Peter Fineran
Prof. and Head of Phage-host interactions (Phi) lab. Phage defences, counter-defences, CRISPR-Cas, toxin-antitoxin. FRSNZ / James Cook Fellow
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- Excited to be hosting @jcornlab.bsky.social on his sabbatical @universityofotago.bsky.social @otagomicroimmuno.bsky.social
- Reposted by Peter Fineran@peterfineran.bsky.social and colleagues develop Tn-seq for phages by leveraging anti-CRISPR (Acr) as a positive selectable marker in the presence of CRISPR-Cas counter-selection, and identify essential genes in phage from non model orgs www.biorxiv.org/content/10.6...
- Reposted by Peter Fineran✨New preprint! 🧵1/4 Excited to share our work on AI-guided design of minimal RNA-guided nucleases. Amazing work by @petrskopintsev.bsky.social @isabelesain.bsky.social @evandeturk.bsky.social et al! Multi-lab collaboration @banfieldlab.bsky.social @jhdcate.bsky.social @jacobsenucla.bsky.social🧬 🔗👇
- Reposted by Peter Fineran🚨Preprint alert - this is a big one! We transfer the revolutionary power of TnSeq to bacteriophages. Our HIDEN-SEQ links the "dark matter" genes of your favorite phage to any selectable phenotype, guiding the path from fun observations to molecular mechanisms. A thread 1/8
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- Reposted by Peter FineranHot off the press! Our latest paper led by @fernpizza.bsky.social, understanding how plasmids evolve inside cells. These small, self-replicating DNA circles live inside bacteria and carry antibiotic resistance genes, but also compete with one another to replicate. 1/ www.science.org/doi/10.1126/...
- Reposted by Peter FineranBacteria can sense when a virus starts shredding their genome — by detecting methylated mononucleotides. Here’s the story of how we discovered the Metis defense system 👇 www.biorxiv.org/content/10.1...
- Really excited to be hosting @jcornlab.bsky.social here at @universityofotago.bsky.social next year. Looking forward to lots of fun science ahead.
- Reposted by Peter FineranUse antisense oligomers to silence phage genes and discover new biology. @jorg-vogel-lab.bsky.social @helmholtz-hiri.bsky.social @helmholtzhzi.bsky.social @uni-wuerzburg.de print: www.nature.com/articles/s41... highlight: www.nature.com/articles/s41... briefing: www.nature.com/articles/d41...
- Reposted by Peter FineranThe Wilkinson Lab is open for science! @mskcancercenter.bsky.social 🧬We'll be finding funky new RNA biology, mainly by looking at reverse transcriptases (i.e. the Best Enzymes In The World)🧬 annnd: I'm hiring - come join! Especially postdocs and PhD students - please get in touch (NYC is great)
- Reposted by Peter FineranPlease RT: We have an opening for a junior group leader position in „Phage Biology & Biotechnology“. www.fz-juelich.de/de/karriere/... Interested candidates are encouraged to contact me via email for further details. @spp2330.bsky.social; @mibinet.bsky.social
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- Reposted by Peter FineranCome and work with me and @ariannebabina.bsky.social on #Streptomyces evolution and antibiotic production Origins of a tangled bank: Adaptation and evolution in antibiotic-producing Streptomyces www.gla.ac.uk/postgraduate... please repost
- Reposted by Peter FineranThe Department of Biology at Colorado State University is hiring an Assistant Professor in the area of plant-microbe interactions! Please spread the word! jobs.colostate.edu/postings/165...
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- Reposted by Peter FineranWilling to join us @pasteur.fr for a PhD for a project on how interactions between mobile genetic elements shape bacterial adaptation? Subject to be tailored to candidates with keen interest in evolution, genomics, computational biology, microbiology. Check www.pasteur.fr/en/education...
- 🎓 Applications for Institut Pasteur's PhD programs open Sept 1-Oct 20, 2025 for October 2026 entry. Apply to up to 4 projects across 6 programs: PPU, PPU-IMAGINE @institutimagine.bsky.social, PPU-@ox.ac.uk, PPU-EID @upcite.bsky.social & more 🧬 Register now ✍️ www.pasteur.fr/en/education...
- Reposted by Peter FineranWe're looking for a technician at Institut Pasteur for experimental work on satellite-phage-bacteria interactions, working directly with @jmouradesousa.bsky.social and myself in the lab of @epcrocha.bsky.social ! ANR funded. Link to the job emploi.pasteur.fr/offre-de-emp... Thx for sharing!
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Check out our new paper: a review of translational coupling, the phenomenon where translation of one prokaryotic gene can promote translation of the gene downstream. We cover the history, and delve into the mechanism, which is still not fully understood. journals.asm.org/doi/10.1128/... - Reposted by Peter FineranNo Genetics? Try ASOs – A non-genetic approach to silence genes at the phage-host interface. We use it to study jumbo phage biology and anti-phage defence. @jorg-vogel-lab.bsky.social @helmholtz-hiri.bsky.social @uni-wuerzburg.de @helmholtzhzi.bsky.social published now in @nature.com
- Reposted by Peter FineranThrilled to share our two latest papers with the @tcostalab.bsky.social lab! In the first, we uncover a new mechanism of satellite transfer: cf-PICIs hijack tails from diverse phages to spread across species. @imperialcollegeldn.bsky.social www.cell.com/cell/fulltex...
- Reposted by Peter FineranThe ecology and evolution of bacterial immune systems'. #phage #phagesky A bunch of interesting reviews royalsocietypublishing.org/doi/10.1098/...
- Reposted by Peter FineranPhage defence-system abundances vary across environments and increase with viral density Phil. Trans. R. Soc. B by @seanmeaden.bsky.social, Edze Westra and @peterfineran.bsky.social royalsocietypublishing.org/doi/10.1098/...
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- Ever wondered why some bacteria have multiple CRISPR-Cas systems? Our new study led by Leah Smith shows how type I CRISPR systems can promote the acquisition and retention of new spacers into a co-occuring type III system. www.sciencedirect.com/science/arti...
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- Reposted by Peter FineranFeels surreal to say but: I'm hiring! If you are or know anyone interested in looking at the evolution of phage resistance using A. baumannii and natural transformation, then this might be for you www.jobbnorge.no/en/available...
- Reposted by Peter FineranStoked to finally have a preprint out for Phold, our tool that uses protein structural information to enhance phage genome annotation #phagesky 1/n www.biorxiv.org/content/10.1...
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- Reposted by Peter FineranReady to lead pioneering research that bridges systems-level investigations of biological systems to molecular mechanism? The EMBL Molecular Systems Biology Unit in Heidelberg is hiring a Group Leader!
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- Reposted by Peter Fineran🦠🧍♀️From bacterial to human immunity. We report in @science.org the discovery of a human homolog of SIR2 antiphage proteins that participates in the TLR pathway of animal innate immunity. Co-led wt @enzopoirier.bsky.social by D. Bonhomme and @hugovaysset.bsky.social www.science.org/doi/10.1126/...
- Reposted by Peter Fineran1/16 New pre-print from the Sternberg Lab! We uncover how temperate phages can use RNA-guided transcription factors to remodel the flagellar composition of their bacterial host and enhance their fitness. Find the preprint and full story here: tinyurl.com/mshwjd77
- Reposted by Peter Fineran🌟 Exciting news! We’re launching three fully-funded postdoc positions for "New Horizons for Synthetic Phages” Join us in tackling antimicrobial resistance with cutting-edge synthetic biology + AI bioinformatics. Based at Flinders Uni in vibrant Adelaide. 👇 Read on for details! #Phage
- Was great to be hosted recently by Rafa Pinilla-Redondo in Copenhagen. Fun mini symposium and meet new people and friends and colleagues.
- Reposted by Peter FineranA new preprint led by Sonomi Yamaguchi in our lab describes a bacterial anti-phage defense system named Clover that uses nucleotide signals to both activate and inhibit host immunity. www.biorxiv.org/content/10.1...
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- Reposted by Peter FineranPreprint: “Structural modeling reveals viral proteins that manipulate host immune signaling” Using AI-guided structural modeling, we find new families of viral proteins that sequester or cleave host immune signaling molecules Congrats Nitzan Tal! www.biorxiv.org/content/10.1...
- Reposted by Peter FineranHere we show how the type III signalling molecule SAM-AMP is bound and degraded by a specialised lyase enzyme encoded in cellular and phage genomes. More great work by @haotianchi.bsky.social and the team. @uniofstandrews.bsky.social academic.oup.com/nar/article/...
- Fantastic visit to @w-u-r.bsky.social to celebrate the amazing career and achievements of John van der Oost. He is a huge influence and contributor to the #crispr field. I had a great sabbatical here (some years ago). So fun to see friends and collaborators again!
- Great timing a couple of weeks ago where I got to present our work on the discovery of new phage DNA modifications and their implications for phage defence at #EESMicrobiology one hour after the paper came out in @cp-cellhostmicrobe.bsky.social! Fantastic conference!
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- Reposted by Peter FineranI will be recruiting new postdocs with start dates end 2025 - early 2026. If you'd like to work at the Pasteur Institute in the heart of Paris surrounded by amazing scientists, reach out to discuss possible projects on SynBio / Bacterial Immunity!
- Reposted by Peter FineranOut in Nature today: A new immune signaling molecule, His-ADPR, is produced by defensive TIR domain proteins in bacteria to protect from phage Joint work with the Tamulaitienė and Kranzusch labs www.nature.com/articles/s41... Congrats Carmel Avraham, Dziugas Sabonis, Renee Chang and co-authors!
- Reposted by Peter FineranA beautiful discovery by Joel Tan and Philip Kranzusch, out today in Nature: A DNA-gated molecular guard controls bacterial Hailong anti-phage defence Congrats Joel and Philip! Was a pleasure to contribute to this discovery together with Sarah Melamed www.nature.com/articles/s41...
- Reposted by Peter FineranPhD position available - plant-microbe-pollinator interactions in Kowhai flowers! With myself & Prof Jacqueline Beggs, based at Manaaki Whenua, Lincoln. Details below, or DM me! @microbiologysociety.org @evoldir.bsky.social @aucklanduni.bsky.social @microbiologynz.bsky.social
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- Reposted by Peter FineranNew postdoc position in our lab (2 y+): evolutionary genomics of integrons and MGEs with focus on vibrio-phage interactions. Great environment @pasteur.fr for science, career building. Super collaborators @celineloot.bsky.social @amazeld.bsky.social @fredoleroux.bsky.social 3 weeks to apply!
- Was my pleasure to chair the #crispr2025 meeting earlier this year in my hometown in NZ @crisprmeeting.bsky.social
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