Stefan Rothenburg
Virology, Host-Virus Interactions and Evolution, Poxviruses, Arboviruses, PKR, RNase L, Translational Regulation
University of California, Davis
health.ucdavis.edu/medmicro/faculty/ro…
- Reposted by Stefan RothenburgI just leaned that my former postdoc mentor, Fred Heffron, passed away last week. I have fond memories from my time in Portland. Fred was smart, funny, and gave us the freedom to develop our own ideas. I am indebted to him for getting my academic career started in the US. Thank you and R.I.P.
- Reposted by Stefan RothenburgEver wondered how you can specifically inhibit #AIM2 #inflammasomes? @y-m-tesfamariam.bsky.social generated inhibitory AIM2 #nanobodies to dissect inflammasome responses to #poxvirus infections in human #PrimaryCells @unibonn.bsky.social @immunosens.bsky.social link.springer.com/article/10.1...
- Reposted by Stefan RothenburgHi Bluesky! I’m a molecular virologist studying how innate immune defences restrict cross-species transmission and shape disease severity. I just joined, so reposts appreciated to help me reconnect with virology, immunology, and host–pathogen interaction folks. (whiteboard art from Zhuonan Li)
- Great structure of a poxvirus entry fusion complex! Cryo-EM structure of the vaccinia virus entry fusion complex reveals a multicomponent fusion machinery | Science Advances www.science.org/doi/10.1126/...
- Reposted by Stefan RothenburgHappy to share our new paper on retroviruses in amphibians - a labour of love for our team @unswbabs.bsky.social with Prof. Peter White. We explore 102 amphibian species to understand what type of retroviruses infect them and their evolution, highlights below 🧵 link.springer.com/article/10.1...
- 1/1 New publication from my lab further elucidated the molecular basis for the host and virus-specific inhibition of PKR. My previous graduate student, Chorong Park, and other lab members compared orthologous PKR inhibitors from vaccinia virus (K3L) and capripoxviruses (011). www.mdpi.com/3608128
- A novel antiviral role of ankyrin repeat and LEM domain-containing 2 (ANKLE2) in restricting vaccinia virus through barrier to autointegration factor (BAF) | Journal of Virology journals.asm.org/doi/10.1128/...
- Now with the correct link: We reviewed the "Molecular Mechanisms of Poxvirus Evolution" We show that poxviruses have highly adaptable genomes, and are not sluggishly evolving, as often described. journals.asm.org/doi/10.1128/...
- We reviewed the "Molecular Mechanisms of Poxvirus Evolution" | mBio journals.asm.org/doi/10.1128/... We show that poxviruses have highly adaptable genomes, and are not sluggishly evolving, as often described.
- Locally acquired Mpox case from infection of the more virulent monkeypox virus clade I in California. No need to panic, but it's important to stay vigilant. We need a functional CDC. lbpost.com/news/health/...
- Reposted by Stefan RothenburgCongratulations @ucdavisvetmed.bsky.social and @ucdavishealth.bsky.social 🎉
- The NIH has awarded a training grant to UC Davis for a joint program for residents in both veterinary and human internal medicine. It's the first joint program of its kind in the US @ucdavishealth.bsky.social @ucdavisvetmed.bsky.social health.ucdavis.edu/news/headlin...
- Happy Weekend
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- Reposted by Stefan RothenburgNew out in #mBio from our lab! Dr. Ile Agu reviewed developments on *host* influences on influenza deletion containing viral genomes (DelVGs, fka defective viral genomes). Hoping for more research in this area. So much promising basic and applied science! journals.asm.org/doi/10.1128/... @asm.org
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- Defying the laws of physics.
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- Reposted by Stefan RothenburgThe Senate appropriations committee has voiced its intent to ignore the request by President Donald Trump to slash the budgets of the National Science Foundation and NASA science programs. scim.ag/4nW7XWi
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- Reposted by Stefan RothenburgValerie Rodriguez Irizarry’s tour de force paper on murine norovirus adaptation/egress is now out in peer-reviewed form @plosbiology.org. It highlights the power of forward genetics in virology research. 🧵 1/10 journals.plos.org/plosbiology/...
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- Great paper investigating the functional and structural basis for specific translational regulation of host and viral mRNAs during poxvirus infection. One of the most rewarding aspects of my job is when former trainees excel. Very proud of my former graduate student leading this study. rdcu.be/eowH7
- Poxvirus structural biology for application to vaccine design www.sciencedirect.com/science/arti...
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- The study we all waited for. rdcu.be/eljJY
- Reposted by Stefan RothenburgA great story showcasing the brilliant Yi Ning Fu, who I had the privilege of supervising last year as a student with the equally fantastic @agrowlipowli.bsky.social. It's a huge pleasure scienceing with them.
- “Tasmanian devils are the world's largest remaining marsupial carnivore and have a very important ecological niche,” says Yi Ning (Sabrina) Fu, @jcsmr.bsky.social. “And they are cute and adorable—we need to save them.” That's where cutting-edge virology comes in. science.anu.edu.au/news-events/...
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Chikungunya virus and other emerging arthritogenic alphaviruses www.nature.com/articles/s41... - Reposted by Stefan RothenburgReally excited to share the final version of Rechel Geiger’s PhD thesis paper with help from friends www.science.org/doi/10.1126/... Rechel is now back in medical school training to become a kickass physician-scientist
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- Reposted by Stefan RothenburgOur study exploring the evolutionary mechanism of alphavirus opal codon retention is now online! www.science.org/doi/10.1126/...
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- Another nice example of a host-acquired gene in poxviruses, which modulates the host immune response. dx.plos.org/10.1371/jour...
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- Reposted by Stefan RothenburgDr Peter Marks, "Vaccines have been studied very extensively for being potentially associated with autism" "That theory has been debunked" "One study in Denmark, over 600,000 children. It shows that if anything, children had a lower rate of autism than unvaccinated children"
- Exciting structure of the eIF2alpha kinase GCN2 in complex with the large ribosomal subunit to keep it inactive and in close proximity to where the translation action takes place. PKR is probably controlled in a similar way. www.pnas.org/doi/abs/10.1...
- Reposted by Stefan RothenburgGreat to see this analysis of ocular complications from a cohort of mpox patients from 2007-2011. Always a privilege to work with such a fantastic team of world experts www.medrxiv.org/content/10.1...
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- Molecular cloning and host range analysis of three cytomegaloviruses from Mastomys natalensis | Journal of Virology journals.asm.org/doi/10.1128/...
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- Reposted by Stefan RothenburgLate #WeekendRead: We describe a novel reporter to visualize endogenous #inflammasome assembly. Suitable for cell lines, primary cells, and tissues as well as quantification by #microscopy and #flowcytometry. Happy to share. www.biorxiv.org/content/10.1...
- The 99 - Son Volt www.youtube.com/watch?v=JeGa...
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- Timely review from poxvirus gene regulation expert Zhilong Yang and colleagues. Temporal expression classes and functions of vaccinia virus and mpox (monkeypox) virus genes | mBio journals.asm.org/doi/10.1128/...
- Important paper demonstrates host-species specific inhibition of IFIT1 by different #poxviruses. A poxvirus ankyrin protein LSDV012 inhibits IFIT1 in a host-species-specific manner by compromising its RNA binding ability: dx.plos.org/10.1371/jour...
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- Reposted by Stefan RothenburgIt is worth paying close attention to the new bill "Dangerous Viral Gain of Function Research Moratorium Act" introduced by Senator Roger Marshall. If enacted, it will effectively stop all of virological research, including for vaccines. www.marshall.senate.gov/wp-content/u... 🧵👇
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- Reposted by Stefan RothenburgEvery news outlet reporting Elon Musk's comment about accidentally canceling Ebola prevention efforts and quickly restoring them should also say they haven't been restored, they're still canceled, the outbreak-fighting teams are dismantled, the money is gone www.washingtonpost.com/politics/202...
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- Reposted by Stefan RothenburgWe are looking for a #postdoc to discover cell-autonomous innate immune antiviral factors in mammals, based on newly-identified defense of prokaryotes! #EvoCure #comparativeImmunology #virology Please share @inserm.fr @ciri-lyon.bsky.social @cnrsbiologie.bsky.social ciri.ens-lyon.fr/teams/lp2l/j...
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