Tuuli Lappalainen
Professor at KTH, NY Genome Center, SciLifeLab, working on functional genomics and human genetics.
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- Reposted by Tuuli LappalainenPlease share: we're hiring a new tenure-track faculty member to our Department of Genetics at Albert Einstein College of Medicine. faculty-einstein.icims.com/jobs/17847/a...
- Reposted by Tuuli LappalainenI think it's best for everyone to understand that the unified class project of billionaires right now is to do to white collar workers what globalization and neoliberalism did to blue collar workers.
- Reposted by Tuuli LappalainenI started offering career advice to two junior colleagues today in separate meetings, and both times I caught myself thinking that, if I'm honest, I don't have very good advice on navigating the current funding and job climate. I think it's important to say that no one does.
- Reposted by Tuuli LappalainenKohta paljastuu kaikille, että hyvinvointivaltio tukikin rakenteellisesti taloutta ja talouskasvua, jolloin sen romuttaminen oli onneton rakenteellinen uudistus negatiivisin pitkän aikavälin vaikutuksin. Kiitos! #talous #politiikka #yhteiskunta
- Reposted by Tuuli LappalainenNature and Science journalists denied entry to event featuring NIH Director
- I'm at the Willard Hotel where I've been denied entry and kicked out of the Reclaiming Science event with NIH director Bhattacharya & other top agency leaders. @jocelynkaiser.bsky.social and I registered for the event months ago yet were told capacity was full, even as they let in dozens of others.
- Reposted by Tuuli LappalainenDoes the noncoding genome actually carry more genetic information than coding seqs? Motivated by this question we mutated every bp in the 10kb MYC locus. Results are even more exciting: Decoding the MYC locus reveals a druggable ultraconserved RNA element www.biorxiv.org/content/10.6...
- Reposted by Tuuli LappalainenBecause of technical issues with the SciENcv website, NIH is extending a period of leniency accepting old format biosketches through May 2026 (see FAQ #5): grants.nih.gov/faqs#/common...
- Reposted by Tuuli LappalainenRFKJr's principal accomplishment as the nation's health guardian.
- A want new mandatory course in school curricula worldwide: Everyday logistics in urban environments. Content: How to exit the subway. How to enter the subway. How to move in stairs. How to queue.
- Reposted by Tuuli LappalainenWHO removing Us Flag
- Reposted by Tuuli LappalainenNEW | Wind and solar generated more power than fossil fuels in the EU for the FIRST time ever. 🌪️ and ☀️ made up a RECORD 30% of 🇪🇺 electricity, up from 20% just five years ago. ember-energy.org/latest-insights/eur…
- Reposted by Tuuli LappalainenThe interesting applications of AI are all, like, "we built an open framework that uses processors on recycled cell phones to identify and triangulate the location of rare bugs in tropical rainforests" while big tech is going "what if we burned down that rainforest to summarize your emails?"
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- Reposted by Tuuli LappalainenTrump has been in office for one year. We at @nature.com did a deep dive looking at the administration's disruption of science in numbers. Take a look—the numbers are staggering. By me, @dangaristo.bsky.social, Jeff Tollefson, @kimay.bsky.social, & help from @noamross.net @scott-delaney.bsky.social
- Reposted by Tuuli LappalainenI just woke up from a nap and somehow while I was asleep, everyone on the bus has figured out we are not going to the right place
- Reposted by Tuuli LappalainenNew preprint on technologies to scale up CRISPR screens. We use them to map 665,856 pairwise genetic perturbations and outline a path to comprehensive interaction mapping in human cells. We also introduce an approach for cloning lentiviral libraries with billions of elements.
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- Reposted by Tuuli LappalainenMy specific experience is with NIH, but I’ll stand up and say it: The people who work at NIH are together one of the great wonders of the world. US biomedical science, cancer cures, dementia research all are built on their talent and dedication.
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- Reposted by Tuuli Lappalainenvery sad news. Peer Bork was one of the leaders of our field, a wonderful scientist, and he's much too young to be gone. www.embl.org/news/embl-an...
- Reposted by Tuuli LappalainenFull survey results show American public have high levels of confidence in scientists while revealing some partisan differences (including on how to fund science), but statements asserting lost trust should be read instead as intentional efforts to degrade trust. www.pewresearch.org/science/2026...
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I am looking for a postdoc to develop high-performance algorithms in computational genomics. Email or DM me if interested. For more information, see hlilab.github.io/vacancies. RTs appreciated! - TL;DR: Indirect costs as a percentage of total costs - like the private sector tends to calculate it - for NIH grants is typically around 30-35%.
- Reposted by Tuuli LappalainenInterpretable inflammation landscape of circulating immune cells @naturemedicine.bsky.social @fcraighero.bsky.social @hoheyn.bsky.social @dmaspero.bsky.social @saguilarfer.bsky.social@broadinstitute.org @cnag-eu.bsky.social www.nature.com/articles/s41...
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- Reposted by Tuuli LappalainenBIG FIGHT AT POLAND’S WROCLAW ZOO!!!
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- Reposted by Tuuli Lappalainen🔬 pertpy: a unified, scalable framework for single-cell perturbation analysis, now out in Nature Methods Designed for modern perturbation data - CRISPR, drug screens, patient treatments - scaling to millions of cells and 1000s of conditions. 👉 www.nature.com/articles/s41...
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- Reposted by Tuuli LappalainenThe U.S. Congress has delivered another rebuke of President Donald Trump’s plans to slash this year’s budgets of several science agencies. scim.ag/49G7Zwe
- Reposted by Tuuli LappalainenIf you like larger sample sizes, then do check out our reprocessed and fine mapped cis-eQTLs and cis-sQTLs (leafCutter and MAJIQ!) from the INTERVAL cohort (whole blood, n up to 4,729)! zenodo.org/records/1795... These will be on the eQTL Catalogue FTP soon as well. cc @yosephbarash.bsky.social
- Reposted by Tuuli LappalainenExcited to see this out www.nature.com/articles/s41...! Nonparametric kernel-based tests for spatially variable isoform usage in spatial transcriptomics. So many interesting examples in the CNS and cancer, we're only scratching the surface!
- Reposted by Tuuli LappalainenThe district court injunction that prevented NIH from capping indirects at 15% was upheld today on appeal! www.reuters.com/world/trump-...
- Reposted by Tuuli LappalainenHow well does TWAS estimate a gene’s direction of effect on a trait? We think of this as an important stress-test for the accuracy of TWAS. In a new pre-print, we find that TWAS gets the sign wrong around 20-30% of the time! doi.org/10.64898/202... 1/n
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- Reposted by Tuuli LappalainenMamdani: For too long, those fluent in the good grammar of civility have deployed decorum to mask agendas of cruelty
- Reposted by Tuuli LappalainenJoin @stirlingchurchman.bsky.social, @moffittlab.bsky.social, @saramostafavi.bsky.social, me and all speakers for the 2026 CSHL meeting Systems Biology: Global Regulation of Gene Expression, March 11-14. Abstract deadline January 9! More infos and registration at meetings.cshl.edu/meetings.asp...
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