Yi-Wei Chang
Assistant Professor of Biochemistry and Biophysics, University of Pennsylvania
yiweichanglab.org
Structural biology; cryo-electron tomography; host-pathogen interactions
- Congratulations to Melanie Ohi for this very well-deserved recognition!
- Excited to share our new @science.org paper! Led by postdocs Ruchao Peng and Xin Xu, we used cryo-EM/ET to reveal the influenza ribonucleoprotein complex structure and its strand-sliding mechanism for RNA synthesis, paving the way for new antivirals. www.science.org/doi/10.1126/...
- ...and big thanks to @jiwasa.bsky.social for making this amazing video to illustrate the strand-sliding mechanism!
- Reposted by Yi-Wei ChangThrilled to share our @elife.bsky.social paper "Inflammasomes primarily restrict cytosolic Salmonella replication within human macrophages" by 1st author Dr. @marisaegan.bsky.social (@cambupenn.bsky.social alum, now faculty @swarthmorecollege.bsky.social)! elifesciences.org/articles/90107 🧵(1/n)
- Reposted by Yi-Wei Chang
Exciting update on the CryoET Data Portal! A new annotation set from Mart Last & team is now live. They’ve doubled available annotations with >1,800 tomograms of Chlamydomonas reinhardtii which now have almost fully dense labels, and all can be visualized in the browser using Neuroglancer.- Scaling data analyses in cellular cryoET using comprehensive segmentation [new] Comprehensive segmentation of cryoET data enables ontology-based voxel ID, used for context-aware particle picking and faster template matching.
- Thrilled to share that our work with the Ben Black Lab, led by a co-mentored star MD/PhD student Katie Kixmoeller, now is formally published! We used cryo-ET to study kinetochore features in human mitotic chromosomes. 🧬🔬❄️
