Marios Koutsakos
Influenza virologist in ViralVaxLab at TheDohertyInst
viralvaxlab.com
Influenza immunity, evolution & vaccines.
- Reposted by Marios KoutsakosAre influenza B viruses really “human only”? New review synthesises evidence from serology & metagenomics for #IBV / IBV-like viruses in animals and aquatic hosts. One Health gaps remain. With @marioskoutsakos.viralvaxlab.com @duckswabber.bsky.social www.mdpi.com/1999-4915/17...
- Reposted by Marios KoutsakosMolecular basis of influenza ribonucleoprotein complex assembly and processive RNA synthesis @science.org @yiweichang.bsky.social www.science.org/doi/10.1126/...
- Reposted by Marios KoutsakosHappy to be able to contribute to this very cool preprint Characterization of the glycoproteins of novel fish influenza B-like viruses #glycotime #lovevirology @uu-cbdd.bsky.social www.biorxiv.org/content/10.1...
- Reposted by Marios KoutsakosIn unexposed adults, frequency of memory B cells with cross-reactive recognition of H5 + H7 low, & lower in unexposed vs humans w seasonal H1N1/H3N2 HA-specific B cells. Boosting B cell responses against HPAI following seasonal immunisation = sporadic. 👉 www.biorxiv.org/content/10.1...
- Reposted by Marios KoutsakosHappy to finally share this work!
- Happy #DayofImmunology! Congrats @ramadhenni.bsky.social & Alexandra Carey Hoppé it's out (finally!) @cp-cell.bsky.social! Incredibly grateful to co-leads @mlmunier.bsky.social, Vanessa Venturi & Tony Kelleher & all brilliant folks @garvaninstitute.bsky.social & Kirby Inst. for fantastic collab! 🧵
- Reposted by Marios KoutsakosCheck out the latest from @viralvaxlab.bsky.social postdoc Wen Shi Lee, developing monoclonal antibodies that neutralise the NL63 coronavirus!
Potent neutralising monoclonal antibodies targeting the spike of NL63 coronavirus www.nature.com/articles/s44...
- Reposted by Marios KoutsakosHappy to report that Mitchell's paper on CD4 T cells and AIM assays is now available online at Science Advances! www.science.org/doi/10.1126/... Thanks to all our collaborators in @viralvaxlab.bsky.social and @thedohertyinst.bsky.social, including @assocprofashhaque.bsky.social lab
- As a first #ImmunoSky post, I’m excited to share our latest pre-print, by the fantastic Mitchell Zheng! www.biorxiv.org/content/10.1... Our group is interested in virus-specific CD4 T cells, which means we often use in vitro stimulations (like the AIM assay) to find our cells of interest. 🧵 1/9
- Reposted by Marios KoutsakosNew preprint alert 🚨 My team and I are pleased to share our most recent story about how bacterial pathogen (Streptococcus pyogenes, Strep A) exposure induces antibody responses against glycan and protein antigens. For paper: SSRN ssrn.com/abstract=519... biorxiv : doi: doi.org/10.1101/2025...
- Reposted by Marios KoutsakosToday @natmedicine.bsky.social published our study showing the older individuals born prior to 1968 have more antibodies that cross-react to #H5N1 relative to younger individuals. If H5N1 causes a pandemic, children will likely be the most susceptible. 1/2 www.nature.com/articles/s41...
- Reposted by Marios KoutsakosThe Virology Unit at IPC has 3 positions open in #OneHealth: *Postdoc – Reconstructing Past Outbreaks *Postdoc – Environmental Surveillance *Clinical Manager These aren’t just jobs. They’re front-row seats to global health in action. Ready? tinyurl.com/57rvxcau #ViroSky #IDSky 🦠🔬🧬🥼🧪
- Reposted by Marios Koutsakos1/ Hot off the press in @jimmunol.bsky.social. We investigated how same side (ipsilateral) vs alternate side (contralateral) prime-boost vaccination impacts germinal center (GC) dynamics & antibody responses against SARS-CoV-2 spike in mice.💉🦠#immunology #vaccines @thedohertyinst.bsky.social
- Reposted by Marios KoutsakosNew research from @thedohertyinst.bsky.social suggests that receiving multiple doses of a vaccine in the same limb leads to faster antibody development, an important strategy for providing #immunity quickly during a pandemic or disease #outbreak. #ReadTheJI #immunology ow.ly/c28N50VeRGR
- Reposted by Marios KoutsakosAntigenic map of H5 influenza viruses spanning their evolutionary history. 3 clusters (surprisingly few!) w no cross immunity. 6 key aa identified. 2344b, 2321a, 2344h in different clusters. Big jump in antigenicity from 234 to 2344b important finding. 👉 www.researchsquare.com/article/rs-6...
- Reposted by Marios KoutsakosNegative-Strand RNA Virus meeting #NSV2025 registration is now open! Visit www.negativestrandvirus.org/home
- Reposted by Marios Koutsakos
- Reposted by Marios KoutsakosReally proud to share our preprint describing early adaptation of H5N1 to US dairy cattle, and showing how these mutations enhance the ability of the virus to infect other mammals, such as pigs and humans. With @influenzal.bsky.social @vidhid.bsky.social @drclairesmith.bsky.social and many more!
- Reposted by Marios Koutsakos8/9 In short, we suggest in vitro stimulation activates ag-specific T cells, which secrete cytokines and activate Treg and Th17/22 cells. Without careful phenotyping, all of these cells can get picked up as AIM+, accounting for the Th17-like memory cells found in many virus-specific AIM datasets.
- Tracking tetramer-binding cells during re-stimulation showed that CXCR4-CD137+ cells provide a more accurate measure of the Ag-specific population than standard AIM readouts @jenjuno.viralvaxlab.com doi.org/10.1101/2024...
- Reposted by Marios KoutsakosThanks @ausvirologysoc.bsky.social for a great meeting. Where else can you turn the evolution of flu A vs flu B strains as described by @marioskoutsakos.bsky.social into a dance move. Having Jenna Guthmiller here from the US was a highlight for me! See you all in Adelaide in 2026
- Reposted by Marios KoutsakosI have a few brief thoughts on this just released Science paper on the adaptation potential of bovine #H5N1 HA. Its very good work by very good group at Scripps! Think people need to be cautious in assessing the actualized risk out of this one study. #influenza www.science.org/doi/10.1126/...
- Reposted by Marios KoutsakosNext up is Marios Koutsakos @marioskoutsakos.bsky.social who is presenting Antigenic evolution of the influenza B virus HA over 80 years of circulation in humans. Marios has apologised for only including one phylogenetic tree in his talk in this evolutionary virology session. #AVS12
- Reposted by Marios KoutsakosI've made a starter pack for Aussie virologists joining Bluesky at #AVS12. Let me know if you would like to be added- please share 🤗 @ausvirologysoc.bsky.social go.bsky.app/FgBEzfcat://did:plc:q5x5wlbe4gr6pg47d5cnq7aj/app.bsky.graph.starterpack/3lch3zsj52u2q
