Augustinas Silale
Structural biology, membrane proteins, microbiology. Postdoc. Newcastle upon Tyne. 🧪🧫❄️🔬🇱🇹🏳️🌈
- Reposted by Augustinas SilaleA gift of an article from the inimitable Colin Kleanthous as he says a moving farewell to his laboratory. A brave, unrepentant and scientifically brilliant journey is described - please have a read, friends. www.jbc.org/article/S002...
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- Reposted by Augustinas SilaleBBSSRC (NEEDL) funded PhD studentship in my lab co-supervised by @thecopperdoctor.bsky.social and @mycobacterium-ncl.bsky.social If you're interested in structural biology and membrane transport processes, check out www.findaphd.com/phds/project... deadline 27th of Feb! Get in touch for more info
- Reposted by Augustinas SilaleFully funded four-year PhD position available in my lab! Combining structural and synthetic biology to understand iron transport. Deadline 27th of Feb, get in touch for more details! www.findaphd.com/phds/project...
- Reposted by Augustinas Silale💊 We are excited to share our preprint that describes an inhibitor of the widespread and highly conserved Two-Partner Secretion (TPS) system that is critical for Gram-negative pathogens to export a multitude of diverse virulence factors. (1/6) www.biorxiv.org/content/10.6...
- Reposted by Augustinas SilaleHi fellow membrane protein #StructuralBiology people! Do you use maltoside detergents / model them in your stuctures? Watch out! ⚠️ Most PDB models of LMNG and GDN are wrong ❌, yet continue to be re-used. Spread the word! See more: doi.org/10.1021/acsc... (w. @sebvidalchem.bsky.social ) #cryoEM
- Reposted by Augustinas SilaleGood news! Erasmus is a great scheme. www.bbc.com/news/article...
- Reposted by Augustinas SilaleFab afternoon at the MHD festive gathering 🎉 congratulations to the winning quiz team and @johncorrigall.bsky.social for most festive outfit.
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- Reposted by Augustinas SilaleStructure and organization of AMPA receptor-TARP complexes in the mammalian cerebellum | Science www.science.org/doi/10.1126/...
- Reposted by Augustinas SilaleOur paper on polymyxin interacting with the E. coli outer membrane is out! Simulations by the very talented @dheerajprakaash.bsky.social www.nature.com/articles/s42... To scale outer membrane protein island simulated at coarse-grained resolution with portions refined at all atom resolution.
- Reposted by Augustinas SilaleFantastic to have Prof Matthias Wilmanns from EMBL Hamburg hosted by @kshbeckham.bsky.social to give a @mhd-newcastle.bsky.social seminar on mycobacterial infection #dreamtheme
- Reposted by Augustinas SilaleType VII ABC transporters underpin many core activities in the bacterial cell envelope - including efflux, cell division and lipoprotein trafficking. A new paper in PLOS Biology reveals YbbAP-TesA as a novel Type VII system in E. coli. dx.plos.org/10.1371/jour...
- Reposted by Augustinas SilaleExcited to share our latest research in @natmicrobiol.nature.com . We uncover hundreds of inhibitory interactions between common chemical pollutants and human gut bacteria. A thread🧵 (1/10) #microbiomesky #microsky @kiranrpatil.bsky.social lab @mrc-tu.bsky.social www.nature.com/articles/s41...
- Reposted by Augustinas SilalePleased to share our recent article in PNAS - a collaboration with @jessicaandreani.bsky.social & Pablo Radicella, with important roles played by many members of each team. A tripartite protein complex promotes DNA transport during natural transformation in Firmicutes www.pnas.org/doi/10.1073/...
- Reposted by Augustinas SilaleHappy to see work I contributed to during my MSc at @bioscienceleeds.bsky.social with Jennifer Tomlinson’s lab out in @pnas.org! Everyone Bluesky-less except @antoncalabrese.bsky.social www.pnas.org/doi/10.1073/... #AMR #MRSA #NMR
- Reposted by Augustinas Silalerdcu.be/eRxNf here our new study on the characterization of the lipopolysaccharide holotranslocon, LptDE and the newly identified subunits LptM and LptY. Great collaboration with @fronzeslab.bsky.social @pstansfeld.bsky.social @JulienMarcoux @YvesQuentin
- Reposted by Augustinas SilaleProteins are dynamic structures, but structural biology often shows them as static snapshots. Inspired by long-exposure photography and generative art, I built ProteinCHAOS, an artistic tool inspired by molecular dynamics to capture protein flexibility over time, much like long-exposure images.
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- Reposted by Augustinas SilalePleased to see this collaboration with a great PhD student Pei Cing Ng, from Prof. Luning Liu's lab at Liverpool University published. Structure of the H. neapolitanus carbonic anhydrase and localisation in a mini-carboxysome: www.pnas.org/doi/epdf/10....
- Reposted by Augustinas SilaleI am excited to share our new preprint on our structural and biochemical analyses of human methionine synthase (MTR). This was the hard work of Douglas Ferreira who carried out this research as a significant part of his PhD. #CryoEM www.biorxiv.org/content/10.1...
- Reposted by Augustinas SilaleAn Asgard archaeon with internal membrane compartments Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors! www.biorxiv.org/content/10.1...
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- Reposted by Augustinas SilaleDive into our November issue featuring: 🪆nested archaeal symbioses 🌱microbiota driven drought responses in plants 🏗️ BAM complex in Bacteroidota 💨microbial fermentative growth in the gut 🍸hospital-specific phage therapy cocktail and much more..! www.nature.com/nmicrobiol/v...
- Reposted by Augustinas SilaleIf you are interested in researching how drug resistant bacteria evade killing by our immune system, them this PhD project is for you. Come join the our team at Newcastle, in collaboration with University of Liverpool, and lead research at the interface of microbiology, immunology and metabolomics.
- Reposted by Augustinas SilaleWant to find ways to combat TB? Check out this PhD position 👇
- PhD opportunity with me and @kshbeckham.bsky.social www.findaphd.com/phds/project...
- Reposted by Augustinas SilaleWant to work within a multidisciplinary group to combat antifungal resistance in Candida spp? Fully-funded MRC PhD studentship in collaboration with @nclfungalgroup.bsky.social and Francesco Del Carratore on the mode of action of a new class of antifungal drugs. www.findaphd.com/phds/project...
- Reposted by Augustinas SilaleInterested in a PhD at the intersection of biophysics and microbiology? Apply for this MRC-funded opportunity at Newcastle University to do cutting-edge microscopy in Mycobacterium tuberculosis! 🔬🦠 Closing 4 Dec! www.findaphd.com/phds/project...
- Reposted by Augustinas SilaleProspective PhD Students! The MRC DiMeN Doctoral Training Partnership PhD Projects are now online.. lots of exciting opportunities to join us here in Newcastle. Take a look 👀 www.findaphd.com/phds/mrc-dim...
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- Reposted by Augustinas SilaleIf you’re interested in metals, microbes and maths 🤘 - please check out this PhD on the impact of metals on microbial communities with @thecopperdoctor.bsky.social @blindmath.bsky.social Denis Patterson and myself, you’d be based in Durham & be part of a vibrant interdisciplinary research group
- We're advertising a PhD at the intersection of mathematical ecology, metallobiology, and microbiology to study the impact of metals on microbial communities with @thecopperdoctor.bsky.social @kateduncan.bsky.social and Denis Patterson. Come join us in lovely Durham! iapetus.ac.uk/studentships...
- Reposted by Augustinas SilalePlease RT. Post-doc opportunity alert! 💥 closing 10th December.. Come join our team (www.thelowlab.org) at Imperial, London, working on the structure and mechanism of bacterial secretion systems. For more details and to apply please see www.imperial.ac.uk/jobs/search-...
- Reposted by Augustinas SilaleShortlisted candidates will be invited to give a seminar at the Fellows Conference, which will be held on 10 March 2026. Candidates who win Fellowships will be offered a Tenure Track Group Leader position from the outset, initially for 5 years. Find out more: www.jic.ac.uk/training-car...
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- Reposted by Augustinas SilaleWe’ve kept registrations open till the end of this week so get your last minute applications in for posters and talks!
- The CCP4 Northern Structural Biology Meeting is back again in Newcastle 6-7th November 2025. If you are a structural biologist/biochemist in the North of the UK please register and submit abstracts by this Friday 17th. nusbf.ncl.ac.uk/ccp4-norther...
- Reposted by Augustinas SilaleThe CCP4 Northern Structural Biology Meeting is back again in Newcastle 6-7th November 2025. If you are a structural biologist/biochemist in the North of the UK please register and submit abstracts by this Friday 17th. nusbf.ncl.ac.uk/ccp4-norther...
- Reposted by Augustinas SilaleProf Quinn telling us about her novel findings on bacterial type-VI secretion mediated killing of fungi. @mhd-newcastle.bsky.social @nclfungalgroup.bsky.social #Candida2025
- Reposted by Augustinas SilaleCheck it out! A proper team effort from past and present group members and a great collaboration with @sergemostowylab.bsky.social
- The Staphylococcus aureus LXG-domain toxins EsxX and SAR0287 do not promote virulence in a zebrafish larval infection model biorxiv.org/content/10.1101/202…
- Our paper on the Bacteroidota BAM complex is out in @natmicrobiol.nature.com! With @madejmar.bsky.social We found that BAM in Bacteroides and Porphyromonas gingivalis has a distinct architecture from BAM in Proteobacteria. doi.org/10.1038/s415...
- We think this much larger BAM enables biogenesis of outer membrane β-barrel and surface-exposed lipoprotein complexes, which are a hallmark of the Bacteroidota.
- Berks and @smlea.bsky.social labs also found yet a different BAM architecture in Flavobacterium johnsoniae, another member of Bacteroidota. doi.org/10.1038/s415...
- Reposted by Augustinas SilaleSpending some time collecting memories of Harry today 🥺 - this is when he was elected a Fellow of the Royal Society. If anyone in the #glycotime universe has pictures or memories of Harry Gilbert they want to share please send them my way 💚
- Reposted by Augustinas SilaleNow we are on Bluesky, over the next couple of days we would like to introduce some of the MHD groups on Bluesky who you can follow for more research updates. Or check out our handy MHD starter pack 😀 go.bsky.app/SoVnvW3at://did:plc:iqtttg5s5livb5pfnvbdfarj/app.bsky.graph.starterpack/3lz2dtzymch2v
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- Reposted by Augustinas SilaleExclusion systems, far from slowing down plasmid spread, are in fact essential to preserve host cell viability and thereby ensure the successful dissemination of conjugative plasmids and antibiotic resistance genes. @nfrk92.bsky.social @narjournal.bsky.social academic.oup.com/nar/article/...
- Reposted by Augustinas SilaleReally excited to share my first paper from the Whitney lab, alongside an amazing grad student, Polina. Here we identify a chaperone family required for the folding of a central domain of T7SS toxins, and solve the structure of the chaperone-toxin complex. www.pnas.org/doi/10.1073/...
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- Reposted by Augustinas SilaleAbsolutely delighted to share the labs latest work. We identify and characterise two pathways for D-ribulose utilisation in pathogenic EHEC and Citrobacter.
- Reposted by Augustinas Silale#microsky We challenge the long-standing view that peptidoglycan alone protects cells from bursting. Our study shows that the periplasm — enclosed by OM–PG connections — acts as a pressure buffer essential for osmoprotection in Gram-negative bacteria. 📄 www.nature.com/articles/s41...
- Reposted by Augustinas Silale*JOB AD*: interested in doing a postdoc in microbial metabolomics? Passionate about natural products mass spec? Come join the group! Informal enquires welcome! Closing Date: 19 August 2025 jobs.ncl.ac.uk/job/Newcastl...
- Reposted by Augustinas SilaleMy wonderful colleage Colin Kleanthous is raising money for the MND association. Please support Colin in this worthy endeavor! www.justgiving.com/page/colin-k... (Please repost!)
