Robert de Vries
Virologist turned glycoscientist... Associate Prof @ Utrecht University Chemical Biology & Drug Discovery
- Super happy to receive an M-2 weave grant from the NWO (Dutch Research Council). Together with Sayed Abd El-Whab we will study the molecular features of H5Nx HA and NA proteins. #glycotime www.nwo.nl/en/news/gran...
- #glycotime alert! Zhiyong synthesized O-acetylated GD3 gangliosides, which were used to examine viral receptor specificities in a cellular context by @LiangRuonan great work by @zeshi_li and @TheBoonsGroup @uu-cbdd.bsky.social www.biorxiv.org/content/10.1...
- Very happy that our paper on the receptor binding properties of contemporary H3N2 viruses is now published @CellReports # glycotime www.cell.com/cell-reports...
- We previously demonstrated that human H3N2 viruses can have very strict specificities to complex N-glycans and that this can very depending on antigenic pressure pubs.acs.org/doi/full/10.... www.nature.com/articles/s41...
- And now published! #glycotime "Sialic Acid-Containing Glycolipids Extend the Receptor Repertoire of Enterovirus-D68" fantastic collaboration with @lisabauervirus.bsky.social @debbyvanriel.bsky.social @TheBoonsGroup enjoy 👍https://pubs.acs.org/doi/10.1021/acsinfecdis.5c00063
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- New paper of Yunfei! Here, he synthesized sulfonates in different sialylated epitopes... although not better ligands for most lectins tested, they were tolerated and even preferred by siglec-4. #glycotime pubs.acs.org/doi/10.1021/...
- What a great thread and very interesting preprint 👍
- In new study led by @timyu.bsky.social, we measure how mutations to H3 flu HA affect cell entry, stability & antibody escape We find pleiotropic effects of mutations on these phenotypes shape evolution: epistasis alleviates cell-entry but not stability constraints www.biorxiv.org/content/10.1...
- Happy Eurovision! Basel is awesome, getting ready for the final!🏳️🌈🇫🇮
- Bijvoet symposia 👍 #glycotime @uu-cbdd.bsky.social
- Happy to be able to contribute to this very cool preprint Characterization of the glycoproteins of novel fish influenza B-like viruses #glycotime #lovevirology @uu-cbdd.bsky.social www.biorxiv.org/content/10.1...
- Excited to have this story out on bioRxv! #glycotime #lovevirology #H5N1 The receptor binding properties of H5Nx influenza A viruses have evolved to promiscuously bind to avian-type mucin-like O-glycans. www.biorxiv.org/content/10.1...
- Now published in PNAS, this is a fantastic paper on how HA moves within a virion upon receptor binding. By the way, do check the #badglycans in Figure 6 😐 www.pnas.org/doi/10.1073/...
- Reposted by Robert de VriesWe a looking for a Postdoc! Interested in virology, stem-cell derived models, glycans? Apply before 29th of October! @thijskuiken.bsky.social @lisabauervirus.bsky.social @marionkoopmans.bsky.social @rpdevrieslab.bsky.social www.werkenbijerasmusmc.nl/en/vacancy/1...
- Now out in Nature! Bovine H5 maintains binding to avian-type receptors. #glycotyme #H5N1 @uu-cbdd.bsky.social www.nature.com/articles/s41...
- Happy to have this story now published in @PNAS The Q226L mutation can convert a highly pathogenic H5 2.3.4.4e virus to bind human-type receptors | PNAS #glycotime www.pnas.org/doi/10.1073/...
- Maria and our colleagues at @scrippsresearch have done fantastic work on this. A 2.3.4.4e H5 only needed a single Q226L mutant to bind canonical human-type receptors! A representative H5 from the current cow outbreak did not shift receptor binding with the Q226L only.
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- This will be tons of fun.... 👍
- Finally! A group picture! Enjoying the DAVS #lovevirology
- The DAVS is always a blast! Happy to have it in Utrecht. Fyi same location for glycoscienceNL late June 😉
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- I have a PhD position open in my lab! viruses and glycans... who does not love that combo😉. Please share!. #glycotime #lovevirology www.uu.nl/en/organisat...
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- Reposted by Robert de VriesOnderzoeker en viroloog John van der Oost wint de #Beijerinck #Virologie Prijs voor zijn CRISPR-Cas onderzoek. Early career onderzoekers Carmen Embregts & Puck van Kasteren ontvangen de #BeijerinckPremie. www.knaw.nl/nieuws/voorb... @rdo-erasmusmc.bsky.social @rivm-nl.bsky.social @w-u-r.bsky.social
- Now out in structure... I really question the biological relevance, as in a virus, the NA will take care of that SIA 😉 www.sciencedirect.com/science/arti...
- Save the date! June 27th is our 3rd GlycoScienceNL symposium...Geertekerk Utrecht! major #glycotime! @uu-cbdd.bsky.social @uuuips.bsky.social nvbmb.kncv.nl/glycoscience Please tag and RT at will!
- Please see this fantastic thread by @lisabauervirus.bsky.social about our recent preprint on the glycan binding properties of enteroviruses. It was great working with her team at @erasmusmc.bsky.social and, with @debbyvanriel.bsky.social, as we started this project some years ago. #glycotime
- We have a new preprint on the receptor specificity of 2.3.4.4 H5 viruses. We introduced the hallmark Q226L mutation in several antigenic backgrounds and observed different phenotypes. #H5N1 #glycotime www.biorxiv.org/content/10.1...
- Happy new year all... look what i just found in the graphical abstract... #badglycans www.sciencedirect.com/science/arti...
- Save the date! #glycotime @uu-cbdd.bsky.social
- The ESWI awards application season will start early next year. Submit your paperwork! @eswinfluenza.bsky.social eswiconference.org/eswi-awards/
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- Another win in the yearly students vs teachers volleyball tournament organized by "Unitas Pharmaceuticorum"... @uuuips.bsky.social @lightzone.bsky.social
- I'm super excited that our consortium has been funded by the NWO! Can't wait to get started! @debbyvanriel.bsky.social @lisabauervirus.bsky.social @uuuips.bsky.social #glycotime www.nwo.nl/en/news/64-m...
- Happy belated secret sinterklaas! @mriosc.bsky.social @uuuips.bsky.social
