Navin B. Ramakrishna
Sr Research Fellow, Jay Shin Lab, Genome Inst Singapore. Collab Bruno Reversade Lab
PhD Eric Miska & Azim Surani Labs, Gurdon Inst, Cambridge
Biochem Grad, Oxford
- Reposted by Navin B. RamakrishnaJob alert! 📣 I’m looking for a research assistant to join my new team @idrm.ox.ac.uk Were using #zebrafish to understand gene-environment interactions that shape the heart 🫀generate natural diversity 🐸🐭 and contribute to congenital defects ❤️🩹 Full info below, and please share! 🫶🏻 bit.ly/467TO0M
- Reposted by Navin B. Ramakrishna📣 I'm excited to share our latest preprint! We adapt and characterise a neurosphere-based CNCC differentiation protocol, and demonstrate utility for quantitative phenotyping and craniofacial disease modelling! 🧫 Read about Array-CNCC here: www.biorxiv.org/content/10.6... @uoe-igc.bsky.social
- Reposted by Navin B. RamakrishnaArray-CNCC: precise aggregation and arrayed plating facilitate quantitative phenotyping of human cranial neural crest cells and craniofacial disease modelling biorxiv.org/content/10.64898/20…
- Reposted by Navin B. RamakrishnaIssue 12 is complete! Cover: Members of BiO's community, including a founding Editor, past & present Editors-in-Chief, our academic Editors and some of the reviewers from BiO's Fast & Fair peer review initiative. We would like to thank them all. bit.ly/4piig6y
- Reposted by Navin B. RamakrishnaInterested in the unexpected? How about a link between piRNAs and maternal histone mRNAs … Great collab with @sebastianfalk.bsky.social, @koenig-lab.bsky.social and Florian Steiner. #piRNA #histone #mRNA #maternal #RNAbiology #RNASky www.biorxiv.org/content/10.6...
- Reposted by Navin B. RamakrishnaOur paper on the newest version of the Registry of candidate cis-Regulatory Elements (cCREs) is out 🧬 Huge thanks to the many collaborators, experimentalists, analysts and software developers who made this work possible — truly a team effort! A "meme-torial" of the science is coming soon 👀
- Reposted by Navin B. RamakrishnaThis went under the radar but answers a fundamental question in Epigenetics... From many hundreds of olfactory receptor genes, each neuron selects expression of only single one (near-randomly). How? Outstanding work from Mathieu Boulard and colleagues www.biorxiv.org/content/10.6...
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- Reposted by Navin B. RamakrishnaI don't think scientists should work for anyone else. They should work for discovery and for their own curiosity. –Maria Leptin, ERC President @marialep.bsky.social on 'The Night Science Podcast'
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- High-quality mouse reference genomes [PacBio Long Read genomes of 17 strains] reveal the structural complexity of the murine protein-coding landscape, Cell Genomics. www.cell.com/cell-genomic... Genomes and annotations here: projects.ensembl.org/mouse_genomes/
- Reposted by Navin B. Ramakrishna🚨Reposts appreciated‼️If I had read this PhD offer five years ago, I wouldn’t have hesitated for a second to apply 😉 Passionate about gene regulation, chromatin, and developmental biology? Just contact @radaiglesiaslab.bsky.social at @ibbtec.bsky.social 🧬✨ #PhD #3DGenome
- Research Highlight: Mouse In vitro oogenesis breaks free of the ovary www.cell.com/developmenta... @cp-devcell.bsky.social
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- Reposted by Navin B. RamakrishnaWe are recuiting two new Associate Professors here in Oxford Biochemistry. Come join us! Reach out to me if you have any questions. Please repost! tinyurl.com/mr3m7bd3
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- The quest to make babies with lab-grown eggs and sperm. An excellent news feature by Nature: tempered optimism, with critical caveats underscored. And great to see commentary from so many names in the field! www.nature.com/articles/d41...
- Reposted by Navin B. RamakrishnaThe 'Handler genome' of OSCs, a rare and stably growing cell line that runs a piRNA pathway to silence transposons. Dominik (@86dominik.bsky.social) assembled the genome of this Drosophila cell line. Besides making some cool findings, the goal was to turn this into useful resource for the field.
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- Reposted by Navin B. RamakrishnaIt is with great sadness that we share the news of the death of our founder, colleague, mentor and friend, Professor Sir John Gurdon. His vision and dedication will continue to inspire generations of scientists. 🔗 www.gurdon.cam.ac.uk/nobel-laurea...
- Sad to hear this. John was a brilliant scientist and also someone who engaged with everyone personally & as equals, especially young scientists and students. www.cam.ac.uk/research/new...
- Reposted by Navin B. RamakrishnaSo sad to hear the news - John truly was an inspiration to so many, and one of a kind. www.cam.ac.uk/research/new...
- Very candid responses from Azim Surani here on his initially turbulent scientific journey, & accounts of genomic imprinting and the pioneering of mammalian scRNA-seq. Great to see this put together by Ashley Moffett & @geraldinejowett.bsky.social journals.biologists.com/dev/article/...
- Reposted by Navin B. RamakrishnaToday in @nature.com, we present our work leveraging functional genomics and human blastoids to uncover a human-specific mechanism in preimplantation development driven by the endogenous retrovirus HERVK. Special thanks to the reviewers whose comments improved our manuscript a lot! rdcu.be/eI3tD
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- Reposted by Navin B. RamakrishnaThis year @ericmiska.bsky.social lab celebrates 20 years of science! 🥳We marked the occasion with a wonderful gathering of past and present members, sharing memories, discoveries, and friendships. Here’s to the next 20 years of breakthroughs and collaboration🥂 @cambiochem.bsky.social
- Reposted by Navin B. RamakrishnaOur study on the role of LTR5HS and SVAs in regulation of human neural crest migration is now published as peer-reviewed paper on @molsystbiol.org! Congrats to first author brilliant postdoc Laura Deelen, and all the authors involved! @imperialsci.bsky.social www.embopress.org/doi/full/10....
- New preprint from my group! Here we studied the contribution of a subset of human- and hominoid-specific transposons (SVA, LTR5HS) to the evolution of human craniofacial development. We specifically focussed on cranial neural crest (CNCC) formation and migration 1/n www.biorxiv.org/content/10.1...
- Reposted by Navin B. Ramakrishna✨Exciting news: the main story of my PhD is out in Science! Together with Christine Moene @cmoene.bsky.social, we explored what happens when you scramble the genome—revealing how Sox2’s position shapes enhancer activation. 📖 Read the full story here: www.science.org/doi/10.1126/...
- Reposted by Navin B. RamakrishnaThrilled to share that our Group Leader Prof. Azim Surani, together with Prof. Davor Solter, has been awarded the 2026 Paul Ehrlich & Ludwig Darmstaedter Prize 🎉 for discovering genomic imprinting—a breakthrough that reshaped genetics and launched modern epigenetics.
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[Not loaded yet] - Reposted by Navin B. RamakrishnaPIWI clade Argonautes are essential for transposon silencing. Without them, animals are sterile due to massive transposon activity. But how does piRNA-guided target interaction translate into silencing? PhD student Júlia Portell Montserrat has an intriguing answer www.cell.com/molecular-ce...
- Clearly a hot topic - 2 timely review articles on human primordial germ cell specification in the span of 5 days! In @biologists.bsky.social (Development) doi.org/10.1242/dev...., & @natrevmcb.nature.com below:
- Great to see this commentatry on the need for systematic single-cell mapping of cis-regualtory elements: from Yi Xiang, Tim Stuart and Jay Shin @astar-gis.bsky.social @jayshin.bsky.social
- Schematics of our increasing knowledge of in vivo human primordial germ cell development, and a summary of the exciting hPGCLC maturation protocols: @dev-journal.bsky.social @biologists.bsky.social
- Excited to share our Review on human PGC development covering the latest in vivo observations & in vitro developments, esp. in the last 5 years. Have a read! journals.biologists.com/dev/article/... From: @astar-gis.bsky.social @ki.se Warwick University, @gurdoninstitute.bsky.social
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- Reposted by Navin B. Ramakrishnarecord 17,058 Marie Curie proposals in 2025 vs. 10,360 in 2024!!! the reason is pretty obvious, but wow that is a huge jump marie-sklodowska-curie-actions.ec.europa.eu/news/msca-po...
- Excited to share our Review on human PGC development covering the latest in vivo observations & in vitro developments, esp. in the last 5 years. Have a read! journals.biologists.com/dev/article/... From: @astar-gis.bsky.social @ki.se Warwick University, @gurdoninstitute.bsky.social
- We focus on the 1st trimester of hPGC development: specification, migration and gonadal development, focusing on the niche, epigenetics & transcriptome. We then comment on how such profiles can benchmark early in vitro gametogenesis (IVG) - i.e. hPGCLC protocols spanning this period.
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- Reposted by Navin B. RamakrishnaEdith Heard our new CEO shares ten lessons from her life in science, from curiosity, courage and coffee to the secrets of our genetic code. www.crick.ac.uk/news/2025-09...
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- Reposted by Navin B. RamakrishnaJust out in @dev-journal.bsky.social - important discussion on the availability of human embryos for research. Thanks @marta-shahbazi.bsky.social and co-authors for contributing this: journals.biologists.com/dev/article/...
- Reposted by Navin B. Ramakrishna1/11 In @science.org: A new perspective on how our intestines renew. Cells are not “pushed out” by crowding or die from apoptosis. Instead, cells play a mechanical tug-of-war, where weaker cells extrude, reframing gut renewal as force-regulated. www.science.org/doi/10.1126/...
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- Reposted by Navin B. RamakrishnaI’m super happy to present the first discoveries of the RIKEN-Cambridge Joint Crop Symbiosis Research Team, based in Japan 🇯🇵 doi.org/10.1101/2025... A thread 👇
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- Reposted by Navin B. RamakrishnaNew paper from our lab! We found that LINE-1 transposons contribute to early human brain development. Funded by @asapresearch.parkinsonsroadmap.org www.cell.com/cell-genomic...
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- Reposted by Navin B. Ramakrishna"The Genetic and Epigenetic Landscape of Male Infertility" by Emma R. James, Kenneth I. Aston, and colleagues "[T]he testis is one of the most transcriptionally and translationally complex tissues in the human body..." FREE access till Oct. 10th here: authors.elsevier.com/a/1leHvcQbJF...
- Reposted by Navin B. RamakrishnaThis is not a HiC map! Ever wondered if multiple enhancers get activated simultaneously? We measured chromatin accessibility on thousands of molecules by nanopore to create genome-wide co-accessibility maps. Proud of @mathias-boulanger.bsky.social @kasitc.bsky.social Biology in the thread👇
- Activity of most genes is controlled by multiple enhancers, but is there activation coordinated? We leveraged Nanopore to identify a specific set of elements that are simultaneously accessible on the same DNA molecules and are coordinated in their activation. www.biorxiv.org/content/10.1...
- Reposted by Navin B. RamakrishnaActivity of most genes is controlled by multiple enhancers, but is there activation coordinated? We leveraged Nanopore to identify a specific set of elements that are simultaneously accessible on the same DNA molecules and are coordinated in their activation. www.biorxiv.org/content/10.1...
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- Allele frequency selection and no age-related increase in human oocyte mitochondrial mutations www.science.org/doi/10.1126/...
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