACH! www.nature.com/articles/s41...
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- Reposted by Sean RuddExcited to share our lab’s latest preprint! We identify DDIAS as a novel single-stranded DNA-binding component of the TOPBP1–CIP2A complex, which acts in a mitotic DNA damage response pathway to protect chromosome integrity. Short summary below, and read it here: www.biorxiv.org/content/10.1...
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- Reposted by Sean RuddMy first post on bsky to share our latest research in @nature.com: “DNA2 enables growth by restricting recombination-restarted replication” - defines DNA2’s essential function & elucidates links with primordial dwarfism and cancer. Thanks to the lab, collaborators & @ukri.org @acmedsci.bsky.social
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- Reposted by Sean RuddIt is not always safe to repair DNA Damage. Sometimes, cells "just bypass it". During DNA replication, repair of lesions on DNA can be dangerous. Cells instead "tolerate" DNA damage and focus on finishing replication. Read our review and find out why and how: doi.org/10.1016/j.ti...
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- High tide or low tide: the transport and metabolism of mitochondrial nucleotides portlandpress.com/biochemj/art...
- Reposted by Sean Ruddnew out in Nature www.nature.com/articles/s41...
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- Reposted by Sean Rudd"if we do the work only for rewards and recognition, we have gone astray. It becomes hollow. Creative work of every sort (not just science) occurs in a niche where the inner drive to understand or express and the outer drive to be rewarded achieve some balance."
- Why would anyone want to be a scientist? Check out our new Essay from Martin Schwartz: journals.biologists.com/jcs/article/...
- Reposted by Sean Rudd#ResearchHighlight 🚨 In a recent study, the Nussenzweig lab investigated the mechanisms underlying #cytarabine-induced neurotoxicity and provide a mechanistic explanation for the differing neurotoxicity profiles of #gemcitabine. 📖⬇️
- Reposted by Sean RuddA paper from the JUMP Cell Painting Consortium presents image-based phenotypic profiles for 75% of the protein coding genome of human U-2 OS cells, offering a valuable resource for exploring gene relationships. @shantanu-singh.cc @drannecarpenter.bsky.social www.nature.com/articles/s41...
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- Reposted by Sean RuddWe wrote a review on the free nucleotide pool as a central playground in human, bacterial, and plant immunity – now out in Nature Reviews in Immunology www.nature.com/articles/s41... Was fun to write this piece with Dina Hochhauser! Here is a thread to explain the premises 1/
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- Reposted by Sean RuddBetter version of the meme.
- Scientists overwhelmingly recognize the value of sharing null results, but rarely publish them in the research literature go.nature.com/450KElr
- Reposted by Sean RuddNew preprint! We solve a mystery you didn't know existed. Mitotic cells lack new transcription but require ongoing translation. Interphase mRNA half life is only 2-4 hrs. So how do cells arrest in mitosis for hours without depleting their transcriptomes? www.biorxiv.org/content/10.1...
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- Reposted by Sean RuddFabulous post by @randomwalker.bsky.social & Sayash raising the same concern many of us have about whether we're on the right track with how we're using AI for science. Everyone should read it, take a deep breath & think through the implications. www.aisnakeoil.com/p/could-ai-s...
