David Tscharke
I'm a highly distractible virologist and immunologist at the Australian National University in Canberra.
- Ever looked for evidence that epitope abundance correlates with immungenicity for antiviral CD8 T cells? It's here along with the first quantification of viral epitope levels in vivo. By the brilliant @virotuned.bsky.social and Nathan Croft. #ImmunoSky #ViroSky doi.org/10.1126/scia...
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- Great people doing outstanding science!
- A great story showcasing the brilliant Yi Ning Fu, who I had the privilege of supervising last year as a student with the equally fantastic @agrowlipowli.bsky.social. It's a huge pleasure scienceing with them.
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- Reposted by David TscharkeAfter 8 months of peer review, our manuscript was published today @nature.com showing that bovine H5N1 viruses bind poorly to human-type sialic acid receptors. We now know that the virus is only 1 HA substitution away from efficiently binding human receptors. www.nature.com/articles/s41...
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- Reposted by David TscharkeThe vaccine against Shingles helps protect against dementia, results of a natural experiment, adding to prior evidence "implications are profound" New @nature.com www.nature.com/articles/d41... nature.com/articles/s41...
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- Reposted by David TscharkeBig news
- 🎉 bioRxiv & medRxiv are now managed by openRxiv, a new independent nonprofit. This transition allows for more flexibility and innovation. Our mission remains being a free service to authors ensuring rapid sharing of scientific information before peer review. ℹ️ openrxiv.org/introducing-...
- Reposted by David TscharkeHate that it has come to this, but it's time to consider PubMed vulnerable to enshittification. My latest post @plos.org discusses the lines we need to fight to hold – and alternatives we can rely on internationally: absolutelymaybe.plos.org/2025/02/14/w... #medlibs
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- Reposted by David TscharkeTimely study by Katherine Kedzierska and Jamie Rossjohn and colleagues defining key structural features of #Tcell binding to circulating #influenza strains from 1918 to ~present #ImmunoSky www.science.org/doi/10.1126/...
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- Reposted by David Tscharke@charlesgaba.com is a hero and downloaded CDC’s entire website. A small group of us has come together to preserve this critical resource and make it accessible to the scientific community. More to come. These data are public and they are ours. Deletion disobedience is one way to fight back.
- 📣 UPDATE: OK, still working with some others to figure out the best way to present it all, but in the meantime here's the first batch of links to the most-recent archived versions of every page at the CDC prior to the Trump/Musk Purge: acasignups.net/25/02/02/whi...
- Reposted by David Tscharke📣 UPDATE: OK, still working with some others to figure out the best way to present it all, but in the meantime here's the first batch of links to the most-recent archived versions of every page at the CDC prior to the Trump/Musk Purge: acasignups.net/25/02/02/whi...
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- Reposted by David TscharkeThe #H5N1 #birdflu virus from a severe case in Louisiana shows it was developing mutations that could help it attach to cells in human respiratory tracts, including a mutation seen in a recent severe case in British Columbia, Canada, the #CDC reported today. www.statnews.com/2024/12/26/c...
- Reposted by David TscharkeThere's a really interesting new paper out in Science for people who care about immunity to flu (which should be everyone because flu is a VERY big problem): www.science.org/doi/10.1126/... Here's my thread explaining this work🧵
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- Amazing enough for the potential impact on HIV, but this line caught my eye "other viruses have their own capsid proteins... ...this drug's triumph raises the exciting prospect that similar capsid inhibitors could fight other viral diseases." www.science.org/content/arti...
- This is the result of the continuous development and improvement of our methods by @agrowlipowli.bsky.social and Stewart Smith. Key applications are vaccines and virolytic cancer therapies. Hit us up if you can't see past the paywall - we're happy to help with methods and tips.
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- Reposted by David TscharkeIf an #H5N1 pandemic starts tomorrow or in three months, there will be little mystery as to how it happened. The conditions are all there. They have been for a while. So in some ways the more interesting question to me at the moment is: Why aren’t we in a pandemic yet? Story here, 🧵 to come: 🧪#IDSky
- Reposted by David TscharkeA great intro to our work on a crazy Tassie devil virus from @julienmelade.bsky.social in the #AVS science bites session. Find out more at poster 102 this evening
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- Reposted by David TscharkeAVS is now on bluesky - just in time for our biennial meeting starting today #AVS12
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- Reposted by David TscharkeWe are recruiting an associate or full Professor of Infection and/or Immunity to the school biological sciences in Cambridge. Full details here: www.jobs.cam.ac.uk/job/49381/ #immunology #virology
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- #ViroSky #Mpox 🧪 A piece on Mpox by Reuters. It's a bit gruesome, but Mpox is not a pleasant thing to have. And it's spreading, especially in parts of Africa. We now have 2 separately emerged stains. www.reuters.com/graphics/HEA...
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- Reposted by David TscharkeThe strain on scientific publishing: we set out to characterise the remarkable growth of the scientific literature in the last few years, in spite of declining growth in total scientists. What is going on? direct.mit.edu/qss/article/... A 🧵 1/n #AcademicSky #PhDchat #ScientificPublishing #SciPub
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- Reposted by David Tscharke📢 Bluesky is emerging as the New Platform for Academia, but what's missing? 📊 Altmetric integration to track attention for articles 🔄 Share and ♥️ Like if you agree! 🙏 @altmetric.com please tell us it’s going to happen!
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- Reposted by David TscharkeOur Herpesfolds paper is out in Nature Communications! rdcu.be/d1uM7 Congrats to Timothy Soh, @sofiaaognibene , Saskia Sanders, Robin Schaeper and Benedikt Kaufer! Have a look at our database at herpesfolds.org by Malte Kansy
- Tell me you are a virologist in one picture. #ViroSky
- Reposted by David Tscharke🎨 In case anyone need… The NIH BioArt Source is an awesome library of *free* professionally drawn illustrations for scientific presentations or figures. Downloadable in HD. Thank you NIH for this invaluable tool 🙏! Check it out 👇 bioart.niaid.nih.gov
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- Reposted by David TscharkeDid you know there’s a site to search for starter packs of people to follow? Built by @mubashariqbal.com blueskydirectory.com/starter-pack...
- Reposted by David TscharkeWe strongly suggest that academic publishers and other platforms that host research rapidly implement a Share to Bluesky button for their articles. Here's how: docs.bsky.app/docs/advance... #AcademicSky #HigherEd #Altmetrics
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- Reposted by David TscharkeFabulous work with colleagues in Burundi, who took up Mpox sequencing to understand the situation AND are willing to share pre-publication, shows the expanding tree, and evidence for several introductions not taking off. In progress virological.org/t/preliminar...
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- This study from my former student Navneet Singh vame out when I was in purgatory between X and here. It finds that the expression of lytic genes in HSV latency depends on where they are in the genome. #virosky journals.asm.org/doi/10.1128/...
- I'm new here and very excited about this work. So please forgive me for posting, re-posting and replying lots. Big congrats to @virotuned.bsky.social, Nathan Croft and Tony Purcell - the main crew who made this happen. #immunology, #virology, #poxvirus,
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