Ross Chapman
DNA damage & repair biologist | Cancer Research UK Senior Fellow | PI at the MRC Weatherall Institute in Oxford | Science, papers, lab news & some personal views & opinions
- Reposted by Ross ChapmanAre you fascinated by cancer biology and also ❤️ 💻 ? Feel like this ->😻<- at the thought of exploring oodles of cancer genomes, single cells and spatial multiomics data? Then our core Data Science Team at @icr.ac.uk might be the place for you. Vacancy here: jobs.icr.ac.uk/vacancies/14...
- Reposted by Ross ChapmanAn early Christmas present for those interested in chromatin and transcription! Fantastic work from @au-ho-yu.bsky.social and @aleksszczurek.bsky.social . Thanks to Inge and Michiel for their help. Please repost! www.biorxiv.org/content/10.6...
- Reposted by Ross ChapmanMy PhD work is out as a preprint! Have a read 😊👇🏻
- New lab preprint! ERCC6L2 disease is a recessive bone marrow failure syndrome caused by mutations in the putative DNA helicase ERCC6L2. Using mouse genetics, biochemistry and AF3 we uncover ERCC6L2-MRI as a KU-regulatory complex stimulating NHEJ at staggered DSBs: www.biorxiv.org/content/10.1...
- New lab preprint! ERCC6L2 disease is a recessive bone marrow failure syndrome caused by mutations in the putative DNA helicase ERCC6L2. Using mouse genetics, biochemistry and AF3 we uncover ERCC6L2-MRI as a KU-regulatory complex stimulating NHEJ at staggered DSBs: www.biorxiv.org/content/10.1...
- Its DNA structural-specificity is defined using IG class-switching & dysfunctional telomeres with staggered vs blunt DNA ends. Surprisingly, bone marrow HSPCs in ERCC6L2-knockout mice are surprisingly resilient. We therefore speculate as to why bone marrow fails in ERCC6L2-deficient man but not mice
- Special credits go to lead author (& recent lab PhD graduate) @pia-rei.bsky.social and to fantastic collaborators Adam Wilkinson, Ben Davies and Francisca Lottersberger. @ukri.org, CRUK & @thelisterinstitute.bsky.social for funding! Reach out if you have any questions.
- When the work of your colleagues really blows your mind 🤯🔥. Congratulations @jojdavies.bsky.social, team and collaborators! 🥂
- Our latest paper has just been published in Cell! doi.org/10.1016/j.ce... We developed a new method called MCC ultra, which allows 3D chromatin structure to be visualised with a 1 base pair pixel size.
- Thanks Shan Zha for hosting my Social DNA’ing on Thursday. Was a honour to celebrate the 5th anniversary of this epic series. If you didn’t catch it, pls check out the recorded webinar to find out what we’ve been up to with research support from @cruk-ci.bsky.social! fast.wistia.com/embed/channe...
- Congrats Kelly! 🥂
- Congratulations to @kellythd-nguyen.bsky.social, Group Leader in the LMB’s Structural Studies Division, who has been awarded the 2025 Research Prize from @thelisterinstitute.bsky.social . Read more here: www2.mrc-lmb.cam.ac.uk/kelly-nguyen... #LMBNews
- Reposted by Ross ChapmanExcited to share our new paper on Nature - how Ku accommodates Alu expansion in primates by binding to dsRNA, providing a clue for both the high levels of Ku and its essentiality in human cells. Thank @chaolinzhang @hchung03 @LenaSteckelberg More to come www.nature.com/articles/s41...
- Reposted by Ross ChapmanA new treatment significantly improves survival rates for women with aggressive, inherited breast cancer involving BRCA1 or BRCA2 gene mutations. Giving them the targeted drug olaparib before surgery greatly reduced the chances of the cancer coming back. 🧪🧬💊 #medsky www.bbc.com/news/article...
- Reposted by Ross ChapmanDon’t miss the 2025 César Milstein Lecture, by David Pellman from the Dana-Farber Cancer Institute and Harvard University. Join us at 10am (BST) on Thu 24th April to learn about “Mechanisms driving the rapid evolution of genomes” More details: www2.mrc-lmb.cam.ac.uk/news-and-eve... #LMBSeminar
- Reposted by Ross ChapmanPlease repost! Post-doc studying novel mechanisms of post-replicative gap-filling available in my lab here in beautiful Snowdonia, between July 2025 to end Nov 2026. Generous travel budget. Lab is full of friendly and supportive colleagues. Link below, or DM me/email c.staples@bangor.ac.uk for info
- Reposted by Ross ChapmanRegister and submit your abstract now: The ageing genome: from mechanisms to disease www.embl.org/about/info/c...
- Reposted by Ross ChapmanBRCA1 turned 30 🎉 To celebrate, Jos Jonkers and I explored three decades of BRCA1 research - what we’ve learned about its biology, its role in tumorigenesis and future directions to improve the life of BRCA1 mutation carriers. Now out in Cancer Discovery ⬇️: aacrjournals.org/cancerdiscov...
- Reposted by Ross ChapmanWe show transcriptomic buffering of tumour suppressor loss via syn. lethal genes is not anecdotal but a cancer hallmark. Buffering also seen in BRCAness, predicts penetrant syn leth effects and outcome. @icr.ac.uk @cancerresearchuk.org @breastcancernow.bsky.social www.nature.com/articles/s41...
- Reposted by Ross ChapmanReally cool work, demonstrating TRF2-RAP1 mediated inhibition of the NHEJ machinery at chromosome ends! www.biorxiv.org/content/10.1...
