Tommy Vierbuchen
Assistant Professor, Developmental Biology, Center for Stem Cell Biology at Sloan Kettering. Building next generation stem cell models to study genetics of brain development.
mskcc.org/research/ski/labs/t…
- Reposted by Tommy VierbuchenFor anyone interested in the history of molecular biology, I cannot recommend Judson's The Eighth Day of Creation highly enough. One of the great book on the history of science. I have two copies because a actually wore out the first one (paperback) www.cshlpress.com/default.tpl?...
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- Reposted by Tommy Vierbuchen1/ Our new study, led by Jingwen Ding, examines the role of transcription factors during human neurogenesis to identify gene regulatory networks influencing cell fate, maturation, and subtype specification www.nature.com/articles/s41...
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- Reposted by Tommy VierbuchenVery important research to establish African ancestry cell lines! #Neuroskyence www.thetransmitter.org/cellular-neu...
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- Reposted by Tommy VierbuchenRegistration for the 2026 NY Area Population Genetics meeting is now open, at events.simonsfoundation.org/e0mEoL?rt=8k.... Registration is free but required; if you are submitting an abstract, note that the deadline is *January 30th*.
- SAVE THE DATE: the yearly NY Population Genetics meeting will be back on March 9 2026, generously hosted by the @simonsfoundation.org. Details to follow. Please RT.
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- Reposted by Tommy VierbuchenThere's still time to apply to be a 2026 @dev-journal.bsky.social Pathway to Independence fellow For those about to apply for their first independent academic position, the programme offers - mentoring - leadership training - profile rising - networking journals.biologists.com/dev/pages/pi...
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- Reposted by Tommy VierbuchenWhy do some individuals defy their polygenic score? In the largest study of its kind (402k UKB individuals; 7 continuous traits + 3 diseases), we asked: If your phenotype deviates from common-variant polygenic score prediction, what's driving that difference? www.medrxiv.org/content/10.6...
- We had a great experience publishing in Development (doi.org/10.1242/dev....). High-quality reviews, quick turnaround, and our editor (Jim Wells) was very helpful and provided feedback about the reviewers comments.
- The "Hard Truth" about how hard it is to publish in Development. We wrote this to really drive the point that we are a discerning community journal, and we really want to publish your best developmental and stem cell biology contributions. journals.biologists.com/dev/article/...
- Reposted by Tommy VierbuchenDynamic subtype- and context-specific subcellular RNA regulation in growth cones of developing neurons in the cerebral cortex. rdcu.be/eXuwg
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- Reposted by Tommy VierbuchenAs usual this time of year, started drafting the list of gene regulation conferences for 2026, enjoy! generegulation.org/conferences-... Know of a relevant event that’s missing? Please reply below
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- Reposted by Tommy VierbuchenVery interesting pre-print from Chris Baker's lab at JAX on the mechanistic link between trans-acting genetic variants and heterochromatin formation in mice. #heterochromatin #epigenetics #variants www.biorxiv.org/content/10.6...
- Reposted by Tommy VierbuchenOur preprint "Predictive design of tissue-specific mammalian enhancers that function in vivo in the mouse embryo" is on bioRxiv: www.biorxiv.org/content/10.6... . Amazing collaboration by @shenzhichen1999.bsky.social, Vincent Loubiere (@impvienna.bsky.social,@viennabiocenter.bsky.social),... (1/2)
- One of the best reviews I read this year...
- I have a chapter in there on Variability in Neural Circuit Formation pubmed.ncbi.nlm.nih.gov/38253418/
- Reposted by Tommy VierbuchenHi all! We developed CAD-C to map chromatin organization at high res in yeast. It revealed an unexpected tight alignment: nucleosomes covering the same sequence tend to be associated across sister chromatids. www.biorxiv.org/content/10.6... #3DGenome #chromatin #Cohesin #centromere
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- Nice preview of our paper by Hanwen Yu and Yan Liu. Generating 3D mouse organoids for cortex development and evo-devo: Developmental Cell www.cell.com/developmenta...
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- Reposted by Tommy VierbuchenTIL about a memorial ceremony in Iceland in 2019 to mark the end of a glacier, changing the place name from Okjökull to Ok (jökull = glacier). Uncompromising wording on the bronze plaque: "This is to acknowledge that we know what is happening and what needs to be done. Only you know if we did it".
- Reposted by Tommy VierbuchenVery happy to see this published! 🎉🎉🎉 Amazing collaboration with Max Yun and her team @maxyunlab.bsky.social @crtd-tud.bsky.social on Axolotl Thymus regeneration. Thanks also to @claireolingy.bsky.social for coverage, and grateful for December cover #scienceimmunology www.science.org/doi/10.1126/...
- Reposted by Tommy VierbuchenWe are excited to share our new preprint: SMARCA2/4-Dependent Chromatin Remodelling Establishes Gene Regulatory Programs in Early Human Embryos and Blastoids. www.biorxiv.org/content/10.64898/2025.12.01.691499v1
- Reposted by Tommy VierbuchenHigh-quality mouse reference genomes [PacBio Long Read genomes of 17 strains] reveal the structural complexity of the murine protein-coding landscape, Cell Genomics. www.cell.com/cell-genomic... Genomes and annotations here: projects.ensembl.org/mouse_genomes/
- Last bit of fall still hanging on in Central Park
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- Reposted by Tommy VierbuchenNow live, and thanks to @erictopol.bsky.social for organising this!
- Reposted by Tommy VierbuchenNew work from our lab: a simple motif-based model can distinguish between distal cell type specific regulatory elements with extremely high accuracy - in all metazoans including plants. www.nature.com/articles/s41...
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- Reposted by Tommy VierbuchenI wrote a little bit about the "missing heritability" question and several recent studies that have brought it to a close. A short 🧵
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- Reposted by Tommy VierbuchenMajor new direction in the lab: hacking human cell biology with pathogen effectors (eORFs) - amazing collaboration with @miketilapia.bsky.social lab. Huge congrats to first authors Tomas & He & all co-authors! Check out the pre-print on @biorxivpreprint.bsky.social www.biorxiv.org/content/10.1...
- Reposted by Tommy VierbuchenThe link between the gut #microbiome and autism is not backed by science, researchers say. Read the full opinion piece in @cp-neuron.bsky.social: spkl.io/63322AbxpA @wiringthebrain.bsky.social, @statsepi.bsky.social, & @deevybee.bsky.social
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- Reposted by Tommy VierbuchenWe're very excited to welcome Dr. @sumrubayin.bsky.social from the @gurdoninstitute.bsky.social onto the next episode of the podcast! 🎉 Her lab studies the mouse #cerebellum to better understand the regulation of #neural stem cell behavior. 🧠
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- Reposted by Tommy VierbuchenIn the most recent episode of the Epigenetics Podcast, we talked with Ryan Corces from @gladstoneinst.bsky.social about his work on the impact of chromatin architecture on Alzheimer's and Parkinson's Disease. #podacst #chromatin #epigenetics Listen here: www.activemotif.com/podcasts-rya...
- Reposted by Tommy VierbuchenOur new manuscript, led by Emily Corrigan, examines inhibitory neuron diversity across approximately 160 million years of evolutionary divergence, as part of BRAIN Initiative Cell Atlas Network (BICAN) developing brain atlas package: www.nature.com/articles/s41...
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- Reposted by Tommy VierbuchenThe Kim Lab (sskimlab.org) at UC Irvine is recruiting motivated grad students interested in uncovering how transcriptional regulators direct cell fates. We accept students through the CMB (cmb.uci.edu) and MCSB (ccbs.uci.edu/education/mcsb/) PhD programs. Please share with prospective grad students!
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- Reposted by Tommy VierbuchenTalk about an in-flight meal. For the first time, researchers have captured rats hunting bats by grabbing them from the sky. Learn more: scim.ag/3Jqldmn
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- Reposted by Tommy VierbuchenFor over 20 years, the mouse model organism has helped scientists uncover the biology behind human health and disease. But the mouse reference genomes still have missing pieces. The first collection of telomere-to-telomere mouse genomes are now available for two key mouse strains. 🧬💻
